m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00139)
Target Name microRNA let-7g (MIRLET7G)
Synonyms
MIRLET7G; MIRNLET7G; hsa-let-7g
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Gene Name MIRLET7G
Chromosomal Location 3p21.2
Family MicroRNA MIRLET7 family
Gene ID 406890
HGNC ID
HGNC:31485
miRBase ID
MI0000433
Ensembl Gene ID
ENSG00000199150
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MIRLET7G can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary HBXIP up-regulates METTL3 by suppressing microRNA let-7g (MIRLET7G), in which METTL3 increased HBXIP expression forming a positive feedback loop of HBXIP/let-7g/METTL3/HBXIP, leading to accelerated cell proliferation in breast cancer.
Target Regulation Down regulation
Responsed Disease Breast cancer ICD-11: 2C60
 Disease Info 
Cell Process Cell differentiation and apoptosis
Glutamine metabolism
Apoptosis (hsa04210)
Breast cancer [ICD-11: 2C60]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary HBXIP up-regulates METTL3 by suppressing microRNA let-7g (MIRLET7G), in which METTL3 increased HBXIP expression forming a positive feedback loop of HBXIP/let-7g/METTL3/HBXIP, leading to accelerated cell proliferation in breast cancer.
Responsed Disease Breast cancer [ICD-11: 2C60]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
Cell Process Cell differentiation and apoptosis
Glutamine metabolism
Apoptosis (hsa04210)
References
Ref 1 HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g. Cancer Lett. 2018 Feb 28;415:11-19. doi: 10.1016/j.canlet.2017.11.018. Epub 2017 Nov 22.