m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00232)

Target Name	Dual specificity protein phosphatase 2 (DUSP2)
Synonyms	Dual specificity protein phosphatase PAC-1; PAC1 Click to Show/Hide
Gene Name	DUSP2
Chromosomal Location	2q11.2
Family	protein-tyrosine phosphatase family; Non-receptor class dual specificity subfamily
Function	Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. Click to Show/Hide
Gene ID	1844
Uniprot ID	DUS2_HUMAN
HGNC ID	HGNC:3068
KEGG ID	hsa:1844

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

DUSP2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL3*
Cell Line	Caco-2 cell line	Homo sapiens
Treatment: shMETTL3 Caco-2 cells Control: shNTC Caco-2 cells		GSE167075
Regulation		logFC: 7.70E-01 p-value: 1.05E-14
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene			[1]
Response Summary	METTL3-mediated formation of EV miR-93, facilitated by m6A, is implicated in the aberrant cross-talk of epithelium-macrophages, indicating that this process is involved in the smoking-related emphysema. EV miR-93 was used as a novel risk biomarker for CS-induced emphysema. MiR-93 activated the JNK pathway by targeting Dual specificity protein phosphatase 2 (DUSP2), which elevated the levels of matrix metalloproteinase 9 (MMP9) and matrix metalloproteinase 12 (MMP12) and induced elastin degradation, leading to emphysema.
Target Regulation	Down regulation
Responsed Disease	Emphysema	ICD-11: CA21	Disease Info
Pathway Response	MAPK signaling pathway		hsa04010

Emphysema [ICD-11: CA21]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response			[1]
Response Summary	METTL3-mediated formation of EV miR-93, facilitated by m6A, is implicated in the aberrant cross-talk of epithelium-macrophages, indicating that this process is involved in the smoking-related emphysema. EV miR-93 was used as a novel risk biomarker for CS-induced emphysema. MiR-93 activated the JNK pathway by targeting Dual specificity protein phosphatase 2 (DUSP2), which elevated the levels of matrix metalloproteinase 9 (MMP9) and matrix metalloproteinase 12 (MMP12) and induced elastin degradation, leading to emphysema.
Responsed Disease	Emphysema [ICD-11: CA21]
Target Regulator	Methyltransferase-like 3 (METTL3)	WRITER	Regulator Info
Target Regulation	Down regulation
Pathway Response	MAPK signaling pathway		hsa04010

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00232)

Dual specificity protein phosphatase 2 (DUSP2)

5-methylcytidine (m5C)

In total 4 m6A sequence/site(s) in this target gene
mod ID: M5CSITE002379		Click to Show/Hide the Full List
mod site	chr2:96143688-96143689:-		[3]
Sequence	CTCAGAGTTTCAGAAGCCCCCACATGGGGGCTCTAGGAATG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000288943.5
External Link	RMBase: m5C_site_26881
mod ID: M5CSITE002380		Click to Show/Hide the Full List
mod site	chr2:96143689-96143690:-		[3]
Sequence	CCTCAGAGTTTCAGAAGCCCCCACATGGGGGCTCTAGGAAT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000288943.5
External Link	RMBase: m5C_site_26882
mod ID: M5CSITE002381		Click to Show/Hide the Full List
mod site	chr2:96143690-96143691:-		[3]
Sequence	TCCTCAGAGTTTCAGAAGCCCCCACATGGGGGCTCTAGGAA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000288943.5
External Link	RMBase: m5C_site_26883
mod ID: M5CSITE002382		Click to Show/Hide the Full List
mod site	chr2:96143691-96143692:-		[3]
Sequence	CTCCTCAGAGTTTCAGAAGCCCCCACATGGGGGCTCTAGGA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000288943.5
External Link	RMBase: m5C_site_26884

N6-methyladenosine (m6A)

In total 13 m6A sequence/site(s) in this target gene
mod ID: M6ASITE046232		Click to Show/Hide the Full List
mod site	chr2:96143384-96143385:-		[4]
Sequence	TGTTCCTGGGGAAGCTGGGGACTTGGGAAGTGATGGGTGTG
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000288943.5
External Link	RMBase: m6A_site_483812
mod ID: M6ASITE046233		Click to Show/Hide the Full List
mod site	chr2:96143471-96143472:-		[4]
Sequence	CAGCCTGAGAGCTCCAAGGAACAAGCTGTGACAACCAGGAG
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000288943.5
External Link	RMBase: m6A_site_483813
mod ID: M6ASITE046234		Click to Show/Hide the Full List
mod site	chr2:96143594-96143595:-		[4]
Sequence	GCCCTCATTCGGGGTCGGGAACCAAGGGTGTGTCTGCTCTT
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000288943.5
External Link	RMBase: m6A_site_483814
mod ID: M6ASITE046235		Click to Show/Hide the Full List
mod site	chr2:96143624-96143625:-		[4]
Sequence	TGGTGCTCTTCTGCTGGGGGACTGAGGCTGGCCCTCATTCG
Motif Score	4.065041667
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000288943.5
External Link	RMBase: m6A_site_483815
mod ID: M6ASITE046236		Click to Show/Hide the Full List
mod site	chr2:96143768-96143769:-		[4]
Sequence	CTGGCAGGAGCTGACTGTGGACTGGTGGGCTCCCCTCTGGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; H1A; H1B; GM12878; CD8T; HEK293A-TOA; endometrial
Seq Type List	m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000488952.1; ENST00000288943.5
External Link	RMBase: m6A_site_483816
mod ID: M6ASITE046237		Click to Show/Hide the Full List
mod site	chr2:96143842-96143843:-		[4]
Sequence	GGCAGCTGCTGCAGTTTGAGACCCAGGTGCTGTGTCACTGA
Motif Score	2.876744048
Cell/Tissue List	HeLa; GM12878; HEK293A-TOA; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000488952.1; ENST00000288943.5
External Link	RMBase: m6A_site_483817
mod ID: M6ASITE046238		Click to Show/Hide the Full List
mod site	chr2:96144024-96144025:-		[4]
Sequence	CCTTGCAGACTGGGTGAAGAACAGCGGAGGCCGGGTGCTGG
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000488952.1; ENST00000288943.5
External Link	RMBase: m6A_site_483818
mod ID: M6ASITE046239		Click to Show/Hide the Full List
mod site	chr2:96144484-96144485:-		[4]
Sequence	ACCTGTCTCAGGTCAGGAGGACTGGCTGAGGAGTCCTCTTG
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000488952.1; ENST00000288943.5
External Link	RMBase: m6A_site_483819
mod ID: M6ASITE046241		Click to Show/Hide the Full List
mod site	chr2:96144798-96144799:-		[4]
Sequence	TGCCGCCAACAGGGGACAAAACCAGCCGCTCCGACTCCAGG
Motif Score	2.185083333
Cell/Tissue List	HeLa; MT4; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000288943.5
External Link	RMBase: m6A_site_483820
mod ID: M6ASITE046242		Click to Show/Hide the Full List
mod site	chr2:96144803-96144804:-		[4]
Sequence	TGCGCTGCCGCCAACAGGGGACAAAACCAGCCGCTCCGACT
Motif Score	3.643047619
Cell/Tissue List	HeLa; MT4; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000288943.5
External Link	RMBase: m6A_site_483821
mod ID: M6ASITE046243		Click to Show/Hide the Full List
mod site	chr2:96145002-96145003:-		[4]
Sequence	TGGCCGCGCTGCTGCACGAGACCCGCGCGGGGCCCACTGCC
Motif Score	2.876744048
Cell/Tissue List	HeLa; MT4; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000288943.5
External Link	RMBase: m6A_site_483822
mod ID: M6ASITE046244		Click to Show/Hide the Full List
mod site	chr2:96145262-96145263:-		[5]
Sequence	GGAACGCACGCTGCTGCTGGACTGCCGCCCCTTCCTGGCCT
Motif Score	4.065041667
Cell/Tissue List	HeLa; Jurkat; CD4T; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000288943.5
External Link	RMBase: m6A_site_483823
mod ID: M6ASITE046245		Click to Show/Hide the Full List
mod site	chr2:96145385-96145386:-		[4]
Sequence	GAGCCCGGGACGCGGGAAAGACCGAAAGGAAGAGGAAGAGG
Motif Score	2.876744048
Cell/Tissue List	HeLa; H1A; MT4; Jurkat; CD4T; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000288943.5
External Link	RMBase: m6A_site_483824

Ref 1	The aberrant cross-talk of epithelium-macrophages via METTL3-regulated extracellular vesicle miR-93 in smoking-induced emphysema. Cell Biol Toxicol. 2022 Feb;38(1):167-183. doi: 10.1007/s10565-021-09585-1. Epub 2021 Mar 4.
Ref 2	ABCB1 gene polymorphisms are associated with fatal intoxications involving venlafaxine but not citalopram. Int J Legal Med. 2013 May;127(3):579-86. doi: 10.1007/s00414-013-0849-0. Epub 2013 Mar 21.
Ref 3	Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6784-6789. doi: 10.1073/pnas.1817334116. Epub 2019 Mar 14.
Ref 4	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 5	RNA m(6)A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail. Nat Commun. 2019 May 6;10(1):2065. doi: 10.1038/s41467-019-09865-9.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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