m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00074)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
LINC02598
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | Overexpression of METTL3 upregulates Long intergenic non-protein coding RNA 2598 (LINC02598/RP11) expression in colorectal cancer cells. Overexpression of ALKBH5 downregulates RP11 expression. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Colorectal cancer | ICD-11: 2B91 | ||
| Pathway Response | Ubiquitin mediated proteolysis | hsa04120 | ||
| Cell Process | Ubiquitination degradation | |||
| In-vitro Model | HCT 15 | Colon adenocarcinoma | Homo sapiens | CVCL_0292 |
| HCT 8 | Colon adenocarcinoma | Homo sapiens | CVCL_2478 | |
| NCM460 | Normal | Homo sapiens | CVCL_0460 | |
RNA demethylase ALKBH5 (ALKBH5) [ERASER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | Overexpression of METTL3 upregulates Long intergenic non-protein coding RNA 2598 (LINC02598/RP11) expression in colorectal cancer cells. Overexpression of ALKBH5 downregulates RP11 expression. | |||
| Target Regulation | Down regulation | |||
| Responsed Disease | Colorectal cancer | ICD-11: 2B91 | ||
Colorectal cancer [ICD-11: 2B91]
| In total 2 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | Overexpression of METTL3 upregulates Long intergenic non-protein coding RNA 2598 (LINC02598/RP11) expression in colorectal cancer cells. Overexpression of ALKBH5 downregulates RP11 expression. | |||
| Responsed Disease | Colorectal cancer [ICD-11: 2B91] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | Ubiquitin mediated proteolysis | hsa04120 | ||
| Cell Process | Ubiquitination degradation | |||
| In-vitro Model | HCT 15 | Colon adenocarcinoma | Homo sapiens | CVCL_0292 |
| HCT 8 | Colon adenocarcinoma | Homo sapiens | CVCL_2478 | |
| NCM460 | Normal | Homo sapiens | CVCL_0460 | |
| Experiment 2 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | Overexpression of METTL3 upregulates Long intergenic non-protein coding RNA 2598 (LINC02598/RP11) expression in colorectal cancer cells. Overexpression of ALKBH5 downregulates RP11 expression. | |||
| Responsed Disease | Colorectal cancer [ICD-11: 2B91] | |||
| Target Regulator | RNA demethylase ALKBH5 (ALKBH5) | ERASER | ||
| Target Regulation | Down regulation | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: RNA demethylase ALKBH5 (ALKBH5)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05460 | ||
| Epigenetic Regulator | Long intergenic non-protein coding RNA 2598 (LINC02598/RP11) | |
| Regulated Target | E3 ubiquitin-protein ligase SIAH1 (SIAH1) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Colorectal cancer | |
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05461 | ||
| Epigenetic Regulator | Long intergenic non-protein coding RNA 2598 (LINC02598/RP11) | |
| Regulated Target | F-box/SPRY domain-containing protein 1 (FBXO45) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Colorectal cancer | |