m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00572)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
NPM1
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Fat mass and obesity-associated protein (FTO) [ERASER]
Representative RNA-seq result indicating the expression of this target gene regulated by FTO | ||
Cell Line | NB4 cell line | Homo sapiens |
Treatment: shFTO NB4 cells
Control: shNS NB4 cells
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GSE103494 | |
Regulation |
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logFC: -7.88E-01 p-value: 1.66E-04 |
More Results | Click to View More RNA-seq Results |
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | FTO depended on its m6A RNA demethylase activity to activate PDGFRB/ERK signaling axis. FTO-mediated m6A demethylation plays an oncogenic role in Nucleophosmin (NPM1)-mutated Acute myeloid leukemia(AML). | |||
Target Regulation | Up regulation | |||
Responsed Disease | Acute myeloid leukaemia | ICD-11: 2A60 | ||
In-vitro Model | OCI-AML-3 | Adult acute myeloid leukemia | Homo sapiens | CVCL_1844 |
OCI-AML-2 | Adult acute myeloid leukemia | Homo sapiens | CVCL_1619 | |
Acute myeloid leukaemia [ICD-11: 2A60]
In total 1 item(s) under this disease | ||||
Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | FTO depended on its m6A RNA demethylase activity to activate PDGFRB/ERK signaling axis. FTO-mediated m6A demethylation plays an oncogenic role in Nucleophosmin (NPM1)-mutated Acute myeloid leukemia(AML). | |||
Responsed Disease | Acute myeloid leukaemia [ICD-11: 2A60] | |||
Target Regulator | Fat mass and obesity-associated protein (FTO) | ERASER | ||
Target Regulation | Up regulation | |||
In-vitro Model | OCI-AML-3 | Adult acute myeloid leukemia | Homo sapiens | CVCL_1844 |
OCI-AML-2 | Adult acute myeloid leukemia | Homo sapiens | CVCL_1619 | |