m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0031)
| Name |
Inflammatory polyneuropathy
|
||||
|---|---|---|---|---|---|
| ICD |
ICD-11: 8C01
|
||||
Full List of Target Gene(s) of This m6A-centered Disease Response
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1/eIF2-Alpha)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | Zika virus (ZIKV) is a mosquito-borne virus associated with neurological disorders such as Guillain-Barre syndrome and microcephaly. This review summarizes relevant aspects of the complex crosstalk between RNA metabolism and cellular stress responses against ZIKV and discusses their possible impact on viral pathogenesis. ZIKV replication is known to induce cellular stress, which triggers both the expression of innate immune genes and the phosphorylation of eukaryotic translation initiation factor 2 (eIF2-alpha), shutting-off host protein synthesis. | |||
| Responsed Disease | Guillain-Barre syndrome syndrome [ICD-11: 8C01.0] | |||
| Pathway Response | Apoptosis | hsa04210 | ||
| Cell Process | Cellular Stress Responses | |||
| Cell apoptosis | ||||