m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00043)
Target Name hsa-miR-766-5p
Gene Name hsa-miR-766-5p
miRBase ID
MIMAT0022714
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
hsa-miR-766-5p can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3-mediated m6A modification induced the aberrant expression of NEAT1 in chronic myelocytic leukemia. Overexpression of NEAT1 inhibited cell viability and promoted the apoptosis of chronic myelocytic leukemia cells. hsa-miR-766-5p was upregulated in CML PBMCs and abrogated the effects of NEAT1 on cell viability and apoptosis of the chronic myelocytic leukemia cells.
Target Regulation Up regulation
Responsed Disease Chronic myeloid leukaemia ICD-11: 2B33.2
 Disease Info 
Cell Process Cell viability and apoptosis
In-vitro Model BV-173 Chronic myelogenous leukemia Homo sapiens CVCL_0181
K-562 Chronic myelogenous leukemia Homo sapiens CVCL_0004
KCL-22 Chronic myelogenous leukemia Homo sapiens CVCL_2091
MEG-01 Chronic myelogenous leukemia Homo sapiens CVCL_0425
Malignant haematopoietic neoplasm [ICD-11: 2B33]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3-mediated m6A modification induced the aberrant expression of NEAT1 in chronic myelocytic leukemia. Overexpression of NEAT1 inhibited cell viability and promoted the apoptosis of chronic myelocytic leukemia cells. hsa-miR-766-5p was upregulated in CML PBMCs and abrogated the effects of NEAT1 on cell viability and apoptosis of the chronic myelocytic leukemia cells.
Responsed Disease Chronic myeloid leukaemia [ICD-11: 2B33.2]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell viability and apoptosis
In-vitro Model BV-173 Chronic myelogenous leukemia Homo sapiens CVCL_0181
K-562 Chronic myelogenous leukemia Homo sapiens CVCL_0004
KCL-22 Chronic myelogenous leukemia Homo sapiens CVCL_2091
MEG-01 Chronic myelogenous leukemia Homo sapiens CVCL_0425
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05503
 Crosstalk Info 
Epigenetic Regulator hsa-miR-766-5p
Regulated Target Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Crosstalk relationship m6A → ncRNA
Disease Chronic myeloid leukaemia
 Disease Info 
References
Ref 1 m(6)A Modification of lncRNA NEAT1 Regulates Chronic Myelocytic Leukemia Progression via miR-766-5p/CDKN1A Axis. Front Oncol. 2021 Jul 20;11:679634. doi: 10.3389/fonc.2021.679634. eCollection 2021.