General Information of the m6A Target Gene (ID: M6ATAR00442)
Target Name Ubiquilin-4 (UBQLN4)
Synonyms
Ataxin-1 interacting ubiquitin-like protein; A1Up; Ataxin-1 ubiquitin-like-interacting protein A1U; Connexin43-interacting protein of 75 kDa; CIP75; C1orf6; CIP75; UBIN
    Click to Show/Hide
Gene Name UBQLN4
Chromosomal Location 1q22
Function
Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins. Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain. Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome. MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation. Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm. Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion.
    Click to Show/Hide
Gene ID 56893
Uniprot ID
UBQL4_HUMAN
HGNC ID
HGNC:1237
Ensembl Gene ID
ENSG00000160803
KEGG ID
hsa:56893
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
UBQLN4 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Disease
Solid tumour/cancer [ICD-11: 2A00-2F9Z]
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response []
Response Summary The role of Ubiquilin-4 (UBQLN4) in pan-cancer for the first time. Based on the comprehensive analysis of multiomics data, we identified UBQLN4 as a potential molecular biomarker for prognosis and treatment in oncotherapy.
Responsed Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Pathway Response PI3K-Akt signaling pathway hsa04151
mTOR signaling pathway hsa04150
Cell Process Microsatellite instability
Mismatch repair
In-vitro Model ()