m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00407)

Target Name	Transcription factor Sp2 (SP2)
Synonyms	KIAA0048 Click to Show/Hide
Gene Name	SP2
Chromosomal Location	17q21.32
Family	Sp1 C2H2-type zinc-finger protein family
Function	Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. Click to Show/Hide
Gene ID	6668
Uniprot ID	SP2_HUMAN
HGNC ID	HGNC:11207
KEGG ID	hsa:6668

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

SP2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL3*
Cell Line	Pancreatic islets	Mus musculus
Treatment: Mettl3 knockout mice Control: Mettl3 flox/flox mice		GSE155612
Regulation		logFC: 8.11E-01 p-value: 3.84E-03
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	Genes regulated by METTL3 in this way are necessary for acute myeloid leukaemia. Two genes expressing the transcription factors SP1 and Transcription factor Sp2 (SP2), which have promoters occupied by METTL3.
Responsed Disease	Acute myeloid leukaemia		ICD-11: 2A60	Disease Info
Cell Process	Cell cycle
In-vitro Model	EoL-1	Chronic eosinophilic leukemia	Homo sapiens	CVCL_0258
	HEL	Erythroleukemia	Homo sapiens	CVCL_0001
	HL-60	Adult acute myeloid leukemia	Homo sapiens	CVCL_0002
	Jurkat	T acute lymphoblastic leukemia	Homo sapiens	CVCL_0065
	K-562	Chronic myelogenous leukemia	Homo sapiens	CVCL_0004
	KG-1	Adult acute myeloid leukemia	Homo sapiens	CVCL_0374
	Loucy	Adult T acute lymphoblastic leukemia	Homo sapiens	CVCL_1380
	MOLM-13	Adult acute myeloid leukemia	Homo sapiens	CVCL_2119
	MV4-11	Childhood acute monocytic leukemia	Homo sapiens	CVCL_0064
	NOMO-1	Adult acute monocytic leukemia	Homo sapiens	CVCL_1609
	RN2c (Acute myeloid leukemia cell line)
	THP-1	Childhood acute monocytic leukemia	Homo sapiens	CVCL_0006
In-vivo Model	Performed an ex vivo genome wide CRISPR dropout screen (Screen 1) using Cas9-expressing mouse primary leukaemia cells driven by an MLL-AF9 fusion gene and a FLT3 internal tandem duplication.

Acute myeloid leukaemia [ICD-11: 2A60]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	Genes regulated by METTL3 in this way are necessary for acute myeloid leukaemia. Two genes expressing the transcription factors SP1 and Transcription factor Sp2 (SP2), which have promoters occupied by METTL3.
Responsed Disease	Acute myeloid leukaemia [ICD-11: 2A60]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Cell Process	Cell cycle
In-vitro Model	EoL-1	Chronic eosinophilic leukemia	Homo sapiens	CVCL_0258
	HEL	Erythroleukemia	Homo sapiens	CVCL_0001
	HL-60	Adult acute myeloid leukemia	Homo sapiens	CVCL_0002
	Jurkat	T acute lymphoblastic leukemia	Homo sapiens	CVCL_0065
	K-562	Chronic myelogenous leukemia	Homo sapiens	CVCL_0004
	KG-1	Adult acute myeloid leukemia	Homo sapiens	CVCL_0374
	Loucy	Adult T acute lymphoblastic leukemia	Homo sapiens	CVCL_1380
	MOLM-13	Adult acute myeloid leukemia	Homo sapiens	CVCL_2119
	MV4-11	Childhood acute monocytic leukemia	Homo sapiens	CVCL_0064
	NOMO-1	Adult acute monocytic leukemia	Homo sapiens	CVCL_1609
	RN2c (Acute myeloid leukemia cell line)
	THP-1	Childhood acute monocytic leukemia	Homo sapiens	CVCL_0006
In-vivo Model	Performed an ex vivo genome wide CRISPR dropout screen (Screen 1) using Cas9-expressing mouse primary leukaemia cells driven by an MLL-AF9 fusion gene and a FLT3 internal tandem duplication.

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00407)

Transcription factor Sp2 (SP2)

5-methylcytidine (m5C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE001204		Click to Show/Hide the Full List
mod site	chr17:47916544-47916545:+
Sequence	CTCACCAACCAGATCCAGATCATCCCTGGCACCAACCAAGC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000613139.1; ENST00000376741.5
External Link	RMBase: m5C_site_19373

N6-methyladenosine (m6A)

In total 47 m6A sequence/site(s) in this target gene
mod ID: M6ASITE033490		Click to Show/Hide the Full List
mod site	chr17:47897830-47897831:+		[2]
Sequence	GAAGGGGGCGAATCTATCAGACAACCTATCAATTGGGCTGA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000613139.1; ENST00000637314.1; ENST00000637943.1; ENST00000376741.5; ENST00000635868.1; ENST00000642065.1
External Link	RMBase: m6A_site_368882
mod ID: M6ASITE033491		Click to Show/Hide the Full List
mod site	chr17:47915319-47915320:+		[2]
Sequence	TTCTTCCAACAGATCCACAGACCAGCATGGCTGCCACTGCT
Motif Score	2.876744048
Cell/Tissue List	HeLa; A549; Jurkat; CD4T; GSC-11; TIME; iSLK; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000642065.1; ENST00000376741.5; ENST00000637314.1; ENST00000635868.1; ENST00000613139.1; ENST00000637943.1
External Link	RMBase: m6A_site_368899
mod ID: M6ASITE033492		Click to Show/Hide the Full List
mod site	chr17:47916268-47916269:+		[3]
Sequence	CCACAGCCCACACCGCGGAAACTTGTCCCTATCAAACCTGC
Motif Score	2.627720238
Cell/Tissue List	HepG2; HEK293T; HeLa; A549; U2OS; Huh7; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000613139.1; ENST00000637314.1; ENST00000376741.5
External Link	RMBase: m6A_site_368900
mod ID: M6ASITE033493		Click to Show/Hide the Full List
mod site	chr17:47916283-47916284:+		[4]
Sequence	CGGAAACTTGTCCCTATCAAACCTGCCCCTCTCCCTCTCAG
Motif Score	2.185083333
Cell/Tissue List	HEK293T; A549; U2OS; Huh7; iSLK; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000637314.1; ENST00000613139.1; ENST00000376741.5
External Link	RMBase: m6A_site_368901
mod ID: M6ASITE033494		Click to Show/Hide the Full List
mod site	chr17:47916367-47916368:+		[5]
Sequence	ATACTTCAGATTCAGGGGTCACAACTGAGCGCCTCCTATCC
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000613139.1; ENST00000376741.5; ENST00000637314.1
External Link	RMBase: m6A_site_368902
mod ID: M6ASITE033495		Click to Show/Hide the Full List
mod site	chr17:47916432-47916433:+		[5]
Sequence	CCAGAATCCCACCATGATCAACAAAGGGACCCGATCAAATG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000613139.1; ENST00000376741.5
External Link	RMBase: m6A_site_368903
mod ID: M6ASITE033496		Click to Show/Hide the Full List
mod site	chr17:47916440-47916441:+		[2]
Sequence	CCACCATGATCAACAAAGGGACCCGATCAAATGCCAATATC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; A549; MT4; Huh7; AML
Seq Type List	m6A-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000613139.1; ENST00000376741.5
External Link	RMBase: m6A_site_368904
mod ID: M6ASITE033497		Click to Show/Hide the Full List
mod site	chr17:47916503-47916504:+		[6]
Sequence	TTCAGGCAAGCAATTCCCAAACCATCCAAGTACAGCCCAAT
Motif Score	2.185083333
Cell/Tissue List	HEK293T; HeLa; hESCs; fibroblasts; A549; MT4; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000376741.5; ENST00000613139.1
External Link	RMBase: m6A_site_368905
mod ID: M6ASITE033498		Click to Show/Hide the Full List
mod site	chr17:47916591-47916592:+		[5]
Sequence	CACCCCCTCACCGTCCAGTCACAAGCCTGTCCCCATCAAGC
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000613139.1; ENST00000376741.5
External Link	RMBase: m6A_site_368906
mod ID: M6ASITE033499		Click to Show/Hide the Full List
mod site	chr17:47916720-47916721:+		[5]
Sequence	GACGCTCACTCTGCCCGTCAACAACCTTGTGAACGCCAGTG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000613139.1; ENST00000376741.5
External Link	RMBase: m6A_site_368907
mod ID: M6ASITE033500		Click to Show/Hide the Full List
mod site	chr17:47916797-47916798:+		[2]
Sequence	CCCCAACCCCGCTGTCTAAGACTAACAAGAAAGCAAGGAAG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000376741.5; ENST00000613139.1
External Link	RMBase: m6A_site_368908
mod ID: M6ASITE033501		Click to Show/Hide the Full List
mod site	chr17:47916801-47916802:+		[5]
Sequence	AACCCCGCTGTCTAAGACTAACAAGAAAGCAAGGAAGAAGA
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000376741.5; ENST00000613139.1
External Link	RMBase: m6A_site_368909
mod ID: M6ASITE033502		Click to Show/Hide the Full List
mod site	chr17:47916884-47916885:+		[2]
Sequence	TGGAGACGGTGCTGATCGAGACCACCGCGGACAACATCATC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1B; H1A; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000376741.5; ENST00000613139.1
External Link	RMBase: m6A_site_368910
mod ID: M6ASITE033503		Click to Show/Hide the Full List
mod site	chr17:47916894-47916895:+		[2]
Sequence	GCTGATCGAGACCACCGCGGACAACATCATCCAGGCAGGAA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hESC-HEK293T; H1B; H1A; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; endometrial
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000613139.1; ENST00000376741.5
External Link	RMBase: m6A_site_368911
mod ID: M6ASITE033504		Click to Show/Hide the Full List
mod site	chr17:47923043-47923044:+		[5]
Sequence	AACAGCTGCAGCCACCTCTAACACCACCTGTAGCAGCCCTG
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368914
mod ID: M6ASITE033505		Click to Show/Hide the Full List
mod site	chr17:47923090-47923091:+		[7]
Sequence	GTGCTCCCCATCTGAGTGGGACCAGCAAAAAGCACTCAGCT
Motif Score	3.622404762
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368915
mod ID: M6ASITE033506		Click to Show/Hide the Full List
mod site	chr17:47923220-47923221:+		[5]
Sequence	CCAGGCAATGCAGACCATCAACATCAATGGTGTCCAGGTCC
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368916
mod ID: M6ASITE033507		Click to Show/Hide the Full List
mod site	chr17:47924932-47924933:+		[8]
Sequence	CCACAGGGCAGCAGCAGCTGACAGTGCAGAATGTTTCTGGG
Motif Score	2.859755952
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368917
mod ID: M6ASITE033508		Click to Show/Hide the Full List
mod site	chr17:47924954-47924955:+		[5]
Sequence	AGTGCAGAATGTTTCTGGGAACAACCTGACCATCAGTGGGC
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368918
mod ID: M6ASITE033509		Click to Show/Hide the Full List
mod site	chr17:47925006-47925007:+		[5]
Sequence	CAGATCCAGCTGCAAATGGAACAAGCCCTGGCCGGAGAGAC
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368919
mod ID: M6ASITE033510		Click to Show/Hide the Full List
mod site	chr17:47925382-47925383:+		[5]
Sequence	CAAGAAGAAGCACGTGTGCCACATCCCCGACTGTGGCAAGA
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368920
mod ID: M6ASITE033511		Click to Show/Hide the Full List
mod site	chr17:47925445-47925446:+		[5]
Sequence	GCGTGCCCATGTGCGCCTGCACACTGGCGAGCGGCCCTTTG
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368921
mod ID: M6ASITE033512		Click to Show/Hide the Full List
mod site	chr17:47925498-47925499:+		[5]
Sequence	TCTTCTGTGGGAAGAGGTTCACACGGAGTGACGAGCTCCAA
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368922
mod ID: M6ASITE033513		Click to Show/Hide the Full List
mod site	chr17:47927726-47927727:+		[5]
Sequence	GCATCTCCTCTTCCCAGGGGACAAACGCTTCGAGTGCGCCC
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368923
mod ID: M6ASITE033514		Click to Show/Hide the Full List
mod site	chr17:47927792-47927793:+		[5]
Sequence	TGACCACCTCACCAAGCATTACAAGACCCACCTGGTCACGA
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368924
mod ID: M6ASITE033515		Click to Show/Hide the Full List
mod site	chr17:47927797-47927798:+		[9]
Sequence	ACCTCACCAAGCATTACAAGACCCACCTGGTCACGAAGAAC
Motif Score	2.876744048
Cell/Tissue List	MT4; Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368925
mod ID: M6ASITE033516		Click to Show/Hide the Full List
mod site	chr17:47927816-47927817:+		[9]
Sequence	GACCCACCTGGTCACGAAGAACTTGTAAGGCCAACTGCGGC
Motif Score	3.373380952
Cell/Tissue List	MT4; Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368926
mod ID: M6ASITE033517		Click to Show/Hide the Full List
mod site	chr17:47927945-47927946:+		[10]
Sequence	AGCCCCACTCCTGTTCTGCAACTGTCCCCACAGGAAGGGGC
Motif Score	2.595904762
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368927
mod ID: M6ASITE033518		Click to Show/Hide the Full List
mod site	chr17:47928050-47928051:+		[2]
Sequence	CGAGCTCCCGGCCTGCCCAGACTGTGGACACTGGCCGTGCC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; hESCs; fibroblasts; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq; DART-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368928
mod ID: M6ASITE033519		Click to Show/Hide the Full List
mod site	chr17:47928057-47928058:+		[2]
Sequence	CCGGCCTGCCCAGACTGTGGACACTGGCCGTGCCCAATGAG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; hESCs; fibroblasts; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368929
mod ID: M6ASITE033520		Click to Show/Hide the Full List
mod site	chr17:47928087-47928088:+		[2]
Sequence	TGCCCAATGAGACGTTCTAAACCAGGACGCGTGGGAACCCT
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; hESCs; fibroblasts; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368930
mod ID: M6ASITE033521		Click to Show/Hide the Full List
mod site	chr17:47928103-47928104:+		[2]
Sequence	CTAAACCAGGACGCGTGGGAACCCTTATTTCCAAAGGAAAA
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; hESCs; fibroblasts; GM12878; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368931
mod ID: M6ASITE033522		Click to Show/Hide the Full List
mod site	chr17:47928124-47928125:+		[2]
Sequence	CCCTTATTTCCAAAGGAAAAACATGCATTTCACTCCGTCGA
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; A549; hESC-HEK293T; HepG2; U2OS; hESCs; fibroblasts; GM12878; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq; DART-seq; MAZTER-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368932
mod ID: M6ASITE033523		Click to Show/Hide the Full List
mod site	chr17:47928189-47928190:+		[5]
Sequence	CACCCCGATCCCCGCTCCCAACACTGCCGGAGTCGCGTCAT
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368933
mod ID: M6ASITE033524		Click to Show/Hide the Full List
mod site	chr17:47928191-47928192:+		[10]
Sequence	CCCCGATCCCCGCTCCCAACACTGCCGGAGTCGCGTCATGC
Motif Score	2.506922619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368934
mod ID: M6ASITE033525		Click to Show/Hide the Full List
mod site	chr17:47928290-47928291:+		[2]
Sequence	TGGCACCCACCTCTGGAGAAACTCGGGGCCACCTCCACTCC
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; A549
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368935
mod ID: M6ASITE033526		Click to Show/Hide the Full List
mod site	chr17:47928328-47928329:+		[5]
Sequence	TCCATGTGCCCAGCCCCGCCACAACCTCTCCTCCAGCACAT
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368936
mod ID: M6ASITE033527		Click to Show/Hide the Full List
mod site	chr17:47928345-47928346:+		[10]
Sequence	GCCACAACCTCTCCTCCAGCACATTCCAGCTCTATTTAAAA
Motif Score	2.830589286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368937
mod ID: M6ASITE033528		Click to Show/Hide the Full List
mod site	chr17:47928373-47928374:+		[2]
Sequence	GCTCTATTTAAAAAGTAAAGACACCCACCGACTCCTGATCC
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; A549
Seq Type List	m6A-seq; MeRIP-seq; DART-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368938
mod ID: M6ASITE033529		Click to Show/Hide the Full List
mod site	chr17:47928444-47928445:+		[5]
Sequence	TACTCTACTTCAGATGATGAACACTGTGTACTGTGTGTGCT
Motif Score	2.951386905
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368939
mod ID: M6ASITE033530		Click to Show/Hide the Full List
mod site	chr17:47928453-47928454:+		[10]
Sequence	TCAGATGATGAACACTGTGTACTGTGTGTGCTTTAAAGAAG
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368940
mod ID: M6ASITE033531		Click to Show/Hide the Full List
mod site	chr17:47928577-47928578:+		[10]
Sequence	GAGCATATGAATTTTTTCTCACTCTAGCAATTCCCTTTTCT
Motif Score	2.469291667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368941
mod ID: M6ASITE033532		Click to Show/Hide the Full List
mod site	chr17:47928603-47928604:+		[5]
Sequence	GCAATTCCCTTTTCTAAATGACACAGCATTTAAACTCAAAT
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368942
mod ID: M6ASITE033533		Click to Show/Hide the Full List
mod site	chr17:47928616-47928617:+		[10]
Sequence	CTAAATGACACAGCATTTAAACTCAAATCTGGATTCAGATA
Motif Score	2.627720238
Cell/Tissue List	HEK293T; Huh7
Seq Type List	DART-seq; MeRIP-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368943
mod ID: M6ASITE033534		Click to Show/Hide the Full List
mod site	chr17:47928648-47928649:+		[10]
Sequence	ATTCAGATAACAGCACCTGCACATCCTGCACCTCCTCCCTC
Motif Score	2.830589286
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368944
mod ID: M6ASITE033535		Click to Show/Hide the Full List
mod site	chr17:47928732-47928733:+		[7]
Sequence	CAGTGTATATTGTATAATAGACAATTGTGTCTACTACATGT
Motif Score	2.897386905
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368945
mod ID: M6ASITE033536		Click to Show/Hide the Full List
mod site	chr17:47928806-47928807:+		[10]
Sequence	TTAAATTAAACAAAAATCCAACTTTATTTTTAGTTGTAACT
Motif Score	2.595904762
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m6A_site_368946

N7-methylguanosine (m7G)

In total 1 m6A sequence/site(s) in this target gene
mod ID: m7GSITE000043		Click to Show/Hide the Full List
mod site	chr17:47928372-47928373:+		[11]
Sequence	AGCTCTATTTAAAAAGTAAAGACACCCACCGACTCCTGATC
Cell/Tissue List	A549; HeLa; HepG2
Seq Type List	BoRed-seq&m7G-RIP-seq; m7G-seq
Transcript ID List	ENST00000376741.5
External Link	RMBase: m7G_site_377

Pseudouridine (Pseudo)

In total 1 m6A sequence/site(s) in this target gene
mod ID: PSESITE000097		Click to Show/Hide the Full List
mod site	chr17:47927988-47927989:+		[12]
Sequence	TGTTCCCTGTATTGTCCTCCTTCTGAAGCCCCTTGGCTCTG
Transcript ID List	ENST00000376741.5
External Link	RMBase: Pseudo_site_2208

Ref 1	Promoter-bound METTL3 maintains myeloid leukaemia by m(6)A-dependent translation control. Nature. 2017 Dec 7;552(7683):126-131. doi: 10.1038/nature24678. Epub 2017 Nov 27.
Ref 2	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 3	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 4	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 5	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 6	N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505(7481):117-20. doi: 10.1038/nature12730. Epub 2013 Nov 27.
Ref 7	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 8	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 9	Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells. Nat Microbiol. 2016 Feb 22;1:16011. doi: 10.1038/nmicrobiol.2016.11.
Ref 10	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 11	METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation. Mol Cell. 2019 Jun 20;74(6):1278-1290.e9. doi: 10.1016/j.molcel.2019.03.040. Epub 2019 Apr 25.
Ref 12	Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome. Nat Chem Biol. 2015 Aug;11(8):592-7. doi: 10.1038/nchembio.1836. Epub 2015 Jun 15.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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