m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00397)

Target Name	Mothers against decapentaplegic homolog 7 (SMAD7)
Synonyms	MAD homolog 7; Mothers against DPP homolog 7; Mothers against decapentaplegic homolog 8; MAD homolog 8; Mothers against DPP homolog 8; SMAD family member 7; SMAD 7; Smad7; hSMAD7; MADH7; MADH8 Click to Show/Hide
Gene Name	SMAD7
Chromosomal Location	18q21.1
Family	dwarfin/SMAD family
Function	Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Click to Show/Hide
Gene ID	4092
Uniprot ID	SMAD7_HUMAN
HGNC ID	HGNC:6773
KEGG ID	hsa:4092

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

SMAD7 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

YTH domain-containing family protein 2 (YTHDF2) [READER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by YTHDF2*
Cell Line	Human umbilical cord blood CD34+ cells	Homo sapiens
Treatment: YTHDF2 knockdown UCB CD34+ cells Control: Wild type UCB CD34+ cells		GSE107956
Regulation		logFC: -6.53E-01 p-value: 1.90E-03
More Results	Click to View More RNA-seq Results
*Representative RIP-seq result supporting the interaction between SMAD7 and the regulator*
Cell Line	Hela	Homo sapiens
Regulation	logFC: 1.67E+00	GSE49339

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	METTL3 knockdown inhibits osteoblast differentiation and Smad-dependent signaling by stabilizing Mothers against decapentaplegic homolog 7 (SMAD7) and Smurf1 mRNA transcripts via YTHDF2 involvement and activates the inflammatory response by regulating MAPK signaling in LPS-induced inflammation.
Target Regulation	Down regulation
Responsed Disease	Inflammatory response		ICD-11: MG46	Disease Info
Pathway Response	MAPK signaling pathway			hsa04010
Cell Process	RNA stability
In-vitro Model	MC3T3-E1	Normal	Mus musculus	CVCL_0409

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL3*
Cell Line	mouse embryonic stem cells	Mus musculus
Treatment: METTL3-/- ESCs Control: Wild type ESCs		GSE145309
Regulation		logFC: -6.27E-01 p-value: 8.80E-36
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	METTL3 knockdown inhibits osteoblast differentiation and Smad-dependent signaling by stabilizing Mothers against decapentaplegic homolog 7 (SMAD7) and Smurf1 mRNA transcripts via YTHDF2 involvement and activates the inflammatory response by regulating MAPK signaling in LPS-induced inflammation.
Target Regulation	Down regulation
Responsed Disease	Inflammatory response		ICD-11: MG46	Disease Info
Pathway Response	MAPK signaling pathway			hsa04010
Cell Process	RNA stability
In-vitro Model	MC3T3-E1	Normal	Mus musculus	CVCL_0409

Inflammatory response [ICD-11: MG46]

Disease Info

In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	METTL3 knockdown inhibits osteoblast differentiation and Smad-dependent signaling by stabilizing Mothers against decapentaplegic homolog 7 (SMAD7) and Smurf1 mRNA transcripts via YTHDF2 involvement and activates the inflammatory response by regulating MAPK signaling in LPS-induced inflammation.
Responsed Disease	Inflammatory response [ICD-11: MG46]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Down regulation
Pathway Response	MAPK signaling pathway			hsa04010
Cell Process	RNA stability
In-vitro Model	MC3T3-E1	Normal	Mus musculus	CVCL_0409
Experiment 2 Reporting the m6A-centered Disease Response				[1]
Response Summary	METTL3 knockdown inhibits osteoblast differentiation and Smad-dependent signaling by stabilizing Mothers against decapentaplegic homolog 7 (SMAD7) and Smurf1 mRNA transcripts via YTHDF2 involvement and activates the inflammatory response by regulating MAPK signaling in LPS-induced inflammation.
Responsed Disease	Inflammatory response [ICD-11: MG46]
Target Regulator	YTH domain-containing family protein 2 (YTHDF2)		READER	Regulator Info
Target Regulation	Down regulation
Pathway Response	MAPK signaling pathway			hsa04010
Cell Process	RNA stability
In-vitro Model	MC3T3-E1	Normal	Mus musculus	CVCL_0409

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

DNA modification

m6A Regulator: RNA demethylase ALKBH5 (ALKBH5)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02035		Crosstalk Info
Epigenetic Regulator	DNA (cytosine-5)-methyltransferase 1 (DNMT1)
Regulated Target	RNA demethylase ALKBH5 (ALKBH5)
Crosstalk relationship	DNA modification → m6A
Disease	Lung cancer	Disease Info

m6A Regulator: YTH domain-containing family protein 2 (YTHDF2)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02038		Crosstalk Info
Epigenetic Regulator	DNA (cytosine-5)-methyltransferase 1 (DNMT1)
Regulated Target	RNA demethylase ALKBH5 (ALKBH5)
Crosstalk relationship	DNA modification → m6A
Disease	Lung cancer	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00397)

Mothers against decapentaplegic homolog 7 (SMAD7)

5-methylcytidine (m5C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE001496		Click to Show/Hide the Full List
mod site	chr18:48950169-48950170:-
Sequence	GCCGCGGGCGCCGGCGCGGCCGGGGGCGCCGAGGCGGATCT
Cell/Tissue List	muscle
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000589634.1; ENST00000262158.7
External Link	RMBase: m5C_site_20996

N6-methyladenosine (m6A)

In total 55 m6A sequence/site(s) in this target gene
mod ID: M6ASITE037093		Click to Show/Hide the Full List
mod site	chr18:48919952-48919953:-		[3]
Sequence	TGCCAAATTAAAAAAGATAAACACAAGATTGGTGTTTTTTT
Motif Score	2.20572619
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000262158.7
External Link	RMBase: m6A_site_400817
mod ID: M6ASITE037094		Click to Show/Hide the Full List
mod site	chr18:48920027-48920028:-		[3]
Sequence	GTATTGTGCAATGTGTATAAACAAGAAAAATAAAGAAAAGA
Motif Score	2.20572619
Cell/Tissue List	HEK293T; Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000262158.7; ENST00000545051.2
External Link	RMBase: m6A_site_400818
mod ID: M6ASITE037095		Click to Show/Hide the Full List
mod site	chr18:48920144-48920145:-		[4]
Sequence	GAAAGGACTCCTGAAAAAAAACCTGAGATTTATTAAAGAAA
Motif Score	2.185083333
Cell/Tissue List	HEK293T; A549; Huh7; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000262158.7; ENST00000545051.2
External Link	RMBase: m6A_site_400819
mod ID: M6ASITE037096		Click to Show/Hide the Full List
mod site	chr18:48920158-48920159:-		[4]
Sequence	AGTGCTTTGAGAGAGAAAGGACTCCTGAAAAAAAACCTGAG
Motif Score	4.065041667
Cell/Tissue List	HEK293T; A549; CD8T; Huh7; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000262158.7; ENST00000545051.2
External Link	RMBase: m6A_site_400820
mod ID: M6ASITE037097		Click to Show/Hide the Full List
mod site	chr18:48920214-48920215:-		[4]
Sequence	AACTACAAAGGTTTAAATGAACAAGAGAAGCATTCTCATTG
Motif Score	2.951386905
Cell/Tissue List	HEK293T; A549; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000545051.2; ENST00000262158.7
External Link	RMBase: m6A_site_400821
mod ID: M6ASITE037098		Click to Show/Hide the Full List
mod site	chr18:48920251-48920252:-		[5]
Sequence	ATGAGCATGTTTAGACTTTAACATAAGCTATTTTTCTAACT
Motif Score	2.168095238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000262158.7; ENST00000545051.2
External Link	RMBase: m6A_site_400822
mod ID: M6ASITE037099		Click to Show/Hide the Full List
mod site	chr18:48920257-48920258:-		[4]
Sequence	AGCTCAATGAGCATGTTTAGACTTTAACATAAGCTATTTTT
Motif Score	3.319380952
Cell/Tissue List	A549; HEK293A-TOA
Seq Type List	m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000545051.2; ENST00000262158.7
External Link	RMBase: m6A_site_400823
mod ID: M6ASITE037100		Click to Show/Hide the Full List
mod site	chr18:48920494-48920495:-		[3]
Sequence	GTTTTTCCCGGACTTAGAAAACCAGCTCAGCACTGCCTGCT
Motif Score	2.185083333
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000262158.7; ENST00000545051.2
External Link	RMBase: m6A_site_400824
mod ID: M6ASITE037101		Click to Show/Hide the Full List
mod site	chr18:48920503-48920504:-		[3]
Sequence	TGACATCAGGTTTTTCCCGGACTTAGAAAACCAGCTCAGCA
Motif Score	4.065041667
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000545051.2; ENST00000262158.7
External Link	RMBase: m6A_site_400825
mod ID: M6ASITE037102		Click to Show/Hide the Full List
mod site	chr18:48920578-48920579:-		[6]
Sequence	GCTGCCGGGGCAGCCCCCTCACAGTATTGCTCACCCAGTGC
Motif Score	2.047297619
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000545051.2; ENST00000262158.7
External Link	RMBase: m6A_site_400826
mod ID: M6ASITE037103		Click to Show/Hide the Full List
mod site	chr18:48920709-48920710:-		[3]
Sequence	CTGCTAGTGGCCGAACCAGAACCAATTATTTTCATCCTTGT
Motif Score	2.930744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000262158.7; ENST00000545051.2
External Link	RMBase: m6A_site_400827
mod ID: M6ASITE037104		Click to Show/Hide the Full List
mod site	chr18:48920715-48920716:-		[3]
Sequence	GCGAGCCTGCTAGTGGCCGAACCAGAACCAATTATTTTCAT
Motif Score	2.930744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000545051.2; ENST00000262158.7
External Link	RMBase: m6A_site_400828
mod ID: M6ASITE037105		Click to Show/Hide the Full List
mod site	chr18:48920764-48920765:-		[7]
Sequence	CCTCCTCTCCCTCATCAAGGACACGGGCCTGTCCACAGGCT
Motif Score	3.643047619
Cell/Tissue List	HepG2; hESC-HEK293T; Huh7
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000545051.2; ENST00000262158.7
External Link	RMBase: m6A_site_400829
mod ID: M6ASITE037106		Click to Show/Hide the Full List
mod site	chr18:48920887-48920888:-		[8]
Sequence	GTGTCTCTCCTGCCCCTTGGACACGCTCAGTGGGGCAGAGG
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T; endometrial
Seq Type List	MAZTER-seq; m6A-seq
Transcript ID List	ENST00000262158.7; ENST00000545051.2
External Link	RMBase: m6A_site_400830
mod ID: M6ASITE037107		Click to Show/Hide the Full List
mod site	chr18:48920973-48920974:-		[8]
Sequence	CAGGAGCGGCAGATGGGGAGACAACGTGCTCTTTGTTTTGT
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000262158.7; ENST00000545051.2
External Link	RMBase: m6A_site_400831
mod ID: M6ASITE037108		Click to Show/Hide the Full List
mod site	chr18:48921080-48921081:-		[9]
Sequence	AGAAATCCAAGCACCACCAAACACAGTGTATGAAGGGGGGC
Motif Score	2.20572619
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000262158.7; ENST00000545051.2; ENST00000591805.5
External Link	RMBase: m6A_site_400832
mod ID: M6ASITE037109		Click to Show/Hide the Full List
mod site	chr18:48921125-48921126:-		[10]
Sequence	GGGCAGGTATGATCGGCAGGACACCCTGATAGGAAGAGGGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000545051.2; ENST00000262158.7; ENST00000591805.5
External Link	RMBase: m6A_site_400833
mod ID: M6ASITE037110		Click to Show/Hide the Full List
mod site	chr18:48921274-48921275:-		[10]
Sequence	AGTGCTTGCTTTTCATGCAAACTCTTTGGTCGTTTTTTTTT
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; A549; hESCs; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000545051.2; ENST00000591805.5; ENST00000262158.7
External Link	RMBase: m6A_site_400834
mod ID: M6ASITE037111		Click to Show/Hide the Full List
mod site	chr18:48921323-48921324:-		[10]
Sequence	CTGAGCAGGCCACACTTCAAACTACTTTGCTGCTAATATTT
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hESCs; Jurkat; peripheral-blood; HEK293A-TOA; iSLK; MSC; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000545051.2; ENST00000262158.7; ENST00000591805.5
External Link	RMBase: m6A_site_400835
mod ID: M6ASITE037112		Click to Show/Hide the Full List
mod site	chr18:48921355-48921356:-		[10]
Sequence	GGTAGCCGCGTGCGGAGGGGACAGAGCGTGAGCTGAGCAGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hESC-HEK293T; hESCs; Jurkat; peripheral-blood; HEK293A-TOA; iSLK; MSC; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000545051.2; ENST00000591805.5; ENST00000262158.7
External Link	RMBase: m6A_site_400836
mod ID: M6ASITE037113		Click to Show/Hide the Full List
mod site	chr18:48921600-48921601:-		[10]
Sequence	CGCCACACTGGACAACCCGGACTCCAGGACGCTGTTGGTAC
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000591805.5; ENST00000262158.7; ENST00000589634.1; ENST00000586093.1; ENST00000585986.1; ENST00000545051.2; ENST00000587336.1
External Link	RMBase: m6A_site_400837
mod ID: M6ASITE037114		Click to Show/Hide the Full List
mod site	chr18:48921609-48921610:-		[10]
Sequence	CATCAAGTCCGCCACACTGGACAACCCGGACTCCAGGACGC
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000586093.1; ENST00000262158.7; ENST00000587336.1; ENST00000591805.5; ENST00000589634.1; ENST00000545051.2; ENST00000585986.1
External Link	RMBase: m6A_site_400838
mod ID: M6ASITE037115		Click to Show/Hide the Full List
mod site	chr18:48921654-48921655:-		[8]
Sequence	GGTGGATGGTGTGTGGGTGTACAACCGCAGCAGTTACCCCA
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000586093.1; ENST00000545051.2; ENST00000587336.1; ENST00000262158.7; ENST00000591805.5; ENST00000585986.1; ENST00000589634.1; ENST00000588190.1
External Link	RMBase: m6A_site_400839
mod ID: M6ASITE037116		Click to Show/Hide the Full List
mod site	chr18:48921738-48921739:-		[8]
Sequence	CGGACAGCTCAATTCGGACAACAAGAGTCAGCTGGTGCAGA
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000262158.7; ENST00000586093.1; ENST00000589634.1; ENST00000587336.1; ENST00000545051.2; ENST00000588190.1; ENST00000585986.1; ENST00000591805.5
External Link	RMBase: m6A_site_400840
mod ID: M6ASITE037117		Click to Show/Hide the Full List
mod site	chr18:48921741-48921742:-		[10]
Sequence	CCTCGGACAGCTCAATTCGGACAACAAGAGTCAGCTGGTGC
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; CD8T; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000591805.5; ENST00000587336.1; ENST00000262158.7; ENST00000589634.1; ENST00000545051.2; ENST00000588190.1; ENST00000586093.1; ENST00000585986.1
External Link	RMBase: m6A_site_400841
mod ID: M6ASITE037118		Click to Show/Hide the Full List
mod site	chr18:48921755-48921756:-		[10]
Sequence	GGGAATGGCTTTTGCCTCGGACAGCTCAATTCGGACAACAA
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000589634.1; ENST00000588190.1; ENST00000587336.1; ENST00000585986.1; ENST00000586093.1; ENST00000591805.5; ENST00000545051.2; ENST00000262158.7
External Link	RMBase: m6A_site_400842
mod ID: M6ASITE037119		Click to Show/Hide the Full List
mod site	chr18:48921855-48921856:-		[5]
Sequence	ACACTGGTGCGTGGTGGCATACTGGGAGGAGAAGACGAGAG
Motif Score	2.53247619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000545051.2; ENST00000589634.1; ENST00000588190.1; ENST00000591805.5; ENST00000587336.1; ENST00000586093.1; ENST00000585986.1; ENST00000262158.7
External Link	RMBase: m6A_site_400843
mod ID: M6ASITE037120		Click to Show/Hide the Full List
mod site	chr18:48933641-48933642:-		[10]
Sequence	GTGGGGAGTCCAGGAGAGGGACTTGGTCCTTCTGGCTGACT
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000586093.1; ENST00000585986.1; ENST00000262158.7; ENST00000545051.2; ENST00000591805.5; ENST00000588190.1; ENST00000589634.1
External Link	RMBase: m6A_site_400844
mod ID: M6ASITE037121		Click to Show/Hide the Full List
mod site	chr18:48942519-48942520:-		[10]
Sequence	CTGTGCCTTCCTCCGCTGAAACAGGGGGAACGAATTATCTG
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000262158.7; ENST00000585986.1; ENST00000586093.1; ENST00000589634.1; ENST00000545051.2; ENST00000591805.5
External Link	RMBase: m6A_site_400845
mod ID: M6ASITE037122		Click to Show/Hide the Full List
mod site	chr18:48942551-48942552:-		[10]
Sequence	CCTTTTCAAATCCACAGCAGACTGTCCAGATGCTGTGCCTT
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000591805.5; ENST00000262158.7; ENST00000589634.1; ENST00000585986.1; ENST00000586093.1; ENST00000545051.2
External Link	RMBase: m6A_site_400846
mod ID: M6ASITE037123		Click to Show/Hide the Full List
mod site	chr18:48948390-48948391:-		[10]
Sequence	TACCCGATGGATTTTCTCAAACCAACTGGTGAGTAGATGAT
Motif Score	2.185083333
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000589634.1; ENST00000591805.5; ENST00000586093.1; ENST00000262158.7
External Link	RMBase: m6A_site_400847
mod ID: M6ASITE037124		Click to Show/Hide the Full List
mod site	chr18:48949232-48949233:-		[10]
Sequence	AGAGTTGGATGGAAGGCCGAACTGGGTATCTGTCTCCTTTC
Motif Score	3.373380952
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000591805.5; ENST00000589634.1; ENST00000262158.7
External Link	RMBase: m6A_site_400848
mod ID: M6ASITE037125		Click to Show/Hide the Full List
mod site	chr18:48949308-48949309:-		[10]
Sequence	AATACGGAGAATCACGTCGAACACCAGTGGCCCAGATACTG
Motif Score	2.951386905
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000591805.5; ENST00000589634.1; ENST00000262158.7
External Link	RMBase: m6A_site_400849
mod ID: M6ASITE037126		Click to Show/Hide the Full List
mod site	chr18:48949815-48949816:-		[10]
Sequence	CACCTTAGCCGACTCTGCGAACTAGGTGAGAAGTTGTCCCC
Motif Score	3.373380952
Cell/Tissue List	HeLa; Huh7; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000589634.1; ENST00000262158.7
External Link	RMBase: m6A_site_400850
mod ID: M6ASITE037127		Click to Show/Hide the Full List
mod site	chr18:48950026-48950027:-		[10]
Sequence	CCTGCTGCCCGGCCGCCTGGACTGCAGGCTGGGCCCGGGGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; GM12878; Jurkat; GSC-11; HEK293A-TOA; iSLK; MSC; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262158.7; ENST00000589634.1
External Link	RMBase: m6A_site_400851
mod ID: M6ASITE037128		Click to Show/Hide the Full List
mod site	chr18:48950118-48950119:-		[10]
Sequence	ACGCACTCGGTGCTCAAGAAACTGAAGGAGCGGCAGCTGGA
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; HEC-1-A; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000589634.1; ENST00000262158.7
External Link	RMBase: m6A_site_400852
mod ID: M6ASITE037129		Click to Show/Hide the Full List
mod site	chr18:48950293-48950294:-		[10]
Sequence	GCGGGGAGAAGGGGCGACGGACAGCCGAGCGCATGGGGCCG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; TIME; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262158.7; ENST00000589634.1
External Link	RMBase: m6A_site_400853
mod ID: M6ASITE037130		Click to Show/Hide the Full List
mod site	chr18:48950414-48950415:-		[10]
Sequence	CCTCGCCCCGCATGTTCAGGACCAAACGATCTGCGCTCGTC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000589634.1; ENST00000262158.7
External Link	RMBase: m6A_site_400854
mod ID: M6ASITE037131		Click to Show/Hide the Full List
mod site	chr18:48950601-48950602:-		[10]
Sequence	CGCGCCCCGGCCTCCGGGAGACTGGCGCATGCCACGGAGCG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; U2OS
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262158.7
External Link	RMBase: m6A_site_400855
mod ID: M6ASITE037132		Click to Show/Hide the Full List
mod site	chr18:48950855-48950856:-		[10]
Sequence	TTCGTTTTTTGCCCCCGCGGACCTTCCATGTAGGAAGCCGA
Motif Score	3.622404762
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262158.7
External Link	RMBase: m6A_site_400856
mod ID: M6ASITE037133		Click to Show/Hide the Full List
mod site	chr18:48951178-48951179:-		[10]
Sequence	TTCCAGCCGGACGCCCCCAGACCTCTGAGGTTCGAGGAGGT
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; HepG2; A549; GM12878; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262158.7
External Link	RMBase: m6A_site_400857
mod ID: M6ASITE037134		Click to Show/Hide the Full List
mod site	chr18:48951205-48951206:-		[10]
Sequence	TAAACATTTTCTTTTTTTAAACCCCAGTTCCAGCCGGACGC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; HepG2; A549; GM12878; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262158.7
External Link	RMBase: m6A_site_400858
mod ID: M6ASITE037135		Click to Show/Hide the Full List
mod site	chr18:48951222-48951223:-		[10]
Sequence	CATCTTGTTATACTTTGTAAACATTTTCTTTTTTTAAACCC
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; HepG2; A549; GM12878; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262158.7
External Link	RMBase: m6A_site_400859
mod ID: M6ASITE037136		Click to Show/Hide the Full List
mod site	chr18:48951243-48951244:-		[10]
Sequence	TACATTTTTCCACCCATCAAACATCTTGTTATACTTTGTAA
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; HepG2; A549; GM12878; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262158.7
External Link	RMBase: m6A_site_400860
mod ID: M6ASITE037137		Click to Show/Hide the Full List
mod site	chr18:48951307-48951308:-		[10]
Sequence	CAGAAGAAAAGGAGAGGAAGACCAGCGGGGCTTTGCAAGGA
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hESCs; fibroblasts; GM12878; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262158.7
External Link	RMBase: m6A_site_400861
mod ID: M6ASITE037138		Click to Show/Hide the Full List
mod site	chr18:48951412-48951413:-		[10]
Sequence	AAGACCAGAGACTCCCCTAAACCACCCAGATGCGCAGGATT
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262158.7
External Link	RMBase: m6A_site_400862
mod ID: M6ASITE037139		Click to Show/Hide the Full List
mod site	chr18:48951422-48951423:-		[10]
Sequence	CGCAGGGGGAAAGACCAGAGACTCCCCTAAACCACCCAGAT
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262158.7
External Link	RMBase: m6A_site_400863
mod ID: M6ASITE037140		Click to Show/Hide the Full List
mod site	chr18:48951429-48951430:-		[10]
Sequence	CCAGGAGCGCAGGGGGAAAGACCAGAGACTCCCCTAAACCA
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262158.7
External Link	RMBase: m6A_site_400864
mod ID: M6ASITE037141		Click to Show/Hide the Full List
mod site	chr18:48951459-48951460:-		[10]
Sequence	CGAGGAAGTCCCCGCCGAGGACCTGGGCCCCCAGGAGCGCA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262158.7
External Link	RMBase: m6A_site_400865
mod ID: M6ASITE037142		Click to Show/Hide the Full List
mod site	chr18:48951646-48951647:-		[10]
Sequence	AGCCGCGGCCAGGGGAAGGGACATCGGCGGCCCCTGCACTA
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; A549; HEK293T; U2OS; H1A; H1B; hESCs; GM12878; LCLs; MM6; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; TREX; MSC; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262158.7
External Link	RMBase: m6A_site_400866
mod ID: M6ASITE037143		Click to Show/Hide the Full List
mod site	chr18:48951733-48951734:-		[10]
Sequence	GAGGAGGAGGCGCCGAGAGGACACCGGGGCCTCCTGCCGCC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; A549; HEK293T; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; MM6; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262158.7
External Link	RMBase: m6A_site_400867
mod ID: M6ASITE037144		Click to Show/Hide the Full List
mod site	chr18:48951789-48951790:-		[10]
Sequence	CAGGAGAGGGCGGACCGGGGACAAGGAGGCTCCCGGGCGCG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; A549; HEK293T; U2OS; H1A; H1B; hESCs; GM12878; LCLs; MM6; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262158.7
External Link	RMBase: m6A_site_400868
mod ID: M6ASITE037145		Click to Show/Hide the Full List
mod site	chr18:48951796-48951797:-		[10]
Sequence	GGAGCGCCAGGAGAGGGCGGACCGGGGACAAGGAGGCTCCC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; HEK293T; U2OS; H1A; H1B; hESCs; GM12878; LCLs; MM6; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262158.7
External Link	RMBase: m6A_site_400869
mod ID: M6ASITE037146		Click to Show/Hide the Full List
mod site	chr18:48951819-48951820:-		[10]
Sequence	CCCCTGGCGGCGGCAGAAGGACCGGAGCGCCAGGAGAGGGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; HEK293T; U2OS; H1A; H1B; hESCs; GM12878; LCLs; MM6; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262158.7
External Link	RMBase: m6A_site_400870
mod ID: M6ASITE037147		Click to Show/Hide the Full List
mod site	chr18:48951909-48951910:-		[10]
Sequence	GCGGGAGAGAGCTGCCCGAGACAGAGCCAGTCCGTCGGCGC
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; A549; HEK293T; U2OS; H1A; H1B; Jurkat; CD4T; GSC-11; HEK293A-TOA; TREX; iSLK; MSC; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000262158.7
External Link	RMBase: m6A_site_400871

Ref 1	METTL3 Regulates Osteoblast Differentiation and Inflammatory Response via Smad Signaling and MAPK Signaling. Int J Mol Sci. 2019 Dec 27;21(1):199. doi: 10.3390/ijms21010199.
Ref 2	Suppression of m6A mRNA modification by DNA hypermethylated ALKBH5 aggravates the oncological behavior of KRAS mutation/LKB1 loss lung cancer. Cell Death Dis. 2021 May 20;12(6):518. doi: 10.1038/s41419-021-03793-7.
Ref 3	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 4	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 5	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 6	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 7	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 8	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 9	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.
Ref 10	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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