m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00027)
| Target Name | DMDRMR | ||||
|---|---|---|---|---|---|
| Gene Name | DMDRMR | ||||
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
DMDRMR
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) [READER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | DMDRMR is a protumorigenic lncRNA that mediates the stabilization of IGF2BP3 targets in an m6A-dependent manner in clear cell renal cell carcinoma. IGF2BP3 and DMDRMR cooperate to play oncogenic roles. IGF2BP3 cooperates with DMDRMR to regulate CDK4 by enhancing mRNA stability. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Renal cell carcinoma of kidney | ICD-11: 2C90.0 | ||
| Pathway Response | Cell cycle | hsa04110 | ||
| Cell Process | Accelerating the G1-S transition | |||
| Cell invasion and metastasis | ||||
| In-vitro Model | 769-P | Renal cell carcinoma | Homo sapiens | CVCL_1050 |
| 786-O | Renal cell carcinoma | Homo sapiens | CVCL_1051 | |
| ACHN | Papillary renal cell carcinoma | Homo sapiens | CVCL_1067 | |
| Caki-1 | Clear cell renal cell carcinoma | Homo sapiens | CVCL_0234 | |
| In-vivo Model | Stable DMDRMR knockdown (KD) and control cell lines were injected subcutaneously (s.c.; 1 × 107 cells/inoculum) into the flanks of recipient NOD/SCID/IL2Rγ-null (NSG) mice. | |||
Renal cell carcinoma [ICD-11: 2C90]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | DMDRMR is a protumorigenic lncRNA that mediates the stabilization of IGF2BP3 targets in an m6A-dependent manner in clear cell renal cell carcinoma. IGF2BP3 and DMDRMR cooperate to play oncogenic roles. IGF2BP3 cooperates with DMDRMR to regulate CDK4 by enhancing mRNA stability. | |||
| Responsed Disease | Renal cell carcinoma of kidney [ICD-11: 2C90.0] | |||
| Target Regulator | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) | READER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | Cell cycle | hsa04110 | ||
| Cell Process | Accelerating the G1-S transition | |||
| Cell invasion and metastasis | ||||
| In-vitro Model | 769-P | Renal cell carcinoma | Homo sapiens | CVCL_1050 |
| 786-O | Renal cell carcinoma | Homo sapiens | CVCL_1051 | |
| ACHN | Papillary renal cell carcinoma | Homo sapiens | CVCL_1067 | |
| Caki-1 | Clear cell renal cell carcinoma | Homo sapiens | CVCL_0234 | |
| In-vivo Model | Stable DMDRMR knockdown (KD) and control cell lines were injected subcutaneously (s.c.; 1 × 107 cells/inoculum) into the flanks of recipient NOD/SCID/IL2Rγ-null (NSG) mice. | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05454 | ||
| Epigenetic Regulator | DMDRMR | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Renal cell carcinoma | |