m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00229)

Target Name	H/ACA ribonucleoprotein complex subunit DKC1 (DKC1)
Synonyms	CBF5 homolog; Dyskerin; Nopp140-associated protein of 57 kDa; Nucleolar protein NAP57; Nucleolar protein family A member 4; snoRNP protein DKC1; NOLA4 Click to Show/Hide
Gene Name	DKC1
Chromosomal Location	Xq28
Family	pseudouridine synthase TruB family
Function	[Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. [Isoform 3]: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression. Click to Show/Hide
Gene ID	1736
Uniprot ID	DKC1_HUMAN
HGNC ID	HGNC:2890
KEGG ID	hsa:1736

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

DKC1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL3*
Cell Line	Pancreatic islets	Mus musculus
Treatment: Mettl3 knockout mice Control: Mettl3 flox/flox mice		GSE155612
Regulation		logFC: 6.68E-01 p-value: 1.04E-03
More Results	Click to View More RNA-seq Results
*Representative RIP-seq result supporting the interaction between DKC1 and the regulator*
Cell Line	MDA-MB-231	Homo sapiens
Regulation	logFC: 1.61E+00	GSE60213

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	CircMEG3 inhibits the expression of m6A methyltransferase METTL3 dependent on HULC. Moreover, CircMEG3 inhibits the expression of H/ACA ribonucleoprotein complex subunit DKC1 (DKC1), a component of telomere synthetase H/ACA ribonucleoprotein (RNP; catalyst RNA pseudouracil modification) through METTL3 dependent on HULC. These observations provide important basic information for finding effective liver cancer therapeutic targets.
Target Regulation	Down regulation
Responsed Disease	Liver cancer		ICD-11: 2C12	Disease Info
In-vitro Model	Huh-7	Adult hepatocellular carcinoma	Homo sapiens	CVCL_0336
In-vivo Model	Athymic BALB/c mice were injected with LCSC cells at the armpit area subcutaneously. The mice were then sacrificed and the tumors recovered.

Liver cancer [ICD-11: 2C12]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	CircMEG3 inhibits the expression of m6A methyltransferase METTL3 dependent on HULC. Moreover, CircMEG3 inhibits the expression of H/ACA ribonucleoprotein complex subunit DKC1 (DKC1), a component of telomere synthetase H/ACA ribonucleoprotein (RNP; catalyst RNA pseudouracil modification) through METTL3 dependent on HULC. These observations provide important basic information for finding effective liver cancer therapeutic targets.
Responsed Disease	Liver cancer [ICD-11: 2C12]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Down regulation
In-vitro Model	Huh-7	Adult hepatocellular carcinoma	Homo sapiens	CVCL_0336
In-vivo Model	Athymic BALB/c mice were injected with LCSC cells at the armpit area subcutaneously. The mice were then sacrificed and the tumors recovered.

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Non-coding RNA

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05363		Crosstalk Info
Epigenetic Regulator	Circ_MEG3
Regulated Target	Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship	ncRNA → m6A
Disease	Liver cancer	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00229)

H/ACA ribonucleoprotein complex subunit DKC1 (DKC1)

N1-methyladenosine (m1A)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M1ASITE000009		Click to Show/Hide the Full List
mod site	chrX:154765963-154765964:+		[2]
Sequence	CACCTCTTGCATGTGGTTCAAATCCTCTGAAGAGAGAGATT
Cell/Tissue List	HEK293T
Seq Type List	m1A-seq
Transcript ID List	ENST00000473552.1; ENST00000620277.4; ENST00000437719.5; ENST00000452771.5; ENST00000413910.5; ENST00000369550.10
External Link	RMBase: m1A_site_1103

5-methylcytidine (m5C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE004645		Click to Show/Hide the Full List
mod site	chrX:154776181-154776182:+		[3]
Sequence	ACTTAACCAATTGCTTTCATCTCAGCGGAAGCGAGAGAGTG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000492372.1; ENST00000620277.4; ENST00000369550.10; ENST00000426673.5; ENST00000475966.1; ENST00000412124.5
External Link	RMBase: m5C_site_45732

N6-methyladenosine (m6A)

In total 59 m6A sequence/site(s) in this target gene
mod ID: M6ASITE094096		Click to Show/Hide the Full List
mod site	chrX:154762893-154762894:+		[4]
Sequence	TAGCAGCGCGGCCTGACGGGACCAAGGCGGCGGGAGTCTGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; A549; fibroblasts; H1299; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000369550.10; ENST00000475423.1; ENST00000413910.5; ENST00000620277.4
External Link	RMBase: m6A_site_878378
mod ID: M6ASITE094097		Click to Show/Hide the Full List
mod site	chrX:154762934-154762935:+		[4]
Sequence	GGTCGTTCCCTCGGCTGTGGACCGGGCGGCACGCACGCGGT
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; A549; fibroblasts; H1299; Jurkat; CD4T; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000475423.1; ENST00000620277.4; ENST00000413910.5; ENST00000473552.1; ENST00000369550.10
External Link	RMBase: m6A_site_878379
mod ID: M6ASITE094098		Click to Show/Hide the Full List
mod site	chrX:154762963-154762964:+		[5]
Sequence	CACGCACGCGGTGCAGGGTAACATGGCGGATGCGGAAGGTA
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000369550.10; ENST00000473552.1; ENST00000620277.4; ENST00000413910.5; ENST00000475423.1
External Link	RMBase: m6A_site_878380
mod ID: M6ASITE094099		Click to Show/Hide the Full List
mod site	chrX:154764917-154764918:+		[4]
Sequence	GTAATTATTTTGCCAAAGAAACATAAGAAGAAAAAGGAGCG
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; HepG2; A549; hESC-HEK293T; fibroblasts; LCLs; H1299; Jurkat; CD4T; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000620277.4; ENST00000369550.10; ENST00000473552.1; ENST00000413910.5; ENST00000475423.1
External Link	RMBase: m6A_site_878381
mod ID: M6ASITE094100		Click to Show/Hide the Full List
mod site	chrX:154765025-154765026:+		[4]
Sequence	AAAGTTTACTTAAATAACAAACTAAAGGAAAGAAGTGTTTT
Motif Score	2.627720238
Cell/Tissue List	HeLa; A549
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000620277.4; ENST00000452771.5; ENST00000437719.5; ENST00000473552.1; ENST00000475423.1; ENST00000369550.10; ENST00000413910.5
External Link	RMBase: m6A_site_878382
mod ID: M6ASITE094101		Click to Show/Hide the Full List
mod site	chrX:154765448-154765449:+		[5]
Sequence	TCTGTCCTGTCGAAGGAAATACAACACGCTGAAGAATTTCT
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000452771.5; ENST00000369550.10; ENST00000473552.1; ENST00000413910.5; ENST00000437719.5; ENST00000620277.4
External Link	RMBase: m6A_site_878383
mod ID: M6ASITE094102		Click to Show/Hide the Full List
mod site	chrX:154765451-154765452:+		[5]
Sequence	GTCCTGTCGAAGGAAATACAACACGCTGAAGAATTTCTTAT
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000369550.10; ENST00000437719.5; ENST00000620277.4; ENST00000413910.5; ENST00000473552.1; ENST00000452771.5
External Link	RMBase: m6A_site_878384
mod ID: M6ASITE094103		Click to Show/Hide the Full List
mod site	chrX:154765501-154765502:+		[5]
Sequence	ATCCAAAGTTGCTAAGTTGGACACGTCTCAGTGGCCCCTTT
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000413910.5; ENST00000369550.10; ENST00000620277.4; ENST00000452771.5; ENST00000473552.1; ENST00000437719.5
External Link	RMBase: m6A_site_878385
mod ID: M6ASITE094104		Click to Show/Hide the Full List
mod site	chrX:154765930-154765931:+		[5]
Sequence	TTGATAAGCTGAATGTAAGGACAACACACTATACACCTCTT
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000369550.10; ENST00000473552.1; ENST00000437719.5; ENST00000620277.4; ENST00000452771.5; ENST00000413910.5
External Link	RMBase: m6A_site_878386
mod ID: M6ASITE094105		Click to Show/Hide the Full List
mod site	chrX:154765942-154765943:+		[5]
Sequence	ATGTAAGGACAACACACTATACACCTCTTGCATGTGGTTCA
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000473552.1; ENST00000413910.5; ENST00000452771.5; ENST00000620277.4; ENST00000369550.10; ENST00000437719.5
External Link	RMBase: m6A_site_878387
mod ID: M6ASITE094106		Click to Show/Hide the Full List
mod site	chrX:154766235-154766236:+		[6]
Sequence	GACAGGTTTCATTAATCTTGACAAGCCCTCTAACCCCTCTT
Motif Score	2.859755952
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000473552.1; ENST00000452771.5; ENST00000620277.4; ENST00000413910.5; ENST00000369550.10; ENST00000437719.5
External Link	RMBase: m6A_site_878388
mod ID: M6ASITE094107		Click to Show/Hide the Full List
mod site	chrX:154766281-154766282:+		[6]
Sequence	GAGGTGGTAGCCTGGATTCGACGGATACTTCGGGTGGAGAA
Motif Score	2.839505952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000452771.5; ENST00000437719.5; ENST00000473552.1; ENST00000369550.10; ENST00000413910.5; ENST00000620277.4
External Link	RMBase: m6A_site_878389
mod ID: M6ASITE094108		Click to Show/Hide the Full List
mod site	chrX:154766303-154766304:+		[7]
Sequence	GGATACTTCGGGTGGAGAAGACAGGGCACAGTGGTACGCTG
Motif Score	2.897386905
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000473552.1; ENST00000620277.4; ENST00000369550.10; ENST00000437719.5; ENST00000452771.5; ENST00000413910.5
External Link	RMBase: m6A_site_878390
mod ID: M6ASITE094109		Click to Show/Hide the Full List
mod site	chrX:154766386-154766387:+		[5]
Sequence	GCCACTCGCTTGGTGAAGTCACAACAGAGTGCAGGTATGTG
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000437719.5; ENST00000473552.1; ENST00000369550.10; ENST00000620277.4; ENST00000452771.5; ENST00000413910.5
External Link	RMBase: m6A_site_878391
mod ID: M6ASITE094110		Click to Show/Hide the Full List
mod site	chrX:154766423-154766424:+		[8]
Sequence	TGTGGGAGAGGGAGGGAAGGACTGGCTAGAGTGAAAAGCTT
Motif Score	4.065041667
Cell/Tissue List	MT4
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000473552.1; ENST00000369550.10; ENST00000452771.5; ENST00000413910.5; ENST00000620277.4; ENST00000437719.5
External Link	RMBase: m6A_site_878392
mod ID: M6ASITE094111		Click to Show/Hide the Full List
mod site	chrX:154766478-154766479:+		[8]
Sequence	CTATGTTTTGTCTGCTGGAAACTATTTCTTCATTAAGAAAA
Motif Score	2.627720238
Cell/Tissue List	MT4
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000620277.4; ENST00000437719.5; ENST00000413910.5; ENST00000369550.10; ENST00000452771.5; ENST00000473552.1
External Link	RMBase: m6A_site_878393
mod ID: M6ASITE094112		Click to Show/Hide the Full List
mod site	chrX:154767026-154767027:+		[5]
Sequence	TGTGGGGATTGTCCGGCTGCACAATGCTATTGAAGGGGGGA
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000412124.5; ENST00000620277.4; ENST00000452771.5; ENST00000437719.5; ENST00000413910.5; ENST00000369550.10
External Link	RMBase: m6A_site_878394
mod ID: M6ASITE094113		Click to Show/Hide the Full List
mod site	chrX:154767046-154767047:+		[8]
Sequence	ACAATGCTATTGAAGGGGGGACCCAGCTTTCTAGGGTAAGT
Motif Score	3.622404762
Cell/Tissue List	MT4
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000412124.5; ENST00000369550.10; ENST00000452771.5; ENST00000437719.5; ENST00000413910.5; ENST00000620277.4
External Link	RMBase: m6A_site_878395
mod ID: M6ASITE094114		Click to Show/Hide the Full List
mod site	chrX:154767264-154767265:+		[8]
Sequence	TTTGTTCTTAGGCCCTAGAAACTCTGACAGGTGCCTTATTC
Motif Score	2.627720238
Cell/Tissue List	MT4
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000437719.5; ENST00000369550.10; ENST00000412124.5; ENST00000620277.4; ENST00000452771.5; ENST00000413910.5
External Link	RMBase: m6A_site_878396
mod ID: M6ASITE094115		Click to Show/Hide the Full List
mod site	chrX:154767270-154767271:+		[7]
Sequence	CTTAGGCCCTAGAAACTCTGACAGGTGCCTTATTCCAGCGA
Motif Score	2.859755952
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000413910.5; ENST00000620277.4; ENST00000412124.5; ENST00000369550.10; ENST00000437719.5; ENST00000452771.5
External Link	RMBase: m6A_site_878397
mod ID: M6ASITE094116		Click to Show/Hide the Full List
mod site	chrX:154767333-154767334:+		[9]
Sequence	AGAGGCAGCTCCGAGTGAGGACCATCTACGAGAGCAAAATG
Motif Score	3.622404762
Cell/Tissue List	HepG2; MT4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000369550.10; ENST00000620277.4; ENST00000412124.5; ENST00000413910.5; ENST00000452771.5; ENST00000437719.5
External Link	RMBase: m6A_site_878398
mod ID: M6ASITE094117		Click to Show/Hide the Full List
mod site	chrX:154768334-154768335:+		[5]
Sequence	GAGTTGTGAGGCTGGCACCTACATTCGGACATTATGTGTGC
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000413910.5; ENST00000484317.5; ENST00000437719.5; ENST00000412124.5; ENST00000620277.4; ENST00000369550.10; ENST00000452771.5; ENST00000426673.5
External Link	RMBase: m6A_site_878399
mod ID: M6ASITE094118		Click to Show/Hide the Full List
mod site	chrX:154768342-154768343:+		[6]
Sequence	AGGCTGGCACCTACATTCGGACATTATGTGTGCACCTTGGT
Motif Score	3.643047619
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000452771.5; ENST00000412124.5; ENST00000620277.4; ENST00000484317.5; ENST00000413910.5; ENST00000426673.5; ENST00000437719.5; ENST00000369550.10
External Link	RMBase: m6A_site_878400
mod ID: M6ASITE094119		Click to Show/Hide the Full List
mod site	chrX:154769170-154769171:+		[5]
Sequence	CATGGCTGCTTTTCAGGACCACATGGTGACAATGCATGATG
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000620277.4; ENST00000369550.10; ENST00000475966.1; ENST00000413910.5; ENST00000412124.5; ENST00000426673.5; ENST00000452771.5; ENST00000484317.5
External Link	RMBase: m6A_site_878401
mod ID: M6ASITE094120		Click to Show/Hide the Full List
mod site	chrX:154769178-154769179:+		[6]
Sequence	CTTTTCAGGACCACATGGTGACAATGCATGATGTGCTTGAT
Motif Score	2.859755952
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000426673.5; ENST00000452771.5; ENST00000369550.10; ENST00000620277.4; ENST00000412124.5; ENST00000475966.1; ENST00000413910.5; ENST00000484317.5
External Link	RMBase: m6A_site_878402
mod ID: M6ASITE094121		Click to Show/Hide the Full List
mod site	chrX:154769221-154769222:+		[5]
Sequence	TCAGTGGCTGTATGATAACCACAAGGATGAGAGTTACCTGC
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000412124.5; ENST00000475966.1; ENST00000484317.5; ENST00000426673.5; ENST00000620277.4; ENST00000369550.10; ENST00000413910.5
External Link	RMBase: m6A_site_878403
mod ID: M6ASITE094122		Click to Show/Hide the Full List
mod site	chrX:154769274-154769275:+		[6]
Sequence	ACCCTTTGGAAAAGCTGTTGACATCTCATAAACGGCTGGTT
Motif Score	2.859755952
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000412124.5; ENST00000484317.5; ENST00000620277.4; ENST00000475966.1; ENST00000426673.5; ENST00000413910.5; ENST00000369550.10
External Link	RMBase: m6A_site_878404
mod ID: M6ASITE094123		Click to Show/Hide the Full List
mod site	chrX:154769302-154769303:+		[6]
Sequence	TAAACGGCTGGTTATGAAAGACAGTGCAGTAAGTTCCGGGT
Motif Score	2.897386905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000620277.4; ENST00000412124.5; ENST00000426673.5; ENST00000369550.10; ENST00000475966.1; ENST00000484317.5
External Link	RMBase: m6A_site_878405
mod ID: M6ASITE094124		Click to Show/Hide the Full List
mod site	chrX:154773214-154773215:+		[10]
Sequence	GAGAGTGATCATGGAGAGAGACACTTACCCTCGGAAGTGGG
Motif Score	2.897386905
Cell/Tissue List	CD34; hESC-HEK293T; MT4
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000369550.10; ENST00000426673.5; ENST00000620277.4; ENST00000481062.1; ENST00000475966.1; ENST00000412124.5
External Link	RMBase: m6A_site_878406
mod ID: M6ASITE094125		Click to Show/Hide the Full List
mod site	chrX:154774641-154774642:+		[10]
Sequence	GATCAAGCAGGGCCTTCTGGACAAGCATGGGAAGCCCACAG
Motif Score	3.643047619
Cell/Tissue List	CD34; hESC-HEK293T; HepG2; MT4
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000426673.5; ENST00000369550.10; ENST00000481062.1; ENST00000412124.5; ENST00000475966.1; ENST00000620277.4
External Link	RMBase: m6A_site_878407
mod ID: M6ASITE094126		Click to Show/Hide the Full List
mod site	chrX:154774662-154774663:+		[10]
Sequence	CAAGCATGGGAAGCCCACAGACAGCACACCTGCCACCTGGA
Motif Score	2.897386905
Cell/Tissue List	CD34; HepG2; MT4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000481062.1; ENST00000412124.5; ENST00000475966.1; ENST00000369550.10; ENST00000426673.5; ENST00000620277.4
External Link	RMBase: m6A_site_878408
mod ID: M6ASITE094127		Click to Show/Hide the Full List
mod site	chrX:154774837-154774838:+		[4]
Sequence	CTGGACGCAGGAGTACATGGACAACAGGTGAGGAACAGGTG
Motif Score	3.643047619
Cell/Tissue List	HeLa; MT4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000475966.1; ENST00000369550.10; ENST00000426673.5; ENST00000412124.5; ENST00000481062.1; ENST00000620277.4
External Link	RMBase: m6A_site_878409
mod ID: M6ASITE094128		Click to Show/Hide the Full List
mod site	chrX:154774851-154774852:+		[4]
Sequence	ACATGGACAACAGGTGAGGAACAGGTGAGCATGGAGGTTGT
Motif Score	2.951386905
Cell/Tissue List	HeLa; MT4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000481062.1; ENST00000475966.1; ENST00000369550.10; ENST00000412124.5; ENST00000426673.5; ENST00000620277.4
External Link	RMBase: m6A_site_878410
mod ID: M6ASITE094129		Click to Show/Hide the Full List
mod site	chrX:154774910-154774911:+		[4]
Sequence	AGTCACTTGGTTTGGGGCAAACTTGCTAAATGCAGGACCAC
Motif Score	2.627720238
Cell/Tissue List	HeLa; MT4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000369550.10; ENST00000426673.5; ENST00000412124.5; ENST00000481062.1; ENST00000475966.1; ENST00000620277.4
External Link	RMBase: m6A_site_878411
mod ID: M6ASITE094130		Click to Show/Hide the Full List
mod site	chrX:154774926-154774927:+		[4]
Sequence	GCAAACTTGCTAAATGCAGGACCACAGGAACCAGCTCTTCA
Motif Score	3.622404762
Cell/Tissue List	HeLa; MT4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000369550.10; ENST00000475966.1; ENST00000426673.5; ENST00000620277.4; ENST00000412124.5; ENST00000481062.1
External Link	RMBase: m6A_site_878412
mod ID: M6ASITE094131		Click to Show/Hide the Full List
mod site	chrX:154774935-154774936:+		[4]
Sequence	CTAAATGCAGGACCACAGGAACCAGCTCTTCAGCTCCCGTG
Motif Score	2.930744048
Cell/Tissue List	HeLa; MT4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000481062.1; ENST00000369550.10; ENST00000475966.1; ENST00000620277.4; ENST00000412124.5; ENST00000426673.5
External Link	RMBase: m6A_site_878413
mod ID: M6ASITE094132		Click to Show/Hide the Full List
mod site	chrX:154775264-154775265:+		[4]
Sequence	TAGTTGCCGAAGCAGCAAAAACTGCGAAGGTGAGTGGCATG
Motif Score	2.627720238
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; U2OS; hNPCs; fibroblasts; A549; H1299; MM6; Huh7; peripheral-blood
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000412124.5; ENST00000475966.1; ENST00000620277.4; ENST00000481062.1; ENST00000492372.1; ENST00000369550.10; ENST00000426673.5
External Link	RMBase: m6A_site_878414
mod ID: M6ASITE094133		Click to Show/Hide the Full List
mod site	chrX:154776219-154776220:+		[4]
Sequence	GTGAGAGTGAAAGTGACGAGACTCCTCCAGCAGCTCCTCAG
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; U2OS; hNPCs; hESCs; fibroblasts; A549; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000475966.1; ENST00000492372.1; ENST00000426673.5; ENST00000620277.4; ENST00000369550.10; ENST00000412124.5
External Link	RMBase: m6A_site_878415
mod ID: M6ASITE094134		Click to Show/Hide the Full List
mod site	chrX:154776274-154776275:+		[4]
Sequence	AAAGAAGAAGAGTAAGAAGGACAAGAAGGCCAAAGCTGGTC
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; hESC-HEK293T; U2OS; hNPCs; hESCs; fibroblasts; A549; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000369550.10; ENST00000492372.1; ENST00000620277.4
External Link	RMBase: m6A_site_878416
mod ID: M6ASITE094135		Click to Show/Hide the Full List
mod site	chrX:154776799-154776800:+		[5]
Sequence	TCATTCTCTTTCTTTCTAGGACAGTGATACCACCAAGAAGA
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000620277.4; ENST00000492372.1; ENST00000369550.10
External Link	RMBase: m6A_site_878417
mod ID: M6ASITE094136		Click to Show/Hide the Full List
mod site	chrX:154776875-154776876:+		[6]
Sequence	GTTTCTGAGTAGTGAAGGCCACTTGAAGCTGGAGGAGAAAC
Motif Score	2.475107143
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000369550.10; ENST00000620277.4; ENST00000492372.1
External Link	RMBase: m6A_site_878418
mod ID: M6ASITE094137		Click to Show/Hide the Full List
mod site	chrX:154776894-154776895:+		[4]
Sequence	CACTTGAAGCTGGAGGAGAAACTAAAGCCTTATTGAGAAAA
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; hNPCs; fibroblasts; A549; LCLs; H1299; MM6; Huh7; Jurkat; peripheral-blood; NB4
Seq Type List	m6A-seq; MeRIP-seq; DART-seq
Transcript ID List	ENST00000369550.10; ENST00000620277.4; ENST00000492372.1
External Link	RMBase: m6A_site_878419
mod ID: M6ASITE094138		Click to Show/Hide the Full List
mod site	chrX:154776914-154776915:+		[4]
Sequence	ACTAAAGCCTTATTGAGAAAACATGTTATAGATCCTTTTGT
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; hESC-HEK293T; U2OS; LCLs; H1299; MM6; Huh7; Jurkat; peripheral-blood; NB4
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000369550.10; ENST00000620277.4
External Link	RMBase: m6A_site_878420
mod ID: M6ASITE094139		Click to Show/Hide the Full List
mod site	chrX:154776950-154776951:+		[4]
Sequence	TTTGTTGCTGAGAGAGTGGAACATAGGTCCTAGACAGGGTG
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; LCLs; Huh7
Seq Type List	m6A-seq; DART-seq; MeRIP-seq
Transcript ID List	ENST00000369550.10; ENST00000620277.4
External Link	RMBase: m6A_site_878421
mod ID: M6ASITE094140		Click to Show/Hide the Full List
mod site	chrX:154776963-154776964:+		[4]
Sequence	GAGTGGAACATAGGTCCTAGACAGGGTGAAGAGTTCTGGCA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; LCLs; Huh7
Seq Type List	m6A-seq; DART-seq; MeRIP-seq
Transcript ID List	ENST00000369550.10; ENST00000620277.4
External Link	RMBase: m6A_site_878422
mod ID: M6ASITE094141		Click to Show/Hide the Full List
mod site	chrX:154776983-154776984:+		[5]
Sequence	ACAGGGTGAAGAGTTCTGGCACATTTTAGCTGCTACTTTGA
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000369550.10; ENST00000620277.4
External Link	RMBase: m6A_site_878423
mod ID: M6ASITE094142		Click to Show/Hide the Full List
mod site	chrX:154777005-154777006:+		[4]
Sequence	ATTTTAGCTGCTACTTTGAGACCTCGGTGATGTTACCTGGT
Motif Score	2.876744048
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000620277.4; ENST00000369550.10
External Link	RMBase: m6A_site_878424
mod ID: M6ASITE094143		Click to Show/Hide the Full List
mod site	chrX:154777099-154777100:+		[6]
Sequence	AGGCAGAGTTTATCCCAATGACTTCTCTGTTTGAGTTGGGA
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000369550.10; ENST00000620277.4
External Link	RMBase: m6A_site_878425
mod ID: M6ASITE094144		Click to Show/Hide the Full List
mod site	chrX:154777134-154777135:+		[4]
Sequence	TTGGGAAGCCTCACCTTCAGACCCAGTAACTGTCCGCAGCT
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000369550.10; ENST00000620277.4
External Link	RMBase: m6A_site_878426
mod ID: M6ASITE094145		Click to Show/Hide the Full List
mod site	chrX:154777175-154777176:+		[6]
Sequence	GTCTGCTAGTGGTTGTCTTAACATCGTAGTCCTAGTTTGCA
Motif Score	2.168095238
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000369550.10; ENST00000620277.4
External Link	RMBase: m6A_site_878427
mod ID: M6ASITE094146		Click to Show/Hide the Full List
mod site	chrX:154777231-154777232:+		[4]
Sequence	CTGTTTAAAAGGTTTGTAAAACAAAAACAAAAAACTAAGTC
Motif Score	2.20572619
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000620277.4; ENST00000369550.10
External Link	RMBase: m6A_site_878428
mod ID: M6ASITE094147		Click to Show/Hide the Full List
mod site	chrX:154777237-154777238:+		[4]
Sequence	AAAAGGTTTGTAAAACAAAAACAAAAAACTAAGTCTGCTCA
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T
Seq Type List	m6A-seq; DART-seq; MAZTER-seq
Transcript ID List	ENST00000620277.4; ENST00000369550.10
External Link	RMBase: m6A_site_878429
mod ID: M6ASITE094148		Click to Show/Hide the Full List
mod site	chrX:154777244-154777245:+		[4]
Sequence	TTGTAAAACAAAAACAAAAAACTAAGTCTGCTCAGTGAAAT
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; DART-seq
Transcript ID List	ENST00000620277.4; ENST00000369550.10
External Link	RMBase: m6A_site_878430
mod ID: M6ASITE094149		Click to Show/Hide the Full List
mod site	chrX:154777273-154777274:+		[4]
Sequence	GCTCAGTGAAATGCTGTAGAACCCTAAATAAGTGGTAGAAG
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000369550.10; ENST00000620277.4
External Link	RMBase: m6A_site_878431
mod ID: M6ASITE094150		Click to Show/Hide the Full List
mod site	chrX:154777419-154777420:+		[6]
Sequence	CCTAGAGGTCAGTCCTTTGCACTTCCTCAAAGCTTGTGTAC
Motif Score	3.252583333
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000369550.10; ENST00000620277.4
External Link	RMBase: m6A_site_878432
mod ID: M6ASITE094151		Click to Show/Hide the Full List
mod site	chrX:154777462-154777463:+		[6]
Sequence	TGCTCACCTAAATCCATCTGACTACTTGTTCCTGTGCCCTC
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000620277.4; ENST00000369550.10
External Link	RMBase: m6A_site_878433
mod ID: M6ASITE094152		Click to Show/Hide the Full List
mod site	chrX:154777465-154777466:+		[6]
Sequence	TCACCTAAATCCATCTGACTACTTGTTCCTGTGCCCTCTTG
Motif Score	2.500660714
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000369550.10; ENST00000620277.4
External Link	RMBase: m6A_site_878434
mod ID: M6ASITE094153		Click to Show/Hide the Full List
mod site	chrX:154777501-154777502:+		[6]
Sequence	TCTTGTTTTAGGCCTCGTTTACTTTTAAAAAATGAAATTGT
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000369550.10; ENST00000620277.4
External Link	RMBase: m6A_site_878435
mod ID: M6ASITE094154		Click to Show/Hide the Full List
mod site	chrX:154777567-154777568:+		[6]
Sequence	ATTTTTACTTATTAAAGTCAACTTGTTAAGTTTTTTATGTA
Motif Score	2.595904762
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000620277.4; ENST00000369550.10
External Link	RMBase: m6A_site_878436

Pseudouridine (Pseudo)

In total 1 m6A sequence/site(s) in this target gene
mod ID: PSESITE000287		Click to Show/Hide the Full List
mod site	chrX:154765960-154765961:+		[11]
Sequence	ATACACCTCTTGCATGTGGTTCAAATCCTCTGAAGAGAGAG
Transcript ID List	ENST00000413910.5; ENST00000620277.4; ENST00000437719.5; ENST00000369550.10; ENST00000452771.5; ENST00000473552.1
External Link	RMBase: Pseudo_site_5020

Ref 1	CircMEG3 inhibits telomerase activity by reducing Cbf5 in human liver cancer stem cells. Mol Ther Nucleic Acids. 2020 Nov 17;23:310-323. doi: 10.1016/j.omtn.2020.11.009. eCollection 2021 Mar 5.
Ref 2	The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution. Nature. 2017 Nov 9;551(7679):251-255. doi: 10.1038/nature24456. Epub 2017 Oct 25.
Ref 3	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 4	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 5	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 6	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 7	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 8	Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells. Nat Microbiol. 2016 Feb 22;1:16011. doi: 10.1038/nmicrobiol.2016.11.
Ref 9	Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.
Ref 10	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.
Ref 11	Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA. Cell. 2014 Sep 25;159(1):148-162. doi: 10.1016/j.cell.2014.08.028. Epub 2014 Sep 11.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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