m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00552)
Target Name | miR-17-92 | ||||
---|---|---|---|---|---|
Gene Name | MIR17-92 |
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MIR17-92
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | In gastric cancer, m6A facilitated processing of pri-miR-17-92 into the miR-17-92 cluster through an m6A/DGCR8-dependent mechanism. METTL3-high tumors showed preferred sensitivity to an mTOR inhibitor, everolimus. | |||
Target Regulation | Up regulation | |||
Responsed Disease | Gastric cancer | ICD-11: 2B72 | ||
Responsed Drug | Everolimus | Approved | ||
Pathway Response | mTOR signaling pathway | hsa04150 | ||
PI3K-Akt signaling pathway | hsa04151 | |||
Cell Process | miRNA maturation | |||
In-vitro Model | MKN45 | Gastric adenocarcinoma | Homo sapiens | CVCL_0434 |
HGC-27 | Gastric carcinoma | Homo sapiens | CVCL_1279 | |
AGS | Gastric adenocarcinoma | Homo sapiens | CVCL_0139 | |
In-vivo Model | For subcutaneous xenograft models, 0.1 mL of cell suspension containing 106 cells were injected subcutaneously into the right flank of mice (n = 6 for each group). | |||
Gastric cancer [ICD-11: 2B72]
In total 1 item(s) under this disease | ||||
Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | In gastric cancer, m6A facilitated processing of pri-miR-17-92 into the miR-17-92 cluster through an m6A/DGCR8-dependent mechanism. METTL3-high tumors showed preferred sensitivity to an mTOR inhibitor, everolimus. | |||
Responsed Disease | Gastric cancer [ICD-11: 2B72] | |||
Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
Target Regulation | Up regulation | |||
Responsed Drug | Everolimus | Approved | ||
Pathway Response | mTOR signaling pathway | hsa04150 | ||
PI3K-Akt signaling pathway | hsa04151 | |||
Cell Process | miRNA maturation | |||
In-vitro Model | MKN45 | Gastric adenocarcinoma | Homo sapiens | CVCL_0434 |
HGC-27 | Gastric carcinoma | Homo sapiens | CVCL_1279 | |
AGS | Gastric adenocarcinoma | Homo sapiens | CVCL_0139 | |
In-vivo Model | For subcutaneous xenograft models, 0.1 mL of cell suspension containing 106 cells were injected subcutaneously into the right flank of mice (n = 6 for each group). | |||
Everolimus
[Approved]
In total 1 item(s) under this drug | ||||
Experiment 1 Reporting the m6A-centered Drug Response | [1] | |||
Response Summary | In gastric cancer, m6A facilitated processing of pri-miR-17-92 into the miR-17-92 cluster through an m6A/DGCR8-dependent mechanism. METTL3-high tumors showed preferred sensitivity to an mTOR inhibitor, everolimus. | |||
Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
Target Regulation | Up regulation | |||
Responsed Disease | Gastric cancer | ICD-11: 2B72 | ||
Pathway Response | mTOR signaling pathway | hsa04150 | ||
PI3K-Akt signaling pathway | hsa04151 | |||
Cell Process | miRNA maturation | |||
In-vitro Model | MKN45 | Gastric adenocarcinoma | Homo sapiens | CVCL_0434 |
HGC-27 | Gastric carcinoma | Homo sapiens | CVCL_1279 | |
AGS | Gastric adenocarcinoma | Homo sapiens | CVCL_0139 | |
In-vivo Model | For subcutaneous xenograft models, 0.1 mL of cell suspension containing 106 cells were injected subcutaneously into the right flank of mice (n = 6 for each group). | |||