m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00535)

Target Name	P5C reductase 1 (PYCR1)
Synonyms	P5C reductase 1; P5CR 1 Click to Show/Hide
Gene Name	PYCR1
Chromosomal Location	17q25.3
Family	Pyrroline-5-carboxylate reductase family
Function	Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. Click to Show/Hide
Gene ID	5831
Uniprot ID	P5CR1_HUMAN
HGNC ID	HGNC:9721
KEGG ID	hsa:5831

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

PYCR1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Fat mass and obesity-associated protein (FTO) [ERASER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by FTO*
Cell Line	253J cell line	Homo sapiens
Treatment: siFTO 253J cells Control: 253J cells		GSE150239
Regulation		logFC: -8.46E-01 p-value: 2.98E-19
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	FTO decreased N6-methyladenosine methylation level in P5C reductase 1 (PYCR1) through its demethylase enzymatic activity and stabilized PYCR1 transcript to promote bladder cancer initiation and progression.
Target Regulation	Up regulation
Responsed Disease	Bladder cancer		ICD-11: 2C94	Disease Info
Pathway Response	mRNA surveillance pathway			hsa03015
Pathway Response	RNA degradation			hsa03018
Cell Process	RNA stability
In-vitro Model	T24	Bladder carcinoma	Homo sapiens	CVCL_0554
	SV-HUC-1	Normal	Homo sapiens	CVCL_3798
	RT-4	Bladder carcinoma	Homo sapiens	CVCL_0036
	J82	Bladder carcinoma	Homo sapiens	CVCL_0359
	EJ (Human bladder cancer cells)
	5637	Bladder carcinoma	Homo sapiens	CVCL_0126
In-vivo Model	T24 cells were subcutaneously injected into the mice (1 x 10⁶ cells / injecting site).

Bladder cancer [ICD-11: 2C94]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	FTO decreased N6-methyladenosine methylation level in P5C reductase 1 (PYCR1) through its demethylase enzymatic activity and stabilized PYCR1 transcript to promote bladder cancer initiation and progression.
Responsed Disease	Bladder cancer [ICD-11: 2C94]
Target Regulator	Fat mass and obesity-associated protein (FTO)		ERASER	Regulator Info
Target Regulation	Up regulation
Pathway Response	mRNA surveillance pathway			hsa03015
Pathway Response	RNA degradation			hsa03018
Cell Process	RNA stability
In-vitro Model	T24	Bladder carcinoma	Homo sapiens	CVCL_0554
	SV-HUC-1	Normal	Homo sapiens	CVCL_3798
	RT-4	Bladder carcinoma	Homo sapiens	CVCL_0036
	J82	Bladder carcinoma	Homo sapiens	CVCL_0359
	EJ (Human bladder cancer cells)
	5637	Bladder carcinoma	Homo sapiens	CVCL_0126
In-vivo Model	T24 cells were subcutaneously injected into the mice (1 x 10⁶ cells / injecting site).

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00535)

P5C reductase 1 (PYCR1)

5-methylcytidine (m5C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE001400		Click to Show/Hide the Full List
mod site	chr17:81935094-81935095:-
Sequence	CATCCGCTGCATGACCAACACTCCAGTCGTGGTGCGGGAGG
Cell/Tissue List	testis
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000619204.4; ENST00000582198.5; ENST00000629768.2; ENST00000584848.5; ENST00000405481.8; ENST00000402252.6; ENST00000577756.5; ENST00000577624.5; ENST00000579698.5; ENST00000337943.9; ENST00000329875.12; ENST00000579366.5; ENST00000585215.5; ENST00000403172.8
External Link	RMBase: m5C_site_20535
mod ID: M5CSITE001401		Click to Show/Hide the Full List
mod site	chr17:81936740-81936741:-		[2]
Sequence	CTTCACAGCAGCAGGTAGGCCCCCAGGTGGGGGACGGTGAG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000585215.5; ENST00000405481.8; ENST00000584848.5; ENST00000579366.5; ENST00000577756.5; ENST00000582198.5; ENST00000619204.4; ENST00000629768.2; ENST00000581271.5; ENST00000337943.9; ENST00000585244.1; ENST00000577624.5; ENST00000402252.6; ENST00000579698.5; ENST00000403172.8; ENST00000583564.5; ENST00000329875.12
External Link	RMBase: m5C_site_20536

N6-methyladenosine (m6A)

In total 59 m6A sequence/site(s) in this target gene
mod ID: M6ASITE036183		Click to Show/Hide the Full List
mod site	chr17:81932452-81932453:-		[3]
Sequence	GGAGGCCTTCAACTGATTAGACAAGGCCCGCCCACATCTTG
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T
Seq Type List	m6A-seq; DART-seq; MAZTER-seq
Transcript ID List	ENST00000403172.8; ENST00000619204.4; ENST00000329875.12; ENST00000629768.2; ENST00000337943.9
External Link	RMBase: m6A_site_389503
mod ID: M6ASITE036184		Click to Show/Hide the Full List
mod site	chr17:81932461-81932462:-		[4]
Sequence	TGGAATAGTGGAGGCCTTCAACTGATTAGACAAGGCCCGCC
Motif Score	2.595904762
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000403172.8; ENST00000329875.12; ENST00000629768.2; ENST00000337943.9; ENST00000619204.4
External Link	RMBase: m6A_site_389504
mod ID: M6ASITE036185		Click to Show/Hide the Full List
mod site	chr17:81932528-81932529:-		[5]
Sequence	TGTCCTGACTTCTGTCTGCCACATGAGGAGGGAGGCCCTGC
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403172.8; ENST00000619204.4; ENST00000329875.12; ENST00000337943.9; ENST00000629768.2
External Link	RMBase: m6A_site_389505
mod ID: M6ASITE036186		Click to Show/Hide the Full List
mod site	chr17:81932648-81932649:-		[3]
Sequence	GCTCCTTGGGCTGCTGGTGAACTTCTGTGGCCACCACCTCC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; H1A; H1B; hESCs; A549; MM6; GSC-11; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000403172.8; ENST00000329875.12; ENST00000619204.4; ENST00000337943.9; ENST00000629768.2
External Link	RMBase: m6A_site_389512
mod ID: M6ASITE036187		Click to Show/Hide the Full List
mod site	chr17:81932683-81932684:-		[3]
Sequence	CAAGCACGCAGATCCCATGGACATTTGGGGAAAGGGCTCCT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; hESC-HEK293T; H1A; H1B; hESCs; fibroblasts; A549; LCLs; MM6; Huh7; peripheral-blood; GSC-11; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4; AML
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000629768.2; ENST00000329875.12; ENST00000619204.4; ENST00000403172.8; ENST00000337943.9
External Link	RMBase: m6A_site_389513
mod ID: M6ASITE036188		Click to Show/Hide the Full List
mod site	chr17:81932785-81932786:-		[3]
Sequence	TGCCCTCCATTCAGGGAGAAACCTCTCCTTCCCGTGTGAGA
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; MM6; Huh7; MSC; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000629768.2; ENST00000403172.8; ENST00000619204.4; ENST00000329875.12; ENST00000337943.9
External Link	RMBase: m6A_site_389516
mod ID: M6ASITE036189		Click to Show/Hide the Full List
mod site	chr17:81932863-81932864:-		[3]
Sequence	CCTGAGAGCAAAGGTCAAGGACCCCCTCTGTGAAGGCTCAG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000629768.2; ENST00000403172.8; ENST00000329875.12; ENST00000337943.9; ENST00000619204.4
External Link	RMBase: m6A_site_389517
mod ID: M6ASITE036190		Click to Show/Hide the Full List
mod site	chr17:81932961-81932962:-		[3]
Sequence	TGCTCCCAAACCATGTCAGGACCACCTTCCTCTAGAGCTCG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000619204.4; ENST00000584848.5; ENST00000337943.9; ENST00000329875.12; ENST00000629768.2; ENST00000577756.5; ENST00000403172.8; ENST00000402252.6
External Link	RMBase: m6A_site_389518
mod ID: M6ASITE036191		Click to Show/Hide the Full List
mod site	chr17:81932972-81932973:-		[3]
Sequence	CCTTTCTTCTCTGCTCCCAAACCATGTCAGGACCACCTTCC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000629768.2; ENST00000584848.5; ENST00000619204.4; ENST00000402252.6; ENST00000337943.9; ENST00000577756.5; ENST00000403172.8; ENST00000329875.12
External Link	RMBase: m6A_site_389519
mod ID: M6ASITE036192		Click to Show/Hide the Full List
mod site	chr17:81933020-81933021:-		[3]
Sequence	CAAGTGCTTCCCAGCCCAGAACAGGGGTGGATTCCCCAACC
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; A549; MM6; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000577756.5; ENST00000403172.8; ENST00000629768.2; ENST00000619204.4; ENST00000584848.5; ENST00000329875.12; ENST00000402252.6; ENST00000337943.9
External Link	RMBase: m6A_site_389520
mod ID: M6ASITE036193		Click to Show/Hide the Full List
mod site	chr17:81933073-81933074:-		[5]
Sequence	GACATAGCCAGGGAGGGGCCACATCACTTCCCACTGGAAAT
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000584848.5; ENST00000619204.4; ENST00000402252.6; ENST00000577756.5; ENST00000629768.2; ENST00000403172.8; ENST00000337943.9; ENST00000329875.12
External Link	RMBase: m6A_site_389522
mod ID: M6ASITE036194		Click to Show/Hide the Full List
mod site	chr17:81933092-81933093:-		[3]
Sequence	AGCGCAGGGGCCAGCCAGGGACATAGCCAGGGAGGGGCCAC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293; hESC-HEK293T; A549; MM6; Huh7
Seq Type List	m6A-seq; m6A-REF-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000329875.12; ENST00000619204.4; ENST00000577756.5; ENST00000584848.5; ENST00000402252.6; ENST00000629768.2; ENST00000403172.8; ENST00000337943.9
External Link	RMBase: m6A_site_389523
mod ID: M6ASITE036195		Click to Show/Hide the Full List
mod site	chr17:81933155-81933156:-		[3]
Sequence	CTTCTCTTGTCACTAGGGGGACTAGGGGGTCCCCAAAGTGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; A549; MM6; Huh7; HEK293T; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000629768.2; ENST00000619204.4; ENST00000403172.8; ENST00000584848.5; ENST00000577756.5; ENST00000337943.9; ENST00000329875.12; ENST00000402252.6
External Link	RMBase: m6A_site_389524
mod ID: M6ASITE036196		Click to Show/Hide the Full List
mod site	chr17:81933213-81933214:-		[4]
Sequence	GCCCCAGCGGGCAAGGATTGACACGTCCTGCCTGACCACCA
Motif Score	2.859755952
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000403172.8; ENST00000329875.12; ENST00000577756.5; ENST00000584848.5; ENST00000402252.6; ENST00000337943.9; ENST00000629768.2; ENST00000619204.4
External Link	RMBase: m6A_site_389525
mod ID: M6ASITE036197		Click to Show/Hide the Full List
mod site	chr17:81933259-81933260:-		[5]
Sequence	CGCTCTGTCACCTTCTGGCCACACCAAGCTGCTCCCCCGCA
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403172.8; ENST00000584848.5; ENST00000619204.4; ENST00000402252.6; ENST00000329875.12; ENST00000577756.5; ENST00000337943.9; ENST00000629768.2
External Link	RMBase: m6A_site_389526
mod ID: M6ASITE036198		Click to Show/Hide the Full List
mod site	chr17:81933281-81933282:-		[3]
Sequence	AGCTGGACTCCCCTGCAGGGACCGCTCTGTCACCTTCTGGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; MM6; Huh7; peripheral-blood; HEK293T; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000577756.5; ENST00000329875.12; ENST00000403172.8; ENST00000584848.5; ENST00000337943.9; ENST00000619204.4; ENST00000402252.6; ENST00000629768.2
External Link	RMBase: m6A_site_389527
mod ID: M6ASITE036199		Click to Show/Hide the Full List
mod site	chr17:81933295-81933296:-		[3]
Sequence	CCTGGACAAGGTGAAGCTGGACTCCCCTGCAGGGACCGCTC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; MM6; Huh7; peripheral-blood; HEK293T; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000402252.6; ENST00000629768.2; ENST00000403172.8; ENST00000577756.5; ENST00000337943.9; ENST00000329875.12; ENST00000619204.4; ENST00000584848.5
External Link	RMBase: m6A_site_389528
mod ID: M6ASITE036200		Click to Show/Hide the Full List
mod site	chr17:81933310-81933311:-		[3]
Sequence	CATCAAGAAGACCATCCTGGACAAGGTGAAGCTGGACTCCC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; hESC-HEK293T; MM6; peripheral-blood; endometrial; HEC-1-A
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000329875.12; ENST00000337943.9; ENST00000402252.6; ENST00000619204.4; ENST00000577756.5; ENST00000584848.5; ENST00000403172.8; ENST00000629768.2
External Link	RMBase: m6A_site_389529
mod ID: M6ASITE036201		Click to Show/Hide the Full List
mod site	chr17:81933320-81933321:-		[3]
Sequence	CACCAGCCGCCATCAAGAAGACCATCCTGGACAAGGTGAAG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; MM6; peripheral-blood; HEK293T; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000337943.9; ENST00000403172.8; ENST00000402252.6; ENST00000329875.12; ENST00000577756.5; ENST00000629768.2; ENST00000619204.4; ENST00000584848.5
External Link	RMBase: m6A_site_389530
mod ID: M6ASITE036202		Click to Show/Hide the Full List
mod site	chr17:81934329-81934330:-		[5]
Sequence	TGGAGGCCTCCTGCATCCGCACACGGTGGGCCCCCGCGCTG
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000629768.2; ENST00000337943.9; ENST00000577756.5; ENST00000582198.5; ENST00000329875.12; ENST00000619204.4; ENST00000402252.6; ENST00000403172.8; ENST00000584848.5
External Link	RMBase: m6A_site_389531
mod ID: M6ASITE036203		Click to Show/Hide the Full List
mod site	chr17:81934436-81934437:-		[3]
Sequence	GCACCCAGGCCAGCTCAAGGACAACGTCAGCTCTCCTGGTG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; hESC-HEK293T; endometrial; NB4
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000584848.5; ENST00000402252.6; ENST00000403172.8; ENST00000405481.8; ENST00000337943.9; ENST00000577756.5; ENST00000619204.4; ENST00000582198.5; ENST00000629768.2; ENST00000329875.12
External Link	RMBase: m6A_site_389532
mod ID: M6ASITE036204		Click to Show/Hide the Full List
mod site	chr17:81934459-81934460:-		[3]
Sequence	AAGATGCTGCTGCACTCAGAACAGCACCCAGGCCAGCTCAA
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; HEK293; HEK293T; endometrial; NB4
Seq Type List	m6A-seq; m6A-REF-seq
Transcript ID List	ENST00000577756.5; ENST00000329875.12; ENST00000585215.5; ENST00000402252.6; ENST00000405481.8; ENST00000582198.5; ENST00000337943.9; ENST00000619204.4; ENST00000629768.2; ENST00000584848.5; ENST00000403172.8
External Link	RMBase: m6A_site_389533
mod ID: M6ASITE036205		Click to Show/Hide the Full List
mod site	chr17:81934697-81934698:-		[3]
Sequence	GATGGGGGTGTGAAGATGGGACTTCCAAGGCGCCTGGCAGT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; MM6; HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000619204.4; ENST00000405481.8; ENST00000584848.5; ENST00000629768.2; ENST00000577756.5; ENST00000582198.5; ENST00000329875.12; ENST00000402252.6; ENST00000585215.5; ENST00000337943.9; ENST00000403172.8
External Link	RMBase: m6A_site_389534
mod ID: M6ASITE036206		Click to Show/Hide the Full List
mod site	chr17:81934971-81934972:-		[3]
Sequence	CTGCACGGAGGTGGAAGAGGACCTGATTGATGCCGTCACGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; MM6; HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000405481.8; ENST00000403172.8; ENST00000329875.12; ENST00000577624.5; ENST00000582198.5; ENST00000579698.5; ENST00000584848.5; ENST00000402252.6; ENST00000619204.4; ENST00000585215.5; ENST00000337943.9; ENST00000577756.5; ENST00000629768.2
External Link	RMBase: m6A_site_389535
mod ID: M6ASITE036207		Click to Show/Hide the Full List
mod site	chr17:81935097-81935098:-		[5]
Sequence	GGTCATCCGCTGCATGACCAACACTCCAGTCGTGGTGCGGG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000579698.5; ENST00000403172.8; ENST00000337943.9; ENST00000329875.12; ENST00000584848.5; ENST00000629768.2; ENST00000577756.5; ENST00000582198.5; ENST00000405481.8; ENST00000579366.5; ENST00000619204.4; ENST00000577624.5; ENST00000585215.5; ENST00000402252.6
External Link	RMBase: m6A_site_389536
mod ID: M6ASITE036208		Click to Show/Hide the Full List
mod site	chr17:81935387-81935388:-		[5]
Sequence	GGCGCCGACATTGAGGACAGACACATTGTGGTGTCCTGCGC
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000583564.5; ENST00000577756.5; ENST00000337943.9; ENST00000403172.8; ENST00000577624.5; ENST00000581271.5; ENST00000582198.5; ENST00000405481.8; ENST00000584848.5; ENST00000402252.6; ENST00000629768.2; ENST00000579366.5; ENST00000585215.5; ENST00000579698.5; ENST00000329875.12; ENST00000619204.4
External Link	RMBase: m6A_site_389537
mod ID: M6ASITE036209		Click to Show/Hide the Full List
mod site	chr17:81935497-81935498:-		[6]
Sequence	AGAAGATGGGGGTGAAGTTGACACCCCACAACAAGGAGACG
Motif Score	2.859755952
Cell/Tissue List	HEK293
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000585244.1; ENST00000582198.5; ENST00000329875.12; ENST00000337943.9; ENST00000619204.4; ENST00000577756.5; ENST00000579698.5; ENST00000577624.5; ENST00000579366.5; ENST00000402252.6; ENST00000585215.5; ENST00000405481.8; ENST00000581271.5; ENST00000403172.8; ENST00000583564.5; ENST00000584848.5; ENST00000629768.2
External Link	RMBase: m6A_site_389538
mod ID: M6ASITE036210		Click to Show/Hide the Full List
mod site	chr17:81936147-81936148:-		[7]
Sequence	GGCTAGCTCCCCAGACATGGACCTGGCCACAGTTTCTGCTC
Motif Score	3.622404762
Cell/Tissue List	HepG2; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000629768.2; ENST00000585215.5; ENST00000619204.4; ENST00000329875.12; ENST00000581271.5; ENST00000582198.5; ENST00000583564.5; ENST00000579366.5; ENST00000585244.1; ENST00000579698.5; ENST00000402252.6; ENST00000577624.5; ENST00000403172.8; ENST00000584848.5; ENST00000405481.8; ENST00000337943.9; ENST00000577756.5
External Link	RMBase: m6A_site_389539
mod ID: M6ASITE036211		Click to Show/Hide the Full List
mod site	chr17:81936153-81936154:-		[7]
Sequence	GATAATGGCTAGCTCCCCAGACATGGACCTGGCCACAGTTT
Motif Score	2.897386905
Cell/Tissue List	HepG2; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000629768.2; ENST00000402252.6; ENST00000403172.8; ENST00000337943.9; ENST00000584848.5; ENST00000577624.5; ENST00000582198.5; ENST00000405481.8; ENST00000579698.5; ENST00000581271.5; ENST00000583564.5; ENST00000579366.5; ENST00000585244.1; ENST00000585215.5; ENST00000619204.4; ENST00000577756.5; ENST00000329875.12
External Link	RMBase: m6A_site_389540
mod ID: M6ASITE036212		Click to Show/Hide the Full List
mod site	chr17:81936818-81936819:-		[3]
Sequence	TTTGGGCCAGGGGTCTCCGGACAGCATGAGCGTGGGCTTCA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000405481.8; ENST00000582198.5; ENST00000581271.5; ENST00000579698.5; ENST00000577624.5; ENST00000329875.12; ENST00000337943.9; ENST00000577756.5; ENST00000583564.5; ENST00000629768.2; ENST00000579366.5; ENST00000585244.1; ENST00000619204.4; ENST00000585215.5; ENST00000402252.6; ENST00000403172.8
External Link	RMBase: m6A_site_389541
mod ID: M6ASITE036213		Click to Show/Hide the Full List
mod site	chr17:81936953-81936954:-		[3]
Sequence	GGAAAGTTAGACCAGCTGGGACCAGGGGAGGTGGGCACCCG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000403172.8; ENST00000579698.5; ENST00000585244.1; ENST00000337943.9; ENST00000582198.5; ENST00000583564.5; ENST00000619204.4; ENST00000629768.2; ENST00000585215.5; ENST00000402252.6; ENST00000577624.5; ENST00000405481.8; ENST00000579366.5; ENST00000581271.5
External Link	RMBase: m6A_site_389542
mod ID: M6ASITE036214		Click to Show/Hide the Full List
mod site	chr17:81936963-81936964:-		[3]
Sequence	ACAGCAAAGTGGAAAGTTAGACCAGCTGGGACCAGGGGAGG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000579698.5; ENST00000582198.5; ENST00000579366.5; ENST00000629768.2; ENST00000619204.4; ENST00000337943.9; ENST00000585244.1; ENST00000402252.6; ENST00000577624.5; ENST00000583564.5; ENST00000405481.8; ENST00000585215.5; ENST00000581271.5; ENST00000403172.8
External Link	RMBase: m6A_site_389543
mod ID: M6ASITE036215		Click to Show/Hide the Full List
mod site	chr17:81936983-81936984:-		[3]
Sequence	CGAAGCAGTTAACGGGCCGGACAGCAAAGTGGAAAGTTAGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000405481.8; ENST00000583564.5; ENST00000629768.2; ENST00000619204.4; ENST00000579366.5; ENST00000585244.1; ENST00000577624.5; ENST00000579698.5; ENST00000403172.8; ENST00000337943.9; ENST00000402252.6; ENST00000585215.5; ENST00000582198.5; ENST00000581271.5
External Link	RMBase: m6A_site_389544
mod ID: M6ASITE036216		Click to Show/Hide the Full List
mod site	chr17:81937047-81937048:-		[3]
Sequence	ACCCCTCCAGTGGGTGCGGGACCCTAGGCAGCAGGCCAGGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000585215.5; ENST00000585244.1; ENST00000619204.4; ENST00000402252.6; ENST00000629768.2; ENST00000582198.5; ENST00000405481.8; ENST00000579698.5; ENST00000577624.5; ENST00000337943.9; ENST00000581271.5; ENST00000403172.8; ENST00000579366.5; ENST00000583564.5
External Link	RMBase: m6A_site_389545
mod ID: M6ASITE036217		Click to Show/Hide the Full List
mod site	chr17:81937073-81937074:-		[3]
Sequence	CCAGTCATTTCTTCTGCGGAACCTCCACCCCTCCAGTGGGT
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000585244.1; ENST00000579366.5; ENST00000579698.5; ENST00000337943.9; ENST00000405481.8; ENST00000577624.5; ENST00000581271.5; ENST00000583564.5; ENST00000629768.2; ENST00000585215.5; ENST00000582198.5; ENST00000402252.6; ENST00000619204.4; ENST00000403172.8
External Link	RMBase: m6A_site_389546
mod ID: M6ASITE036218		Click to Show/Hide the Full List
mod site	chr17:81937139-81937140:-		[3]
Sequence	GGTGGGAACCCAGACGGGGGACCCCTAGGCGCCGGGCCCTC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000579698.5; ENST00000582198.5; ENST00000405481.8; ENST00000403172.8; ENST00000579366.5; ENST00000585215.5; ENST00000577624.5; ENST00000402252.6; ENST00000629768.2; ENST00000585244.1; ENST00000337943.9; ENST00000619204.4; ENST00000581271.5; ENST00000583564.5
External Link	RMBase: m6A_site_389547
mod ID: M6ASITE036219		Click to Show/Hide the Full List
mod site	chr17:81937152-81937153:-		[3]
Sequence	CAGTTCTGGGCGGGGTGGGAACCCAGACGGGGGACCCCTAG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; A549; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000583564.5; ENST00000585244.1; ENST00000337943.9; ENST00000629768.2; ENST00000582198.5; ENST00000402252.6; ENST00000577624.5; ENST00000403172.8; ENST00000581271.5; ENST00000579366.5; ENST00000405481.8; ENST00000585215.5; ENST00000619204.4; ENST00000579698.5
External Link	RMBase: m6A_site_389548
mod ID: M6ASITE036220		Click to Show/Hide the Full List
mod site	chr17:81939844-81939845:-		[8]
Sequence	TCAAGGGTCCAGTTGCCGAAACTCCTGACGCCGGGGCCATC
Motif Score	2.627720238
Cell/Tissue List	H1A; H1B; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000409745.2; ENST00000579366.5; ENST00000582198.5
External Link	RMBase: m6A_site_389549
mod ID: M6ASITE036221		Click to Show/Hide the Full List
mod site	chr17:81939894-81939895:-		[8]
Sequence	CGGCTGAGGGCGGCCGCTGGACACAGAATCTGGGTACTGCT
Motif Score	3.643047619
Cell/Tissue List	H1A; H1B; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000409745.2; ENST00000579366.5; ENST00000582198.5
External Link	RMBase: m6A_site_389550
mod ID: M6ASITE036222		Click to Show/Hide the Full List
mod site	chr17:81940003-81940004:-		[8]
Sequence	AGCCACGGAGCCCCACCTGGACACTCACCATTGGCTGTGAC
Motif Score	3.643047619
Cell/Tissue List	H1A; H1B
Seq Type List	m6A-seq
Transcript ID List	ENST00000582198.5; ENST00000579366.5; ENST00000409745.2
External Link	RMBase: m6A_site_389551
mod ID: M6ASITE036223		Click to Show/Hide the Full List
mod site	chr17:81940038-81940039:-		[8]
Sequence	GTGCACAGTGGACGGGGAGGACCTGGTTCCGCCATAGCCAC
Motif Score	3.622404762
Cell/Tissue List	H1A; H1B
Seq Type List	m6A-seq
Transcript ID List	ENST00000409745.2; ENST00000579366.5; ENST00000582198.5
External Link	RMBase: m6A_site_389552
mod ID: M6ASITE036224		Click to Show/Hide the Full List
mod site	chr17:81940196-81940197:-		[8]
Sequence	AGAAGGAGCCAGAAATCTGGACCAGCCTCTCCCACCCACGT
Motif Score	3.622404762
Cell/Tissue List	H1A; H1B
Seq Type List	m6A-seq
Transcript ID List	ENST00000409745.2; ENST00000579366.5; ENST00000582198.5
External Link	RMBase: m6A_site_389553
mod ID: M6ASITE036225		Click to Show/Hide the Full List
mod site	chr17:81940261-81940262:-		[8]
Sequence	TCAGAGAGGCAGCTCCCAGAACCCTGGGAAGAGAGCCCTGC
Motif Score	2.930744048
Cell/Tissue List	H1A; H1B
Seq Type List	m6A-seq
Transcript ID List	ENST00000579366.5; ENST00000582198.5; ENST00000409745.2
External Link	RMBase: m6A_site_389554
mod ID: M6ASITE036226		Click to Show/Hide the Full List
mod site	chr17:81940293-81940294:-		[8]
Sequence	GAGGGGCGTGGGGAGCCGGAACCACTCCTGGTTCAGAGAGG
Motif Score	2.930744048
Cell/Tissue List	H1A; H1B
Seq Type List	m6A-seq
Transcript ID List	ENST00000579366.5; ENST00000409745.2; ENST00000582198.5
External Link	RMBase: m6A_site_389555
mod ID: M6ASITE036227		Click to Show/Hide the Full List
mod site	chr17:81940347-81940348:-		[8]
Sequence	ATGACTTCCAGAGGAGACGAACCCAGGAGAGTAGCTGGGCC
Motif Score	2.930744048
Cell/Tissue List	H1A
Seq Type List	m6A-seq
Transcript ID List	ENST00000579366.5; ENST00000409745.2; ENST00000582198.5
External Link	RMBase: m6A_site_389556
mod ID: M6ASITE036228		Click to Show/Hide the Full List
mod site	chr17:81940404-81940405:-		[9]
Sequence	ACCTCCATTAGTGTCTGGAGACCACAGTCAGGCTGGGTAAG
Motif Score	2.876744048
Cell/Tissue List	MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000579366.5; ENST00000409745.2; ENST00000582198.5
External Link	RMBase: m6A_site_389557
mod ID: M6ASITE036229		Click to Show/Hide the Full List
mod site	chr17:81940459-81940460:-		[8]
Sequence	GACCCATTTTGCAGCTGGGGACATGGAGGCTAGAAGCATTT
Motif Score	3.643047619
Cell/Tissue List	H1A
Seq Type List	m6A-seq
Transcript ID List	ENST00000579366.5; ENST00000409745.2; ENST00000582198.5
External Link	RMBase: m6A_site_389558
mod ID: M6ASITE036230		Click to Show/Hide the Full List
mod site	chr17:81940501-81940502:-		[8]
Sequence	CTGGAACATCATAAGGGAAAACTTTAAAGCAGCTGCTGTTG
Motif Score	2.627720238
Cell/Tissue List	H1B; H1A
Seq Type List	m6A-seq
Transcript ID List	ENST00000409745.2; ENST00000582198.5; ENST00000579366.5
External Link	RMBase: m6A_site_389559
mod ID: M6ASITE036231		Click to Show/Hide the Full List
mod site	chr17:81940516-81940517:-		[8]
Sequence	GCTCAGTGCTGGTCACTGGAACATCATAAGGGAAAACTTTA
Motif Score	2.951386905
Cell/Tissue List	H1A; H1B
Seq Type List	m6A-seq
Transcript ID List	ENST00000409745.2; ENST00000582198.5; ENST00000579366.5
External Link	RMBase: m6A_site_389560
mod ID: M6ASITE036232		Click to Show/Hide the Full List
mod site	chr17:81940631-81940632:-		[8]
Sequence	CTCAGAGGGACAAGGGCAGGACAGTAGGGCAGAGGCCCTGA
Motif Score	3.643047619
Cell/Tissue List	H1A; H1B; hESCs; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000582198.5; ENST00000579366.5; ENST00000409745.2
External Link	RMBase: m6A_site_389561
mod ID: M6ASITE036233		Click to Show/Hide the Full List
mod site	chr17:81940642-81940643:-		[8]
Sequence	TCCAGACTGGGCTCAGAGGGACAAGGGCAGGACAGTAGGGC
Motif Score	3.643047619
Cell/Tissue List	H1A; H1B; hESCs; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000579366.5; ENST00000582198.5; ENST00000409745.2
External Link	RMBase: m6A_site_389562
mod ID: M6ASITE036234		Click to Show/Hide the Full List
mod site	chr17:81940657-81940658:-		[8]
Sequence	GGTCACTCCCCGACTTCCAGACTGGGCTCAGAGGGACAAGG
Motif Score	3.319380952
Cell/Tissue List	H1A; H1B; hESCs; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000579366.5; ENST00000409745.2; ENST00000582198.5
External Link	RMBase: m6A_site_389563
mod ID: M6ASITE036235		Click to Show/Hide the Full List
mod site	chr17:81940744-81940745:-		[3]
Sequence	TGCGAGGGAAACTCAGGTGAACCAAAGTGTCAAGTAGCGAG
Motif Score	2.930744048
Cell/Tissue List	HeLa; H1A; H1B; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000579366.5; ENST00000409745.2; ENST00000582198.5
External Link	RMBase: m6A_site_389564
mod ID: M6ASITE036236		Click to Show/Hide the Full List
mod site	chr17:81940754-81940755:-		[3]
Sequence	CTCCAGGCTCTGCGAGGGAAACTCAGGTGAACCAAAGTGTC
Motif Score	2.627720238
Cell/Tissue List	HeLa; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000579366.5; ENST00000582198.5; ENST00000409745.2
External Link	RMBase: m6A_site_389565
mod ID: M6ASITE036237		Click to Show/Hide the Full List
mod site	chr17:81940917-81940918:-		[3]
Sequence	TCGGGGCAGCTGTCCCTGGGACAGCCAGCTGGTGGTGGCCA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000409745.2; ENST00000579366.5; ENST00000582198.5
External Link	RMBase: m6A_site_389566
mod ID: M6ASITE036238		Click to Show/Hide the Full List
mod site	chr17:81941364-81941365:-		[3]
Sequence	CGCCGGCTGTGCTGCCAGGGACTTCCGCCTGGCAGCCAGTG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293A-TOA; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000582198.5; ENST00000409745.2
External Link	RMBase: m6A_site_389567
mod ID: M6ASITE036239		Click to Show/Hide the Full List
mod site	chr17:81941770-81941771:-		[8]
Sequence	GGACCCCAGGGCCTTGGGGGACTGTGTGAGCTGGAAACGTG
Motif Score	4.065041667
Cell/Tissue List	H1A; H1B
Seq Type List	m6A-seq
Transcript ID List	ENST00000582198.5; ENST00000409745.2
External Link	RMBase: m6A_site_389568
mod ID: M6ASITE036240		Click to Show/Hide the Full List
mod site	chr17:81941788-81941789:-		[8]
Sequence	GGGGCCTTGGCCCAGCAGGGACCCCAGGGCCTTGGGGGACT
Motif Score	3.622404762
Cell/Tissue List	H1A; H1B
Seq Type List	m6A-seq
Transcript ID List	ENST00000582198.5; ENST00000409745.2
External Link	RMBase: m6A_site_389569
mod ID: M6ASITE036241		Click to Show/Hide the Full List
mod site	chr17:81941813-81941814:-		[8]
Sequence	ACCTGCCACTACCGCAGAGGACTGAGGGGCCTTGGCCCAGC
Motif Score	4.065041667
Cell/Tissue List	H1A; H1B
Seq Type List	m6A-seq
Transcript ID List	ENST00000582198.5; ENST00000409745.2
External Link	RMBase: m6A_site_389570

2'-O-Methylation (2'-O-Me)

In total 1 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000172		Click to Show/Hide the Full List
mod site	chr17:81933114-81933115:-		[10]
Sequence	CCCACTTTCTGTGGCTCTGATCAGCGCAGGGGCCAGCCAGG
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000577756.5; ENST00000629768.2; ENST00000337943.9; ENST00000584848.5; ENST00000329875.12; ENST00000619204.4; ENST00000403172.8; ENST00000402252.6
External Link	RMBase: Nm_site_2595

Ref 1	Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression. Aging (Albany NY). 2021 Jan 10;13(3):3909-3925. doi: 10.18632/aging.202359. Epub 2021 Jan 10.
Ref 2	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 3	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 4	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 5	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 6	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 7	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 8	m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014 Dec 4;15(6):707-19. doi: 10.1016/j.stem.2014.09.019. Epub 2014 Oct 16.
Ref 9	FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase. Cancer Cell. 2017 Jan 9;31(1):127-141. doi: 10.1016/j.ccell.2016.11.017. Epub 2016 Dec 22.
Ref 10	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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