m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00449)
Target Name Vacuolar protein-sorting-associated protein 25 (VPS25)
Synonyms
hVps25; Dermal papilla-derived protein 9; ELL-associated protein of 20 kDa; ESCRT-II complex subunit VPS25; DERP9; EAP20
    Click to Show/Hide
Gene Name VPS25
Chromosomal Location 17q21.31
Family VPS25 family
Function
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses.
    Click to Show/Hide
Gene ID 84313
Uniprot ID
VPS25_HUMAN
HGNC ID
HGNC:28122
KEGG ID
hsa:84313
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
VPS25 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing protein 1 (YTHDC1) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary YTHDC1 inhibited glioma proliferation by reducing the expression of Vacuolar protein-sorting-associated protein 25 (VPS25).
Target Regulation Down regulation
Responsed Disease Glioma ICD-11: 2A00.0
 Disease Info 
Pathway Response JAK-STAT signaling pathway hsa04630
Cell Process Arrest cell cycle at G0/G1 phase
Cell apoptosis
In-vitro Model U251 (Fibroblasts or fibroblast like cells)
U-87MG ATCC Glioblastoma Homo sapiens CVCL_0022
In-vivo Model The U87MG cells (1 × 107 cells in 0.1 ml PBS) were injected subcutaneously into BALB/c nude mice. Tumor width and length were recorded every 5 days.
Brain cancer [ICD-11: 2A00]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary YTHDC1 inhibited glioma proliferation by reducing the expression of Vacuolar protein-sorting-associated protein 25 (VPS25).
Responsed Disease Glioma [ICD-11: 2A00.0]
Target Regulator YTH domain-containing protein 1 (YTHDC1) READER
 Regulator Info 
Target Regulation Down regulation
Pathway Response JAK-STAT signaling pathway hsa04630
Cell Process Arrest cell cycle at G0/G1 phase
Cell apoptosis
In-vitro Model U251 (Fibroblasts or fibroblast like cells)
U-87MG ATCC Glioblastoma Homo sapiens CVCL_0022
In-vivo Model The U87MG cells (1 × 107 cells in 0.1 ml PBS) were injected subcutaneously into BALB/c nude mice. Tumor width and length were recorded every 5 days.
RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00449)
Vacuolar protein-sorting-associated protein 25 (VPS25)
Adenosine-to-Inosine editing (A-to-I)
In total 4 m6A sequence/site(s) in this target gene
mod ID: A2ISITE008049 Click to Show/Hide the Full List
mod site chr17:42777795-42777796:+ [2]
Sequence TACATAGCGTAAACACTCTTAGTTCTTTTTCTCCGACTCCA
Transcript ID List ENST00000590339.5; ENST00000589520.1; ENST00000253794.7
External Link RMBase: RNA-editing_site_57656
mod ID: A2ISITE008050 Click to Show/Hide the Full List
mod site chr17:42778300-42778301:+ [2]
Sequence TCAAGTGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGAT
Transcript ID List ENST00000253794.7; ENST00000590339.5; ENST00000589520.1
External Link RMBase: RNA-editing_site_57657
mod ID: A2ISITE008051 Click to Show/Hide the Full List
mod site chr17:42778403-42778404:+ [3]
Sequence CATGTTGGCCAGGGTGGTCTAGAACTCCTGATCTCAAGTGA
Transcript ID List ENST00000253794.7; ENST00000590339.5; ENST00000589520.1
External Link RMBase: RNA-editing_site_57658
mod ID: A2ISITE008052 Click to Show/Hide the Full List
mod site chr17:42778604-42778605:+ [2]
Sequence ATCCTCTAGGGTCAGTGTCTAGTGACAATGGCTCCGATCTC
Transcript ID List ENST00000589520.1; ENST00000590339.5; ENST00000253794.7
External Link RMBase: RNA-editing_site_57659
5-methylcytidine (m5C)
In total 3 m6A sequence/site(s) in this target gene
mod ID: M5CSITE001141 Click to Show/Hide the Full List
mod site chr17:42778544-42778545:+
Sequence TGCTGGAGTTTAACAGTCTCCTGGCCAGGGGTACTGGCTAT
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List ENST00000589520.1; ENST00000253794.7; ENST00000590339.5
External Link RMBase: m5C_site_19044
mod ID: M5CSITE001142 Click to Show/Hide the Full List
mod site chr17:42778953-42778954:+ [4]
Sequence TCTGCCTATCTCTCCCTGTTCAGAGTTCCACGGGCTGGATG
Seq Type List Bisulfite-seq
Transcript ID List ENST00000589520.1; ENST00000590339.5; ENST00000253794.7
External Link RMBase: m5C_site_19045
mod ID: M5CSITE001143 Click to Show/Hide the Full List
mod site chr17:42779076-42779077:+ [4]
Sequence CAAGTTCTTCTAGCAGGGACCTGTCTCCCTTTACTTCTTAC
Seq Type List Bisulfite-seq
Transcript ID List ENST00000589520.1; ENST00000253794.7
External Link RMBase: m5C_site_19046
N6-methyladenosine (m6A)
In total 33 m6A sequence/site(s) in this target gene
mod ID: M6ASITE032908 Click to Show/Hide the Full List
mod site chr17:42773539-42773540:+ [5]
Sequence CTTCTTTACGTGAGGCTCAGACCCCAAGAAGCACCGCTGTG
Motif Score 2.876744048
Cell/Tissue List HeLa; A549; HepG2; H1B; HEK293T; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000589520.1; ENST00000591584.1; ENST00000253794.7; ENST00000589219.1; ENST00000590339.5; ENST00000589577.1
External Link RMBase: m6A_site_364308
mod ID: M6ASITE032909 Click to Show/Hide the Full List
mod site chr17:42773579-42773580:+ [5]
Sequence GCCTCCCTCCCCTCCCCCGGACCCTGGGCTCAGCCCTGATG
Motif Score 3.622404762
Cell/Tissue List HeLa; A549; HepG2; H1B; HEK293T; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000591584.1; ENST00000589520.1; ENST00000253794.7; ENST00000589577.1; ENST00000589219.1; ENST00000590339.5
External Link RMBase: m6A_site_364309
mod ID: M6ASITE032911 Click to Show/Hide the Full List
mod site chr17:42773625-42773626:+ [5]
Sequence TATGGGGAGGGGGAGAAAAGACCCGTCGGCCAACACCCTCA
Motif Score 2.876744048
Cell/Tissue List HeLa; A549; H1B; HEK293A-TOA; iSLK; MSC; TIME
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000589219.1; ENST00000589520.1; ENST00000589577.1; ENST00000591584.1; ENST00000253794.7; ENST00000590339.5
External Link RMBase: m6A_site_364310
mod ID: M6ASITE032912 Click to Show/Hide the Full List
mod site chr17:42773735-42773736:+ [6]
Sequence CTCCCTTCACCCGGCAGGTTACAACCGAATGTGGACACTCG
Motif Score 2.07285119
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000590339.5; ENST00000589577.1; ENST00000589520.1; ENST00000253794.7; ENST00000591584.1; ENST00000589219.1
External Link RMBase: m6A_site_364311
mod ID: M6ASITE032913 Click to Show/Hide the Full List
mod site chr17:42773749-42773750:+ [5]
Sequence CAGGTTACAACCGAATGTGGACACTCGGCAGAAGCAGCTGG
Motif Score 3.643047619
Cell/Tissue List A549; hESC-HEK293T; Huh7; peripheral-blood; GSC-11; iSLK; endometrial
Seq Type List MeRIP-seq; MAZTER-seq; m6A-seq
Transcript ID List ENST00000589577.1; ENST00000589520.1; ENST00000590339.5; ENST00000253794.7; ENST00000589219.1; ENST00000591584.1
External Link RMBase: m6A_site_364312
mod ID: M6ASITE032914 Click to Show/Hide the Full List
mod site chr17:42773809-42773810:+ [6]
Sequence CCTGTCCTTCTGCCGCCTGCACAAACAGTCCAGCATGACGG
Motif Score 2.830589286
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000589577.1; ENST00000590339.5; ENST00000589219.1; ENST00000591584.1; ENST00000253794.7; ENST00000589520.1
External Link RMBase: m6A_site_364313
mod ID: M6ASITE032915 Click to Show/Hide the Full List
mod site chr17:42773813-42773814:+ [5]
Sequence TCCTTCTGCCGCCTGCACAAACAGTCCAGCATGACGGTGAT
Motif Score 2.20572619
Cell/Tissue List A549; HeLa; Huh7; peripheral-blood; GSC-11; endometrial
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000589219.1; ENST00000591584.1; ENST00000590339.5; ENST00000589520.1; ENST00000589577.1; ENST00000253794.7
External Link RMBase: m6A_site_364314
mod ID: M6ASITE032916 Click to Show/Hide the Full List
mod site chr17:42773860-42773861:+ [6]
Sequence TCAGGAGAGCCCGCTCTTCAACAACGTCAAGCTACAGCGTA
Motif Score 2.173910714
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000590339.5; ENST00000589219.1; ENST00000589577.1; ENST00000589520.1; ENST00000591584.1; ENST00000253794.7
External Link RMBase: m6A_site_364315
mod ID: M6ASITE032917 Click to Show/Hide the Full List
mod site chr17:42774320-42774321:+ [7]
Sequence AGGCTGAAGGAAGGCAACAGACAGAGGGTGAGGAATGACAG
Motif Score 2.897386905
Cell/Tissue List peripheral-blood
Seq Type List m6A-seq
Transcript ID List ENST00000589577.1; ENST00000589219.1; ENST00000590339.5; ENST00000253794.7; ENST00000591584.1; ENST00000589520.1
External Link RMBase: m6A_site_364316
mod ID: M6ASITE032918 Click to Show/Hide the Full List
mod site chr17:42774685-42774686:+ [7]
Sequence ATCCAGATTGTATTAGAGGAACTGAGGAAGAAAGGTGGGTT
Motif Score 3.373380952
Cell/Tissue List peripheral-blood
Seq Type List m6A-seq
Transcript ID List ENST00000590339.5; ENST00000589219.1; ENST00000589520.1; ENST00000253794.7; ENST00000589577.1
External Link RMBase: m6A_site_364317
mod ID: M6ASITE032919 Click to Show/Hide the Full List
mod site chr17:42775383-42775384:+ [7]
Sequence AAGTATCTGTTTTACAGGGAACCTCGAGTGGTTGGATAAGA
Motif Score 2.930744048
Cell/Tissue List peripheral-blood
Seq Type List m6A-seq
Transcript ID List ENST00000589577.1; ENST00000589520.1; ENST00000253794.7; ENST00000590339.5
External Link RMBase: m6A_site_364318
mod ID: M6ASITE032920 Click to Show/Hide the Full List
mod site chr17:42775453-42775454:+ [7]
Sequence AGGCCAGAAGAATGGGGGAAACTCATCTATCAGTGGGTGAG
Motif Score 2.627720238
Cell/Tissue List peripheral-blood; NB4
Seq Type List m6A-seq
Transcript ID List ENST00000589577.1; ENST00000589520.1; ENST00000253794.7; ENST00000590339.5
External Link RMBase: m6A_site_364319
mod ID: M6ASITE032922 Click to Show/Hide the Full List
mod site chr17:42776263-42776264:+ [6]
Sequence GGTTTCCAGGAGTGGCCAGAACAACTCCGTCTTTACCCTGT
Motif Score 2.951386905
Cell/Tissue List hESC-HEK293T; peripheral-blood; NB4
Seq Type List MAZTER-seq; m6A-seq
Transcript ID List ENST00000590339.5; ENST00000253794.7; ENST00000589520.1; ENST00000589577.1
External Link RMBase: m6A_site_364320
mod ID: M6ASITE032923 Click to Show/Hide the Full List
mod site chr17:42776288-42776289:+ [7]
Sequence TCCGTCTTTACCCTGTATGAACTGACTAATGGGGAAGACAC
Motif Score 3.373380952
Cell/Tissue List peripheral-blood; NB4
Seq Type List m6A-seq
Transcript ID List ENST00000253794.7; ENST00000589520.1; ENST00000589577.1; ENST00000590339.5
External Link RMBase: m6A_site_364321
mod ID: M6ASITE032924 Click to Show/Hide the Full List
mod site chr17:42776305-42776306:+ [6]
Sequence TGAACTGACTAATGGGGAAGACACAGAGGATGAGGGTAATG
Motif Score 2.897386905
Cell/Tissue List hESC-HEK293T; NB4
Seq Type List MAZTER-seq; m6A-seq
Transcript ID List ENST00000590339.5; ENST00000589577.1; ENST00000253794.7; ENST00000589520.1
External Link RMBase: m6A_site_364322
mod ID: M6ASITE032925 Click to Show/Hide the Full List
mod site chr17:42779016-42779017:+ [6]
Sequence GCAGGCCCTACAGCAGGAGCACAAGGCCGAGATCATCACTG
Motif Score 2.830589286
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000589520.1; ENST00000253794.7
External Link RMBase: m6A_site_364323
mod ID: M6ASITE032926 Click to Show/Hide the Full List
mod site chr17:42779074-42779075:+ [8]
Sequence GTCAAGTTCTTCTAGCAGGGACCTGTCTCCCTTTACTTCTT
Motif Score 3.622404762
Cell/Tissue List HeLa; HepG2; A549; HEK293T; peripheral-blood; MSC; TREX; NB4; MM6
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000589520.1; ENST00000253794.7
External Link RMBase: m6A_site_364324
mod ID: M6ASITE032927 Click to Show/Hide the Full List
mod site chr17:42779088-42779089:+ [9]
Sequence GCAGGGACCTGTCTCCCTTTACTTCTTACCTCCCACCTTTC
Motif Score 2.494845238
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000589520.1; ENST00000253794.7
External Link RMBase: m6A_site_364325
mod ID: M6ASITE032928 Click to Show/Hide the Full List
mod site chr17:42779095-42779096:+ [9]
Sequence CCTGTCTCCCTTTACTTCTTACCTCCCACCTTTCCAGGGCT
Motif Score 2.052208333
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000589520.1; ENST00000253794.7
External Link RMBase: m6A_site_364326
mod ID: M6ASITE032929 Click to Show/Hide the Full List
mod site chr17:42779127-42779128:+ [8]
Sequence TCCAGGGCTTTCAAAAGGAGACAGACCCAGTGTCCCCCAAA
Motif Score 2.897386905
Cell/Tissue List HeLa; HepG2; A549; hESC-HEK293T; H1A; H1B; hNPCs; hESCs; LCLs; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4; MM6
Seq Type List m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List ENST00000253794.7; ENST00000589520.1
External Link RMBase: m6A_site_364327
mod ID: M6ASITE032930 Click to Show/Hide the Full List
mod site chr17:42779131-42779132:+ [10]
Sequence GGGCTTTCAAAAGGAGACAGACCCAGTGTCCCCCAAAGACT
Motif Score 2.876744048
Cell/Tissue List A549
Seq Type List m6A-CLIP/IP
Transcript ID List ENST00000589520.1; ENST00000253794.7
External Link RMBase: m6A_site_364328
mod ID: M6ASITE032931 Click to Show/Hide the Full List
mod site chr17:42779149-42779150:+ [8]
Sequence AGACCCAGTGTCCCCCAAAGACTGGATCTGTGACTCCACCA
Motif Score 3.319380952
Cell/Tissue List HeLa; HepG2; A549; HEK293T; H1A; H1B; hNPCs; hESCs; LCLs; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4; MM6
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000253794.7; ENST00000589520.1
External Link RMBase: m6A_site_364329
mod ID: M6ASITE032933 Click to Show/Hide the Full List
mod site chr17:42779171-42779172:+ [8]
Sequence TGGATCTGTGACTCCACCAGACTCAAAAGGACTCCAGTCCT
Motif Score 3.319380952
Cell/Tissue List HeLa; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; LCLs; CD8T; MM6; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List m6A-seq; DART-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List ENST00000253794.7; ENST00000589520.1
External Link RMBase: m6A_site_364330
mod ID: M6ASITE032934 Click to Show/Hide the Full List
mod site chr17:42779181-42779182:+ [8]
Sequence ACTCCACCAGACTCAAAAGGACTCCAGTCCTGAAGGCTGGG
Motif Score 4.065041667
Cell/Tissue List HeLa; HepG2; A549; HEK293T; H1A; H1B; hNPCs; hESCs; fibroblasts; LCLs; MM6; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000589520.1; ENST00000253794.7
External Link RMBase: m6A_site_364331
mod ID: M6ASITE032935 Click to Show/Hide the Full List
mod site chr17:42779202-42779203:+ [8]
Sequence CTCCAGTCCTGAAGGCTGGGACCTGGGGATGGGTTTCTCAC
Motif Score 3.622404762
Cell/Tissue List HeLa; HepG2; A549; HEK293T; H1A; H1B; hNPCs; hESCs; fibroblasts; LCLs; MM6; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000253794.7; ENST00000589520.1
External Link RMBase: m6A_site_364332
mod ID: M6ASITE032936 Click to Show/Hide the Full List
mod site chr17:42779221-42779222:+ [9]
Sequence GACCTGGGGATGGGTTTCTCACACCCCATATGTCTGTCCCT
Motif Score 2.047297619
Cell/Tissue List HEK293T; hESC-HEK293T
Seq Type List DART-seq; MAZTER-seq
Transcript ID List ENST00000253794.7; ENST00000589520.1
External Link RMBase: m6A_site_364333
mod ID: M6ASITE032937 Click to Show/Hide the Full List
mod site chr17:42779315-42779316:+ [11]
Sequence TACCTCCTTTCCCATCCTAGACTGTCCTTGAGCCAGGGTCT
Motif Score 3.319380952
Cell/Tissue List HepG2; HEK293T; HeLa; A549; iSLK; MSC; TREX
Seq Type List m6A-seq; DART-seq; MeRIP-seq
Transcript ID List ENST00000253794.7; ENST00000589520.1
External Link RMBase: m6A_site_364334
mod ID: M6ASITE032938 Click to Show/Hide the Full List
mod site chr17:42779340-42779341:+ [8]
Sequence CCTTGAGCCAGGGTCTGTAAACCTGACACTTTATATGTGTT
Motif Score 2.185083333
Cell/Tissue List HeLa; A549; iSLK; TREX; AML
Seq Type List m6A-seq; MeRIP-seq; miCLIP
Transcript ID List ENST00000253794.7; ENST00000589520.1
External Link RMBase: m6A_site_364335
mod ID: M6ASITE032939 Click to Show/Hide the Full List
mod site chr17:42779345-42779346:+ [6]
Sequence AGCCAGGGTCTGTAAACCTGACACTTTATATGTGTTCACAC
Motif Score 2.859755952
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000589520.1; ENST00000253794.7
External Link RMBase: m6A_site_364336
mod ID: M6ASITE032940 Click to Show/Hide the Full List
mod site chr17:42779374-42779375:+ [9]
Sequence ATGTGTTCACACATGTAAGTACATACACACATGCGCCTGCA
Motif Score 2.856142857
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000253794.7
External Link RMBase: m6A_site_364337
mod ID: M6ASITE032941 Click to Show/Hide the Full List
mod site chr17:42779378-42779379:+ [9]
Sequence GTTCACACATGTAAGTACATACACACATGCGCCTGCAGCAC
Motif Score 2.110482143
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000253794.7
External Link RMBase: m6A_site_364338
mod ID: M6ASITE032942 Click to Show/Hide the Full List
mod site chr17:42779397-42779398:+ [6]
Sequence TACACACATGCGCCTGCAGCACATGCTTCTGTCTCCTCCTC
Motif Score 2.830589286
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000253794.7
External Link RMBase: m6A_site_364339
mod ID: M6ASITE032943 Click to Show/Hide the Full List
mod site chr17:42779565-42779566:+ [6]
Sequence GCAGTGAGAGGTGTGGCCCCACACCGATTTATGATATTAAA
Motif Score 2.053113095
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000253794.7
External Link RMBase: m6A_site_364340
Pseudouridine (Pseudo)
In total 1 m6A sequence/site(s) in this target gene
mod ID: PSESITE000090 Click to Show/Hide the Full List
mod site chr17:42773471-42773472:+ [12]
Sequence TTCCGGGTTTCCTGGGCTACTACGATGGCGATGAGTTTCGA
Transcript ID List ENST00000589219.1; ENST00000253794.7; ENST00000591584.1; ENST00000589577.1
External Link RMBase: Pseudo_site_2016