m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00056)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
hsa-miR-140-3p
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | METTL3/SNHG1/hsa-miR-140-3p/UBE2C axis plays a crucial role in cancer progression and the immune response in non-small cell lung cancer. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Non-small-cell lung carcinoma | ICD-11: 2C25.Y | ||
| In-vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens | CVCL_0023 |
| BEAS-2B | Normal | Homo sapiens | CVCL_0168 | |
| NCI-H1299 | Lung large cell carcinoma | Homo sapiens | CVCL_0060 | |
| NCI-H1975 | Lung adenocarcinoma | Homo sapiens | CVCL_1511 | |
Lung cancer [ICD-11: 2C25]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | METTL3/SNHG1/hsa-miR-140-3p/UBE2C axis plays a crucial role in cancer progression and the immune response in non-small cell lung cancer. | |||
| Responsed Disease | Non-small-cell lung carcinoma [ICD-11: 2C25.Y] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| In-vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens | CVCL_0023 |
| BEAS-2B | Normal | Homo sapiens | CVCL_0168 | |
| NCI-H1299 | Lung large cell carcinoma | Homo sapiens | CVCL_0060 | |
| NCI-H1975 | Lung adenocarcinoma | Homo sapiens | CVCL_1511 | |
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05544 | ||
| Epigenetic Regulator | hsa-miR-140-3p | |
| Regulated Target | Ubiquitin-conjugating enzyme E2 C (UBE2C) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Non-small cell lung cancer | |
RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00056)
| In total 1 m6A sequence/site(s) in this target gene | |||
| mod ID: M6ASITE028304 | Click to Show/Hide the Full List | ||
| mod site | chr16:69933155-69933156:+ | [2] | |
| Sequence | CTGTTCTACCACAGGGTAGAACCACGGACAGGATACCGGGG | ||
| Motif Score | 2.930744048 | ||
| Cell/Tissue List | BGC823 | ||
| Seq Type List | m6A-seq | ||
| Transcript ID List | ENST00000566463.5; ENST00000544162.5; ENST00000568684.1; ENST00000569297.5; MIMAT0004597; ENST00000356003.6; ENST00000359154.6; ENST00000568818.1; ENST00000385282.3 | ||
| External Link | RMBase: m6A_site_328684 | ||
References