m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00546)

Target Name	A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9)
Synonyms	ADAM-TS 9; ADAM-TS9; ADAMTS-9 Click to Show/Hide
Gene Name	ADAMTS9
Chromosomal Location	3p14.1
Function	Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-\|-Ala-1839' site) and versican (at the '1428-Glu-\|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. Click to Show/Hide
Gene ID	56999
Uniprot ID	ATS9_HUMAN
HGNC ID	HGNC:13202
KEGG ID	hsa:56999

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

ADAMTS9 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL3*
Cell Line	HUVEC cell line	Homo sapiens
Treatment: shMETTL3 HUVEC cells Control: shScramble HUVEC cells		GSE157544
Regulation		logFC: 8.11E-01 p-value: 4.51E-05
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	METTL3 facilitates GC progression through the A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9)-mediated PI3K/AKT pathway.
Target Regulation	Down regulation
Responsed Disease	Gastric cancer		ICD-11: 2B72	Disease Info
Pathway Response	PI3K-Akt signaling pathway			hsa04151
Cell Process	RNA stability
In-vitro Model	HGC-27	Gastric carcinoma	Homo sapiens	CVCL_1279
In-vitro Model	AGS	Gastric adenocarcinoma	Homo sapiens	CVCL_0139
In-vivo Model	For the formation of xenograft tumors, 5 × 10⁶ AGS cells mixed in Matrigel (BD Biosciences, Franklin Lakes, NJ, USA) were subcutaneously injected into BALB/c nude mice (5-week-old male).

Gastric cancer [ICD-11: 2B72]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	METTL3 facilitates GC progression through the A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9)-mediated PI3K/AKT pathway.
Responsed Disease	Gastric cancer [ICD-11: 2B72]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Down regulation
Pathway Response	PI3K-Akt signaling pathway			hsa04151
Cell Process	RNA stability
In-vitro Model	HGC-27	Gastric carcinoma	Homo sapiens	CVCL_1279
In-vitro Model	AGS	Gastric adenocarcinoma	Homo sapiens	CVCL_0139
In-vivo Model	For the formation of xenograft tumors, 5 × 10⁶ AGS cells mixed in Matrigel (BD Biosciences, Franklin Lakes, NJ, USA) were subcutaneously injected into BALB/c nude mice (5-week-old male).

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Histone modification

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03655		Crosstalk Info
Epigenetic Regulator	Histone-lysine N-methyltransferase EZH2 (EZH2)
Regulated Target	Histone H3 lysine 27 trimethylation (H3K27me3)
Crosstalk relationship	Histone modification → m6A
Disease	Gastric cancer	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00546)

A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9)

Adenosine-to-Inosine editing (A-to-I)

In total 2 m6A sequence/site(s) in this target gene
mod ID: A2ISITE011980		Click to Show/Hide the Full List
mod site	chr3:64532110-64532111:-		[2]
Sequence	TCTCACCGTGGGTGTATAGTAGAATCACCTGAGGAATTTTT
Transcript ID List	ENST00000498707.5; ENST00000295903.8; ENST00000481060.2; ENST00000467257.5; rmsk_988251
External Link	RMBase: RNA-editing_site_97769
mod ID: A2ISITE011981		Click to Show/Hide the Full List
mod site	chr3:64631829-64631830:-		[2]
Sequence	TCATGCAAAACAGTGGCAGGAACATTTAATACAGTACATTA
Transcript ID List	ENST00000482490.5; ENST00000295903.8; ENST00000475557.5; ENST00000498707.5
External Link	RMBase: RNA-editing_site_97770

N6-methyladenosine (m6A)

In total 57 m6A sequence/site(s) in this target gene
mod ID: M6ASITE061654		Click to Show/Hide the Full List
mod site	chr3:64515766-64515767:-		[3]
Sequence	GCAGTATTCTCCAACTCCAAACAAGCTCTAGAGTGCTCCAG
Motif Score	2.20572619
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000477180.1; ENST00000498707.5
External Link	RMBase: m6A_site_597215
mod ID: M6ASITE061655		Click to Show/Hide the Full List
mod site	chr3:64515810-64515811:-		[3]
Sequence	AACCCTGCCCACTTCCAAAGACCAAAGAGATTAGGAAAAGC
Motif Score	2.876744048
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000498707.5; ENST00000477180.1
External Link	RMBase: m6A_site_597216
mod ID: M6ASITE061656		Click to Show/Hide the Full List
mod site	chr3:64515829-64515830:-		[3]
Sequence	GAAGACACTTGGTTTGAGAAACCCTGCCCACTTCCAAAGAC
Motif Score	2.185083333
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000295903.8; ENST00000498707.5; ENST00000477180.1
External Link	RMBase: m6A_site_597217
mod ID: M6ASITE061657		Click to Show/Hide the Full List
mod site	chr3:64515845-64515846:-		[3]
Sequence	TTGCCAATGGCCCATGGAAGACACTTGGTTTGAGAAACCCT
Motif Score	2.897386905
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000498707.5; ENST00000477180.1; ENST00000295903.8
External Link	RMBase: m6A_site_597218
mod ID: M6ASITE061658		Click to Show/Hide the Full List
mod site	chr3:64515993-64515994:-		[4]
Sequence	ACGTTTGTGTGAAGAAATGAACTGTGGAGTACAAAATGCTT
Motif Score	3.373380952
Cell/Tissue List	HEK293T; A549; H1B; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; GSCs
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000477180.1; ENST00000498707.5; ENST00000295903.8
External Link	RMBase: m6A_site_597219
mod ID: M6ASITE061659		Click to Show/Hide the Full List
mod site	chr3:64516013-64516014:-		[5]
Sequence	CATGCCCGCTGCAGTAATGGACGTTTGTGTGAAGAAATGAA
Motif Score	3.616982143
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000498707.5; ENST00000477180.1; ENST00000295903.8
External Link	RMBase: m6A_site_597220
mod ID: M6ASITE061660		Click to Show/Hide the Full List
mod site	chr3:64516049-64516050:-		[6]
Sequence	CTCTTCAGGCCATGAGCCTAACACCCTGCCGGTTTTCATGC
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000295903.8; ENST00000498707.5; ENST00000477180.1
External Link	RMBase: m6A_site_597221
mod ID: M6ASITE061661		Click to Show/Hide the Full List
mod site	chr3:64516091-64516092:-		[7]
Sequence	CGATTGCCTTTTGCATGAAAACATCGGCTGGTGATGTGACT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; kidney; A549; H1B; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; GSCs
Seq Type List	MeRIP-seq; m6A-REF-seq; m6A-seq
Transcript ID List	ENST00000498707.5; ENST00000295903.8; ENST00000477180.1
External Link	RMBase: m6A_site_597222
mod ID: M6ASITE061662		Click to Show/Hide the Full List
mod site	chr3:64516130-64516131:-		[4]
Sequence	CACACCTGGAGAAATTCAGAACCAGGTTCTGAATCATCACG
Motif Score	2.930744048
Cell/Tissue List	HEK293T; A549; hNPCs; Huh7; GSC-11; iSLK; TIME; endometrial; HEC-1-A; GSCs
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000295903.8; ENST00000498707.5; ENST00000477180.1
External Link	RMBase: m6A_site_597223
mod ID: M6ASITE061663		Click to Show/Hide the Full List
mod site	chr3:64516191-64516192:-		[8]
Sequence	CCAAGTTTACCAGTAGAAAGACACAGGATGCACAGAATGGG
Motif Score	2.897386905
Cell/Tissue List	HEK293T; hNPCs; A549; Huh7; TIME; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000498707.5; ENST00000295903.8; ENST00000477180.1
External Link	RMBase: m6A_site_597224
mod ID: M6ASITE061664		Click to Show/Hide the Full List
mod site	chr3:64516309-64516310:-		[7]
Sequence	CACGGTGCCTTGGTCTCTCCACAATCAAATGGAGGATCCCC
Motif Score	2.053113095
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000498707.5; ENST00000295903.8; ENST00000477180.1
External Link	RMBase: m6A_site_597225
mod ID: M6ASITE061665		Click to Show/Hide the Full List
mod site	chr3:64516377-64516378:-		[8]
Sequence	CTTTTTTGGAAGAGACTTAGACTTTATCCTTATTGTTGTTA
Motif Score	3.319380952
Cell/Tissue List	HEK293T; U2OS; A549; Huh7; iSLK; MSC; TIME; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000498707.5; ENST00000295903.8; ENST00000477180.1
External Link	RMBase: m6A_site_597226
mod ID: M6ASITE061666		Click to Show/Hide the Full List
mod site	chr3:64516383-64516384:-		[8]
Sequence	ATATGCCTTTTTTGGAAGAGACTTAGACTTTATCCTTATTG
Motif Score	3.319380952
Cell/Tissue List	HEK293T; U2OS; A549; Huh7; iSLK; MSC; TIME; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000477180.1; ENST00000295903.8; ENST00000498707.5
External Link	RMBase: m6A_site_597227
mod ID: M6ASITE061667		Click to Show/Hide the Full List
mod site	chr3:64516428-64516429:-		[8]
Sequence	AATCACTTGGATGAAATAAGACCAGCTCTTTACCCTTATTT
Motif Score	2.876744048
Cell/Tissue List	HEK293T; U2OS; A549; Huh7; iSLK; MSC; TIME; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000498707.5; ENST00000295903.8; ENST00000477180.1
External Link	RMBase: m6A_site_597228
mod ID: M6ASITE061668		Click to Show/Hide the Full List
mod site	chr3:64516466-64516467:-		[7]
Sequence	TGAAAGGGAGGAACGGAAGGACAATTTCCAGTGCACAGAAT
Motif Score	3.643047619
Cell/Tissue List	HEK293T; kidney; A549; Huh7; iSLK
Seq Type List	MeRIP-seq; m6A-REF-seq; m6A-seq
Transcript ID List	ENST00000295903.8; ENST00000498707.5; ENST00000477180.1
External Link	RMBase: m6A_site_597229
mod ID: M6ASITE061669		Click to Show/Hide the Full List
mod site	chr3:64516496-64516497:-		[9]
Sequence	CATCCGACTCAGAAATATAAACACTTTTAATGAAAGGGAGG
Motif Score	2.20572619
Cell/Tissue List	HEK293T; A549; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000295903.8; ENST00000477180.1; ENST00000498707.5
External Link	RMBase: m6A_site_597230
mod ID: M6ASITE061670		Click to Show/Hide the Full List
mod site	chr3:64541908-64541909:-		[3]
Sequence	GCAATGTTTAACCAATGAGGACCAACCCAGCCACTTATGCC
Motif Score	3.622404762
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000481060.2; ENST00000498707.5; ENST00000295903.8
External Link	RMBase: m6A_site_597231
mod ID: M6ASITE061671		Click to Show/Hide the Full List
mod site	chr3:64546800-64546801:-		[3]
Sequence	TCACCCCTGTTACCTGAGGGACTGCCCTGTCTCGGCCACCT
Motif Score	4.065041667
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000498707.5; ENST00000295903.8; ENST00000481060.2
External Link	RMBase: m6A_site_597232
mod ID: M6ASITE061672		Click to Show/Hide the Full List
mod site	chr3:64546858-64546859:-		[3]
Sequence	ATTATGAATACAGCTACCAAACCACCATCAACTGCCCAGGC
Motif Score	2.185083333
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000498707.5; ENST00000481060.2; ENST00000295903.8
External Link	RMBase: m6A_site_597233
mod ID: M6ASITE061673		Click to Show/Hide the Full List
mod site	chr3:64546922-64546923:-		[3]
Sequence	ACCTGTGGAAAAGGCTACAAACAAAGGCTTGTCTCGTGCAG
Motif Score	2.20572619
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000481060.2; ENST00000295903.8; ENST00000498707.5
External Link	RMBase: m6A_site_597234
mod ID: M6ASITE061674		Click to Show/Hide the Full List
mod site	chr3:64550162-64550163:-		[3]
Sequence	ACCCTTTTTAATGGTAATAAACCAGTAGTAATCATAGCATG
Motif Score	2.185083333
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000498707.5; ENST00000481060.2; ENST00000482490.5; ENST00000295903.8
External Link	RMBase: m6A_site_597235
mod ID: M6ASITE061675		Click to Show/Hide the Full List
mod site	chr3:64550876-64550877:-		[3]
Sequence	TCAGAGGTACCGTCCTGGGAACTGTAACCATCGTCAGCTCA
Motif Score	3.373380952
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000481060.2; ENST00000498707.5; ENST00000482490.5; ENST00000295903.8
External Link	RMBase: m6A_site_597236
mod ID: M6ASITE061676		Click to Show/Hide the Full List
mod site	chr3:64550952-64550953:-		[3]
Sequence	CGTGAGCAAGCGGCCGGTGGACCGTGAAAGCTGTAGTTTGC
Motif Score	3.622404762
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000482490.5; ENST00000498707.5; ENST00000481060.2; ENST00000295903.8
External Link	RMBase: m6A_site_597237
mod ID: M6ASITE061677		Click to Show/Hide the Full List
mod site	chr3:64551052-64551053:-		[3]
Sequence	GTATTTAACAGTGCACCAAGACCTGCGGCGAAGGCTCCAGG
Motif Score	2.876744048
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000295903.8; ENST00000482490.5; ENST00000481060.2; ENST00000498707.5
External Link	RMBase: m6A_site_597238
mod ID: M6ASITE061678		Click to Show/Hide the Full List
mod site	chr3:64561649-64561650:-		[3]
Sequence	GAGTGCAACCCATACACCAGACCGGAGTCGGAACGCGACTG
Motif Score	2.876744048
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000498707.5; ENST00000482490.5; ENST00000295903.8; ENST00000481060.2
External Link	RMBase: m6A_site_597240
mod ID: M6ASITE061679		Click to Show/Hide the Full List
mod site	chr3:64561672-64561673:-		[3]
Sequence	CACACAAAATAGCCAGAGAGACCGAGTGCAACCCATACACC
Motif Score	2.876744048
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000482490.5; ENST00000295903.8; ENST00000481060.2; ENST00000498707.5
External Link	RMBase: m6A_site_597241
mod ID: M6ASITE061680		Click to Show/Hide the Full List
mod site	chr3:64561693-64561694:-		[3]
Sequence	ATGTGGGCTGTCAGATCGGAACACACAAAATAGCCAGAGAG
Motif Score	2.951386905
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000498707.5; ENST00000481060.2; ENST00000295903.8; ENST00000482490.5
External Link	RMBase: m6A_site_597242
mod ID: M6ASITE061681		Click to Show/Hide the Full List
mod site	chr3:64596895-64596896:-		[3]
Sequence	GACTGTGTGGAGAGAATAAAACCTGATGAGCAAAGAGCCTG
Motif Score	2.185083333
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000482490.5; ENST00000498707.5; ENST00000295903.8; ENST00000481060.2
External Link	RMBase: m6A_site_597246
mod ID: M6ASITE061682		Click to Show/Hide the Full List
mod site	chr3:64601960-64601961:-		[3]
Sequence	TCGGTGGAAACCAGTGGAGAACTGGCCCCTGGGGAGCAGTG
Motif Score	3.373380952
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000295903.8; ENST00000482490.5; ENST00000498707.5; ENST00000481060.2
External Link	RMBase: m6A_site_597247
mod ID: M6ASITE061683		Click to Show/Hide the Full List
mod site	chr3:64601971-64601972:-		[3]
Sequence	CACCCATGTGCTCGGTGGAAACCAGTGGAGAACTGGCCCCT
Motif Score	2.185083333
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000295903.8; ENST00000482490.5; ENST00000481060.2; ENST00000498707.5
External Link	RMBase: m6A_site_597248
mod ID: M6ASITE061684		Click to Show/Hide the Full List
mod site	chr3:64602022-64602023:-		[3]
Sequence	GCACCCCTTCCAAAATGAGGACTATCGTCCCCGGAGCGCCA
Motif Score	4.065041667
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000295903.8; ENST00000481060.2; ENST00000482490.5; ENST00000498707.5
External Link	RMBase: m6A_site_597249
mod ID: M6ASITE061685		Click to Show/Hide the Full List
mod site	chr3:64602058-64602059:-		[3]
Sequence	ATGCCCTCAAAGGACCCCAGACAGTGGCTTAGCTCAGCACC
Motif Score	2.897386905
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000482490.5; ENST00000295903.8; ENST00000481060.2; ENST00000498707.5
External Link	RMBase: m6A_site_597250
mod ID: M6ASITE061686		Click to Show/Hide the Full List
mod site	chr3:64602065-64602066:-		[3]
Sequence	TGTCACCATGCCCTCAAAGGACCCCAGACAGTGGCTTAGCT
Motif Score	3.622404762
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000498707.5; ENST00000482490.5; ENST00000481060.2; ENST00000295903.8
External Link	RMBase: m6A_site_597251
mod ID: M6ASITE061687		Click to Show/Hide the Full List
mod site	chr3:64602094-64602095:-		[3]
Sequence	TATCCCAGAAACTGACCAGGACTGTTCCATGTCACCATGCC
Motif Score	4.065041667
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000295903.8; ENST00000482490.5; ENST00000498707.5; ENST00000481060.2
External Link	RMBase: m6A_site_597252
mod ID: M6ASITE061688		Click to Show/Hide the Full List
mod site	chr3:64602100-64602101:-		[5]
Sequence	GGATTATATCCCAGAAACTGACCAGGACTGTTCCATGTCAC
Motif Score	2.839113095
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000295903.8; ENST00000481060.2; ENST00000498707.5; ENST00000482490.5
External Link	RMBase: m6A_site_597253
mod ID: M6ASITE061689		Click to Show/Hide the Full List
mod site	chr3:64602104-64602105:-		[3]
Sequence	ACCAGGATTATATCCCAGAAACTGACCAGGACTGTTCCATG
Motif Score	2.627720238
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000498707.5; ENST00000481060.2; ENST00000295903.8; ENST00000482490.5
External Link	RMBase: m6A_site_597254
mod ID: M6ASITE061690		Click to Show/Hide the Full List
mod site	chr3:64603931-64603932:-		[3]
Sequence	TGGGCAATGGAAGGCCTTGGACTGGAGCTCTGTAAGCCAGT
Motif Score	4.065041667
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000295903.8; ENST00000481060.2; ENST00000498707.5; ENST00000482490.5
External Link	RMBase: m6A_site_597255
mod ID: M6ASITE061691		Click to Show/Hide the Full List
mod site	chr3:64603987-64603988:-		[3]
Sequence	GCCTGTGCTACCCTGCCTAGACCAGTGGCAAAGGAAGAATG
Motif Score	2.876744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000295903.8; ENST00000481060.2; ENST00000498707.5; ENST00000482490.5
External Link	RMBase: m6A_site_597256
mod ID: M6ASITE061692		Click to Show/Hide the Full List
mod site	chr3:64614913-64614914:-		[3]
Sequence	CTTTGAAATAAGAGAATTAGACCCCAGGGAGTGACCTCTCT
Motif Score	2.876744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000475557.5; ENST00000498707.5; ENST00000482490.5; ENST00000481060.2; ENST00000295903.8
External Link	RMBase: m6A_site_597257
mod ID: M6ASITE061693		Click to Show/Hide the Full List
mod site	chr3:64641852-64641853:-		[3]
Sequence	GCCATTCGAGAGTGCAACAGACCAGAGTAAGTCCTAGAATG
Motif Score	2.876744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000475557.5; ENST00000295903.8; ENST00000498707.5; ENST00000482490.5
External Link	RMBase: m6A_site_597258
mod ID: M6ASITE061694		Click to Show/Hide the Full List
mod site	chr3:64641875-64641876:-		[3]
Sequence	CATGTGGAGGGGGCATCAAAACAGCCATTCGAGAGTGCAAC
Motif Score	2.20572619
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000295903.8; ENST00000482490.5; ENST00000498707.5; ENST00000475557.5
External Link	RMBase: m6A_site_597259
mod ID: M6ASITE061695		Click to Show/Hide the Full List
mod site	chr3:64641896-64641897:-		[3]
Sequence	CCTTTGGAACCTGCTCCAGAACATGTGGAGGGGGCATCAAA
Motif Score	2.951386905
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000482490.5; ENST00000295903.8; ENST00000498707.5; ENST00000475557.5
External Link	RMBase: m6A_site_597260
mod ID: M6ASITE061696		Click to Show/Hide the Full List
mod site	chr3:64641908-64641909:-		[3]
Sequence	GAAGTTGGAGTCCCTTTGGAACCTGCTCCAGAACATGTGGA
Motif Score	2.930744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000295903.8; ENST00000498707.5; ENST00000482490.5; ENST00000475557.5
External Link	RMBase: m6A_site_597261
mod ID: M6ASITE061697		Click to Show/Hide the Full List
mod site	chr3:64658535-64658536:-		[3]
Sequence	GGTTTCATACCATGGAGAAAACCTTCAACACTATATTTTAA
Motif Score	2.185083333
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000498707.5; ENST00000459780.1; ENST00000295903.8; ENST00000475557.5; ENST00000482490.5
External Link	RMBase: m6A_site_597262
mod ID: M6ASITE061698		Click to Show/Hide the Full List
mod site	chr3:64658565-64658566:-		[3]
Sequence	AGAAGTCTTGGTGGTGGCAGACAACAGAATGGTTTCATACC
Motif Score	2.897386905
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000498707.5; ENST00000459780.1; ENST00000295903.8; ENST00000475557.5; ENST00000482490.5
External Link	RMBase: m6A_site_597263
mod ID: M6ASITE061699		Click to Show/Hide the Full List
mod site	chr3:64658617-64658618:-		[8]
Sequence	AAAAGAGGACCCACAGAAGGACAAAACGTTTTTTATCCTAT
Motif Score	3.643047619
Cell/Tissue List	HEK293T; hNPCs; Huh7; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000482490.5; ENST00000475557.5; ENST00000295903.8; ENST00000498707.5; ENST00000459780.1
External Link	RMBase: m6A_site_597264
mod ID: M6ASITE061700		Click to Show/Hide the Full List
mod site	chr3:64658629-64658630:-		[8]
Sequence	ACAACACAAGAGAAAAGAGGACCCACAGAAGGACAAAACGT
Motif Score	3.622404762
Cell/Tissue List	HEK293T; hNPCs; Huh7; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000295903.8; ENST00000459780.1; ENST00000482490.5; ENST00000475557.5; ENST00000498707.5
External Link	RMBase: m6A_site_597265
mod ID: M6ASITE061701		Click to Show/Hide the Full List
mod site	chr3:64658649-64658650:-		[6]
Sequence	TGCTTATGGTAATAAGACGGACAACACAAGAGAAAAGAGGA
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T; hNPCs; A549; Huh7; HEC-1-A
Seq Type List	MAZTER-seq; MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000498707.5; ENST00000482490.5; ENST00000295903.8; ENST00000475557.5; ENST00000459780.1
External Link	RMBase: m6A_site_597266
mod ID: M6ASITE061702		Click to Show/Hide the Full List
mod site	chr3:64658697-64658698:-		[8]
Sequence	TGGTGACGTAGCAGCATTAAACAGCGGCTTAGCAACAGAGG
Motif Score	2.20572619
Cell/Tissue List	HEK293T; hNPCs; Huh7; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000482490.5; ENST00000498707.5; ENST00000459780.1; ENST00000475557.5; ENST00000295903.8
External Link	RMBase: m6A_site_597267
mod ID: M6ASITE061703		Click to Show/Hide the Full List
mod site	chr3:64658755-64658756:-		[9]
Sequence	ACAGTAAAGACAAGAAGAAAACCAGAGCAAGAAAATGGGGA
Motif Score	2.185083333
Cell/Tissue List	hNPCs; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000475557.5; ENST00000459780.1; ENST00000295903.8; ENST00000482490.5; ENST00000498707.5
External Link	RMBase: m6A_site_597268
mod ID: M6ASITE061704		Click to Show/Hide the Full List
mod site	chr3:64658766-64658767:-		[9]
Sequence	CAAAAATAGGCACAGTAAAGACAAGAAGAAAACCAGAGCAA
Motif Score	2.897386905
Cell/Tissue List	hNPCs; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000475557.5; ENST00000295903.8; ENST00000498707.5; ENST00000482490.5; ENST00000459780.1
External Link	RMBase: m6A_site_597269
mod ID: M6ASITE061705		Click to Show/Hide the Full List
mod site	chr3:64686900-64686901:-		[3]
Sequence	CGAGTGAACGCTCTCGGAGAACCCTTTCCCACGAACGTCCA
Motif Score	2.930744048
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000475557.5; ENST00000459780.1; ENST00000498707.5; ENST00000295903.8
External Link	RMBase: m6A_site_597275
mod ID: M6ASITE061706		Click to Show/Hide the Full List
mod site	chr3:64686953-64686954:-		[3]
Sequence	CCGCAGTGAAATTATTAGAGACCCTGAGCGAATACGAAATC
Motif Score	2.876744048
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000295903.8; ENST00000475557.5; ENST00000498707.5; ENST00000459780.1
External Link	RMBase: m6A_site_597276
mod ID: M6ASITE061707		Click to Show/Hide the Full List
mod site	chr3:64687562-64687563:-		[3]
Sequence	CGCGGCGGCCGTGCGCAAGGACAGGCTGCACCCGAGGCAAG
Motif Score	3.643047619
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000295903.8; ENST00000475557.5; ENST00000498707.5; ENST00000459780.1
External Link	RMBase: m6A_site_597277
mod ID: M6ASITE061708		Click to Show/Hide the Full List
mod site	chr3:64687610-64687611:-		[3]
Sequence	GCTAACGCTCCTGGTGCGGGACCTGGCCGAGATGGGGAGCC
Motif Score	3.622404762
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000498707.5; ENST00000459780.1; ENST00000475557.5; ENST00000295903.8
External Link	RMBase: m6A_site_597278
mod ID: M6ASITE061709		Click to Show/Hide the Full List
mod site	chr3:64687801-64687802:-		[10]
Sequence	GACGGGACCCTCGCAGCGAGACCTCAGCGACTCCTAAAGTC
Motif Score	2.876744048
Cell/Tissue List	GSC-11; HEK293T; iSLK; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000498707.5; ENST00000459780.1
External Link	RMBase: m6A_site_597279
mod ID: M6ASITE061710		Click to Show/Hide the Full List
mod site	chr3:64687815-64687816:-		[10]
Sequence	CTCAGCCGAGCGCAGACGGGACCCTCGCAGCGAGACCTCAG
Motif Score	3.622404762
Cell/Tissue List	GSC-11; HEK293T; iSLK; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000459780.1; ENST00000498707.5
External Link	RMBase: m6A_site_597280

Ref 1	METTL3-Mediated ADAMTS9 Suppression Facilitates Angiogenesis and Carcinogenesis in Gastric Cancer. Front Oncol. 2022 Apr 28;12:861807. doi: 10.3389/fonc.2022.861807. eCollection 2022.
Ref 2	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 3	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 4	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 5	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 6	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 7	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 8	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 9	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 10	m(6)A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. Cancer Cell. 2017 Apr 10;31(4):591-606.e6. doi: 10.1016/j.ccell.2017.02.013. Epub 2017 Mar 23.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

Visitor Map