m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00091)
Target Name Colon cancer associated transcript 2 (CCAT2)
Synonyms
CCAT2; colon cancer associated transcript 2 (non-protein coding); NCCP1; LINC00873; long intergenic non-protein coding RNA 873; non-coding RNA involved in cancer predisposition 1
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Gene Name CCAT2
Chromosomal Location 8q24.21
Family Long non-coding RNAs with non-systematic symbols
Gene ID 101805488
HGNC ID
HGNC:47044
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
CCAT2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Protein virilizer homolog (VIRMA) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary VIRMA downregulation attenuates the aggressive phenotype of prostate cancer by overall reduction of m6A-levels decreasing stability and abundance of oncogenic lncRNAs. VIRMA depletion and m6A reduction decreased the stability and abundance of Colon cancer associated transcript 2 (CCAT2) transcripts.
Target Regulation Up regulation
Responsed Disease Prostate cancer ICD-11: 2C82
 Disease Info 
Cell Process RNA stability
In-vitro Model 22Rv1 Prostate carcinoma Homo sapiens CVCL_1045
DU145 Prostate carcinoma Homo sapiens CVCL_0105
LNCaP Prostate carcinoma Homo sapiens CVCL_0395
PC-3 Prostate carcinoma Homo sapiens CVCL_0035
VCaP Prostate carcinoma Homo sapiens CVCL_2235
Prostate cancer [ICD-11: 2C82]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary VIRMA downregulation attenuates the aggressive phenotype of prostate cancer by overall reduction of m6A-levels decreasing stability and abundance of oncogenic lncRNAs. VIRMA depletion and m6A reduction decreased the stability and abundance of Colon cancer associated transcript 2 (CCAT2) transcripts.
Responsed Disease Prostate cancer [ICD-11: 2C82]
Target Regulator Protein virilizer homolog (VIRMA) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process RNA stability
In-vitro Model 22Rv1 Prostate carcinoma Homo sapiens CVCL_1045
DU145 Prostate carcinoma Homo sapiens CVCL_0105
LNCaP Prostate carcinoma Homo sapiens CVCL_0395
PC-3 Prostate carcinoma Homo sapiens CVCL_0035
VCaP Prostate carcinoma Homo sapiens CVCL_2235
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: Protein virilizer homolog (VIRMA)
 Regulator Info 
In total 3 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05428
 Crosstalk Info 
Epigenetic Regulator Colon cancer associated transcript 2 (CCAT2)
Regulated Target Myc proto-oncogene protein (MYC)
Crosstalk relationship m6A → ncRNA
Disease Prostate cancer
 Disease Info 
Drug Actinomycin D
 Drug Info 
Crosstalk ID: M6ACROT05966
 Crosstalk Info 
Epigenetic Regulator Colon cancer associated transcript 2 (CCAT2)
Regulated Target MicroRNA 145 (MIR145)
Crosstalk relationship m6A → ncRNA
Disease Prostate cancer
 Disease Info 
Drug Actinomycin D
 Drug Info 
Crosstalk ID: M6ACROT05967
 Crosstalk Info 
Epigenetic Regulator MicroRNA 145 (MIR145)
Regulated Target Myc proto-oncogene protein (MYC)
Crosstalk relationship m6A → ncRNA
Disease Prostate cancer
 Disease Info 
Drug Actinomycin D
 Drug Info 
References
Ref 1 VIRMA-Dependent N6-Methyladenosine Modifications Regulate the Expression of Long Non-Coding RNAs CCAT1 and CCAT2 in Prostate Cancer. Cancers (Basel). 2020 Mar 25;12(4):771. doi: 10.3390/cancers12040771.