m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00009)
Target Name hsa-miR-873-5p
Gene Name hsa-miR-873-5p
miRBase ID
MIMAT0004953
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
hsa-miR-873-5p can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 interacts with the microprocessor protein DGCR8 and positively modulates hsa-miR-873-5p mature process in an m6A-dependent manner.METTL3/m6A in colistin-induced nephrotoxicity and provide a new insight on m6A modification in drug induced toxicity.
Target Regulation Up regulation
Responsed Disease Diseases of the urinary system ICD-11: GC2Z
 Disease Info 
Cell Process Oxidative stress and apoptosis
In-vitro Model mRTEC (Mouse renal tubular epithelial cells)
Diseases of the urinary system [ICD-11: GC2Z]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 interacts with the microprocessor protein DGCR8 and positively modulates hsa-miR-873-5p mature process in an m6A-dependent manner.METTL3/m6A in colistin-induced nephrotoxicity and provide a new insight on m6A modification in drug induced toxicity.
Responsed Disease Diseases of the urinary system [ICD-11: GC2Z]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process Oxidative stress and apoptosis
In-vitro Model mRTEC (Mouse renal tubular epithelial cells)
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05380
 Crosstalk Info 
Epigenetic Regulator hsa-miR-873-5p
Regulated Target Kelch-like ECH-associated protein 1 (KEAP1)
Crosstalk relationship m6A → ncRNA
Disease Diseases of the urinary system
 Disease Info 
References
Ref 1 METTL3/m(6)A/miRNA-873-5p Attenuated Oxidative Stress and Apoptosis in Colistin-Induced Kidney Injury by Modulating Keap1/Nrf2 Pathway. Front Pharmacol. 2019 May 15;10:517. doi: 10.3389/fphar.2019.00517. eCollection 2019.