m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00287)
Target Name Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1/eIF2-Alpha)
Synonyms
Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha; EIF2A
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Gene Name EIF2S1
Chromosomal Location 14q23.3
Family eIF-2-alpha family
Function
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. EIF2S1/eIF-2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming.
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Gene ID 1965
Uniprot ID
IF2A_HUMAN
HGNC ID
HGNC:3265
Ensembl Gene ID
ENSG00000134001
KEGG ID
hsa:1965
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
EIF2S1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Disease
Inflammatory polyneuropathy [ICD-11: 8C01]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response []
Response Summary Zika virus (ZIKV) is a mosquito-borne virus associated with neurological disorders such as Guillain-Barre syndrome and microcephaly. This review summarizes relevant aspects of the complex crosstalk between RNA metabolism and cellular stress responses against ZIKV and discusses their possible impact on viral pathogenesis. ZIKV replication is known to induce cellular stress, which triggers both the expression of innate immune genes and the phosphorylation of eukaryotic translation initiation factor 2 (eIF2-alpha), shutting-off host protein synthesis.
Responsed Disease Guillain-Barre syndrome syndrome [ICD-11: 8C01.0]
Pathway Response Apoptosis hsa04210
Cell Process Cellular Stress Responses
Cell apoptosis
Cerebral development anomalies [ICD-11: LA05]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response []
Response Summary Zika virus (ZIKV) is a mosquito-borne virus associated with neurological disorders such as Guillain-Barre syndrome and microcephaly. This review summarizes relevant aspects of the complex crosstalk between RNA metabolism and cellular stress responses against ZIKV and discusses their possible impact on viral pathogenesis. ZIKV replication is known to induce cellular stress, which triggers both the expression of innate immune genes and the phosphorylation of eukaryotic translation initiation factor 2 (eIF2-alpha), shutting-off host protein synthesis.
Responsed Disease Microcephaly [ICD-11: LA05.0]
Pathway Response Apoptosis hsa04210
Cell Process Cellular Stress Responses
Cell apoptosis