m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00256)

Target Name	Forkhead box protein C2 (FOXC2)
Synonyms	Forkhead-related protein FKHL14; Mesenchyme fork head protein 1; MFH-1 protein; Transcription factor FKH-14; FKHL14; MFH1 Click to Show/Hide
Gene Name	FOXC2
Chromosomal Location	16q24.1
Function	Transcriptional activator. Might be involved in the formation of special mesenchymal tissues. Click to Show/Hide
Gene ID	2303
Uniprot ID	FOXC2_HUMAN
HGNC ID	HGNC:3801
KEGG ID	hsa:2303

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

FOXC2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL3*
Cell Line	Mesenchymal stem cell line	Mus musculus
Treatment: Mettl3 knockout mesenchymal stem cells Control: Wild type mesenchymal stem cells		GSE114933
Regulation		logFC: -2.30E+00 p-value: 6.85E-05
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	METTL3-mediated circNRIP1 exhibits oncogenic roles in osteosarcoma by regulating Forkhead box protein C2 (FOXC2) via sponging miR-199a, which provides new ideas for the treatment of osteosarcoma.
Target Regulation	Up regulation
Responsed Disease	Osteosarcoma		ICD-11: 2B51	Disease Info
Cell Process	Cell apoptosis
In-vitro Model	hFOB 1.19	Normal	Homo sapiens	CVCL_3708
	MG-63	Osteosarcoma	Homo sapiens	CVCL_0426
	U2OS	Osteosarcoma	Homo sapiens	CVCL_0042

Osteosarcoma [ICD-11: 2B51]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	METTL3-mediated circNRIP1 exhibits oncogenic roles in osteosarcoma by regulating Forkhead box protein C2 (FOXC2) via sponging miR-199a, which provides new ideas for the treatment of osteosarcoma.
Responsed Disease	Osteosarcoma [ICD-11: 2B51]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Up regulation
Cell Process	Cell apoptosis
In-vitro Model	hFOB 1.19	Normal	Homo sapiens	CVCL_3708
	MG-63	Osteosarcoma	Homo sapiens	CVCL_0426
	U2OS	Osteosarcoma	Homo sapiens	CVCL_0042

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00256)

Forkhead box protein C2 (FOXC2)

5-methylcytidine (m5C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE000802		Click to Show/Hide the Full List
mod site	chr16:86566972-86566973:+		[3]
Sequence	GCGCCCCTCCTCGCGCGGGCCGAGGGTCCACCTGGGTCCCC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000320354.6; ENST00000649859.1
External Link	RMBase: m5C_site_16972
mod ID: M5CSITE000803		Click to Show/Hide the Full List
mod site	chr16:86568186-86568187:+		[4]
Sequence	CTGCGAACGTCGCCGCCGGGCGGAGAGCTGAGCCCGGGGGC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000320354.6; ENST00000649859.1
External Link	RMBase: m5C_site_16973

N6-methyladenosine (m6A)

In total 21 m6A sequence/site(s) in this target gene
mod ID: M6ASITE028895		Click to Show/Hide the Full List
mod site	chr16:86566895-86566896:+		[5]
Sequence	TCAGCGGGGCAGCCGCTCGGACCCCGGCGCGCTGACCCTCG
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000320354.6; ENST00000649859.1
External Link	RMBase: m6A_site_335267
mod ID: M6ASITE028896		Click to Show/Hide the Full List
mod site	chr16:86567540-86567541:+		[5]
Sequence	CCAGCCCGCGGCGCCTAAGGACCTGGTGAAGCCGCCCTACA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; fibroblasts; HEK293A-TOA; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000320354.6; ENST00000649859.1
External Link	RMBase: m6A_site_335268
mod ID: M6ASITE028898		Click to Show/Hide the Full List
mod site	chr16:86567645-86567646:+		[5]
Sequence	CATCTACCAGTTCATCATGGACCGCTTCCCCTTCTACCGGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; A549; fibroblasts; HEK293A-TOA; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000649859.1; ENST00000320354.6
External Link	RMBase: m6A_site_335270
mod ID: M6ASITE028899		Click to Show/Hide the Full List
mod site	chr16:86567669-86567670:+		[5]
Sequence	CTTCCCCTTCTACCGGGAGAACAAGCAGGGCTGGCAGAACA
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; A549; fibroblasts; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000649859.1; ENST00000320354.6
External Link	RMBase: m6A_site_335271
mod ID: M6ASITE028900		Click to Show/Hide the Full List
mod site	chr16:86567687-86567688:+		[5]
Sequence	GAACAAGCAGGGCTGGCAGAACAGCATCCGCCACAACCTCT
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; A549; fibroblasts; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000320354.6; ENST00000649859.1
External Link	RMBase: m6A_site_335272
mod ID: M6ASITE028901		Click to Show/Hide the Full List
mod site	chr16:86567773-86567774:+		[5]
Sequence	CCGGCAAGGGCAGTTACTGGACCCTGGACCCGGACTCCTAC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; hNPCs; fibroblasts; GSC-11; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000649859.1; ENST00000320354.6
External Link	RMBase: m6A_site_335273
mod ID: M6ASITE028902		Click to Show/Hide the Full List
mod site	chr16:86567780-86567781:+		[5]
Sequence	GGGCAGTTACTGGACCCTGGACCCGGACTCCTACAACATGT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; hNPCs; fibroblasts; GSC-11; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000649859.1; ENST00000320354.6
External Link	RMBase: m6A_site_335274
mod ID: M6ASITE028903		Click to Show/Hide the Full List
mod site	chr16:86567786-86567787:+		[5]
Sequence	TTACTGGACCCTGGACCCGGACTCCTACAACATGTTCGAGA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; hNPCs; fibroblasts; GSC-11; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000320354.6; ENST00000649859.1
External Link	RMBase: m6A_site_335275
mod ID: M6ASITE028904		Click to Show/Hide the Full List
mod site	chr16:86568155-86568156:+		[5]
Sequence	GCCTGGCTTCAGCGTGGAGAACATCATGACCCTGCGAACGT
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293A-TOA; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000320354.6; ENST00000649859.1
External Link	RMBase: m6A_site_335276
mod ID: M6ASITE028905		Click to Show/Hide the Full List
mod site	chr16:86568413-86568414:+		[5]
Sequence	CCTGGACGAGGCCCTCTCGGACCACCCGAGCGGCCCCACGT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000320354.6; ENST00000649859.1
External Link	RMBase: m6A_site_335277
mod ID: M6ASITE028906		Click to Show/Hide the Full List
mod site	chr16:86568626-86568627:+		[5]
Sequence	GTATCTCAACCACAGCGGGGACCTGAACCACCTCCCCGGCC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; fibroblasts; HEK293A-TOA; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000320354.6; ENST00000649859.1
External Link	RMBase: m6A_site_335278
mod ID: M6ASITE028907		Click to Show/Hide the Full List
mod site	chr16:86568632-86568633:+		[5]
Sequence	CAACCACAGCGGGGACCTGAACCACCTCCCCGGCCACACGT
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T; fibroblasts; HEK293A-TOA; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000320354.6; ENST00000649859.1
External Link	RMBase: m6A_site_335279
mod ID: M6ASITE028909		Click to Show/Hide the Full List
mod site	chr16:86568670-86568671:+		[5]
Sequence	CGTTCGCGGCCCAGCAGCAAACTTTCCCCAACGTGCGGGAG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; fibroblasts; HEK293A-TOA; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000649859.1; ENST00000320354.6
External Link	RMBase: m6A_site_335280
mod ID: M6ASITE028910		Click to Show/Hide the Full List
mod site	chr16:86568722-86568723:+		[5]
Sequence	CCACCGGCTGGGGATTGAGAACTCGACCCTCGGGGAGTCCC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; fibroblasts; MM6; GSC-11; HEK293A-TOA; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000649859.1; ENST00000320354.6
External Link	RMBase: m6A_site_335281
mod ID: M6ASITE028911		Click to Show/Hide the Full List
mod site	chr16:86568852-86568853:+		[5]
Sequence	AAATACTGACGTGTCCCGGGACCTCCCCTCCCCGGCCCGCT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; fibroblasts; MM6; HEK293A-TOA; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000320354.6; ENST00000649859.1
External Link	RMBase: m6A_site_335282
mod ID: M6ASITE028912		Click to Show/Hide the Full List
mod site	chr16:86568905-86568906:+		[5]
Sequence	CCCAGCCCCGACCCAACCAGACAATTAAGGGGCTGCAGAGA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; A549; hESC-HEK293T; HepG2; hNPCs; fibroblasts; MM6; HEK293A-TOA; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000649859.1; ENST00000320354.6
External Link	RMBase: m6A_site_335283
mod ID: M6ASITE028913		Click to Show/Hide the Full List
mod site	chr16:86568938-86568939:+		[5]
Sequence	TGCAGAGACGCAAAAAAGAAACAAAACATGTCCACCAACCT
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; hNPCs; fibroblasts; MM6; HEK293A-TOA; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000320354.6; ENST00000649859.1
External Link	RMBase: m6A_site_335284
mod ID: M6ASITE028914		Click to Show/Hide the Full List
mod site	chr16:86568943-86568944:+		[5]
Sequence	AGACGCAAAAAAGAAACAAAACATGTCCACCAACCTTTTCT
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; hNPCs; fibroblasts; MM6; HEK293A-TOA; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000320354.6; ENST00000649859.1
External Link	RMBase: m6A_site_335285
mod ID: M6ASITE028915		Click to Show/Hide the Full List
mod site	chr16:86568967-86568968:+		[5]
Sequence	GTCCACCAACCTTTTCTCAGACCCGGGAGCAGAGAGCGGGC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; hNPCs; fibroblasts; MM6; HEK293A-TOA; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000649859.1; ENST00000320354.6
External Link	RMBase: m6A_site_335286
mod ID: M6ASITE028916		Click to Show/Hide the Full List
mod site	chr16:86569061-86569062:+		[5]
Sequence	CGTTTCTGGGATCCCAGGAAACCCCTCCAAAGGGACGCAGC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; A549; fibroblasts; HEK293A-TOA; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000649859.1; ENST00000320354.6
External Link	RMBase: m6A_site_335287
mod ID: M6ASITE028917		Click to Show/Hide the Full List
mod site	chr16:86569173-86569174:+		[5]
Sequence	TTTCAAAAGTTAAGTTATGGACCAAATCCCATAGCGAGCCC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; A549; fibroblasts; HEK293A-TOA; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000320354.6; ENST00000649859.1
External Link	RMBase: m6A_site_335288

Ref 1	Circular RNA circNRIP1 plays oncogenic roles in the progression of osteosarcoma. Mamm Genome. 2021 Dec;32(6):448-456. doi: 10.1007/s00335-021-09891-3. Epub 2021 Jul 10.
Ref 2	P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93. doi: 10.1023/b:pham.0000033017.52484.81.
Ref 3	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 4	Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6784-6789. doi: 10.1073/pnas.1817334116. Epub 2019 Mar 14.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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