m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00424)
Target Name Transcriptional enhancer factor TEF-4 (TEAD2)
Synonyms
TEA domain family member 2; TEAD-2; TEF4
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Gene Name TEAD2
Chromosomal Location 19q13.33
Function
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
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Gene ID 8463
Uniprot ID
TEAD2_HUMAN
HGNC ID
HGNC:11715
Ensembl Gene ID
ENSG00000074219
KEGG ID
hsa:8463
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
TEAD2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Fat mass and obesity-associated protein (FTO) [ERASER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by FTO
Cell Line Cerebral cortex Mus musculus
Treatment: METTL3 (f/f, Emx1-cre) cerebral cortex
Control: Wild type cerebral cortex
 GSE154992
Regulation
logFC: 6.75E-01
p-value: 4.59E-03
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary RNA decay assay showed that oncogene Transcriptional enhancer factor TEF-4 (TEAD2) mRNA stability was impaired by FTO. The overexpression of FTO suppressed tumor growth in vivo. In conclusion, our study demonstrated the critical roles of FTO in Intrahepatic cholangiocarcinoma.
Target Regulation Down regulation
Responsed Disease Intrahepatic cholangiocarcinoma ICD-11: 2C12.10
 Disease Info 
Cell Process Cell cycle
Cell proliferation
In-vitro Model HCCC-9810 Intrahepatic cholangiocarcinoma Homo sapiens CVCL_6908
HIBEPIC (Human intrahepatic bile duct epithelial cells)
HuCC-T1 Intrahepatic cholangiocarcinoma Homo sapiens CVCL_0324
RBE Intrahepatic cholangiocarcinoma Homo sapiens CVCL_4896
TFK-1 Cholangiocarcinoma Homo sapiens CVCL_2214
In-vivo Model 1.5 × 106 TFK1 cells with or without FTO overexpression were injected subcutaneously into the left and right flanks of 6-week-old female athymic nude mice
YTH domain-containing family protein 2 (YTHDF2) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [2]
Response Summary YTHDF3 recruits the PAN2-PAN3 deadenylase complex and conduces to reprogramming by promoting mRNA clearance of somatic genes, including Tead2 and Tgfb1, which parallels the activity of the YTHDF2-CCR4-NOT deadenylase complex. YTHDF2/3 deficiency suppressed the mRNA clearance of MEF-related genes, especially Transcriptional enhancer factor TEF-4 (TEAD2). YTHDF2/3 couples RNA deadenylation and regulation with the clearance of somatic genes and provides insights into iPSC reprogramming at the posttranscriptional level.
Target Regulation Down regulation
Pathway Response Hippo signaling pathway hsa04390
Cell Process Epithelial-mesenchymal transition
Chromatin silencing
In-vitro Model Plat-E Normal Homo sapiens CVCL_B488
OG2 mESCs (Male OG2 mESCs were derived from E3.5 embryos ICM from female 129 mice crossing male OG2 mice)
MEF (Mouse embryonic fibroblasts)
iPSC (Mouse induced pluripotent stem cells (iPSCs))
HEK293T Normal Homo sapiens CVCL_0063
In-vivo Model OG2 (Oct4-GFP reporter) transgenic mice (CBA/CaJ × C57BL/6J) were original from Jackson Laboratory (Mouse strain datasheet: 004654).
YTH domain-containing family protein 3 (YTHDF3) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [2]
Response Summary YTHDF3 recruits the PAN2-PAN3 deadenylase complex and conduces to reprogramming by promoting mRNA clearance of somatic genes, including Tead2 and Tgfb1, which parallels the activity of the YTHDF2-CCR4-NOT deadenylase complex. YTHDF2/3 deficiency suppressed the mRNA clearance of MEF-related genes, especially Transcriptional enhancer factor TEF-4 (TEAD2). YTHDF2/3 couples RNA deadenylation and regulation with the clearance of somatic genes and provides insights into iPSC reprogramming at the posttranscriptional level.
Target Regulation Down regulation
Pathway Response Hippo signaling pathway hsa04390
Cell Process Epithelial-mesenchymal transition
Chromatin silencing
In-vitro Model Plat-E Normal Homo sapiens CVCL_B488
OG2 mESCs (Male OG2 mESCs were derived from E3.5 embryos ICM from female 129 mice crossing male OG2 mice)
MEF (Mouse embryonic fibroblasts)
iPSC (Mouse induced pluripotent stem cells (iPSCs))
HEK293T Normal Homo sapiens CVCL_0063
In-vivo Model OG2 (Oct4-GFP reporter) transgenic mice (CBA/CaJ × C57BL/6J) were original from Jackson Laboratory (Mouse strain datasheet: 004654).
Liver cancer [ICD-11: 2C12]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary RNA decay assay showed that oncogene Transcriptional enhancer factor TEF-4 (TEAD2) mRNA stability was impaired by FTO. The overexpression of FTO suppressed tumor growth in vivo. In conclusion, our study demonstrated the critical roles of FTO in Intrahepatic cholangiocarcinoma.
Responsed Disease Intrahepatic cholangiocarcinoma [ICD-11: 2C12.10]
Target Regulator Fat mass and obesity-associated protein (FTO) ERASER
 Regulator Info 
Target Regulation Down regulation
Cell Process Cell cycle
Cell proliferation
In-vitro Model HCCC-9810 Intrahepatic cholangiocarcinoma Homo sapiens CVCL_6908
HIBEPIC (Human intrahepatic bile duct epithelial cells)
HuCC-T1 Intrahepatic cholangiocarcinoma Homo sapiens CVCL_0324
RBE Intrahepatic cholangiocarcinoma Homo sapiens CVCL_4896
TFK-1 Cholangiocarcinoma Homo sapiens CVCL_2214
In-vivo Model 1.5 × 106 TFK1 cells with or without FTO overexpression were injected subcutaneously into the left and right flanks of 6-week-old female athymic nude mice
References
Ref 1 Downregulation of Fat Mass and Obesity Associated (FTO) Promotes the Progression of Intrahepatic Cholangiocarcinoma. Front Oncol. 2019 May 9;9:369. doi: 10.3389/fonc.2019.00369. eCollection 2019.
Ref 2 YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways. Cell Rep. 2020 Sep 8;32(10):108120. doi: 10.1016/j.celrep.2020.108120.