m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00460)

Target Name	Histone H2AX (H2AX)
Synonyms	H2a/x; Histone H2A.X; H2AFX Click to Show/Hide
Gene Name	H2AX
Chromosomal Location	11q23.3
Family	histone H2A family. {ECO:0000305}.
Function	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. {ECO:0000269\|PubMed:10959836, ECO:0000269\|PubMed:12419185, ECO:0000269\|PubMed:12607005, ECO:0000269\|PubMed:15201865, ECO:0000269\|PubMed:17709392, ECO:0000269\|PubMed:26438602}. Click to Show/Hide
Gene ID	3014
Uniprot ID	H2AX_HUMAN
HGNC ID	HGNC:4739
KEGG ID	hsa:3014

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

H2AX can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

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Protein virilizer homolog (VIRMA) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by VIRMA*
Cell Line	Human umbilical vein endothelial cells	Homo sapiens
Treatment: siVIRMA HUVECs Control: siControl HUVECs		GSE167067
Regulation		logFC: -1.09E+00 p-value: 1.68E-02
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	VIRMA has an oncogenic role in germ cell tumor confirming our previous tissue-based study and is further involved in response to cisplatin by interfering with DNA repair. Enhanced response to cisplatin after VIRMA knockdown was related to significant increase in DNA damage (with higher Histone H2AX (H2AX) and GADD45B levels) and downregulation of XLF and MRE11.
Target Regulation	Down regulation
Responsed Disease	Germ cell tumour of testis		ICD-11: 2C80.2	Disease Info
Responsed Drug	Cisplatin		Approved	Drug Info
In-vitro Model	2102EP	Embryonal carcinoma	Homo sapiens	CVCL_C522
	NCC-IT	Testicular embryonal carcinoma	Homo sapiens	CVCL_1451
	NT2	Malignant neoplasms	Mus musculus	CVCL_JA57
	TCam-2	Testicular seminoma	Homo sapiens	CVCL_T012

Testicular cancer [ICD-11: 2C80]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	VIRMA has an oncogenic role in germ cell tumor confirming our previous tissue-based study and is further involved in response to cisplatin by interfering with DNA repair. Enhanced response to cisplatin after VIRMA knockdown was related to significant increase in DNA damage (with higher Histone H2AX (H2AX) and GADD45B levels) and downregulation of XLF and MRE11.
Responsed Disease	Germ cell tumour of testis [ICD-11: 2C80.2]
Target Regulator	Protein virilizer homolog (VIRMA)		WRITER	Regulator Info
Target Regulation	Down regulation
Responsed Drug	Cisplatin		Approved	Drug Info
In-vitro Model	2102EP	Embryonal carcinoma	Homo sapiens	CVCL_C522
	NCC-IT	Testicular embryonal carcinoma	Homo sapiens	CVCL_1451
	NT2	Malignant neoplasms	Mus musculus	CVCL_JA57
	TCam-2	Testicular seminoma	Homo sapiens	CVCL_T012

Cisplatin [Approved]

Drug Info

In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response				[1]
Response Summary	VIRMA has an oncogenic role in germ cell tumor confirming our previous tissue-based study and is further involved in response to cisplatin by interfering with DNA repair. Enhanced response to cisplatin after VIRMA knockdown was related to significant increase in DNA damage (with higher Histone H2AX (H2AX) and GADD45B levels) and downregulation of XLF and MRE11.
Target Regulator	Protein virilizer homolog (VIRMA)		WRITER	Regulator Info
Target Regulation	Down regulation
Responsed Disease	Germ cell tumour of testis		ICD-11: 2C80.2	Disease Info
In-vitro Model	2102EP	Embryonal carcinoma	Homo sapiens	CVCL_C522
	NCC-IT	Testicular embryonal carcinoma	Homo sapiens	CVCL_1451
	NT2	Malignant neoplasms	Mus musculus	CVCL_JA57
	TCam-2	Testicular seminoma	Homo sapiens	CVCL_T012

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00460)

Histone H2AX (H2AX)

5-methylcytidine (m5C)

In total 7 m6A sequence/site(s) in this target gene
mod ID: M5CSITE005389		Click to Show/Hide the Full List
mod site	chr11:119094472-119094473:-		[4]
Sequence	GGCAGTCCAGGCCGAGAGGCCGGCGGCCCTGAAGGTGAGTG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000530167.1; ENST00000375167.1
External Link	RMBase: m5C_site_9084
mod ID: M5CSITE005390		Click to Show/Hide the Full List
mod site	chr11:119095178-119095179:-		[4]
Sequence	CTGGCGGGCAATGCGGCCCGCGACAACAAGAAGACGCGAAT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000375167.1; ENST00000530167.1
External Link	RMBase: m5C_site_9085
mod ID: M5CSITE005391		Click to Show/Hide the Full List
mod site	chr11:119095180-119095181:-		[4]
Sequence	AGCTGGCGGGCAATGCGGCCCGCGACAACAAGAAGACGCGA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000375167.1; ENST00000530167.1
External Link	RMBase: m5C_site_9086
mod ID: M5CSITE005392		Click to Show/Hide the Full List
mod site	chr11:119095181-119095182:-		[4]
Sequence	GAGCTGGCGGGCAATGCGGCCCGCGACAACAAGAAGACGCG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000375167.1; ENST00000530167.1
External Link	RMBase: m5C_site_9087
mod ID: M5CSITE005393		Click to Show/Hide the Full List
mod site	chr11:119095182-119095183:-		[4]
Sequence	GGAGCTGGCGGGCAATGCGGCCCGCGACAACAAGAAGACGC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000530167.1; ENST00000375167.1
External Link	RMBase: m5C_site_9088
mod ID: M5CSITE005394		Click to Show/Hide the Full List
mod site	chr11:119095190-119095191:-		[4]
Sequence	GAGATCCTGGAGCTGGCGGGCAATGCGGCCCGCGACAACAA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000375167.1; ENST00000530167.1
External Link	RMBase: m5C_site_9089
mod ID: M5CSITE005395		Click to Show/Hide the Full List
mod site	chr11:119095194-119095195:-		[4]
Sequence	CGCTGAGATCCTGGAGCTGGCGGGCAATGCGGCCCGCGACA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000530167.1; ENST00000375167.1
External Link	RMBase: m5C_site_9090

N6-methyladenosine (m6A)

In total 30 m6A sequence/site(s) in this target gene
mod ID: M6ASITE009373		Click to Show/Hide the Full List
mod site	chr11:119093906-119093907:-		[5]
Sequence	CATTGGGGAGTTTTAGATGGACTAATTTTATTAAAGGATTG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; DART-seq
Transcript ID List	ENST00000375167.1; ENST00000530167.1
External Link	RMBase: m6A_site_166785
mod ID: M6ASITE009374		Click to Show/Hide the Full List
mod site	chr11:119093934-119093935:-		[5]
Sequence	CTAACCCTTCCACGACTAGAACCTTAGGCATTGGGGAGTTT
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000375167.1; ENST00000530167.1
External Link	RMBase: m6A_site_166786
mod ID: M6ASITE009375		Click to Show/Hide the Full List
mod site	chr11:119093940-119093941:-		[6]
Sequence	CTGCAGCTAACCCTTCCACGACTAGAACCTTAGGCATTGGG
Motif Score	3.287565476
Cell/Tissue List	HEK293T; A549
Seq Type List	DART-seq; m6A-CLIP/IP
Transcript ID List	ENST00000375167.1; ENST00000530167.1
External Link	RMBase: m6A_site_166787
mod ID: M6ASITE009376		Click to Show/Hide the Full List
mod site	chr11:119093943-119093944:-		[6]
Sequence	ATTCTGCAGCTAACCCTTCCACGACTAGAACCTTAGGCATT
Motif Score	2.027047619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000375167.1; ENST00000530167.1
External Link	RMBase: m6A_site_166788
mod ID: M6ASITE009377		Click to Show/Hide the Full List
mod site	chr11:119093969-119093970:-		[5]
Sequence	GAGCCTCCGTTGGCTTCTGAACTGGAATTCTGCAGCTAACC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000530167.1; ENST00000375167.1
External Link	RMBase: m6A_site_166789
mod ID: M6ASITE009378		Click to Show/Hide the Full List
mod site	chr11:119093992-119093993:-		[5]
Sequence	GTCGGTTAATCCCTGTCTGGACTGAGCCTCCGTTGGCTTCT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000530167.1; ENST00000375167.1
External Link	RMBase: m6A_site_166790
mod ID: M6ASITE009379		Click to Show/Hide the Full List
mod site	chr11:119094016-119094017:-		[7]
Sequence	CCAAGCACCTAGATACCAGCACAAGTCGGTTAATCCCTGTC
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000375167.1; ENST00000530167.1
External Link	RMBase: m6A_site_166791
mod ID: M6ASITE009380		Click to Show/Hide the Full List
mod site	chr11:119094046-119094047:-		[6]
Sequence	TTTCCCTTCCAGCAAACTCAACTCGGCAATCCAAGCACCTA
Motif Score	2.595904762
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000530167.1; ENST00000375167.1
External Link	RMBase: m6A_site_166792
mod ID: M6ASITE009381		Click to Show/Hide the Full List
mod site	chr11:119094051-119094052:-		[5]
Sequence	CCCCATTTCCCTTCCAGCAAACTCAACTCGGCAATCCAAGC
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; DART-seq
Transcript ID List	ENST00000530167.1; ENST00000375167.1
External Link	RMBase: m6A_site_166793
mod ID: M6ASITE009382		Click to Show/Hide the Full List
mod site	chr11:119094134-119094135:-		[5]
Sequence	CTTCACGGCTGGCTATGTGGACAGCAAGAGTCGTTTTCGCG
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; brain; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000530167.1; ENST00000375167.1
External Link	RMBase: m6A_site_166794
mod ID: M6ASITE009383		Click to Show/Hide the Full List
mod site	chr11:119094187-119094188:-		[5]
Sequence	AGTGACTGCCTCCTAGGAGGACATTTAGGGGAGGGCAGAGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000375167.1; ENST00000530167.1
External Link	RMBase: m6A_site_166795
mod ID: M6ASITE009384		Click to Show/Hide the Full List
mod site	chr11:119094227-119094228:-		[7]
Sequence	CCGGGACGAAGCACTTGGTAACAGGCACATCTTCCTCCCGA
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T; A549; AML
Seq Type List	MAZTER-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000375167.1; ENST00000530167.1
External Link	RMBase: m6A_site_166796
mod ID: M6ASITE009385		Click to Show/Hide the Full List
mod site	chr11:119094242-119094243:-		[8]
Sequence	AGGTCTGCGCTGGGGCCGGGACGAAGCACTTGGTAACAGGC
Motif Score	3.616982143
Cell/Tissue List	CD8T; A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000530167.1; ENST00000375167.1
External Link	RMBase: m6A_site_166797
mod ID: M6ASITE009386		Click to Show/Hide the Full List
mod site	chr11:119094291-119094292:-		[7]
Sequence	GGCCGGGACCCAGGCCTTTCACATCAGCTCTCCCTCCATCT
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000375167.1; ENST00000530167.1
External Link	RMBase: m6A_site_166798
mod ID: M6ASITE009387		Click to Show/Hide the Full List
mod site	chr11:119094304-119094305:-		[5]
Sequence	GCGCCCCTTCTGCGGCCGGGACCCAGGCCTTTCACATCAGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000375167.1; ENST00000530167.1
External Link	RMBase: m6A_site_166799
mod ID: M6ASITE009388		Click to Show/Hide the Full List
mod site	chr11:119094390-119094391:-		[5]
Sequence	GGCGTGGTGCTTAGCCCAGGACTTTCAGACGCGGCCGCTGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000375167.1; ENST00000530167.1
External Link	RMBase: m6A_site_166800
mod ID: M6ASITE009389		Click to Show/Hide the Full List
mod site	chr11:119094526-119094527:-		[5]
Sequence	GCCGCAGCACCTTCTGGAAGACTTGGCCTTCCGCTCTGACG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000530167.1; ENST00000375167.1
External Link	RMBase: m6A_site_166801
mod ID: M6ASITE009390		Click to Show/Hide the Full List
mod site	chr11:119094588-119094589:-		[9]
Sequence	TGCCCGCCTCGGCGTTCGTGACTCAGCCGCCCCATCCCGAG
Motif Score	3.28175
Cell/Tissue List	AML
Seq Type List	miCLIP
Transcript ID List	ENST00000530167.1; ENST00000375167.1
External Link	RMBase: m6A_site_166802
mod ID: M6ASITE009391		Click to Show/Hide the Full List
mod site	chr11:119094646-119094647:-		[5]
Sequence	GGACCTCCGTGGCGCGGAAGACCCGAGCCTGCCGGGGGGAG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; GM12878; LCLs; MT4; H1299; MM6; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; TIME; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000530167.1; ENST00000375167.1
External Link	RMBase: m6A_site_166803
mod ID: M6ASITE009392		Click to Show/Hide the Full List
mod site	chr11:119094664-119094665:-		[5]
Sequence	GGCTTGGGCGCTCTTCGGGGACCTCCGTGGCGCGGAAGACC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; GM12878; LCLs; MT4; H1299; MM6; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; TIME; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000530167.1; ENST00000375167.1
External Link	RMBase: m6A_site_166804
mod ID: M6ASITE009393		Click to Show/Hide the Full List
mod site	chr11:119094860-119094861:-		[5]
Sequence	AAAGAGCTGAGCCGCTTCAGACTGCGGGGCAAGCGGGCCGC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; CD8T; MT4; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000530167.1; ENST00000375167.1
External Link	RMBase: m6A_site_166805
mod ID: M6ASITE009394		Click to Show/Hide the Full List
mod site	chr11:119094917-119094918:-		[7]
Sequence	CCAGGCCTCCCCATGCCACCACAAAGGCCCTTTTAAGGGCC
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000530167.1; ENST00000375167.1
External Link	RMBase: m6A_site_166806
mod ID: M6ASITE009395		Click to Show/Hide the Full List
mod site	chr11:119095033-119095034:-		[5]
Sequence	CCGTGCTGCTGCCCAAGAAGACCAGCGCCACCGTGGGGCCG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; hNPCs; LCLs; MT4; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; TIME; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000375167.1; ENST00000530167.1
External Link	RMBase: m6A_site_166807
mod ID: M6ASITE009396		Click to Show/Hide the Full List
mod site	chr11:119095062-119095063:-		[7]
Sequence	CCAGGGAGGCGTCCTGCCCAACATCCAGGCCGTGCTGCTGC
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000530167.1; ENST00000375167.1
External Link	RMBase: m6A_site_166808
mod ID: M6ASITE009397		Click to Show/Hide the Full List
mod site	chr11:119095110-119095111:-		[7]
Sequence	CCGCAACGACGAGGAGCTCAACAAGCTGCTGGGCGGCGTGA
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000375167.1; ENST00000530167.1
External Link	RMBase: m6A_site_166809
mod ID: M6ASITE009398		Click to Show/Hide the Full List
mod site	chr11:119095173-119095174:-		[7]
Sequence	GGGCAATGCGGCCCGCGACAACAAGAAGACGCGAATCATCC
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000530167.1; ENST00000375167.1
External Link	RMBase: m6A_site_166810
mod ID: M6ASITE009399		Click to Show/Hide the Full List
mod site	chr11:119095176-119095177:-		[7]
Sequence	GGCGGGCAATGCGGCCCGCGACAACAAGAAGACGCGAATCA
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000530167.1; ENST00000375167.1
External Link	RMBase: m6A_site_166811
mod ID: M6ASITE009400		Click to Show/Hide the Full List
mod site	chr11:119095301-119095302:-		[7]
Sequence	CAGTTCCCAGTGGGCCGTGTACACCGGCTGCTGCGGAAGGG
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000375167.1; ENST00000530167.1
External Link	RMBase: m6A_site_166812
mod ID: M6ASITE009401		Click to Show/Hide the Full List
mod site	chr11:119095375-119095376:-		[5]
Sequence	GCATGTCGGGCCGCGGCAAGACTGGCGGCAAGGCCCGCGCC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; A549; fibroblasts; Jurkat; CD4T; GSC-11; HEK293T; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000530167.1; ENST00000375167.1
External Link	RMBase: m6A_site_166813
mod ID: M6ASITE009402		Click to Show/Hide the Full List
mod site	chr11:119095457-119095458:-		[7]
Sequence	GCGCGCGCGCGACAGCAGTTACACTGCGGCGGGCGTCTGTT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000530167.1
External Link	RMBase: m6A_site_166814

Ref 1	The component of the m(6)A writer complex VIRMA is implicated in aggressive tumor phenotype, DNA damage response and cisplatin resistance in germ cell tumors. J Exp Clin Cancer Res. 2021 Aug 25;40(1):268. doi: 10.1186/s13046-021-02072-9.
Ref 2	Differential Influence of the Antiretroviral Pharmacokinetic Enhancers Ritonavir and Cobicistat on Intestinal P-Glycoprotein Transport and the Pharmacokinetic/Pharmacodynamic Disposition of Dabigatran. Antimicrob Agents Chemother. 2017 Oct 24;61(11):e01201-17. doi: 10.1128/AAC.01201-17. Print 2017 Nov.
Ref 3	Ninlaro- European Medicines Agency - European Union
Ref 4	Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6784-6789. doi: 10.1073/pnas.1817334116. Epub 2019 Mar 14.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 7	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 8	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 9	The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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