m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00406)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
SP1
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3 | ||
Cell Line | Mouse testis | Mus musculus |
Treatment: Mettl3 knockout mouse testis
Control: Mouse testis
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GSE99771 | |
Regulation |
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logFC: -5.88E+00 p-value: 2.22E-06 |
More Results | Click to View More RNA-seq Results |
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | Genes regulated by METTL3 in this way are necessary for acute myeloid leukaemia. Two genes expressing the transcription factors Transcription factor Sp1 (SP1) and SP2, which have promoters occupied by METTL3. | |||
Responsed Disease | Acute myeloid leukaemia | ICD-11: 2A60 | ||
Cell Process | Cell cycle | |||
In-vitro Model | EoL-1 | Chronic eosinophilic leukemia | Homo sapiens | CVCL_0258 |
HEL | Erythroleukemia | Homo sapiens | CVCL_0001 | |
HL-60 | Adult acute myeloid leukemia | Homo sapiens | CVCL_0002 | |
Jurkat | T acute lymphoblastic leukemia | Homo sapiens | CVCL_0065 | |
K-562 | Chronic myelogenous leukemia | Homo sapiens | CVCL_0004 | |
KG-1 | Adult acute myeloid leukemia | Homo sapiens | CVCL_0374 | |
Loucy | Adult T acute lymphoblastic leukemia | Homo sapiens | CVCL_1380 | |
MOLM-13 | Adult acute myeloid leukemia | Homo sapiens | CVCL_2119 | |
MV4-11 | Childhood acute monocytic leukemia | Homo sapiens | CVCL_0064 | |
NOMO-1 | Adult acute monocytic leukemia | Homo sapiens | CVCL_1609 | |
RN2c (Acute myeloid leukemia cell line) | ||||
THP-1 | Childhood acute monocytic leukemia | Homo sapiens | CVCL_0006 | |
In-vivo Model | Performed an ex vivo genome wide CRISPR dropout screen (Screen 1) using Cas9-expressing mouse primary leukaemia cells driven by an MLL-AF9 fusion gene and a FLT3 internal tandem duplication. | |||
Acute myeloid leukaemia [ICD-11: 2A60]
In total 1 item(s) under this disease | ||||
Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | Genes regulated by METTL3 in this way are necessary for acute myeloid leukaemia. Two genes expressing the transcription factors Transcription factor Sp1 (SP1) and SP2, which have promoters occupied by METTL3. | |||
Responsed Disease | Acute myeloid leukaemia [ICD-11: 2A60] | |||
Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
Cell Process | Cell cycle | |||
In-vitro Model | EoL-1 | Chronic eosinophilic leukemia | Homo sapiens | CVCL_0258 |
HEL | Erythroleukemia | Homo sapiens | CVCL_0001 | |
HL-60 | Adult acute myeloid leukemia | Homo sapiens | CVCL_0002 | |
Jurkat | T acute lymphoblastic leukemia | Homo sapiens | CVCL_0065 | |
K-562 | Chronic myelogenous leukemia | Homo sapiens | CVCL_0004 | |
KG-1 | Adult acute myeloid leukemia | Homo sapiens | CVCL_0374 | |
Loucy | Adult T acute lymphoblastic leukemia | Homo sapiens | CVCL_1380 | |
MOLM-13 | Adult acute myeloid leukemia | Homo sapiens | CVCL_2119 | |
MV4-11 | Childhood acute monocytic leukemia | Homo sapiens | CVCL_0064 | |
NOMO-1 | Adult acute monocytic leukemia | Homo sapiens | CVCL_1609 | |
RN2c (Acute myeloid leukemia cell line) | ||||
THP-1 | Childhood acute monocytic leukemia | Homo sapiens | CVCL_0006 | |
In-vivo Model | Performed an ex vivo genome wide CRISPR dropout screen (Screen 1) using Cas9-expressing mouse primary leukaemia cells driven by an MLL-AF9 fusion gene and a FLT3 internal tandem duplication. | |||