m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00493)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
hsa-miR-582-3p
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | NKILA physically interacted with and suppressed hsa-miR-582-3p, which was regulated by METTL3-mediated N6 -methyladenosine (m6A) modification. YAP1 was a target of NKILA via miR-582-3p and NKILA functioned partially via YAP1 in CCA. | |||
| Responsed Disease | Intrahepatic cholangiocarcinoma | ICD-11: 2C12.10 | ||
| In-vitro Model | TFK-1 | Cholangiocarcinoma | Homo sapiens | CVCL_2214 |
| RBE | Intrahepatic cholangiocarcinoma | Homo sapiens | CVCL_4896 | |
| HuH-28 | Cholangiocarcinoma | Homo sapiens | CVCL_2955 | |
| HuCC-T1 | Intrahepatic cholangiocarcinoma | Homo sapiens | CVCL_0324 | |
| HIBEpic (Human intrahepatic bile duct epithelial cells) | ||||
| CC-LP-1 | Intrahepatic cholangiocarcinoma | Homo sapiens | CVCL_0205 | |
| In-vivo Model | To detect the effect of NKILA on CAA growth, 5 × 106 control and NKILA-depleted HuCCT1 cells (n = 4 per group) were subcutaneously injected into male BALB/c nude mice (4-6 weeks old). | |||
Liver cancer [ICD-11: 2C12]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | NKILA physically interacted with and suppressed hsa-miR-582-3p, which was regulated by METTL3-mediated N6 -methyladenosine (m6A) modification. YAP1 was a target of NKILA via miR-582-3p and NKILA functioned partially via YAP1 in CCA. | |||
| Responsed Disease | Intrahepatic cholangiocarcinoma [ICD-11: 2C12.10] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| In-vitro Model | TFK-1 | Cholangiocarcinoma | Homo sapiens | CVCL_2214 |
| RBE | Intrahepatic cholangiocarcinoma | Homo sapiens | CVCL_4896 | |
| HuH-28 | Cholangiocarcinoma | Homo sapiens | CVCL_2955 | |
| HuCC-T1 | Intrahepatic cholangiocarcinoma | Homo sapiens | CVCL_0324 | |
| HIBEpic (Human intrahepatic bile duct epithelial cells) | ||||
| CC-LP-1 | Intrahepatic cholangiocarcinoma | Homo sapiens | CVCL_0205 | |
| In-vivo Model | To detect the effect of NKILA on CAA growth, 5 × 106 control and NKILA-depleted HuCCT1 cells (n = 4 per group) were subcutaneously injected into male BALB/c nude mice (4-6 weeks old). | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
RNA modification
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 2 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT00012 | ||
| Epigenetic Regulator | Y-box-binding protein 1 (YBX1) | |
| Regulated Target | NF-kappaB interacting lncRNA (NKILA) | |
| Crosstalk relationship | m5C → m6A | |
| Disease | Intrahepatic cholangiocarcinoma | |
| Crosstalk ID: M6ACROT00013 | ||
| Epigenetic Regulator | RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) | |
| Regulated Target | NF-kappaB interacting lncRNA (NKILA) | |
| Crosstalk relationship | m5C → m6A | |
| Disease | Intrahepatic cholangiocarcinoma | |
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 2 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05568 | ||
| Epigenetic Regulator | hsa-miR-582-3p | |
| Regulated Target | Transcriptional coactivator YAP1 (YAP1) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Intrahepatic cholangiocarcinoma | |
| Crosstalk ID: M6ACROT05640 | ||
| Epigenetic Regulator | hsa-miR-582-3p | |
| Regulated Target | Transcriptional coactivator YAP1 (YAP1) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Intrahepatic cholangiocarcinoma | |