m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00397)
Target Name Mothers against decapentaplegic homolog 7 (SMAD7)
Synonyms
MAD homolog 7; Mothers against DPP homolog 7; Mothers against decapentaplegic homolog 8; MAD homolog 8; Mothers against DPP homolog 8; SMAD family member 7; SMAD 7; Smad7; hSMAD7; MADH7; MADH8
    Click to Show/Hide
Gene Name SMAD7
Chromosomal Location 18q21.1
Family dwarfin/SMAD family
Function
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
    Click to Show/Hide
Gene ID 4092
Uniprot ID
SMAD7_HUMAN
HGNC ID
HGNC:6773
Ensembl Gene ID
ENSG00000101665
KEGG ID
hsa:4092
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
SMAD7 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing family protein 2 (YTHDF2) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by YTHDF2
Cell Line Human umbilical cord blood CD34+ cells Homo sapiens
Treatment: YTHDF2 knockdown UCB CD34+ cells
Control: Wild type UCB CD34+ cells
 GSE107956
Regulation
logFC: -6.53E-01
p-value: 1.90E-03
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between SMAD7 and the regulator
Cell Line Hela Homo sapiens
Regulation logFC: 1.67E+00 GSE49339
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 knockdown inhibits osteoblast differentiation and Smad-dependent signaling by stabilizing Mothers against decapentaplegic homolog 7 (SMAD7) and Smurf1 mRNA transcripts via YTHDF2 involvement and activates the inflammatory response by regulating MAPK signaling in LPS-induced inflammation.
Target Regulation Down regulation
Responsed Disease Inflammatory response ICD-11: MG46
 Disease Info 
Pathway Response MAPK signaling pathway hsa04010
Cell Process RNA stability
In-vitro Model MC3T3-E1 Normal Mus musculus CVCL_0409
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line mouse embryonic stem cells Mus musculus
Treatment: METTL3-/- ESCs
Control: Wild type ESCs
 GSE145309
Regulation
logFC: -6.27E-01
p-value: 8.80E-36
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 knockdown inhibits osteoblast differentiation and Smad-dependent signaling by stabilizing Mothers against decapentaplegic homolog 7 (SMAD7) and Smurf1 mRNA transcripts via YTHDF2 involvement and activates the inflammatory response by regulating MAPK signaling in LPS-induced inflammation.
Target Regulation Down regulation
Responsed Disease Inflammatory response ICD-11: MG46
 Disease Info 
Pathway Response MAPK signaling pathway hsa04010
Cell Process RNA stability
In-vitro Model MC3T3-E1 Normal Mus musculus CVCL_0409
Inflammatory response [ICD-11: MG46]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 knockdown inhibits osteoblast differentiation and Smad-dependent signaling by stabilizing Mothers against decapentaplegic homolog 7 (SMAD7) and Smurf1 mRNA transcripts via YTHDF2 involvement and activates the inflammatory response by regulating MAPK signaling in LPS-induced inflammation.
Responsed Disease Inflammatory response [ICD-11: MG46]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
Pathway Response MAPK signaling pathway hsa04010
Cell Process RNA stability
In-vitro Model MC3T3-E1 Normal Mus musculus CVCL_0409
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 knockdown inhibits osteoblast differentiation and Smad-dependent signaling by stabilizing Mothers against decapentaplegic homolog 7 (SMAD7) and Smurf1 mRNA transcripts via YTHDF2 involvement and activates the inflammatory response by regulating MAPK signaling in LPS-induced inflammation.
Responsed Disease Inflammatory response [ICD-11: MG46]
Target Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
Target Regulation Down regulation
Pathway Response MAPK signaling pathway hsa04010
Cell Process RNA stability
In-vitro Model MC3T3-E1 Normal Mus musculus CVCL_0409
References
Ref 1 METTL3 Regulates Osteoblast Differentiation and Inflammatory Response via Smad Signaling and MAPK Signaling. Int J Mol Sci. 2019 Dec 27;21(1):199. doi: 10.3390/ijms21010199.