m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00599)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
hsa-miR-193b
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
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Methyltransferase-like 3 (METTL3) [WRITER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | METTL3 modulates miR-193b mature process in an m6A-dependent manner. Reintroduction of hsa-miR-193b profoundly inhibits tumorigenesis of cervical cancer cells both in vivo and in vitro through CCND1 targeting. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Cervical cancer | ICD-11: 2C77 | ||
| In-vitro Model | SiHa | Cervical squamous cell carcinoma | Homo sapiens | CVCL_0032 |
| HeLa | Endocervical adenocarcinoma | Homo sapiens | CVCL_0030 | |
| In-vivo Model | Mice were divided into two groups (n = 4/group) randomly. 3×106 cells suspended in 200 uL PBS were administered via subcutaneous injection over the right flank region of nude mice. After the development of palpable tumors (average volume, 50 mm3), intratumoral injection of synthetic miR-193b, or negative control complexed with siPORT Amine transfection reagent (Ambion, USA) was given 6 times at a 4-day interval. | |||
Cervical cancer [ICD-11: 2C77]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | METTL3 modulates miR-193b mature process in an m6A-dependent manner. Reintroduction of hsa-miR-193b profoundly inhibits tumorigenesis of cervical cancer cells both in vivo and in vitro through CCND1 targeting. | |||
| Responsed Disease | Cervical cancer [ICD-11: 2C77] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| In-vitro Model | SiHa | Cervical squamous cell carcinoma | Homo sapiens | CVCL_0032 |
| HeLa | Endocervical adenocarcinoma | Homo sapiens | CVCL_0030 | |
| In-vivo Model | Mice were divided into two groups (n = 4/group) randomly. 3×106 cells suspended in 200 uL PBS were administered via subcutaneous injection over the right flank region of nude mice. After the development of palpable tumors (average volume, 50 mm3), intratumoral injection of synthetic miR-193b, or negative control complexed with siPORT Amine transfection reagent (Ambion, USA) was given 6 times at a 4-day interval. | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
RNA modification
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 5 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT00584 | ||
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | |
| Regulated Target | G1/S-specific cyclin-D1 (CCND1) | |
| Crosstalk relationship | m6A → A-to-I | |
| Crosstalk ID: M6ACROT00585 | ||
| Epigenetic Regulator | Y-box-binding protein 1 (YBX1) | |
| Regulated Target | G1/S-specific cyclin-D1 (CCND1) | |
| Crosstalk relationship | m6A → m5C | |
| Crosstalk ID: M6ACROT00586 | ||
| Epigenetic Regulator | Methylcytosine dioxygenase TET1 (TET1) | |
| Regulated Target | G1/S-specific cyclin-D1 (CCND1) | |
| Crosstalk relationship | m6A → m5C | |
| Crosstalk ID: M6ACROT00587 | ||
| Epigenetic Regulator | Fat mass and obesity-associated protein (FTO) | |
| Regulated Target | G1/S-specific cyclin-D1 (CCND1) | |
| Crosstalk relationship | m6A → m6Am | |
| Crosstalk ID: M6ACROT00588 | ||
| Epigenetic Regulator | Methyltransferase-like protein 1 (METTL1) | |
| Regulated Target | G1/S-specific cyclin-D1 (CCND1) | |
| Crosstalk relationship | m6A → m7G | |
Histone modification
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 2 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT03508 | ||
| Epigenetic Regulator | Histone acetyltransferase p300 (P300) | |
| Regulated Target | Histone H3 lysine 27 acetylation (H3K27ac) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Cervical cancer | |
| Crosstalk ID: M6ACROT03521 | ||
| Epigenetic Regulator | WD repeat-containing protein 5 (WDR5) | |
| Regulated Target | Histone H3 lysine 4 trimethylation (H3K4me3) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Cervical cancer | |
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05593 | ||
| Epigenetic Regulator | hsa-miR-193b | |
| Regulated Target | G1/S-specific cyclin-D1 (CCND1) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Cervical cancer | |