m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00102)

Target Name	THAP7 antisense RNA 1 (THAP7-AS1)
Synonyms	THAP7-AS1; THAP7 antisense RNA 1 (non-protein coding) Click to Show/Hide
Gene Name	THAP7-AS1
Chromosomal Location	22q11.21
Family	Antisense RNAs
Gene ID	439931
HGNC ID	HGNC:41013

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

THAP7-AS1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL3*
Cell Line	DKO-1 cell line	Homo sapiens
Treatment: METTL3 knockdown DKO-1 cell Control: DKO-1 cell		GSE182382
Regulation		logFC: -1.23E+00 p-value: 1.77E-02
More Results	Click to View More RNA-seq Results
*Representative RIP-seq result supporting the interaction between THAP7-AS1 and the regulator*
Cell Line	MDA-MB-231	Homo sapiens
Regulation	logFC: 5.66E+00	GSE60213

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene			[1]
Response Summary	LV-sh-THAP7 antisense RNA 1 (THAP7-AS1) treatment could suppress gastric cancer growth. THAP7-AS1, transcriptionally activated by SP1 and then modified by METTL3-mediated m6A, exerts oncogenic functions, by promoting interaction between NLS and importin alpha-1 and then improving the CUL4B protein entry into the nucleus to repress the transcription of miR-22-3p and miR-320a.
Target Regulation	Up regulation
Responsed Disease	Gastric cancer	ICD-11: 2B72	Disease Info
Pathway Response	PI3K-Akt signaling pathway		hsa04151
Cell Process	Cell growth
	Cell invasion
	Cell metastasis

Gastric cancer [ICD-11: 2B72]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response			[1]
Response Summary	LV-sh-THAP7 antisense RNA 1 (THAP7-AS1) treatment could suppress gastric cancer growth. THAP7-AS1, transcriptionally activated by SP1 and then modified by METTL3-mediated m6A, exerts oncogenic functions, by promoting interaction between NLS and importin alpha-1 and then improving the CUL4B protein entry into the nucleus to repress the transcription of miR-22-3p and miR-320a.
Responsed Disease	Gastric cancer [ICD-11: 2B72]
Target Regulator	Methyltransferase-like 3 (METTL3)	WRITER	Regulator Info
Target Regulation	Up regulation
Pathway Response	PI3K-Akt signaling pathway		hsa04151
Cell Process	Cell growth
	Cell invasion
	Cell metastasis

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Histone modification

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03652		Crosstalk Info
Epigenetic Regulator	Histone-lysine N-methyltransferase EZH2 (EZH2)
Regulated Target	Histone H3 lysine 27 trimethylation (H3K27me3)
Crosstalk relationship	Histone modification → m6A
Disease	Gastric cancer	Disease Info

Non-coding RNA

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05522		Crosstalk Info
Epigenetic Regulator	THAP7 antisense RNA 1 (THAP7-AS1)
Regulated Target	Cullin 4B (CUL4B)
Crosstalk relationship	m6A → ncRNA
Disease	Gastric cancer	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00102)

THAP7 antisense RNA 1 (THAP7-AS1)

Adenosine-to-Inosine editing (A-to-I)

In total 1 m6A sequence/site(s) in this target gene
mod ID: A2ISITE011082		Click to Show/Hide the Full List
mod site	chr22:21005766-21005767:+		[2]
Sequence	CAGGAGCTCGAGACCAGCTTAGCCAACATGGTGAAACCCTG
Transcript ID List	rmsk_5250205; ENST00000436079.1; ENST00000452284.1
External Link	RMBase: RNA-editing_site_90941

5-methylcytidine (m5C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE002872		Click to Show/Hide the Full List
mod site	chr22:21003231-21003232:+		[3]
Sequence	ATTGGCCTCAGAAATGGGAGCTCATTAAAAATCAGAGCTGT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000429962.1; ENST00000436079.1; ENST00000452284.1
External Link	RMBase: m5C_site_30406
mod ID: M5CSITE002873		Click to Show/Hide the Full List
mod site	chr22:21003233-21003234:+		[3]
Sequence	TGGCCTCAGAAATGGGAGCTCATTAAAAATCAGAGCTGTGG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000429962.1; ENST00000436079.1; ENST00000452284.1
External Link	RMBase: m5C_site_30407

N6-methyladenosine (m6A)

In total 37 m6A sequence/site(s) in this target gene
mod ID: M6ASITE056600		Click to Show/Hide the Full List
mod site	chr22:21002154-21002155:+		[4]
Sequence	CGGAAGTTGGTACCATAGAGACTGGAGAGCCGGAGGTGCCC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000429962.1; ENST00000436079.1
External Link	RMBase: m6A_site_556360
mod ID: M6ASITE056601		Click to Show/Hide the Full List
mod site	chr22:21002276-21002277:+		[4]
Sequence	GCGTCGTCCCAGCTCCCTGGACTACCAGTATTGTCGCCCAC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293A-TOA; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000452284.1; ENST00000429962.1; ENST00000436079.1
External Link	RMBase: m6A_site_556361
mod ID: M6ASITE056602		Click to Show/Hide the Full List
mod site	chr22:21002341-21002342:+		[4]
Sequence	GGCCTCACTTTTCTCCGTAAACACCCCGGCACGATGGAGCG
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; GSC-11; HEK293A-TOA; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000429962.1; ENST00000436079.1; ENST00000452284.1
External Link	RMBase: m6A_site_556362
mod ID: M6ASITE056603		Click to Show/Hide the Full List
mod site	chr22:21002493-21002494:+		[5]
Sequence	ACGGGGCCTGGGACGCTTGCACGAAAGAACCCGACAAAAAC
Motif Score	2.80452381
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000429962.1; ENST00000452284.1; ENST00000436079.1
External Link	RMBase: m6A_site_556363
mod ID: M6ASITE056604		Click to Show/Hide the Full List
mod site	chr22:21002501-21002502:+		[4]
Sequence	TGGGACGCTTGCACGAAAGAACCCGACAAAAACCAGAGCCC
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; GM12878; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000436079.1; ENST00000452284.1; ENST00000429962.1
External Link	RMBase: m6A_site_556364
mod ID: M6ASITE056605		Click to Show/Hide the Full List
mod site	chr22:21002512-21002513:+		[4]
Sequence	CACGAAAGAACCCGACAAAAACCAGAGCCCGCACTCACTCT
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; GM12878; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000452284.1; ENST00000436079.1; ENST00000429962.1
External Link	RMBase: m6A_site_556365
mod ID: M6ASITE056606		Click to Show/Hide the Full List
mod site	chr22:21002549-21002550:+		[4]
Sequence	CTCTCGTACTGGGGAGGTGGACTTCAGGGAGGGTTATCTGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; GM12878; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000429962.1; ENST00000452284.1; ENST00000436079.1
External Link	RMBase: m6A_site_556366
mod ID: M6ASITE056607		Click to Show/Hide the Full List
mod site	chr22:21002605-21002606:+		[4]
Sequence	AAGTACAACACAGGAGAAAGACAGTATCGCAATACAGAAAT
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; GM12878; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000452284.1; ENST00000429962.1; ENST00000436079.1
External Link	RMBase: m6A_site_556367
mod ID: M6ASITE056608		Click to Show/Hide the Full List
mod site	chr22:21002658-21002659:+		[6]
Sequence	TTTATTATTATTTTCCTGAGACCGGAGTCTCGCTCTGTCGC
Motif Score	2.876744048
Cell/Tissue List	HepG2; HeLa; HEK293T; U2OS; H1B; H1A; GM12878; Huh7; HEK293A-TOA; TREX; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000436079.1; ENST00000452284.1; ENST00000429962.1
External Link	RMBase: m6A_site_556368
mod ID: M6ASITE056609		Click to Show/Hide the Full List
mod site	chr22:21002719-21002720:+		[7]
Sequence	GCGATCTCGGCTCACTGCAAACTCCGCCTCCCGGGTTCACG
Motif Score	2.627720238
Cell/Tissue List	HeLa; U2OS; HEK293A-TOA; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000436079.1; ENST00000452284.1; ENST00000429962.1
External Link	RMBase: m6A_site_556369
mod ID: M6ASITE056610		Click to Show/Hide the Full List
mod site	chr22:21002774-21002775:+		[7]
Sequence	CACCCTCCACAGTAGCTGGGACTACAAGCGCCCGCCACCAC
Motif Score	4.065041667
Cell/Tissue List	HeLa; U2OS; HEK293A-TOA; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000429962.1; ENST00000436079.1; ENST00000452284.1
External Link	RMBase: m6A_site_556370
mod ID: M6ASITE056611		Click to Show/Hide the Full List
mod site	chr22:21003050-21003051:+		[4]
Sequence	ACTAAGGCGCACTTGGCCGAACTTATGGTCCAGGCAGGCCC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000452284.1; ENST00000429962.1; ENST00000436079.1
External Link	RMBase: m6A_site_556371
mod ID: M6ASITE056612		Click to Show/Hide the Full List
mod site	chr22:21003145-21003146:+		[8]
Sequence	TGGCCAGGTCTCCCACAGGGACCACCGTGGGGGGCTGGTAG
Motif Score	3.622404762
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000452284.1; ENST00000436079.1; ENST00000429962.1
External Link	RMBase: m6A_site_556374
mod ID: M6ASITE056613		Click to Show/Hide the Full List
mod site	chr22:21003254-21003255:+		[8]
Sequence	ATTAAAAATCAGAGCTGTGGACCAGTTCCAACACTGTGTTT
Motif Score	3.622404762
Cell/Tissue List	HEK293T; Huh7; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000429962.1; ENST00000452284.1; ENST00000436079.1
External Link	RMBase: m6A_site_556375
mod ID: M6ASITE056614		Click to Show/Hide the Full List
mod site	chr22:21008756-21008757:+		[4]
Sequence	TGCTTCCTGATGGCACAAGGACTCCACATCACCCAGTCCTA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; U2OS; H1B; H1A; hNPCs; Huh7; HEK293A-TOA; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000436079.1; ENST00000452284.1
External Link	RMBase: m6A_site_556379
mod ID: M6ASITE056615		Click to Show/Hide the Full List
mod site	chr22:21008793-21008794:+		[4]
Sequence	CCTACCTTAAATCCAATCGGACACCAGTCCACAAACTGGTT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; U2OS; H1A; H1B; hNPCs; Huh7; HEK293A-TOA; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000436079.1; ENST00000452284.1
External Link	RMBase: m6A_site_556381
mod ID: M6ASITE056616		Click to Show/Hide the Full List
mod site	chr22:21008807-21008808:+		[4]
Sequence	AATCGGACACCAGTCCACAAACTGGTTGGTGTGCTTGCTCT
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; U2OS; H1A; H1B; hNPCs; Huh7; HEK293A-TOA; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000436079.1; ENST00000452284.1
External Link	RMBase: m6A_site_556383
mod ID: M6ASITE056617		Click to Show/Hide the Full List
mod site	chr22:21008863-21008864:+		[4]
Sequence	CCGCACTGACATCTTTCAGGACCACATCCCCTCTGTACAAC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; U2OS; hNPCs; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000452284.1; ENST00000436079.1
External Link	RMBase: m6A_site_556384
mod ID: M6ASITE056618		Click to Show/Hide the Full List
mod site	chr22:21008975-21008976:+		[4]
Sequence	ACTGGCGATCTTGGCCACGGACAGCTGCTCATGGTAGGCCT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; U2OS; hNPCs; Huh7; HEK293A-TOA; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000436079.1; ENST00000452284.1
External Link	RMBase: m6A_site_556385
mod ID: M6ASITE056619		Click to Show/Hide the Full List
mod site	chr22:21009128-21009129:+		[4]
Sequence	CAGGGAGGCCGTGATGGAGGACACGATCTGCCCAGACGACT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; A549; H1A; hNPCs; hESCs; Huh7; HEK293A-TOA; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000452284.1; ENST00000436079.1
External Link	RMBase: m6A_site_556387
mod ID: M6ASITE056620		Click to Show/Hide the Full List
mod site	chr22:21009167-21009168:+		[4]
Sequence	CTGAGGTTGGTGTACATGGGACACTCGATGTCCAGGTTGTG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; A549; U2OS; H1A; hNPCs; hESCs; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000436079.1; ENST00000452284.1
External Link	RMBase: m6A_site_556388
mod ID: M6ASITE056621		Click to Show/Hide the Full List
mod site	chr22:21009298-21009299:+		[4]
Sequence	GCTCCGTCATGGCCATGGAGACCTGGGGGGCTGGGCAAATG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; hNPCs; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000452284.1; ENST00000436079.1
External Link	RMBase: m6A_site_556391
mod ID: M6ASITE056622		Click to Show/Hide the Full List
mod site	chr22:21009323-21009324:+		[4]
Sequence	GGGGGCTGGGCAAATGGCAAACTCCAGCTTGGACTTCTTCC
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000452284.1; ENST00000436079.1
External Link	RMBase: m6A_site_556392
mod ID: M6ASITE056623		Click to Show/Hide the Full List
mod site	chr22:21009335-21009336:+		[4]
Sequence	AATGGCAAACTCCAGCTTGGACTTCTTCCCGTAGTCCACCG
Motif Score	4.065041667
Cell/Tissue List	HeLa; Huh7; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000452284.1; ENST00000436079.1
External Link	RMBase: m6A_site_556393
mod ID: M6ASITE056624		Click to Show/Hide the Full List
mod site	chr22:21009377-21009378:+		[4]
Sequence	GAGCCGCTTCATGAGCAGAGACACGAACCCAGAGCCAGTGC
Motif Score	2.897386905
Cell/Tissue List	HeLa; Huh7; GSC-11; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000452284.1; ENST00000436079.1
External Link	RMBase: m6A_site_556395
mod ID: M6ASITE056625		Click to Show/Hide the Full List
mod site	chr22:21009383-21009384:+		[4]
Sequence	CTTCATGAGCAGAGACACGAACCCAGAGCCAGTGCCGCCCC
Motif Score	2.930744048
Cell/Tissue List	HeLa; Huh7; GSC-11; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000452284.1; ENST00000436079.1
External Link	RMBase: m6A_site_556396
mod ID: M6ASITE056626		Click to Show/Hide the Full List
mod site	chr22:21009462-21009463:+		[9]
Sequence	CACAGATCTGCCTGAGAGAAACCAGACAACGTAAGCCAATG
Motif Score	2.185083333
Cell/Tissue List	Huh7; GSC-11; HEK293T
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000436079.1; ENST00000452284.1
External Link	RMBase: m6A_site_556398
mod ID: M6ASITE056627		Click to Show/Hide the Full List
mod site	chr22:21009467-21009468:+		[9]
Sequence	ATCTGCCTGAGAGAAACCAGACAACGTAAGCCAATGCCCGT
Motif Score	2.897386905
Cell/Tissue List	Huh7; GSC-11; HEK293T
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000436079.1; ENST00000452284.1
External Link	RMBase: m6A_site_556399
mod ID: M6ASITE056628		Click to Show/Hide the Full List
mod site	chr22:21009560-21009561:+		[9]
Sequence	GAGAGTTGATACGGATTCAGACCATCCATAATGAACACGCA
Motif Score	2.876744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000452284.1; ENST00000436079.1
External Link	RMBase: m6A_site_556400
mod ID: M6ASITE056629		Click to Show/Hide the Full List
mod site	chr22:21009574-21009575:+		[9]
Sequence	ATTCAGACCATCCATAATGAACACGCATCACACTTTGAAGC
Motif Score	2.951386905
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000436079.1; ENST00000452284.1
External Link	RMBase: m6A_site_556401
mod ID: M6ASITE056630		Click to Show/Hide the Full List
mod site	chr22:21009607-21009608:+		[4]
Sequence	TTTGAAGCAGAGAAAAGCAGACAATACAGATCTATGCACAA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000452284.1; ENST00000436079.1
External Link	RMBase: m6A_site_556402
mod ID: M6ASITE056631		Click to Show/Hide the Full List
mod site	chr22:21009711-21009712:+		[4]
Sequence	CACAGAAGAAAAACGGATGGACTAACCAGAGCGCTCAGCCA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; HepG2; H1B; H1A; GM12878; Huh7; HEK293A-TOA; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000452284.1; ENST00000436079.1
External Link	RMBase: m6A_site_556403
mod ID: M6ASITE056632		Click to Show/Hide the Full List
mod site	chr22:21009741-21009742:+		[4]
Sequence	GCGCTCAGCCAGCCTGCTGGACTGGCACCCGTGGCTACAGA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; HepG2; H1A; H1B; GM12878; Huh7; HEK293A-TOA; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000452284.1; ENST00000436079.1
External Link	RMBase: m6A_site_556404
mod ID: M6ASITE056633		Click to Show/Hide the Full List
mod site	chr22:21009761-21009762:+		[4]
Sequence	ACTGGCACCCGTGGCTACAGACACTCTTGTTTAGCACCATG
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; HepG2; H1A; H1B; GM12878; Huh7; HEK293A-TOA; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000436079.1; ENST00000452284.1
External Link	RMBase: m6A_site_556405
mod ID: M6ASITE056634		Click to Show/Hide the Full List
mod site	chr22:21009807-21009808:+		[4]
Sequence	CTCCCTGCACAGAAGCAAGGACTCAGGGCATTGCCCCCTCT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; HepG2; H1A; H1B; GM12878; Huh7; GSC-11; HEK293A-TOA; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000452284.1; ENST00000591411.5; ENST00000436079.1
External Link	RMBase: m6A_site_556406
mod ID: M6ASITE056635		Click to Show/Hide the Full List
mod site	chr22:21009838-21009839:+		[7]
Sequence	TGCCCCCTCTCTACCTGAGAACTAGACTCAGCGCCCAGCAC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; H1A; H1B; GM12878; Huh7; GSC-11; HEK293A-TOA; MSC; TIME
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000436079.1; ENST00000591411.5; ENST00000452284.1
External Link	RMBase: m6A_site_556407
mod ID: M6ASITE056636		Click to Show/Hide the Full List
mod site	chr22:21009843-21009844:+		[7]
Sequence	CCTCTCTACCTGAGAACTAGACTCAGCGCCCAGCACTGGAT
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; H1A; H1B; GM12878; Huh7; GSC-11; HEK293A-TOA; MSC; TIME
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000452284.1; ENST00000591411.5; ENST00000436079.1
External Link	RMBase: m6A_site_556408

Ref 1	lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus. Cell Death Differ. 2022 Mar;29(3):627-641. doi: 10.1038/s41418-021-00879-9. Epub 2021 Oct 4.
Ref 2	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 3	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 4	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 5	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 6	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 7	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 8	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 9	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

Visitor Map