m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00428)

Target Name	Transforming growth factor beta-2 proprotein (TGFB2)
Synonyms	Cetermin; Glioblastoma-derived T-cell suppressor factor; G-TSF; LAP; TGF-beta-2 Click to Show/Hide
Gene Name	TGFB2
Chromosomal Location	1q41
Family	TGF-beta family
Function	Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.; [Latency-associated peptide]: Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 (By similarity).; Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). Click to Show/Hide
Gene ID	7042
Uniprot ID	TGFB2_HUMAN
HGNC ID	HGNC:11768
KEGG ID	hsa:7042

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

TGFB2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

YTH domain-containing protein 2 (YTHDC2) [READER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	Knockdown of YTHDC2 substantially promoted the proliferation rate of esophageal squamous cell carcinoma cells by affecting several cancer-related signaling pathways.
Target Regulation	Up regulation
Responsed Disease	Esophageal squamous cell carcinoma		ICD-11: 2B70.1	Disease Info
Pathway Response	p53 signaling pathway			hsa04115
	NF-kappa B signaling pathway			hsa04064
	JAK-STAT signaling pathway			hsa04630
Cell Process	Genetic variants
In-vitro Model	KYSE-150	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_1348
	KYSE-30	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_1351

Esophageal cancer [ICD-11: 2B70]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	Knockdown of YTHDC2 substantially promoted the proliferation rate of esophageal squamous cell carcinoma cells by affecting several cancer-related signaling pathways.
Responsed Disease	Esophageal squamous cell carcinoma [ICD-11: 2B70.1]
Target Regulator	YTH domain-containing protein 2 (YTHDC2)		READER	Regulator Info
Target Regulation	Up regulation
Pathway Response	p53 signaling pathway			hsa04115
	NF-kappa B signaling pathway			hsa04064
	JAK-STAT signaling pathway			hsa04630
Cell Process	Genetic variants
In-vitro Model	KYSE-150	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_1348
	KYSE-30	Esophageal squamous cell carcinoma	Homo sapiens	CVCL_1351

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00428)

Transforming growth factor beta-2 proprotein (TGFB2)

Adenosine-to-Inosine editing (A-to-I)

In total 1 m6A sequence/site(s) in this target gene
mod ID: A2ISITE002168		Click to Show/Hide the Full List
mod site	chr1:218354737-218354738:+		[2]
Sequence	ATGTAATACATCCATGGAAGAATGGTGGCTCTCCTCTGTTA
Transcript ID List	ENST00000488793.1; ENST00000366930.9; ENST00000366929.4
External Link	RMBase: RNA-editing_site_12368

N6-methyladenosine (m6A)

In total 50 m6A sequence/site(s) in this target gene
mod ID: M6ASITE084408		Click to Show/Hide the Full List
mod site	chr1:218345402-218345403:+		[3]
Sequence	AAGCTCCTGACAAGAGAAAGACAGATTGAGATAGAGATAGA
Motif Score	2.897386905
Cell/Tissue List	A549; U2OS; fibroblasts; Huh7; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	rmsk_386652; ENST00000366930.9
External Link	RMBase: m6A_site_79142
mod ID: M6ASITE084409		Click to Show/Hide the Full List
mod site	chr1:218345442-218345443:+		[3]
Sequence	AAAGAGAAAGAGAGAAAGAGACAGCAGAGCGAGAGCGCAAG
Motif Score	2.897386905
Cell/Tissue List	A549; U2OS; fibroblasts; Huh7; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366930.9; rmsk_386652
External Link	RMBase: m6A_site_79143
mod ID: M6ASITE084410		Click to Show/Hide the Full List
mod site	chr1:218345525-218345526:+		[3]
Sequence	GTCTAGGGAGTCATCCAGGAACAAACTGAGGGGCTGCCCGG
Motif Score	2.951386905
Cell/Tissue List	A549; U2OS; fibroblasts; Huh7; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366930.9
External Link	RMBase: m6A_site_79144
mod ID: M6ASITE084411		Click to Show/Hide the Full List
mod site	chr1:218345552-218345553:+		[4]
Sequence	GAGGGGCTGCCCGGCTGCAGACAGGAGGAGACAGAGAGGAT
Motif Score	2.897386905
Cell/Tissue List	U2OS; fibroblasts; A549; Huh7; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366930.9
External Link	RMBase: m6A_site_79145
mod ID: M6ASITE084412		Click to Show/Hide the Full List
mod site	chr1:218345562-218345563:+		[4]
Sequence	CCGGCTGCAGACAGGAGGAGACAGAGAGGATCTATTTTAGG
Motif Score	2.897386905
Cell/Tissue List	U2OS; fibroblasts; A549; Huh7; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366930.9
External Link	RMBase: m6A_site_79146
mod ID: M6ASITE084413		Click to Show/Hide the Full List
mod site	chr1:218345697-218345698:+		[4]
Sequence	GCAACCCCCTCAGGAATAAAACTCCCCAGCCAGGGTGTCGC
Motif Score	2.627720238
Cell/Tissue List	U2OS; Huh7; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366930.9
External Link	RMBase: m6A_site_79148
mod ID: M6ASITE084414		Click to Show/Hide the Full List
mod site	chr1:218346157-218346158:+		[5]
Sequence	GCGCCGCAGTGGAAGGCAGGACCGAACCGCTCCTTCTTTAA
Motif Score	3.622404762
Cell/Tissue List	A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000366930.9
External Link	RMBase: m6A_site_79149
mod ID: M6ASITE084415		Click to Show/Hide the Full List
mod site	chr1:218346162-218346163:+		[5]
Sequence	GCAGTGGAAGGCAGGACCGAACCGCTCCTTCTTTAAATATA
Motif Score	2.930744048
Cell/Tissue List	A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000366930.9
External Link	RMBase: m6A_site_79150
mod ID: M6ASITE084416		Click to Show/Hide the Full List
mod site	chr1:218346270-218346271:+		[4]
Sequence	CGCCAGCTGCCAGCCCCGGGACCTTTTCATCTCTTCCCTTT
Motif Score	3.622404762
Cell/Tissue List	U2OS; A549; Huh7; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366930.9; ENST00000366929.4
External Link	RMBase: m6A_site_79151
mod ID: M6ASITE084417		Click to Show/Hide the Full List
mod site	chr1:218346334-218346335:+		[4]
Sequence	TCCGCCACTCCGCACCCGAGACTGACACACTGAACTCCACT
Motif Score	3.319380952
Cell/Tissue List	U2OS; A549; Huh7; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000366930.9; ENST00000366929.4
External Link	RMBase: m6A_site_79152
mod ID: M6ASITE084418		Click to Show/Hide the Full List
mod site	chr1:218346347-218346348:+		[4]
Sequence	ACCCGAGACTGACACACTGAACTCCACTTCCTCCTCTTAAA
Motif Score	3.373380952
Cell/Tissue List	U2OS; A549; Huh7; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000366929.4; ENST00000366930.9
External Link	RMBase: m6A_site_79153
mod ID: M6ASITE084419		Click to Show/Hide the Full List
mod site	chr1:218346496-218346497:+		[4]
Sequence	TTAATATTTCCACTTTTGGAACTACTGGCCTTTTCTTTTTA
Motif Score	3.373380952
Cell/Tissue List	HEK293T; U2OS; A549; Huh7; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366929.4; ENST00000366930.9
External Link	RMBase: m6A_site_79154
mod ID: M6ASITE084420		Click to Show/Hide the Full List
mod site	chr1:218346588-218346589:+		[5]
Sequence	GCAAAAGTTTCGCATCAAAAACAACAACAACAAAAAACCAA
Motif Score	2.20572619
Cell/Tissue List	HEK293T; A549; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366930.9; rmsk_386656; ENST00000366929.4
External Link	RMBase: m6A_site_79155
mod ID: M6ASITE084421		Click to Show/Hide the Full List
mod site	chr1:218346604-218346605:+		[5]
Sequence	AAAAACAACAACAACAAAAAACCAAACAACTCTCCTTGATC
Motif Score	2.185083333
Cell/Tissue List	HEK293T; A549; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366929.4; ENST00000366930.9; rmsk_386656
External Link	RMBase: m6A_site_79156
mod ID: M6ASITE084422		Click to Show/Hide the Full List
mod site	chr1:218346609-218346610:+		[5]
Sequence	CAACAACAACAAAAAACCAAACAACTCTCCTTGATCTATAC
Motif Score	2.20572619
Cell/Tissue List	HEK293T; A549; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	rmsk_386656; ENST00000366930.9; ENST00000366929.4
External Link	RMBase: m6A_site_79157
mod ID: M6ASITE084423		Click to Show/Hide the Full List
mod site	chr1:218346663-218346664:+		[6]
Sequence	GATTTCTTTTTTTTATTCTGACTTTTAAAAACAACTTTTTT
Motif Score	3.28175
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000366930.9; ENST00000366929.4
External Link	RMBase: m6A_site_79158
mod ID: M6ASITE084424		Click to Show/Hide the Full List
mod site	chr1:218346673-218346674:+		[5]
Sequence	TTTTATTCTGACTTTTAAAAACAACTTTTTTTTCCACTTTT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; A549; Huh7; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366930.9; ENST00000366929.4
External Link	RMBase: m6A_site_79159
mod ID: M6ASITE084425		Click to Show/Hide the Full List
mod site	chr1:218346789-218346790:+		[3]
Sequence	CTGCAGCACACTCGATATGGACCAGTTCATGCGCAAGAGGA
Motif Score	3.622404762
Cell/Tissue List	HEK293T; A549; U2OS; fibroblasts; Huh7; GSC-11; HEK293A-TOA; iSLK; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366930.9; ENST00000366929.4
External Link	RMBase: m6A_site_79160
mod ID: M6ASITE084426		Click to Show/Hide the Full List
mod site	chr1:218346867-218346868:+		[3]
Sequence	GCTCACCAGTCCCCCAGAAGACTATCCTGAGCCCGAGGAAG
Motif Score	3.319380952
Cell/Tissue List	HEK293T; A549; U2OS; fibroblasts; MM6; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366930.9; ENST00000366929.4
External Link	RMBase: m6A_site_79161
mod ID: M6ASITE084427		Click to Show/Hide the Full List
mod site	chr1:218346927-218346928:+		[3]
Sequence	CATCTACAACAGCACCAGGGACTTGCTCCAGGAGAAGGCGA
Motif Score	4.065041667
Cell/Tissue List	A549; U2OS; fibroblasts; H1299; MM6; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000366929.4; ENST00000366930.9
External Link	RMBase: m6A_site_79162
mod ID: M6ASITE084428		Click to Show/Hide the Full List
mod site	chr1:218347020-218347021:+		[3]
Sequence	CAAGGAGGTTTACAAAATAGACATGCCGCCCTTCTTCCCCT
Motif Score	2.897386905
Cell/Tissue List	A549; U2OS; fibroblasts; H1299; MM6; Huh7; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366930.9; ENST00000366929.4
External Link	RMBase: m6A_site_79163
mod ID: M6ASITE084429		Click to Show/Hide the Full List
mod site	chr1:218363388-218363389:+		[7]
Sequence	GTGGGCAGCTTGTGCTCCAGACAGTCCCAGGTGCTCTGTGG
Motif Score	2.897386905
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000366930.9; ENST00000366929.4; ENST00000488793.1
External Link	RMBase: m6A_site_79164
mod ID: M6ASITE084430		Click to Show/Hide the Full List
mod site	chr1:218437479-218437480:+		[8]
Sequence	CCCGTATTTATGGAGTTCAGACACTCAGCACAGCAGGGTGA
Motif Score	2.897386905
Cell/Tissue List	BGC823
Seq Type List	m6A-seq
Transcript ID List	ENST00000366929.4; ENST00000366930.9; ENST00000479322.1
External Link	RMBase: m6A_site_79165
mod ID: M6ASITE084431		Click to Show/Hide the Full List
mod site	chr1:218441274-218441275:+		[8]
Sequence	TGCGTGTCCCAAGATTTAGAACCTCTAACCATTCTCTACTA
Motif Score	2.930744048
Cell/Tissue List	BGC823; U2OS; fibroblasts; A549
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000366930.9; ENST00000366929.4; ENST00000479322.1
External Link	RMBase: m6A_site_79166
mod ID: M6ASITE084432		Click to Show/Hide the Full List
mod site	chr1:218441305-218441306:+		[8]
Sequence	TTCTCTACTACATTGGCAAAACACCCAAGATTGAACAGCTT
Motif Score	2.20572619
Cell/Tissue List	BGC823; U2OS; fibroblasts; A549; Huh7; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000479322.1; ENST00000366930.9; ENST00000366929.4
External Link	RMBase: m6A_site_79167
mod ID: M6ASITE084433		Click to Show/Hide the Full List
mod site	chr1:218441319-218441320:+		[8]
Sequence	GGCAAAACACCCAAGATTGAACAGCTTTCTAATATGATTGT
Motif Score	2.951386905
Cell/Tissue List	BGC823; U2OS; fibroblasts; A549; Huh7; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000479322.1; ENST00000366930.9; ENST00000366929.4
External Link	RMBase: m6A_site_79168
mod ID: M6ASITE084434		Click to Show/Hide the Full List
mod site	chr1:218441383-218441384:+		[8]
Sequence	ATTCTTGGAAAAGTGGCAAGACCAAAATGACAATGATGATG
Motif Score	2.876744048
Cell/Tissue List	HEK293T; BGC823; U2OS; hNPCs; fibroblasts; A549; Huh7; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000479322.1; ENST00000366929.4; ENST00000366930.9
External Link	RMBase: m6A_site_79169
mod ID: M6ASITE084435		Click to Show/Hide the Full List
mod site	chr1:218441392-218441393:+		[9]
Sequence	AAAGTGGCAAGACCAAAATGACAATGATGATGATAATGATG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T; A549
Seq Type List	MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000366929.4; ENST00000366930.9; ENST00000479322.1; rmsk_386836
External Link	RMBase: m6A_site_79170
mod ID: M6ASITE084436		Click to Show/Hide the Full List
mod site	chr1:218441448-218441449:+		[8]
Sequence	ATGATGCTTGTAACAAGAAAACATAAGAGAGCCTTGGTTCA
Motif Score	2.20572619
Cell/Tissue List	HEK293T; BGC823; U2OS; hNPCs; fibroblasts; A549; MM6; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000479322.1; ENST00000366930.9; ENST00000366929.4
External Link	RMBase: m6A_site_79171
mod ID: M6ASITE084437		Click to Show/Hide the Full List
mod site	chr1:218441509-218441510:+		[10]
Sequence	AAAAGGCGGTACTAGTTCAGACACTTTGGAAGTTTGTGTTC
Motif Score	2.897386905
Cell/Tissue List	HEK293T; U2OS; fibroblasts; A549; MM6; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000479322.1; ENST00000366929.4; ENST00000366930.9
External Link	RMBase: m6A_site_79172
mod ID: M6ASITE084438		Click to Show/Hide the Full List
mod site	chr1:218441541-218441542:+		[10]
Sequence	TTTGTGTTCTGTTTGTTAAAACTGGCATCTGACACAAAAAA
Motif Score	2.627720238
Cell/Tissue List	HEK293T; U2OS; fibroblasts; A549; MM6; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000479322.1; ENST00000366930.9; ENST00000366929.4
External Link	RMBase: m6A_site_79173
mod ID: M6ASITE084439		Click to Show/Hide the Full List
mod site	chr1:218441609-218441610:+		[9]
Sequence	CTACTTTGTAAGTGAGAGAGACAAGAAGCAAATTTTTTTTA
Motif Score	2.897386905
Cell/Tissue List	HEK293T; hESC-HEK293T; U2OS; fibroblasts; A549; MM6; Huh7; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000366929.4; ENST00000479322.1; ENST00000366930.9
External Link	RMBase: m6A_site_79174
mod ID: M6ASITE084440		Click to Show/Hide the Full List
mod site	chr1:218441643-218441644:+		[4]
Sequence	TTTTTTAAAGAAAAAAATAAACACTGGAAGAATTTATTAGT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; U2OS; fibroblasts; A549; Huh7; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366930.9; ENST00000479322.1; ENST00000366929.4
External Link	RMBase: m6A_site_79175
mod ID: M6ASITE084441		Click to Show/Hide the Full List
mod site	chr1:218441677-218441678:+		[4]
Sequence	TATTAGTGTTAATTATGTGAACAACGACAACAACAACAACA
Motif Score	2.951386905
Cell/Tissue List	HEK293T; U2OS; fibroblasts; A549; Huh7; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	rmsk_386837; ENST00000479322.1; ENST00000366929.4; ENST00000366930.9
External Link	RMBase: m6A_site_79176
mod ID: M6ASITE084442		Click to Show/Hide the Full List
mod site	chr1:218441701-218441702:+		[9]
Sequence	CGACAACAACAACAACAACAACAAACAGGAAAATCCCATTA
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T; A549
Seq Type List	MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000366929.4; ENST00000479322.1; rmsk_386837; ENST00000366930.9
External Link	RMBase: m6A_site_79177
mod ID: M6ASITE084443		Click to Show/Hide the Full List
mod site	chr1:218441705-218441706:+		[4]
Sequence	AACAACAACAACAACAACAAACAGGAAAATCCCATTAAGTG
Motif Score	2.20572619
Cell/Tissue List	HEK293T; U2OS; fibroblasts; A549; Huh7; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366929.4; ENST00000366930.9; ENST00000479322.1
External Link	RMBase: m6A_site_79178
mod ID: M6ASITE084444		Click to Show/Hide the Full List
mod site	chr1:218441857-218441858:+		[6]
Sequence	TGTGTGTTACTATATAATGAACGTTTCATTGCCCTTGGAAA
Motif Score	2.925321429
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000366930.9; ENST00000479322.1; ENST00000366929.4
External Link	RMBase: m6A_site_79179
mod ID: M6ASITE084445		Click to Show/Hide the Full List
mod site	chr1:218441883-218441884:+		[4]
Sequence	CATTGCCCTTGGAAAATAAAACAGGTGTATAAAGTGGAGAC
Motif Score	2.20572619
Cell/Tissue List	U2OS; fibroblasts; A549; Huh7; HEK293A-TOA; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000479322.1; ENST00000366929.4; ENST00000366930.9
External Link	RMBase: m6A_site_79180
mod ID: M6ASITE084446		Click to Show/Hide the Full List
mod site	chr1:218441902-218441903:+		[3]
Sequence	AACAGGTGTATAAAGTGGAGACCAAATACTTTGCCAGAAAC
Motif Score	2.876744048
Cell/Tissue List	HEK293T; A549; U2OS; hNPCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000366930.9; ENST00000366929.4; ENST00000479322.1
External Link	RMBase: m6A_site_79181
mod ID: M6ASITE084447		Click to Show/Hide the Full List
mod site	chr1:218441921-218441922:+		[3]
Sequence	GACCAAATACTTTGCCAGAAACTCATGGATGGCTTAAGGAA
Motif Score	2.627720238
Cell/Tissue List	HEK293T; A549; U2OS; hNPCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000479322.1; ENST00000366930.9; ENST00000366929.4
External Link	RMBase: m6A_site_79182
mod ID: M6ASITE084448		Click to Show/Hide the Full List
mod site	chr1:218441941-218441942:+		[3]
Sequence	ACTCATGGATGGCTTAAGGAACTTGAACTCAAACGAGCCAG
Motif Score	3.373380952
Cell/Tissue List	HEK293T; A549; U2OS; hNPCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000366930.9; ENST00000479322.1; ENST00000366929.4
External Link	RMBase: m6A_site_79183
mod ID: M6ASITE084449		Click to Show/Hide the Full List
mod site	chr1:218441947-218441948:+		[3]
Sequence	GGATGGCTTAAGGAACTTGAACTCAAACGAGCCAGAAAAAA
Motif Score	3.373380952
Cell/Tissue List	HEK293T; A549; U2OS; hNPCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000366929.4; ENST00000366930.9; ENST00000479322.1
External Link	RMBase: m6A_site_79184
mod ID: M6ASITE084450		Click to Show/Hide the Full List
mod site	chr1:218441992-218441993:+		[3]
Sequence	GTCATATTAATGGGATGAAAACCCAAGTGAGTTATTATATG
Motif Score	2.185083333
Cell/Tissue List	HEK293T; A549; U2OS; hNPCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000479322.1; ENST00000366929.4; ENST00000366930.9
External Link	RMBase: m6A_site_79185
mod ID: M6ASITE084451		Click to Show/Hide the Full List
mod site	chr1:218442013-218442014:+		[6]
Sequence	CCCAAGTGAGTTATTATATGACCGAGAAAGTCTGCATTAAG
Motif Score	2.839113095
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000366930.9; ENST00000366929.4; ENST00000479322.1
External Link	RMBase: m6A_site_79186
mod ID: M6ASITE084452		Click to Show/Hide the Full List
mod site	chr1:218442040-218442041:+		[3]
Sequence	AAGTCTGCATTAAGATAAAGACCCTGAAAACACATGTTATG
Motif Score	2.876744048
Cell/Tissue List	A549; U2OS; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000479322.1; ENST00000366929.4; ENST00000366930.9
External Link	RMBase: m6A_site_79187
mod ID: M6ASITE084453		Click to Show/Hide the Full List
mod site	chr1:218442049-218442050:+		[3]
Sequence	TTAAGATAAAGACCCTGAAAACACATGTTATGTATCAGCTG
Motif Score	2.20572619
Cell/Tissue List	A549; U2OS; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366930.9; ENST00000366929.4; ENST00000479322.1
External Link	RMBase: m6A_site_79188
mod ID: M6ASITE084454		Click to Show/Hide the Full List
mod site	chr1:218442099-218442100:+		[3]
Sequence	GCTTCTTGTAAGGTCCAAAAACTAAAAAGACTGTTAATAAA
Motif Score	2.627720238
Cell/Tissue List	A549; U2OS; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366930.9; ENST00000366929.4; ENST00000479322.1
External Link	RMBase: m6A_site_79189
mod ID: M6ASITE084455		Click to Show/Hide the Full List
mod site	chr1:218442108-218442109:+		[3]
Sequence	AAGGTCCAAAAACTAAAAAGACTGTTAATAAAAGAAACTTT
Motif Score	3.319380952
Cell/Tissue List	A549; U2OS; fibroblasts; Huh7; iSLK
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000366930.9; ENST00000366929.4; ENST00000479322.1
External Link	RMBase: m6A_site_79190
mod ID: M6ASITE084456		Click to Show/Hide the Full List
mod site	chr1:218442124-218442125:+		[3]
Sequence	AAAGACTGTTAATAAAAGAAACTTTCAGTCAGAATAAGTCT
Motif Score	2.627720238
Cell/Tissue List	A549; U2OS; fibroblasts; Huh7; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000366930.9; ENST00000366929.4; ENST00000479322.1
External Link	RMBase: m6A_site_79191
mod ID: M6ASITE084457		Click to Show/Hide the Full List
mod site	chr1:218444040-218444041:+		[7]
Sequence	ACCATCATCGAGTCTAGAAAACACCTGTGATGCAATAAGAC
Motif Score	2.20572619
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000366930.9; ENST00000366929.4
External Link	RMBase: m6A_site_79192

Ref 1	Genetic variants in m6A modification genes are associated with esophageal squamous-cell carcinoma in the Chinese population. Carcinogenesis. 2020 Jul 10;41(6):761-768. doi: 10.1093/carcin/bgaa012.
Ref 2	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 3	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 4	RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell. 2013 Nov 7;155(4):793-806. doi: 10.1016/j.cell.2013.10.026.
Ref 5	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 6	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 7	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 8	METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer. Mol Cancer. 2019 Oct 13;18(1):142. doi: 10.1186/s12943-019-1065-4.
Ref 9	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 10	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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