m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00572)

Target Name	Nucleophosmin (NPM1)
Synonyms	NPM; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin Click to Show/Hide
Gene Name	NPM1
Chromosomal Location	5q35.1
Family	Nucleoplasmin family
Function	Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes. Click to Show/Hide
Gene ID	4869
Uniprot ID	NPM_HUMAN
HGNC ID	HGNC:7910
KEGG ID	hsa:4869

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

NPM1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Fat mass and obesity-associated protein (FTO) [ERASER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by FTO*
Cell Line	NB4 cell line	Homo sapiens
Treatment: shFTO NB4 cells Control: shNS NB4 cells		GSE103494
Regulation		logFC: -7.88E-01 p-value: 1.66E-04
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	FTO depended on its m6A RNA demethylase activity to activate PDGFRB/ERK signaling axis. FTO-mediated m6A demethylation plays an oncogenic role in Nucleophosmin (NPM1)-mutated Acute myeloid leukemia(AML).
Target Regulation	Up regulation
Responsed Disease	Acute myeloid leukaemia		ICD-11: 2A60	Disease Info
In-vitro Model	OCI-AML-3	Adult acute myeloid leukemia	Homo sapiens	CVCL_1844
In-vitro Model	OCI-AML-2	Adult acute myeloid leukemia	Homo sapiens	CVCL_1619

Acute myeloid leukaemia [ICD-11: 2A60]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	FTO depended on its m6A RNA demethylase activity to activate PDGFRB/ERK signaling axis. FTO-mediated m6A demethylation plays an oncogenic role in Nucleophosmin (NPM1)-mutated Acute myeloid leukemia(AML).
Responsed Disease	Acute myeloid leukaemia [ICD-11: 2A60]
Target Regulator	Fat mass and obesity-associated protein (FTO)		ERASER	Regulator Info
Target Regulation	Up regulation
In-vitro Model	OCI-AML-3	Adult acute myeloid leukemia	Homo sapiens	CVCL_1844
In-vitro Model	OCI-AML-2	Adult acute myeloid leukemia	Homo sapiens	CVCL_1619

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00572)

Nucleophosmin (NPM1)

Adenosine-to-Inosine editing (A-to-I)

In total 14 m6A sequence/site(s) in this target gene
mod ID: A2ISITE001300		Click to Show/Hide the Full List
mod site	chr5:171395017-171395018:+		[2]
Sequence	GTGAAACCCGGTATCTACTAAAAATACAAAAATTAGCTGGG
Transcript ID List	ENST00000517671.5; ENST00000393820.2; ENST00000351986.10; ENST00000296930.9; rmsk_1825990; ENST00000521672.5
External Link	RMBase: RNA-editing_site_113599
mod ID: A2ISITE001301		Click to Show/Hide the Full List
mod site	chr5:171395018-171395019:+		[2]
Sequence	TGAAACCCGGTATCTACTAAAAATACAAAAATTAGCTGGGT
Transcript ID List	ENST00000296930.9; ENST00000393820.2; rmsk_1825990; ENST00000521672.5; ENST00000517671.5; ENST00000351986.10
External Link	RMBase: RNA-editing_site_113600
mod ID: A2ISITE001302		Click to Show/Hide the Full List
mod site	chr5:171396851-171396852:+		[3]
Sequence	GTGTGATGGTGGGCGCTTGCAATCCCAGCTGCTGGGGAGGC
Transcript ID List	ENST00000393820.2; ENST00000296930.9; rmsk_1825994; ENST00000521672.5; ENST00000351986.10; ENST00000517671.5
External Link	RMBase: RNA-editing_site_113601
mod ID: A2ISITE001303		Click to Show/Hide the Full List
mod site	chr5:171398636-171398637:+		[4]
Sequence	AAATTTTAGCTGGGCATGGTAGCGTGTGCCTGTAGTCCCAG
Transcript ID List	rmsk_1826000; ENST00000393820.2; ENST00000296930.9; ENST00000521672.5; ENST00000351986.10; ENST00000517671.5
External Link	RMBase: RNA-editing_site_113602
mod ID: A2ISITE001304		Click to Show/Hide the Full List
mod site	chr5:171401181-171401182:+		[2]
Sequence	AGCCCGGCCAACATCGTGAAACCCTGTCTTTACTAAAAACA
Transcript ID List	ENST00000519955.1; ENST00000517671.5; rmsk_1826009; ENST00000296930.9; ENST00000351986.10; ENST00000393820.2
External Link	RMBase: RNA-editing_site_113603
mod ID: A2ISITE001305		Click to Show/Hide the Full List
mod site	chr5:171401196-171401197:+		[2]
Sequence	GTGAAACCCTGTCTTTACTAAAAACACAAAAATTAGCCAGG
Transcript ID List	ENST00000517671.5; ENST00000519955.1; rmsk_1826009; ENST00000296930.9; ENST00000351986.10; ENST00000393820.2
External Link	RMBase: RNA-editing_site_113604
mod ID: A2ISITE001306		Click to Show/Hide the Full List
mod site	chr5:171401610-171401611:+		[3]
Sequence	CAGGCCCAGCGTATTTTTGTATTTTTGAGTAGAGATGGGGT
Transcript ID List	ENST00000519955.1; ENST00000296930.9; ENST00000393820.2; ENST00000351986.10; ENST00000517671.5
External Link	RMBase: RNA-editing_site_113605
mod ID: A2ISITE001307		Click to Show/Hide the Full List
mod site	chr5:171405129-171405130:+		[2]
Sequence	TTATTCCTTCCTTAAAGGAAAGATTTTAAGAACAAAATTAT
Transcript ID List	ENST00000517671.5; ENST00000393820.2; ENST00000519955.1; ENST00000351986.10; ENST00000296930.9
External Link	RMBase: RNA-editing_site_113606
mod ID: A2ISITE001308		Click to Show/Hide the Full List
mod site	chr5:171409330-171409331:+		[3]
Sequence	GATCTCTGGCTGGGCGTGGTAGTTCATGCCTATAATCCCAG
Transcript ID List	ENST00000351986.10; ENST00000296930.9; ENST00000517671.5; rmsk_1826024; ENST00000524204.1
External Link	RMBase: RNA-editing_site_113607
mod ID: A2ISITE001309		Click to Show/Hide the Full List
mod site	chr5:171409341-171409342:+		[2]
Sequence	GGGCGTGGTAGTTCATGCCTATAATCCCAGCACTTTGGGAG
Transcript ID List	ENST00000296930.9; ENST00000517671.5; rmsk_1826024; ENST00000524204.1; ENST00000351986.10
External Link	RMBase: RNA-editing_site_113608
mod ID: A2ISITE001310		Click to Show/Hide the Full List
mod site	chr5:171409395-171409396:+		[4]
Sequence	ACTCTGTCTCTACTAAAAATACTAAATTTAGCTGGGCATGG
Transcript ID List	rmsk_1826024; ENST00000296930.9; ENST00000517671.5; ENST00000351986.10; ENST00000524204.1
External Link	RMBase: RNA-editing_site_113609
mod ID: A2ISITE001311		Click to Show/Hide the Full List
mod site	chr5:171409780-171409781:+		[5]
Sequence	CCTCTTAAAGTGCTGGGATTACAGGCATGAGCCACCATGCC
Transcript ID List	ENST00000524204.1; ENST00000517671.5; ENST00000296930.9; ENST00000351986.10
External Link	RMBase: RNA-editing_site_113610
mod ID: A2ISITE001312		Click to Show/Hide the Full List
mod site	chr5:171409906-171409907:+		[5]
Sequence	TGGGCTCAGGCAGTCCTCCCACCTCAGCCTCCTGAGTAGCT
Transcript ID List	ENST00000517671.5; ENST00000524204.1; ENST00000351986.10; ENST00000296930.9
External Link	RMBase: RNA-editing_site_113611
mod ID: A2ISITE001313		Click to Show/Hide the Full List
mod site	chr5:171409923-171409924:+		[5]
Sequence	CCCACCTCAGCCTCCTGAGTAGCTGGGCCTCCTGTAGTTGC
Transcript ID List	ENST00000296930.9; ENST00000351986.10; ENST00000524204.1; ENST00000517671.5
External Link	RMBase: RNA-editing_site_113612

2'-O-Methylation (2'-O-Me)

In total 10 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000383		Click to Show/Hide the Full List
mod site	chr5:171391368-171391369:+		[6]
Sequence	AGCAGAGGCAATGAATTACGAAGGCAGTCCAATTAAAGTAA
Cell/Tissue List	HEK293
Seq Type List	RiboMeth-seq
Transcript ID List	ENST00000351986.10; ENST00000521260.1; ENST00000296930.9; ENST00000521672.5; ENST00000521710.1; ENST00000517671.5; ENST00000518587.1; ENST00000523622.1; ENST00000393820.2
External Link	RMBase: Nm_site_5595
mod ID: 2OMSITE000378		Click to Show/Hide the Full List
mod site	chr5:171387881-171387882:+		[11]
Sequence	GATTCCGTCCTGCGCGGTTGTTCTCTGGAGCAGCGTTCTTT
Cell/Tissue List	HEK293
Seq Type List	Nm-seq
Transcript ID List	ENST00000393820.2; ENST00000351986.10; ENST00000523622.1; ENST00000517671.5; ENST00000523339.1; ENST00000296930.9; ENST00000521672.5
External Link	RMBase: Nm_site_5590
mod ID: 2OMSITE000379		Click to Show/Hide the Full List
mod site	chr5:171387882-171387883:+		[11]
Sequence	ATTCCGTCCTGCGCGGTTGTTCTCTGGAGCAGCGTTCTTTT
Cell/Tissue List	HEK293
Seq Type List	Nm-seq
Transcript ID List	ENST00000523622.1; ENST00000517671.5; ENST00000393820.2; ENST00000523339.1; ENST00000351986.10; ENST00000296930.9; ENST00000521672.5
External Link	RMBase: Nm_site_5591
mod ID: 2OMSITE000380		Click to Show/Hide the Full List
mod site	chr5:171387884-171387885:+		[11]
Sequence	TCCGTCCTGCGCGGTTGTTCTCTGGAGCAGCGTTCTTTTAT
Cell/Tissue List	HEK293
Seq Type List	Nm-seq
Transcript ID List	ENST00000523622.1; ENST00000517671.5; ENST00000521672.5; ENST00000351986.10; ENST00000518587.1; ENST00000393820.2; ENST00000296930.9; ENST00000523339.1
External Link	RMBase: Nm_site_5592
mod ID: 2OMSITE000381		Click to Show/Hide the Full List
mod site	chr5:171387897-171387898:+		[11]
Sequence	GTTGTTCTCTGGAGCAGCGTTCTTTTATCTCCGTCCGCCTT
Cell/Tissue List	HEK293
Seq Type List	Nm-seq
Transcript ID List	ENST00000296930.9; ENST00000351986.10; ENST00000517671.5; ENST00000393820.2; ENST00000523339.1; ENST00000521672.5; ENST00000523622.1; ENST00000518587.1
External Link	RMBase: Nm_site_5593
mod ID: 2OMSITE000382		Click to Show/Hide the Full List
mod site	chr5:171387900-171387901:+		[11]
Sequence	GTTCTCTGGAGCAGCGTTCTTTTATCTCCGTCCGCCTTCTC
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000523339.1; ENST00000393820.2; ENST00000296930.9; ENST00000523622.1; ENST00000518587.1; ENST00000517671.5; ENST00000521672.5; ENST00000351986.10
External Link	RMBase: Nm_site_5594
mod ID: 2OMSITE000384		Click to Show/Hide the Full List
mod site	chr5:171391413-171391414:+		[11]
Sequence	GGCAACTTTGAAAATGTCTGTACAGCCAACGGTAAGGGCAC
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000517671.5; ENST00000521710.1; ENST00000521672.5; ENST00000296930.9; ENST00000351986.10; ENST00000518587.1; ENST00000393820.2; ENST00000521260.1
External Link	RMBase: Nm_site_5596
mod ID: 2OMSITE000385		Click to Show/Hide the Full List
mod site	chr5:171392763-171392764:+		[11]
Sequence	GGAGGAGGATGTGAAACTCTTAAGTATATCTGGAAAGCGGT
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000351986.10; ENST00000517671.5; ENST00000393820.2; ENST00000521672.5; ENST00000518587.1; ENST00000296930.9
External Link	RMBase: Nm_site_5597
mod ID: 2OMSITE000386		Click to Show/Hide the Full List
mod site	chr5:171405371-171405372:+		[11]
Sequence	ACCTAGTTCTGTAGAAGACATTAAAGCAAAAATGCAAGCAA
Cell/Tissue List	HEK293; HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000393820.2; ENST00000351986.10; ENST00000517671.5; ENST00000296930.9; ENST00000519955.1
External Link	RMBase: Nm_site_5598
mod ID: 2OMSITE000387		Click to Show/Hide the Full List
mod site	chr5:171405372-171405373:+		[11]
Sequence	CCTAGTTCTGTAGAAGACATTAAAGCAAAAATGCAAGCAAG
Cell/Tissue List	HEK293
Seq Type List	Nm-seq
Transcript ID List	ENST00000296930.9; ENST00000517671.5; ENST00000519955.1; ENST00000351986.10; ENST00000393820.2
External Link	RMBase: Nm_site_5599

5-methylcytidine (m5C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE003686		Click to Show/Hide the Full List
mod site	chr5:171388276-171388277:+
Sequence	GGGCCTGAGGTAAAGTGGAACCGGCCGCCTGGAAGTTCGGC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000517671.5; ENST00000518587.1; ENST00000521672.5; ENST00000523339.1; ENST00000296930.9; ENST00000523622.1; ENST00000351986.10; ENST00000393820.2
External Link	RMBase: m5C_site_36336

N6-methyladenosine (m6A)

In total 48 m6A sequence/site(s) in this target gene
mod ID: M6ASITE072609		Click to Show/Hide the Full List
mod site	chr5:171387789-171387790:+		[7]
Sequence	AGCACGCGCGCGGAGGCGGGACTTGGGAAGCGCTCGCGAGA
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000517671.5; ENST00000296930.9
External Link	RMBase: m6A_site_697307
mod ID: M6ASITE072610		Click to Show/Hide the Full List
mod site	chr5:171387964-171387965:+		[8]
Sequence	CCCGATGGAAGATTCGATGGACATGGACATGAGCCCCCTGA
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T; HepG2; MT4
Seq Type List	MAZTER-seq; m6A-seq; MeRIP-seq
Transcript ID List	ENST00000518587.1; ENST00000351986.10; ENST00000393820.2; ENST00000517671.5; ENST00000296930.9; ENST00000523339.1; ENST00000521672.5; ENST00000523622.1
External Link	RMBase: m6A_site_697308
mod ID: M6ASITE072611		Click to Show/Hide the Full List
mod site	chr5:171387970-171387971:+		[8]
Sequence	GGAAGATTCGATGGACATGGACATGAGCCCCCTGAGGCCCC
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T; HepG2; MT4
Seq Type List	MAZTER-seq; m6A-seq; MeRIP-seq
Transcript ID List	ENST00000521672.5; ENST00000351986.10; ENST00000517671.5; ENST00000523622.1; ENST00000393820.2; ENST00000296930.9; ENST00000518587.1; ENST00000523339.1
External Link	RMBase: m6A_site_697309
mod ID: M6ASITE072612		Click to Show/Hide the Full List
mod site	chr5:171387994-171387995:+		[9]
Sequence	GAGCCCCCTGAGGCCCCAGAACTATCTTTTCGGTAACTGCT
Motif Score	3.373380952
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000518587.1; ENST00000523339.1; ENST00000517671.5; ENST00000393820.2; ENST00000523622.1; ENST00000521672.5; ENST00000296930.9; ENST00000351986.10
External Link	RMBase: m6A_site_697310
mod ID: M6ASITE072613		Click to Show/Hide the Full List
mod site	chr5:171390057-171390058:+		[9]
Sequence	TCTTCATTTACAGGTTGTGAACTAAAGGCCGACAAAGATTA
Motif Score	3.373380952
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000518587.1; ENST00000296930.9; ENST00000523339.1; ENST00000351986.10; ENST00000521672.5; ENST00000517671.5; ENST00000523622.1; ENST00000393820.2
External Link	RMBase: m6A_site_697311
mod ID: M6ASITE072614		Click to Show/Hide the Full List
mod site	chr5:171390068-171390069:+		[8]
Sequence	AGGTTGTGAACTAAAGGCCGACAAAGATTATCACTTTAAGG
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000523622.1; ENST00000518587.1; ENST00000521672.5; ENST00000517671.5; ENST00000296930.9; ENST00000351986.10; ENST00000523339.1; ENST00000393820.2
External Link	RMBase: m6A_site_697312
mod ID: M6ASITE072615		Click to Show/Hide the Full List
mod site	chr5:171390138-171390139:+		[9]
Sequence	TCTTTAAGAACGGTACTTAAACTTTCAAAATAAACTACTTA
Motif Score	2.627720238
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000518587.1; ENST00000523622.1; ENST00000517671.5; ENST00000521672.5; ENST00000351986.10; ENST00000521260.1; ENST00000296930.9; ENST00000393820.2; ENST00000523339.1
External Link	RMBase: m6A_site_697313
mod ID: M6ASITE072616		Click to Show/Hide the Full List
mod site	chr5:171391266-171391267:+		[7]
Sequence	GGGGGTGTAAAATAGGTGGAACTCAAAAGTTGAAGTAGTAT
Motif Score	3.373380952
Cell/Tissue List	HeLa; MT4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000521672.5; ENST00000523622.1; ENST00000393820.2; ENST00000521260.1; ENST00000521710.1; ENST00000296930.9; ENST00000518587.1; ENST00000351986.10; ENST00000517671.5
External Link	RMBase: m6A_site_697314
mod ID: M6ASITE072617		Click to Show/Hide the Full List
mod site	chr5:171391338-171391339:+		[8]
Sequence	TGGTGCAAAGGATGAGTTGCACATTGTTGAAGCAGAGGCAA
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000351986.10; ENST00000393820.2; ENST00000521260.1; ENST00000523622.1; ENST00000521672.5; ENST00000517671.5; ENST00000296930.9; ENST00000521710.1; ENST00000518587.1
External Link	RMBase: m6A_site_697315
mod ID: M6ASITE072618		Click to Show/Hide the Full List
mod site	chr5:171391388-171391389:+		[8]
Sequence	AAGGCAGTCCAATTAAAGTAACACTGGCAACTTTGAAAATG
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000521710.1; ENST00000296930.9; ENST00000351986.10; ENST00000518587.1; ENST00000393820.2; ENST00000517671.5; ENST00000521260.1; ENST00000521672.5
External Link	RMBase: m6A_site_697316
mod ID: M6ASITE072619		Click to Show/Hide the Full List
mod site	chr5:171391729-171391730:+		[8]
Sequence	CCCTTGGGGGCTTTGAAATAACACCACCAGTGGTCTTAAGG
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000393820.2; ENST00000521260.1; ENST00000521710.1; ENST00000517671.5; ENST00000518587.1; ENST00000296930.9; ENST00000521672.5; ENST00000351986.10
External Link	RMBase: m6A_site_697317
mod ID: M6ASITE072620		Click to Show/Hide the Full List
mod site	chr5:171391785-171391786:+		[7]
Sequence	GGGCCAGTGCATATTAGTGGACAGCACTTAGTAGGTATGTT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; fibroblasts; A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000393820.2; ENST00000296930.9; ENST00000517671.5; ENST00000351986.10; ENST00000521672.5; ENST00000518587.1
External Link	RMBase: m6A_site_697318
mod ID: M6ASITE072621		Click to Show/Hide the Full List
mod site	chr5:171392758-171392759:+		[7]
Sequence	GAAGAGGAGGAGGATGTGAAACTCTTAAGTATATCTGGAAA
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; hNPCs; HEK293T; fibroblasts; A549; LCLs; H1299; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000521672.5; ENST00000296930.9; ENST00000517671.5; ENST00000518587.1; ENST00000393820.2; ENST00000351986.10
External Link	RMBase: m6A_site_697319
mod ID: M6ASITE072622		Click to Show/Hide the Full List
mod site	chr5:171392873-171392874:+		[7]
Sequence	GCTTTTAGTTTGGTGATAGAACAGCTCTTGTTCATGAGTAC
Motif Score	2.951386905
Cell/Tissue List	HeLa; BGC823; HepG2; hNPCs; HEK293T; fibroblasts; A549; LCLs; H1299; MM6; Huh7; Jurkat
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000517671.5; ENST00000296930.9; ENST00000518587.1; ENST00000393820.2; ENST00000351986.10; ENST00000521672.5
External Link	RMBase: m6A_site_697320
mod ID: M6ASITE072623		Click to Show/Hide the Full List
mod site	chr5:171392924-171392925:+		[7]
Sequence	TTTTAAAAGAAAAAAGTAAAACTTGCTGCTGATGAAGATGA
Motif Score	2.627720238
Cell/Tissue List	HeLa; BGC823; HepG2; hNPCs; HEK293T; fibroblasts; A549; LCLs; H1299; MM6; Huh7; Jurkat; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000296930.9; ENST00000351986.10; ENST00000521672.5; ENST00000393820.2; ENST00000518587.1; ENST00000517671.5
External Link	RMBase: m6A_site_697321
mod ID: M6ASITE072624		Click to Show/Hide the Full List
mod site	chr5:171400808-171400809:+		[7]
Sequence	CACTGTTGTTGGGGTCAGGGACAGTGATTAAGATAAATTTC
Motif Score	3.643047619
Cell/Tissue List	HeLa; BGC823; HepG2; hNPCs; HEK293T; fibroblasts; A549; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000517671.5; ENST00000351986.10; ENST00000296930.9; ENST00000393820.2; ENST00000519955.1
External Link	RMBase: m6A_site_697322
mod ID: M6ASITE072625		Click to Show/Hide the Full List
mod site	chr5:171400867-171400868:+		[8]
Sequence	GATACTCCAGCCAAAAATGCACAAAAGTCAAATCAGAATGG
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000296930.9; ENST00000519955.1; ENST00000393820.2; ENST00000351986.10; ENST00000517671.5
External Link	RMBase: m6A_site_697323
mod ID: M6ASITE072626		Click to Show/Hide the Full List
mod site	chr5:171400893-171400894:+		[7]
Sequence	GTCAAATCAGAATGGAAAAGACTCAAAACCATCATCAACAC
Motif Score	3.319380952
Cell/Tissue List	HeLa; BGC823; HepG2; hNPCs; HEK293T; fibroblasts; A549; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000393820.2; ENST00000296930.9; ENST00000517671.5; ENST00000519955.1; ENST00000351986.10
External Link	RMBase: m6A_site_697324
mod ID: M6ASITE072627		Click to Show/Hide the Full List
mod site	chr5:171400900-171400901:+		[7]
Sequence	CAGAATGGAAAAGACTCAAAACCATCATCAACACCAAGATC
Motif Score	2.185083333
Cell/Tissue List	HeLa; BGC823; HepG2; hNPCs; HEK293T; fibroblasts; A549; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000517671.5; ENST00000296930.9; ENST00000393820.2; ENST00000351986.10; ENST00000519955.1
External Link	RMBase: m6A_site_697325
mod ID: M6ASITE072628		Click to Show/Hide the Full List
mod site	chr5:171400910-171400911:+		[8]
Sequence	AAGACTCAAAACCATCATCAACACCAAGATCAAAAGTAAGT
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000519955.1; ENST00000351986.10; ENST00000517671.5; ENST00000393820.2; ENST00000296930.9
External Link	RMBase: m6A_site_697326
mod ID: M6ASITE072629		Click to Show/Hide the Full List
mod site	chr5:171405303-171405304:+		[7]
Sequence	AATTCATTTCTTTTTCAGGGACAAGAATCCTTCAAGAAACA
Motif Score	3.643047619
Cell/Tissue List	HeLa; hESC-HEK293T; BGC823; HepG2; hNPCs; fibroblasts; A549; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; endometrial; GSCs; AML
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000296930.9; ENST00000351986.10; ENST00000519955.1; ENST00000393820.2; ENST00000517671.5
External Link	RMBase: m6A_site_697327
mod ID: M6ASITE072630		Click to Show/Hide the Full List
mod site	chr5:171405321-171405322:+		[7]
Sequence	GGACAAGAATCCTTCAAGAAACAGGAAAAAACTCCTAAAAC
Motif Score	2.20572619
Cell/Tissue List	HeLa; liver; hESC-HEK293T; HepG2; hNPCs; fibroblasts; A549; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; endometrial; GSCs
Seq Type List	m6A-seq; m6A-REF-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000519955.1; ENST00000517671.5; ENST00000351986.10; ENST00000296930.9; ENST00000393820.2
External Link	RMBase: m6A_site_697328
mod ID: M6ASITE072631		Click to Show/Hide the Full List
mod site	chr5:171405331-171405332:+		[7]
Sequence	CCTTCAAGAAACAGGAAAAAACTCCTAAAACACCAAAAGGA
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; HepG2; hNPCs; fibroblasts; A549; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; endometrial; GSCs
Seq Type List	m6A-seq; DART-seq; MeRIP-seq
Transcript ID List	ENST00000393820.2; ENST00000351986.10; ENST00000296930.9; ENST00000517671.5; ENST00000519955.1
External Link	RMBase: m6A_site_697329
mod ID: M6ASITE072632		Click to Show/Hide the Full List
mod site	chr5:171405340-171405341:+		[7]
Sequence	AACAGGAAAAAACTCCTAAAACACCAAAAGGACCTAGTTCT
Motif Score	2.20572619
Cell/Tissue List	HeLa; hESC-HEK293T; HepG2; hNPCs; fibroblasts; A549; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; endometrial; GSCs
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000393820.2; ENST00000351986.10; ENST00000296930.9; ENST00000519955.1; ENST00000517671.5
External Link	RMBase: m6A_site_697330
mod ID: M6ASITE072633		Click to Show/Hide the Full List
mod site	chr5:171405342-171405343:+		[10]
Sequence	CAGGAAAAAACTCCTAAAACACCAAAAGGACCTAGTTCTGT
Motif Score	2.064285714
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000393820.2; ENST00000517671.5; ENST00000351986.10; ENST00000296930.9; ENST00000519955.1
External Link	RMBase: m6A_site_697331
mod ID: M6ASITE072634		Click to Show/Hide the Full List
mod site	chr5:171405351-171405352:+		[7]
Sequence	ACTCCTAAAACACCAAAAGGACCTAGTTCTGTAGAAGACAT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; hNPCs; HEK293T; fibroblasts; A549; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000517671.5; ENST00000519955.1; ENST00000296930.9; ENST00000393820.2; ENST00000351986.10
External Link	RMBase: m6A_site_697332
mod ID: M6ASITE072635		Click to Show/Hide the Full List
mod site	chr5:171405368-171405369:+		[7]
Sequence	AGGACCTAGTTCTGTAGAAGACATTAAAGCAAAAATGCAAG
Motif Score	2.897386905
Cell/Tissue List	HeLa; hESC-HEK293T; HepG2; hNPCs; fibroblasts; A549; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; endometrial; GSCs
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000519955.1; ENST00000393820.2; ENST00000351986.10; ENST00000517671.5; ENST00000296930.9
External Link	RMBase: m6A_site_697333
mod ID: M6ASITE072636		Click to Show/Hide the Full List
mod site	chr5:171405426-171405427:+		[7]
Sequence	AGTAAAGTTATCTTAAAAAAACTTTGTCTCCCCCCTCAAAT
Motif Score	2.627720238
Cell/Tissue List	HeLa; hNPCs; HEK293T; fibroblasts; A549; LCLs; H1299; Huh7; Jurkat; CD4T; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000517671.5; ENST00000296930.9; ENST00000393820.2; ENST00000351986.10; ENST00000519955.1
External Link	RMBase: m6A_site_697334
mod ID: M6ASITE072637		Click to Show/Hide the Full List
mod site	chr5:171405469-171405470:+		[7]
Sequence	CACGTGTCTGGTTTGCATAGACTTGAATGTTTCTTGTTTTT
Motif Score	3.319380952
Cell/Tissue List	HeLa; hNPCs; HEK293T; fibroblasts; LCLs; H1299; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000517671.5; ENST00000393820.2; ENST00000519955.1; ENST00000296930.9; ENST00000351986.10
External Link	RMBase: m6A_site_697335
mod ID: M6ASITE072638		Click to Show/Hide the Full List
mod site	chr5:171405692-171405693:+		[7]
Sequence	GTTAAAATAGATCAGTGAAAACCCTTTGCCTATTCTGGTTG
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; fibroblasts; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000296930.9; ENST00000517671.5; ENST00000393820.2; ENST00000351986.10; ENST00000519955.1
External Link	RMBase: m6A_site_697336
mod ID: M6ASITE072639		Click to Show/Hide the Full List
mod site	chr5:171405729-171405730:+		[7]
Sequence	GTTGTAAGATATGCTAGAGAACCAACAGAGGGCGTATGAGA
Motif Score	2.930744048
Cell/Tissue List	HeLa; hNPCs; HEK293T; fibroblasts; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000351986.10; ENST00000296930.9; ENST00000393820.2; ENST00000517671.5; ENST00000519955.1
External Link	RMBase: m6A_site_697337
mod ID: M6ASITE072640		Click to Show/Hide the Full List
mod site	chr5:171406405-171406406:+		[7]
Sequence	TTTAATTGCAGGCGCATTGAACAGTCCTGGGCACTACATGT
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; hNPCs; fibroblasts; Huh7
Seq Type List	m6A-seq; DART-seq; MeRIP-seq
Transcript ID List	ENST00000393820.2; ENST00000517671.5; ENST00000296930.9; ENST00000351986.10
External Link	RMBase: m6A_site_697338
mod ID: M6ASITE072641		Click to Show/Hide the Full List
mod site	chr5:171406420-171406421:+		[10]
Sequence	ATTGAACAGTCCTGGGCACTACATGTAAATTAAGCCCAAAG
Motif Score	2.078666667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000351986.10; ENST00000296930.9; ENST00000393820.2; ENST00000517671.5
External Link	RMBase: m6A_site_697339
mod ID: M6ASITE072642		Click to Show/Hide the Full List
mod site	chr5:171406464-171406465:+		[7]
Sequence	GGGAGAAAGGAAAAGGAGAGACAAATATAGTCCATACTGAG
Motif Score	2.897386905
Cell/Tissue List	HeLa; hNPCs; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000296930.9; ENST00000393820.2; ENST00000517671.5; ENST00000351986.10
External Link	RMBase: m6A_site_697340
mod ID: M6ASITE072643		Click to Show/Hide the Full List
mod site	chr5:171406502-171406503:+		[7]
Sequence	GAGTGTCATCAACAATCCAGACTGAAGTCTTCTATTTTAAT
Motif Score	3.319380952
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000351986.10; ENST00000296930.9; ENST00000393820.2; ENST00000517671.5
External Link	RMBase: m6A_site_697341
mod ID: M6ASITE072644		Click to Show/Hide the Full List
mod site	chr5:171406570-171406571:+		[7]
Sequence	CATGCCTCTTCAGGCTGGAAACAATCTCTTGGTTCCCTAAA
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000351986.10; ENST00000517671.5; ENST00000393820.2; ENST00000296930.9
External Link	RMBase: m6A_site_697342
mod ID: M6ASITE072645		Click to Show/Hide the Full List
mod site	chr5:171406622-171406623:+		[7]
Sequence	TGACTGCTGTGATTCAGTGAACCTTGCCCTTTGCTTTCTAT
Motif Score	2.930744048
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000393820.2; ENST00000351986.10; ENST00000296930.9; ENST00000517671.5
External Link	RMBase: m6A_site_697343
mod ID: M6ASITE072646		Click to Show/Hide the Full List
mod site	chr5:171406644-171406645:+		[10]
Sequence	CTTGCCCTTTGCTTTCTATTACTTGTGCATTTGCCTCACCT
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000517671.5; ENST00000296930.9; ENST00000351986.10; ENST00000393820.2
External Link	RMBase: m6A_site_697344
mod ID: M6ASITE072647		Click to Show/Hide the Full List
mod site	chr5:171406666-171406667:+		[10]
Sequence	TTGTGCATTTGCCTCACCTGACAATGTTTTAAATCGCCTTT
Motif Score	2.859755952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000517671.5; ENST00000351986.10; ENST00000296930.9; ENST00000393820.2
External Link	RMBase: m6A_site_697345
mod ID: M6ASITE072648		Click to Show/Hide the Full List
mod site	chr5:171407187-171407188:+		[10]
Sequence	GTGATTAGTGAAATGTAATTACTGTAATTTTTTCCCCATTC
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000296930.9; ENST00000517671.5; ENST00000351986.10
External Link	RMBase: m6A_site_697346
mod ID: M6ASITE072649		Click to Show/Hide the Full List
mod site	chr5:171410578-171410579:+		[10]
Sequence	TCTTTAAGAAAATAGTTTAAACAATTTGTTAAAAAATTTTC
Motif Score	2.20572619
Cell/Tissue List	HEK293T; hESC-HEK293T; hNPCs; fibroblasts; H1299
Seq Type List	DART-seq; MAZTER-seq; m6A-seq
Transcript ID List	ENST00000524204.1; ENST00000351986.10; ENST00000517671.5; ENST00000296930.9
External Link	RMBase: m6A_site_697347
mod ID: M6ASITE072650		Click to Show/Hide the Full List
mod site	chr5:171410619-171410620:+		[10]
Sequence	CGTCTTATTTCATTTCTGTAACAGTTGATATCTGGCTGTCC
Motif Score	2.168095238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000351986.10; ENST00000524204.1; ENST00000517671.5; ENST00000296930.9
External Link	RMBase: m6A_site_697348
mod ID: M6ASITE072651		Click to Show/Hide the Full List
mod site	chr5:171410750-171410751:+		[7]
Sequence	GTTTAGTTTTTAAAGATGGAACTCCACCCTTTGCTTGGTTT
Motif Score	3.373380952
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000517671.5; ENST00000351986.10; ENST00000296930.9; ENST00000524204.1
External Link	RMBase: m6A_site_697349
mod ID: M6ASITE072652		Click to Show/Hide the Full List
mod site	chr5:171410798-171410799:+		[7]
Sequence	GTATGGAATGTTATGATAGGACATAGTAGTAGCGGTGGTCA
Motif Score	3.643047619
Cell/Tissue List	HeLa; hESC-HEK293T; Huh7
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000524204.1; ENST00000351986.10; ENST00000517671.5; ENST00000296930.9
External Link	RMBase: m6A_site_697350
mod ID: M6ASITE072653		Click to Show/Hide the Full List
mod site	chr5:171410820-171410821:+		[7]
Sequence	ATAGTAGTAGCGGTGGTCAGACATGGAAATGGTGGGGAGAC
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; Huh7
Seq Type List	m6A-seq; DART-seq; MeRIP-seq
Transcript ID List	ENST00000296930.9; ENST00000351986.10; ENST00000524204.1; ENST00000517671.5
External Link	RMBase: m6A_site_697351
mod ID: M6ASITE072654		Click to Show/Hide the Full List
mod site	chr5:171410839-171410840:+		[7]
Sequence	GACATGGAAATGGTGGGGAGACAAAAATATACATGTGAAAT
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; Huh7
Seq Type List	m6A-seq; DART-seq; MeRIP-seq
Transcript ID List	ENST00000351986.10; ENST00000524204.1; ENST00000517671.5; ENST00000296930.9
External Link	RMBase: m6A_site_697352
mod ID: M6ASITE072655		Click to Show/Hide the Full List
mod site	chr5:171410849-171410850:+		[10]
Sequence	TGGTGGGGAGACAAAAATATACATGTGAAATAAAACTCAGT
Motif Score	2.110482143
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000524204.1; ENST00000517671.5; ENST00000296930.9; ENST00000351986.10
External Link	RMBase: m6A_site_697353
mod ID: M6ASITE072656		Click to Show/Hide the Full List
mod site	chr5:171410863-171410864:+		[7]
Sequence	AAATATACATGTGAAATAAAACTCAGTATTTTAATAAAGTA
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; Huh7
Seq Type List	m6A-seq; DART-seq; MeRIP-seq
Transcript ID List	ENST00000296930.9; ENST00000517671.5; ENST00000524204.1; ENST00000351986.10
External Link	RMBase: m6A_site_697354

Pseudouridine (Pseudo)

In total 1 m6A sequence/site(s) in this target gene
mod ID: PSESITE000221		Click to Show/Hide the Full List
mod site	chr5:171391344-171391345:+		[12]
Sequence	AAAGGATGAGTTGCACATTGTTGAAGCAGAGGCAATGAATT
Transcript ID List	ENST00000351986.10; ENST00000296930.9; ENST00000393820.2; ENST00000521260.1; ENST00000521710.1; ENST00000523622.1; ENST00000517671.5; ENST00000518587.1; ENST00000521672.5
External Link	RMBase: Pseudo_site_3985

Ref 1	Mutant NPM1-Regulated FTO-Mediated m(6)A Demethylation Promotes Leukemic Cell Survival via PDGFRB/ERK Signaling Axis. Front Oncol. 2022 Feb 8;12:817584. doi: 10.3389/fonc.2022.817584. eCollection 2022.
Ref 2	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 3	Accurate identification of A-to-I RNA editing in human by transcriptome sequencing. Genome Res. 2012 Jan;22(1):142-50. doi: 10.1101/gr.124107.111. Epub 2011 Sep 29.
Ref 4	Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome. Nat Biotechnol. 2012 Feb 12;30(3):253-60. doi: 10.1038/nbt.2122.
Ref 5	Systematic identification of abundant A-to-I editing sites in the human transcriptome. Nat Biotechnol. 2004 Aug;22(8):1001-5. doi: 10.1038/nbt996. Epub 2004 Jul 18.
Ref 6	High-throughput identification of C/D box snoRNA targets with CLIP and RiboMeth-seq. Nucleic Acids Res. 2017 Mar 17;45(5):2341-2353. doi: 10.1093/nar/gkw1321.
Ref 7	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 8	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 9	Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.
Ref 10	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 11	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.
Ref 12	Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome. Nat Chem Biol. 2015 Aug;11(8):592-7. doi: 10.1038/nchembio.1836. Epub 2015 Jun 15.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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