m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00064)
Target Name hsa_circ_0000231 (circ_ARHGAP12)
Gene Name Circ_ARHGAP12
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
Circ_ARHGAP12 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary m6A-modified hsa_circ_0000231 (circARHGAP12) interacts with IGF2BP2 to enhance FOXM1 mRNA stability, forming circARHGAP12/IGF2BP2/FOXM1 complex, thereby promoting the proliferation and migration of cervical cancer cells.
Target Regulation Up regulation
Responsed Disease Cervical cancer ICD-11: 2C77
 Disease Info 
Pathway Response Cellular senescence hsa04218
In-vitro Model C-33 A Cervical squamous cell carcinoma Homo sapiens CVCL_1094
Ca Ski Cervical squamous cell carcinoma Homo sapiens CVCL_1100
HaCaT Normal Homo sapiens CVCL_0038
HT-3 Cervical carcinoma Homo sapiens CVCL_1293
SiHa Cervical squamous cell carcinoma Homo sapiens CVCL_0032
In-vivo Model CircARHGAP12-stable knockdown cervical cancer cells (100 uL PBS containing 5 × 106 cells) were subcutaneously injected into the lateral flank of BALB/c nude mice.
Cervical cancer [ICD-11: 2C77]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary m6A-modified hsa_circ_0000231 (circARHGAP12) interacts with IGF2BP2 to enhance FOXM1 mRNA stability, forming circARHGAP12/IGF2BP2/FOXM1 complex, thereby promoting the proliferation and migration of cervical cancer cells.
Responsed Disease Cervical cancer [ICD-11: 2C77]
Target Regulator Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) READER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Cellular senescence hsa04218
In-vitro Model C-33 A Cervical squamous cell carcinoma Homo sapiens CVCL_1094
Ca Ski Cervical squamous cell carcinoma Homo sapiens CVCL_1100
HaCaT Normal Homo sapiens CVCL_0038
HT-3 Cervical carcinoma Homo sapiens CVCL_1293
SiHa Cervical squamous cell carcinoma Homo sapiens CVCL_0032
In-vivo Model CircARHGAP12-stable knockdown cervical cancer cells (100 uL PBS containing 5 × 106 cells) were subcutaneously injected into the lateral flank of BALB/c nude mice.
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05505
 Crosstalk Info 
Epigenetic Regulator hsa_circ_0000231 (Circ_ARHGAP12)
Regulated Target Forkhead box protein M1 (FOXM1)
Crosstalk relationship m6A → ncRNA
Disease Cervical cancer
 Disease Info 
References
Ref 1 IGF2BP2-modified circular RNA circARHGAP12 promotes cervical cancer progression by interacting m(6)A/FOXM1 manner. Cell Death Discov. 2021 Aug 14;7(1):215. doi: 10.1038/s41420-021-00595-w.