m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00491)

Target Name	Homeobox protein Hox-B13 (HOXB13)
Gene Name	HOXB13
Chromosomal Location	17q21.32
Family	Abd-B homeobox family
Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA. Click to Show/Hide
Gene ID	10481
Uniprot ID	HXB13_HUMAN
HGNC ID	HGNC:5112
KEGG ID	hsa:10481

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

HOXB13 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Fat mass and obesity-associated protein (FTO) [ERASER]

Regulator Info

In total 2 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	FTO suppresses Homeobox protein Hox-B13 (HOXB13) methytlation; FTO and HOXB13 expression promotes GC cell proliferation, migration, and invasion. HOXB13 expression intensifies GC invasion through PI3K/AKT/mTOR signaling via IGF-1R.
Target Regulation	Down regulation
Responsed Disease	Gastric cancer		ICD-11: 2B72	Disease Info
Pathway Response	PI3K-Akt signaling pathway			hsa04151
Pathway Response	mTOR signaling pathway			hsa04150
Cell Process	Cell proliferation
	Cell migration
	Cell invasion
In-vitro Model	SNU-5	Gastric adenocarcinoma	Homo sapiens	CVCL_0078
	NCI-N87	Gastric tubular adenocarcinoma	Homo sapiens	CVCL_1603
	MKN45	Gastric adenocarcinoma	Homo sapiens	CVCL_0434
	GES-1	Normal	Homo sapiens	CVCL_EQ22
	AGS	Gastric adenocarcinoma	Homo sapiens	CVCL_0139
In-vivo Model	Male nu/nu mice between 4 and 6 weeks of age received subcutaneous injections of equivalent AGS cells expressing either control or LV-HOXB13 within 30 min of harvesting on the right and left flanks.
Experiment 2 Reporting the m6A Methylation Regulator of This Target Gene				[2]
Response Summary	This study found high expression of FTO in metastatic endometrial cancer and that this action promote both metastasis and invasion in vivo and in vitro. Mechanistically, FTO can catalyse demethylation modification in 3'UTR region of Homeobox protein Hox-B13 (HOXB13) mRNA, thereby abolishing m6A modification recognition with the YTHDF2 protein.
Target Regulation	Up regulation
Responsed Disease	Endometrial cancer		ICD-11: 2C76	Disease Info
Pathway Response	Wnt signaling pathway			hsa04310
In-vitro Model	KLE	Endometrial adenocarcinoma	Homo sapiens	CVCL_1329
In-vitro Model	AN3-CA	Endometrial adenocarcinoma	Homo sapiens	CVCL_0028
In-vivo Model	Female SCID-Beige mice (6 weeks old) were purchased from Vitalriver. AN3CA cells with FTO overexpression or silencing or the appropriate controls (1 × 10⁶) were injected into the lower abdominal cavity of mice (n = 5 mice/group). After 4 weeks, the mice were sacrificed, and tumours were harvested, weighed and photographed.

Gastric cancer [ICD-11: 2B72]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	FTO suppresses Homeobox protein Hox-B13 (HOXB13) methytlation; FTO and HOXB13 expression promotes GC cell proliferation, migration, and invasion. HOXB13 expression intensifies GC invasion through PI3K/AKT/mTOR signaling via IGF-1R.
Responsed Disease	Gastric cancer [ICD-11: 2B72]
Target Regulator	Fat mass and obesity-associated protein (FTO)		ERASER	Regulator Info
Target Regulation	Down regulation
Pathway Response	PI3K-Akt signaling pathway			hsa04151
	mTOR signaling pathway			hsa04150
Cell Process	Cell proliferation
	Cell migration
	Cell invasion
In-vitro Model	SNU-5	Gastric adenocarcinoma	Homo sapiens	CVCL_0078
	NCI-N87	Gastric tubular adenocarcinoma	Homo sapiens	CVCL_1603
	MKN45	Gastric adenocarcinoma	Homo sapiens	CVCL_0434
	GES-1	Normal	Homo sapiens	CVCL_EQ22
	AGS	Gastric adenocarcinoma	Homo sapiens	CVCL_0139
In-vivo Model	Male nu/nu mice between 4 and 6 weeks of age received subcutaneous injections of equivalent AGS cells expressing either control or LV-HOXB13 within 30 min of harvesting on the right and left flanks.

Endometrial cancer [ICD-11: 2C76]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[2]
Response Summary	This study found high expression of FTO in metastatic endometrial cancer and that this action promote both metastasis and invasion in vivo and in vitro. Mechanistically, FTO can catalyse demethylation modification in 3'UTR region of Homeobox protein Hox-B13 (HOXB13) mRNA, thereby abolishing m6A modification recognition with the YTHDF2 protein.
Responsed Disease	Endometrial cancer [ICD-11: 2C76]
Target Regulator	Fat mass and obesity-associated protein (FTO)		ERASER	Regulator Info
Target Regulation	Up regulation
Pathway Response	Wnt signaling pathway			hsa04310
In-vitro Model	KLE	Endometrial adenocarcinoma	Homo sapiens	CVCL_1329
In-vitro Model	AN3-CA	Endometrial adenocarcinoma	Homo sapiens	CVCL_0028
In-vivo Model	Female SCID-Beige mice (6 weeks old) were purchased from Vitalriver. AN3CA cells with FTO overexpression or silencing or the appropriate controls (1 × 10⁶) were injected into the lower abdominal cavity of mice (n = 5 mice/group). After 4 weeks, the mice were sacrificed, and tumours were harvested, weighed and photographed.

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00491)

Homeobox protein Hox-B13 (HOXB13)

N6-methyladenosine (m6A)

In total 49 m6A sequence/site(s) in this target gene
mod ID: M6ASITE033633		Click to Show/Hide the Full List
mod site	chr17:48724767-48724768:-		[3]
Sequence	TCGCAATAAATTCAGAGCAAACAAAAGATGTGGAATCTTAG
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369649
mod ID: M6ASITE033635		Click to Show/Hide the Full List
mod site	chr17:48724813-48724814:-		[3]
Sequence	CTCTGCTATCAGAAACTTAAACTTGAGGATTTTCTCTGTTT
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369650
mod ID: M6ASITE033636		Click to Show/Hide the Full List
mod site	chr17:48724819-48724820:-		[3]
Sequence	CCCACACTCTGCTATCAGAAACTTAAACTTGAGGATTTTCT
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369651
mod ID: M6ASITE033637		Click to Show/Hide the Full List
mod site	chr17:48724857-48724858:-		[3]
Sequence	TGGGGGTCTGGAACCTCTGGACTCCCCATGCTCTAACTCCC
Motif Score	4.065041667
Cell/Tissue List	HeLa; A549; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369652
mod ID: M6ASITE033638		Click to Show/Hide the Full List
mod site	chr17:48724865-48724866:-		[3]
Sequence	GAGACCTTTGGGGGTCTGGAACCTCTGGACTCCCCATGCTC
Motif Score	2.930744048
Cell/Tissue List	HeLa; A549; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369653
mod ID: M6ASITE033639		Click to Show/Hide the Full List
mod site	chr17:48724882-48724883:-		[3]
Sequence	CGGAGATGGCCCTGGTAGAGACCTTTGGGGGTCTGGAACCT
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369654
mod ID: M6ASITE033640		Click to Show/Hide the Full List
mod site	chr17:48725295-48725296:-		[3]
Sequence	AAGAGTGTGAGTGCATGCGGACTGGGGGTTCAGGGGAAGAG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; A549; U2OS; H1A; H1B; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369655
mod ID: M6ASITE033641		Click to Show/Hide the Full List
mod site	chr17:48725332-48725333:-		[3]
Sequence	TTACCAAAGAGGAGCCCGGGACTGAGGGAAAAGGCCAAAGA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; H1A; H1B; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369656
mod ID: M6ASITE033642		Click to Show/Hide the Full List
mod site	chr17:48725366-48725367:-		[4]
Sequence	GGGTGGGACGTGACTTAGACACCTACAAATCTATTTACCAA
Motif Score	2.064285714
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369657
mod ID: M6ASITE033643		Click to Show/Hide the Full List
mod site	chr17:48725368-48725369:-		[3]
Sequence	GAGGGTGGGACGTGACTTAGACACCTACAAATCTATTTACC
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; H1B; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369658
mod ID: M6ASITE033644		Click to Show/Hide the Full List
mod site	chr17:48725472-48725473:-		[3]
Sequence	CGGAGCCAGCTCTCCTAGAAACCCCGCGGCGGCCGCCGCAG
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; A549; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369659
mod ID: M6ASITE033646		Click to Show/Hide the Full List
mod site	chr17:48725504-48725505:-		[3]
Sequence	CGGCCGCCACTACCTCGAGGACATTTCCCTCCCGGAGCCAG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; A549; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369660
mod ID: M6ASITE033647		Click to Show/Hide the Full List
mod site	chr17:48725592-48725593:-		[3]
Sequence	AAGTCTGGACAACCCGCAGAACCGAAGCTCCGAGCAGCGGG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369661
mod ID: M6ASITE033648		Click to Show/Hide the Full List
mod site	chr17:48725604-48725605:-		[3]
Sequence	CGCACAGGCCTGAAGTCTGGACAACCCGCAGAACCGAAGCT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369662
mod ID: M6ASITE033649		Click to Show/Hide the Full List
mod site	chr17:48725727-48725728:-		[3]
Sequence	TGGGCTCAGTGCCCGGTGGGACTCATCTCCTGGCCGCGCAG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369663
mod ID: M6ASITE033650		Click to Show/Hide the Full List
mod site	chr17:48725793-48725794:-		[3]
Sequence	GAGCCGGGACTCTGAGAGGGACATGAGGGCCTCTGCCTCTG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; A549
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369664
mod ID: M6ASITE033651		Click to Show/Hide the Full List
mod site	chr17:48725805-48725806:-		[3]
Sequence	GGGCTCTTTGCAGAGCCGGGACTCTGAGAGGGACATGAGGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; A549
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369665
mod ID: M6ASITE033652		Click to Show/Hide the Full List
mod site	chr17:48725831-48725832:-		[3]
Sequence	CGGAATTCTGGAAGCTGGAGACAGACGGGCTCTTTGCAGAG
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; HepG2
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369666
mod ID: M6ASITE033653		Click to Show/Hide the Full List
mod site	chr17:48725865-48725866:-		[3]
Sequence	TGTTTTCCCAGTCCACGTAGACAGATTCACAGTGCGGAATT
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369667
mod ID: M6ASITE033654		Click to Show/Hide the Full List
mod site	chr17:48726243-48726244:-		[5]
Sequence	GCTGACAGCTGGGTAGGTGGACAATTGTAGAGGCTGTCTCT
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369668
mod ID: M6ASITE033655		Click to Show/Hide the Full List
mod site	chr17:48726327-48726328:-		[6]
Sequence	ACCCTGGTAACAGCAGGAAGACTGAGGAGAGGGGAACGGGC
Motif Score	3.319380952
Cell/Tissue List	HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369669
mod ID: M6ASITE033657		Click to Show/Hide the Full List
mod site	chr17:48726369-48726370:-		[6]
Sequence	GCAGGGAAGCTTTCTCTCAGACCCCCTTCCATTACACCTCT
Motif Score	2.876744048
Cell/Tissue List	HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369670
mod ID: M6ASITE033658		Click to Show/Hide the Full List
mod site	chr17:48726442-48726443:-		[7]
Sequence	CTCTGTAGAGCACTTTAGAAACCGCTTTCATGAATTGAGCT
Motif Score	2.185083333
Cell/Tissue List	HEK293T; HeLa; A549; U2OS; iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369671
mod ID: M6ASITE033659		Click to Show/Hide the Full List
mod site	chr17:48726560-48726561:-		[3]
Sequence	TCCACCAGGGTTCCCAAAGAACCTGGCCCAGTCATAATCAT
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; H1A; Jurkat; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369672
mod ID: M6ASITE033660		Click to Show/Hide the Full List
mod site	chr17:48726599-48726600:-		[3]
Sequence	AGTATGTGCAGGGAGACGGAACCCCATGTGACAGCCCACTC
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; H1A; H1B; Jurkat; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369673
mod ID: M6ASITE033661		Click to Show/Hide the Full List
mod site	chr17:48726604-48726605:-		[4]
Sequence	TACCCAGTATGTGCAGGGAGACGGAACCCCATGTGACAGCC
Motif Score	2.871321429
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369674
mod ID: M6ASITE033662		Click to Show/Hide the Full List
mod site	chr17:48726648-48726649:-		[3]
Sequence	CCCAGGCCACTGGCTGCTGGACTGTTCCTCAGGAGCGGCCT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; H1A; H1B; Jurkat; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369675
mod ID: M6ASITE033663		Click to Show/Hide the Full List
mod site	chr17:48726676-48726677:-		[5]
Sequence	CTGAGAGGCCCCTAGAGACAACACCCTTCCCAGGCCACTGG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369676
mod ID: M6ASITE033664		Click to Show/Hide the Full List
mod site	chr17:48726679-48726680:-		[3]
Sequence	CTGCTGAGAGGCCCCTAGAGACAACACCCTTCCCAGGCCAC
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; A549; hESC-HEK293T; HepG2; U2OS; H1A; H1B; Jurkat; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369677
mod ID: M6ASITE033665		Click to Show/Hide the Full List
mod site	chr17:48726702-48726703:-		[3]
Sequence	AGCCCAGGCTGGGGCCAAGGACTCTGCTGAGAGGCCCCTAG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; H1A; H1B; Jurkat; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369678
mod ID: M6ASITE033666		Click to Show/Hide the Full List
mod site	chr17:48726730-48726731:-		[3]
Sequence	GTGTCCTGGGGAGACCAGGAACCTGCCAAGCCCAGGCTGGG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; H1A; H1B; Jurkat; GSC-11; HEK293A-TOA; iSLK; TREX; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369679
mod ID: M6ASITE033668		Click to Show/Hide the Full List
mod site	chr17:48726737-48726738:-		[3]
Sequence	AGTGGGGGTGTCCTGGGGAGACCAGGAACCTGCCAAGCCCA
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; H1A; H1B; Jurkat; GSC-11; HEK293A-TOA; iSLK; TREX; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369680
mod ID: M6ASITE033669		Click to Show/Hide the Full List
mod site	chr17:48726805-48726806:-		[3]
Sequence	GGTTCTCGCCAAGGTGAAGAACAGCGCTACCCCTTAAGAGA
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; H1B; GSC-11; HEK293A-TOA; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369681
mod ID: M6ASITE033670		Click to Show/Hide the Full List
mod site	chr17:48726847-48726848:-		[3]
Sequence	GATTACCATCTGGTTTCAGAACCGCCGGGTCAAAGAGAAGA
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T; HepG2; GSC-11; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369682
mod ID: M6ASITE033671		Click to Show/Hide the Full List
mod site	chr17:48726913-48726914:-		[3]
Sequence	TAACAAGTTCATCACCAAGGACAAGAGGCGCAAGATCTCGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369683
mod ID: M6ASITE033672		Click to Show/Hide the Full List
mod site	chr17:48726931-48726932:-		[5]
Sequence	GGAGCGGGAGTATGCGGCTAACAAGTTCATCACCAAGGACA
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369684
mod ID: M6ASITE033673		Click to Show/Hide the Full List
mod site	chr17:48728027-48728028:-		[3]
Sequence	GTGTTGCCAGGGAGAACAGAACCCACCAGGTCCCTTTTGGA
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369685
mod ID: M6ASITE033674		Click to Show/Hide the Full List
mod site	chr17:48728032-48728033:-		[3]
Sequence	CAGATGTGTTGCCAGGGAGAACAGAACCCACCAGGTCCCTT
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369686
mod ID: M6ASITE033675		Click to Show/Hide the Full List
mod site	chr17:48728057-48728058:-		[3]
Sequence	GGCTCTCGCTGGTGGCTGGAACAGCCAGATGTGTTGCCAGG
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369687
mod ID: M6ASITE033676		Click to Show/Hide the Full List
mod site	chr17:48728093-48728094:-		[3]
Sequence	TGACTCCCTGTTGCCTGTGGACAGTTACCAGTCTTGGGCTC
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369688
mod ID: M6ASITE033677		Click to Show/Hide the Full List
mod site	chr17:48728116-48728117:-		[5]
Sequence	GGTGCTCCTGGAGAACCGCGACATGACTCCCTGTTGCCTGT
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369689
mod ID: M6ASITE033679		Click to Show/Hide the Full List
mod site	chr17:48728122-48728123:-		[3]
Sequence	ACTCTGGGTGCTCCTGGAGAACCGCGACATGACTCCCTGTT
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369690
mod ID: M6ASITE033680		Click to Show/Hide the Full List
mod site	chr17:48728142-48728143:-		[3]
Sequence	TGGACGTGTCTGTGGTGCAGACTCTGGGTGCTCCTGGAGAA
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369691
mod ID: M6ASITE033681		Click to Show/Hide the Full List
mod site	chr17:48728187-48728188:-		[3]
Sequence	TCTATCCGGGATATCCGGGAACCTACCAGCCTATGGCCAGT
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369692
mod ID: M6ASITE033682		Click to Show/Hide the Full List
mod site	chr17:48728256-48728257:-		[3]
Sequence	TGGCCGCGTACCCCGCGGAGACTCCCACGGCCGGGGAAGAG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369693
mod ID: M6ASITE033683		Click to Show/Hide the Full List
mod site	chr17:48728299-48728300:-		[3]
Sequence	GTGTCCCGGAGCTCGCTGAAACCCTGTGCCCAGGCAGCCAC
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369694
mod ID: M6ASITE033684		Click to Show/Hide the Full List
mod site	chr17:48728907-48728908:-		[3]
Sequence	AGCGAGAGAGAGAGACAGAGACAGAGAGAGAGAGAGAGAGA
Motif Score	2.897386905
Cell/Tissue List	HeLa; H1A; H1B; GSC-11; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369695
mod ID: M6ASITE033685		Click to Show/Hide the Full List
mod site	chr17:48728913-48728914:-		[3]
Sequence	CGAGAGAGCGAGAGAGAGAGACAGAGACAGAGAGAGAGAGA
Motif Score	2.897386905
Cell/Tissue List	HeLa; H1A; H1B; GSC-11; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369696
mod ID: M6ASITE033686		Click to Show/Hide the Full List
mod site	chr17:48729039-48729040:-		[8]
Sequence	AACTGGAAAGCAGCGAAAGGACACCTCCTTCCTTTTCTCTC
Motif Score	3.643047619
Cell/Tissue List	H1A
Seq Type List	m6A-seq
Transcript ID List	ENST00000290295.7
External Link	RMBase: m6A_site_369697

Ref 1	HOXB13 promotes gastric cancer cell migration and invasion via IGF-1R upregulation and subsequent activation of PI3K/AKT/mTOR signaling pathway. Life Sci. 2021 Aug 1;278:119522. doi: 10.1016/j.lfs.2021.119522. Epub 2021 Apr 21.
Ref 2	FTO demethylates m6A modifications in HOXB13 mRNA and promotes endometrial cancer metastasis by activating the WNT signalling pathway. RNA Biol. 2021 Sep;18(9):1265-1278. doi: 10.1080/15476286.2020.1841458. Epub 2020 Nov 5.
Ref 3	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 4	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 5	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 6	The U6 snRNA m(6)A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention. Cell. 2017 May 18;169(5):824-835.e14. doi: 10.1016/j.cell.2017.05.003.
Ref 7	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 8	m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014 Dec 4;15(6):707-19. doi: 10.1016/j.stem.2014.09.019. Epub 2014 Oct 16.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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