m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00146)
Target Name LBX2 antisense RNA 1 (LBX2-AS1)
Synonyms
LBX2-AS1; LBX2 antisense RNA 1 (non-protein coding)
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Gene Name LBX2-AS1
Chromosomal Location 2p13.1
Family Antisense RNAs
Gene ID 151534
HGNC ID
HGNC:25136
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
LBX2-AS1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Caco-2 cell line Homo sapiens
Treatment: shMETTL3 Caco-2 cells
Control: shNTC Caco-2 cells
 GSE167075
Regulation
logFC: -8.54E-01
p-value: 2.13E-07
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between LBX2-AS1 and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 6.38E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary The increased LBX2 antisense RNA 1 (LBX2-AS1) in CRC was mediated by METTL3-dependent m6A methylation. LBX2-AS1 serves as a therapeutic target and predictor of 5-FU benefit in colorectal cancer patients.
Target Regulation Up regulation
Responsed Disease Colorectal cancer ICD-11: 2B91
 Disease Info 
Responsed Drug Fluorouracil Approved
 Drug Info 
In-vitro Model HCT 116 Colon carcinoma Homo sapiens CVCL_0291
SW480 Colon adenocarcinoma Homo sapiens CVCL_0546
Colorectal cancer [ICD-11: 2B91]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary The increased LBX2 antisense RNA 1 (LBX2-AS1) in CRC was mediated by METTL3-dependent m6A methylation. LBX2-AS1 serves as a therapeutic target and predictor of 5-FU benefit in colorectal cancer patients.
Responsed Disease Colorectal cancer [ICD-11: 2B91]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Responsed Drug Fluorouracil Approved
 Drug Info 
In-vitro Model HCT 116 Colon carcinoma Homo sapiens CVCL_0291
SW480 Colon adenocarcinoma Homo sapiens CVCL_0546
Fluorouracil [Approved]
 Drug Info 
In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response [1]
Response Summary The increased LBX2 antisense RNA 1 (LBX2-AS1) in CRC was mediated by METTL3-dependent m6A methylation. LBX2-AS1 serves as a therapeutic target and predictor of 5-FU benefit in colorectal cancer patients.
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Responsed Disease Colorectal cancer ICD-11: 2B91
 Disease Info 
In-vitro Model HCT 116 Colon carcinoma Homo sapiens CVCL_0291
SW480 Colon adenocarcinoma Homo sapiens CVCL_0546
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Histone modification
m6A Regulator: Methyltransferase-like 3 (METTL3)
 Regulator Info 
In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03559
 Crosstalk Info 
Epigenetic Regulator Histone acetyltransferase p300 (P300)
Regulated Target Histone H3 lysine 27 acetylation (H3K27ac)
Crosstalk relationship Histone modification → m6A
Disease Colorectal cancer
 Disease Info 
Drug Fluorouracil
 Drug Info 
Crosstalk ID: M6ACROT03604
 Crosstalk Info 
Epigenetic Regulator N-lysine methyltransferase SMYD2 (SMYD2)
Regulated Target Histone H3 lysine 4 trimethylation (H3K4me3)
Crosstalk relationship Histone modification → m6A
Disease Colorectal cancer
 Disease Info 
Drug Fluorouracil
 Drug Info 
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05517
 Crosstalk Info 
Epigenetic Regulator LBX2 antisense RNA 1 (LBX2-AS1)
Regulated Target hsa-miR-422a
Crosstalk relationship m6A → ncRNA
Disease Colorectal cancer
 Disease Info 
Drug 5-FU
 Drug Info 
RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00146)
LBX2 antisense RNA 1 (LBX2-AS1)
N4-acetylcytidine (ac4C)
In total 1 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000026 Click to Show/Hide the Full List
mod site chr2:74503292-74503293:+
Sequence AGCCCGCAGCTGGCCAGCTTCAGCCACCTTGGGAGACGCAG
Cell/Tissue List DLD1
Seq Type List acRIP-seq
Transcript ID List ENST00000603175.1; ENST00000548978.2
External Link RMBase: ac4C_site_1121
N6-methyladenosine (m6A)
In total 29 m6A sequence/site(s) in this target gene
mod ID: M6ASITE045822 Click to Show/Hide the Full List
mod site chr2:74502638-74502639:+ [2]
Sequence AAAGCGCTACTGCGGAGTGAACCGGTCCTTATATCTTAGTT
Motif Score 2.930744048
Cell/Tissue List HepG2; A549; HEK293T; MM6; peripheral-blood; MSC; TIME; TREX; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000548978.2; ENST00000603175.1
External Link RMBase: m6A_site_480189
mod ID: M6ASITE045823 Click to Show/Hide the Full List
mod site chr2:74502784-74502785:+ [3]
Sequence GAAGCAGCCAGCGGTGGGAAACTCCGACGCCCTCCTCGACA
Motif Score 2.627720238
Cell/Tissue List HeLa; HepG2; HEK293T; A549; MM6; peripheral-blood; HEK293A-TOA; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000603175.1; ENST00000548978.2
External Link RMBase: m6A_site_480192
mod ID: M6ASITE045824 Click to Show/Hide the Full List
mod site chr2:74502829-74502830:+ [3]
Sequence TCTCCCCCCAACTCCCCAAGACTCACTTCTAGGGAAGTCCT
Motif Score 3.319380952
Cell/Tissue List HeLa; HepG2; HEK293T; A549; MM6; peripheral-blood; HEK293A-TOA; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000548978.2; ENST00000603175.1
External Link RMBase: m6A_site_480193
mod ID: M6ASITE045825 Click to Show/Hide the Full List
mod site chr2:74502874-74502875:+ [3]
Sequence CCCATCAAGCCCTGGGAAAGACTGGCCAGGCTGAGAGAGGG
Motif Score 3.319380952
Cell/Tissue List HeLa; HepG2; HEK293T; A549; MM6; peripheral-blood; HEK293A-TOA; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000548978.2; ENST00000603175.1
External Link RMBase: m6A_site_480195
mod ID: M6ASITE045826 Click to Show/Hide the Full List
mod site chr2:74502895-74502896:+ [3]
Sequence CTGGCCAGGCTGAGAGAGGGACCCGTCCTCCTCTGTGCCAA
Motif Score 3.622404762
Cell/Tissue List HeLa; HepG2; HEK293T; A549; MM6; peripheral-blood; HEK293A-TOA; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000603175.1; ENST00000548978.2
External Link RMBase: m6A_site_480196
mod ID: M6ASITE045827 Click to Show/Hide the Full List
mod site chr2:74503017-74503018:+ [3]
Sequence GGTTTGGCCCTCAGGCGAGAACCGACGCCTTGTCCCGGAAG
Motif Score 2.930744048
Cell/Tissue List HeLa; HepG2; A549; HEK293T; MM6; CD4T; peripheral-blood; MSC; TREX; TIME; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000548978.2; ENST00000603175.1
External Link RMBase: m6A_site_480199
mod ID: M6ASITE045828 Click to Show/Hide the Full List
mod site chr2:74503166-74503167:+ [3]
Sequence GTCGCGCGAAGCCAGAGAGGACCCTGGGCGTGATTCTCCCT
Motif Score 3.622404762
Cell/Tissue List HeLa; HepG2; A549; HEK293T; H1B; MM6; Jurkat; CD4T; GSC-11; HEK293A-TOA; MSC; TIME; TREX; iSLK; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000603175.1; ENST00000548978.2
External Link RMBase: m6A_site_480202
mod ID: M6ASITE045829 Click to Show/Hide the Full List
mod site chr2:74503204-74503205:+ [3]
Sequence CCTCCCTGGCACAGACGGAGACCCGAGTGACCCCGGGGTCC
Motif Score 2.876744048
Cell/Tissue List HeLa; HepG2; A549; HEK293T; H1A; H1B; GM12878; MM6; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000603175.1; ENST00000548978.2
External Link RMBase: m6A_site_480203
mod ID: M6ASITE045830 Click to Show/Hide the Full List
mod site chr2:74503244-74503245:+ [3]
Sequence CGGGTGGGCGTGGGGAATGGACCCATAGACCCGGGACGAGC
Motif Score 3.622404762
Cell/Tissue List HeLa; HepG2; A549; HEK293T; H1A; H1B; GM12878; MM6; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000548978.2; ENST00000603175.1
External Link RMBase: m6A_site_480205
mod ID: M6ASITE045831 Click to Show/Hide the Full List
mod site chr2:74503252-74503253:+ [3]
Sequence CGTGGGGAATGGACCCATAGACCCGGGACGAGCGGCGCGGA
Motif Score 2.876744048
Cell/Tissue List HeLa; HepG2; HEK293T; A549; H1A; H1B; GM12878; LCLs; MM6; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000548978.2; ENST00000603175.1
External Link RMBase: m6A_site_480206
mod ID: M6ASITE045832 Click to Show/Hide the Full List
mod site chr2:74503334-74503335:+ [3]
Sequence GCAGCTGCCGCTGCTGACAGACAAGACCAAGGCTCGGCTGG
Motif Score 2.897386905
Cell/Tissue List HeLa; HepG2; HEK293T; A549; H1A; H1B; GM12878; MM6; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000548978.2; ENST00000603175.1
External Link RMBase: m6A_site_480207
mod ID: M6ASITE045833 Click to Show/Hide the Full List
mod site chr2:74503339-74503340:+ [3]
Sequence TGCCGCTGCTGACAGACAAGACCAAGGCTCGGCTGGGCCCC
Motif Score 2.876744048
Cell/Tissue List HeLa; HepG2; HEK293T; A549; H1A; H1B; GM12878; MM6; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000548978.2; ENST00000603175.1
External Link RMBase: m6A_site_480208
mod ID: M6ASITE045834 Click to Show/Hide the Full List
mod site chr2:74503476-74503477:+ [3]
Sequence CTCGGCACATTAATCTTCAGACCCGGCTTTTTCGACGCCGA
Motif Score 2.876744048
Cell/Tissue List HeLa; HepG2; HEK293T; A549; MM6; CD4T; HEK293A-TOA; MSC; TIME; TREX; iSLK; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000603175.1; ENST00000548978.2
External Link RMBase: m6A_site_480209
mod ID: M6ASITE045835 Click to Show/Hide the Full List
mod site chr2:74503545-74503546:+ [3]
Sequence TTCCAGGGAGTCCCAGTCAGACTGCTCCCCAGCTCCCGCAG
Motif Score 3.319380952
Cell/Tissue List HeLa; HepG2; HEK293T; A549; GM12878; LCLs; MM6; Huh7; CD4T; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000548978.2; ENST00000603175.1
External Link RMBase: m6A_site_480210
mod ID: M6ASITE045836 Click to Show/Hide the Full List
mod site chr2:74503642-74503643:+ [3]
Sequence CATCCCGTCACTCCTAGGAAACTTTTCGCGCAGAAACTCCT
Motif Score 2.627720238
Cell/Tissue List HeLa; HepG2; HEK293T; A549; H1A; GM12878; LCLs; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000548978.2; ENST00000603175.1
External Link RMBase: m6A_site_480211
mod ID: M6ASITE045837 Click to Show/Hide the Full List
mod site chr2:74503657-74503658:+ [3]
Sequence AGGAAACTTTTCGCGCAGAAACTCCTGGAGAACAGCCCCGG
Motif Score 2.627720238
Cell/Tissue List HeLa; HepG2; HEK293T; A549; H1A; GM12878; LCLs; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000603175.1; ENST00000548978.2
External Link RMBase: m6A_site_480212
mod ID: M6ASITE045838 Click to Show/Hide the Full List
mod site chr2:74503668-74503669:+ [3]
Sequence CGCGCAGAAACTCCTGGAGAACAGCCCCGGCCGCCAGGTAC
Motif Score 2.951386905
Cell/Tissue List HeLa; HepG2; HEK293T; A549; H1A; GM12878; LCLs; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000548978.2; ENST00000603175.1
External Link RMBase: m6A_site_480213
mod ID: M6ASITE045839 Click to Show/Hide the Full List
mod site chr2:74503701-74503702:+ [3]
Sequence CCAGGTACTCGCCCGCCCGGACCGCAAAGCCCACAGAGCTT
Motif Score 3.622404762
Cell/Tissue List HeLa; HepG2; HEK293T; A549; GM12878; LCLs; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000548978.2; ENST00000603175.1
External Link RMBase: m6A_site_480214
mod ID: M6ASITE045840 Click to Show/Hide the Full List
mod site chr2:74503847-74503848:+ [3]
Sequence AAGCTTTGCTAACCTTGGAGACCATGTCAGGAAAGAAGCGT
Motif Score 2.876744048
Cell/Tissue List HeLa; HepG2; A549; MM6; peripheral-blood; MSC; TIME; TREX; iSLK; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000603175.1; ENST00000548978.2
External Link RMBase: m6A_site_480215
mod ID: M6ASITE045841 Click to Show/Hide the Full List
mod site chr2:74503984-74503985:+ [4]
Sequence GAGGCGGAGGTCTCCCGGAAACAGTGTCCGACTGTGGCACC
Motif Score 2.20572619
Cell/Tissue List HepG2; MM6; MSC; TREX; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000603175.1; ENST00000548978.2
External Link RMBase: m6A_site_480216
mod ID: M6ASITE045842 Click to Show/Hide the Full List
mod site chr2:74504196-74504197:+ [2]
Sequence CCTAGAAGCCGTGGAGTCAGACCGGCCAGGGTGGGACCTAG
Motif Score 2.876744048
Cell/Tissue List HepG2; HEK293T; A549; Huh7; MSC; TIME; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000548978.2; ENST00000603175.1
External Link RMBase: m6A_site_480217
mod ID: M6ASITE045843 Click to Show/Hide the Full List
mod site chr2:74504211-74504212:+ [4]
Sequence GTCAGACCGGCCAGGGTGGGACCTAGGTTTTAACTCGGGTT
Motif Score 3.622404762
Cell/Tissue List HepG2; HEK293T; A549; Huh7; MSC; TIME; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000603175.1; ENST00000548978.2
External Link RMBase: m6A_site_480218
mod ID: M6ASITE045844 Click to Show/Hide the Full List
mod site chr2:74504366-74504367:+ [2]
Sequence CTAGCTACCCCACTGAGAGAACCATAGAACAAGGACCCTGG
Motif Score 2.930744048
Cell/Tissue List HepG2; HEK293T; HeLa; A549; U2OS; H1A; GM12878; MM6; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000603175.1; ENST00000548978.2
External Link RMBase: m6A_site_480219
mod ID: M6ASITE045845 Click to Show/Hide the Full List
mod site chr2:74504374-74504375:+ [2]
Sequence CCCACTGAGAGAACCATAGAACAAGGACCCTGGCATGGCAT
Motif Score 2.951386905
Cell/Tissue List HepG2; HEK293T; HeLa; A549; U2OS; H1A; GM12878; MM6; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000548978.2; ENST00000603175.1
External Link RMBase: m6A_site_480220
mod ID: M6ASITE045846 Click to Show/Hide the Full List
mod site chr2:74504380-74504381:+ [2]
Sequence GAGAGAACCATAGAACAAGGACCCTGGCATGGCATACAGAC
Motif Score 3.622404762
Cell/Tissue List HepG2; HEK293T; HeLa; A549; U2OS; H1A; GM12878; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000603175.1; ENST00000548978.2
External Link RMBase: m6A_site_480221
mod ID: M6ASITE045847 Click to Show/Hide the Full List
mod site chr2:74504399-74504400:+ [2]
Sequence GACCCTGGCATGGCATACAGACAAGGAATGTTTGCTGAATT
Motif Score 2.897386905
Cell/Tissue List HepG2; HEK293T; HeLa; A549; U2OS; H1A; GM12878; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000548978.2; ENST00000603175.1
External Link RMBase: m6A_site_480222
mod ID: M6ASITE045848 Click to Show/Hide the Full List
mod site chr2:74504569-74504570:+ [2]
Sequence ACTTGCTGAATCCTGTATGGACAGCCTAAGCCTCCATTTCT
Motif Score 3.643047619
Cell/Tissue List HepG2; HEK293T; A549; U2OS; GM12878; Huh7; iSLK; MSC; TIME; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000603175.1; ENST00000548978.2
External Link RMBase: m6A_site_480223
mod ID: M6ASITE045849 Click to Show/Hide the Full List
mod site chr2:74504626-74504627:+ [4]
Sequence CCACTCCATTTGTTTTTTAGACTTCTCCCTCCTTTTTGTCC
Motif Score 3.319380952
Cell/Tissue List HepG2; HEK293T; Huh7; iSLK; MSC; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000603175.1; ENST00000548978.2
External Link RMBase: m6A_site_480224
mod ID: M6ASITE045850 Click to Show/Hide the Full List
mod site chr2:74504666-74504667:+ [4]
Sequence CCCATCCCCCAAGTTATAAAACTATAATGCAATTCTTTGGA
Motif Score 2.627720238
Cell/Tissue List HepG2; HEK293T; Huh7; MSC
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000603175.1; ENST00000548978.2
External Link RMBase: m6A_site_480225