General Information of the m6A Regulator (ID: REG00007)
Regulator Name Methyltransferase-like 3 (METTL3)
Synonyms
N6-adenosine-methyltransferase catalytic subunit; hMETTL3; N6-adenosine-methyltransferase 70 kDa subunit; MT-A70; MTA70
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Gene Name METTL3
Regulator Type WRITER ERASER READER
Regulator Link Click to View Full Information of This Regulator
Full List of Target Gene(s) of This m6A Regulator and Corresponding Potential Drug Response(s)
Angiopoietin 1 receptor (TEK)
AKB-9778 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Angiopoietin 1 receptor (TEK) is a therapeutic target for AKB-9778. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AKB-9778 through regulating the expression of Angiopoietin 1 receptor (TEK). [1], [2]
DCC-2036 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Angiopoietin 1 receptor (TEK) is a therapeutic target for DCC-2036. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of DCC-2036 through regulating the expression of Angiopoietin 1 receptor (TEK). [1], [3]
Altiratinib [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Angiopoietin 1 receptor (TEK) is a therapeutic target for Altiratinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Altiratinib through regulating the expression of Angiopoietin 1 receptor (TEK). [1], [4]
CEP-11981 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Angiopoietin 1 receptor (TEK) is a therapeutic target for CEP-11981. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CEP-11981 through regulating the expression of Angiopoietin 1 receptor (TEK). [1], [5]
(4-Phenoxy-phenyl)-quinazolin-4-yl-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Angiopoietin 1 receptor (TEK) is a therapeutic target for (4-Phenoxy-phenyl)-quinazolin-4-yl-amine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (4-Phenoxy-phenyl)-quinazolin-4-yl-amine through regulating the expression of Angiopoietin 1 receptor (TEK). [1], [6]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Angiopoietin 1 receptor (TEK) is a therapeutic target for 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione through regulating the expression of Angiopoietin 1 receptor (TEK). [1], [7]
3,4-diphenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Angiopoietin 1 receptor (TEK) is a therapeutic target for 3,4-diphenyl-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3,4-diphenyl-1H-pyrrole-2,5-dione through regulating the expression of Angiopoietin 1 receptor (TEK). [1], [8]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Angiopoietin 1 receptor (TEK) is a therapeutic target for 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione through regulating the expression of Angiopoietin 1 receptor (TEK). [1], [7]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Angiopoietin 1 receptor (TEK) is a therapeutic target for 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione through regulating the expression of Angiopoietin 1 receptor (TEK). [1], [7]
A-420983 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Angiopoietin 1 receptor (TEK) is a therapeutic target for A-420983. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of A-420983 through regulating the expression of Angiopoietin 1 receptor (TEK). [1], [7]
ABTAA [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Angiopoietin 1 receptor (TEK) is a therapeutic target for ABTAA. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ABTAA through regulating the expression of Angiopoietin 1 receptor (TEK). [1], [9]
AP-101 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Angiopoietin 1 receptor (TEK) is a therapeutic target for AP-101. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AP-101 through regulating the expression of Angiopoietin 1 receptor (TEK). [1], [10]
ARRY-614 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Angiopoietin 1 receptor (TEK) is a therapeutic target for ARRY-614. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ARRY-614 through regulating the expression of Angiopoietin 1 receptor (TEK). [1], [11]
Apoptosis mediating surface antigen FAS (FAS)
VB-111 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for VB-111. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of VB-111 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [12], [13]
APG-101 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for APG-101. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of APG-101 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [12], [14]
DE-098 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for DE-098. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of DE-098 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [12], [15]
APO-010 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for APO-010. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of APO-010 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [12], [16]
2-aminophenoxazine-3-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for 2-aminophenoxazine-3-one. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-aminophenoxazine-3-one through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [12], [17]
APG-103 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for APG-103. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of APG-103 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [12], [18]
F61F12 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for F61F12. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of F61F12 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [12], [19]
ISIS 17020 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for ISIS 17020. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 17020 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [12], [20]
Apoptosis regulator BAX (BAX)
Thymoquinone [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator BAX (BAX) is a therapeutic target for Thymoquinone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Thymoquinone through regulating the expression of Apoptosis regulator BAX (BAX). [21], [22]
Apoptosis regulator Bcl-2 (BCL-2)
MCI-186 [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for MCI-186. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MCI-186 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [24]
Venetoclax [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for Venetoclax. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Venetoclax through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [25]
ABT-263 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for ABT-263. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ABT-263 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [26]
Oblimersen [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for Oblimersen. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Oblimersen through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [27]
RG7601 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for RG7601. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RG7601 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [28]
Thymoquinone [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for Thymoquinone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Thymoquinone through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [29]
APG-1252 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for APG-1252. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of APG-1252 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [30]
APG-2575 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for APG-2575. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of APG-2575 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [31]
AZD0466 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for AZD0466. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AZD0466 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [32]
Beclanorsen [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for Beclanorsen. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Beclanorsen through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [33]
Gossypol [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for Gossypol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Gossypol through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [34]
Obatoclax [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for Obatoclax. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Obatoclax through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [18], [23]
PNT-2258 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for PNT-2258. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PNT-2258 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [35]
AI-850 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for AI-850. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AI-850 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [5], [23]
BCL201 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for BCL201. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BCL201 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [36]
BGB-11417 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for BGB-11417. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BGB-11417 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [37]
BP1002 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for BP1002. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BP1002 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [38]
LP-108 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for LP-108. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of LP-108 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [39]
Pc4 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for Pc4. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pc4 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [40]
VOB560 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for VOB560. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of VOB560 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [41]
2,3,4-trihydroxy-5-isopropyl-N-phenyl-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for 2,3,4-trihydroxy-5-isopropyl-N-phenyl-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2,3,4-trihydroxy-5-isopropyl-N-phenyl-benzamide through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [42]
4,5-dibenzylbenzene-1,2-diol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for 4,5-dibenzylbenzene-1,2-diol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4,5-dibenzylbenzene-1,2-diol through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [43]
5,10-Dioxy-2-phenyl-benzo[g]pteridin-4-ylamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for 5,10-Dioxy-2-phenyl-benzo[g]pteridin-4-ylamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5,10-Dioxy-2-phenyl-benzo[g]pteridin-4-ylamine through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [44]
Apogossypol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for Apogossypol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Apogossypol through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [45]
BP-100-1.02 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for BP-100-1.02. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BP-100-1.02 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [46]
modified HA14-1 compounds (cancer) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for modified HA14-1 compounds (cancer). The Methyltransferase-like 3 (METTL3) has potential in affecting the response of modified HA14-1 compounds (cancer) through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [44]
N-phenyl-2,3,4-trihydroxy-5-benzyl-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for N-phenyl-2,3,4-trihydroxy-5-benzyl-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-phenyl-2,3,4-trihydroxy-5-benzyl-benzamide through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [44]
QEDIIRNIARHLAQVGDSMDR [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for QEDIIRNIARHLAQVGDSMDR. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of QEDIIRNIARHLAQVGDSMDR through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [44]
TW-37 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for TW-37. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TW-37 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [47]
WL-276 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for WL-276. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of WL-276 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [48]
ABT-737 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis regulator Bcl-2 (BCL-2) is a therapeutic target for ABT-737. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ABT-737 through regulating the expression of Apoptosis regulator Bcl-2 (BCL-2). [23], [49]
ATM serine/threonine kinase (ATM)
KU-60019 [Clinical trial]
In total 1 mechanisms lead to this potential drug response
Response Summary ATM serine/threonine kinase (ATM) is a therapeutic target for KU-60019. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of KU-60019 through regulating the expression of ATM serine/threonine kinase (ATM). [5], [50]
AZD0156 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary ATM serine/threonine kinase (ATM) is a therapeutic target for AZD0156. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AZD0156 through regulating the expression of ATM serine/threonine kinase (ATM). [50], [51]
AZD1390 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary ATM serine/threonine kinase (ATM) is a therapeutic target for AZD1390. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AZD1390 through regulating the expression of ATM serine/threonine kinase (ATM). [5], [50]
M3541 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary ATM serine/threonine kinase (ATM) is a therapeutic target for M3541. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of M3541 through regulating the expression of ATM serine/threonine kinase (ATM). [5], [50]
CGK733 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ATM serine/threonine kinase (ATM) is a therapeutic target for CGK733. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CGK733 through regulating the expression of ATM serine/threonine kinase (ATM). [50], [52]
ATP-citrate synthase (ACLY)
Bempedoic acid [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary ATP-citrate synthase (ACLY) is a therapeutic target for Bempedoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Bempedoic acid through regulating the expression of ATP-citrate synthase (ACLY). [53], [54]
(-)-hydroxycitrate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ATP-citrate synthase (ACLY) is a therapeutic target for (-)-hydroxycitrate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (-)-hydroxycitrate through regulating the expression of ATP-citrate synthase (ACLY). [53], [55]
SB-201076 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ATP-citrate synthase (ACLY) is a therapeutic target for SB-201076. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SB-201076 through regulating the expression of ATP-citrate synthase (ACLY). [53], [56]
Beta-catenin (CTNNB1)
Recombinant human endostatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Beta-catenin (CTNNB1) is a therapeutic target for Recombinant human endostatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Recombinant human endostatin through regulating the expression of Beta-catenin (CTNNB1). [57], [58]
C 82 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Beta-catenin (CTNNB1) is a therapeutic target for C 82. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C 82 through regulating the expression of Beta-catenin (CTNNB1). [57], [59]
CEQ-508 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Beta-catenin (CTNNB1) is a therapeutic target for CEQ-508. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CEQ-508 through regulating the expression of Beta-catenin (CTNNB1). [57], [60]
Breast cancer resistance protein (ABCG2)
Abacavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Abacavir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Abacavir through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [62]
Acyclovir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Acyclovir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Acyclovir through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [63]
Adefovir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Adefovir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Adefovir through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [64]
Afatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Afatinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Afatinib through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [65]
Alfuzosin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Alfuzosin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Alfuzosin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [66]
Apatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Apatinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Apatinib through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [67]
Apixaban [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Apixaban. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Apixaban through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [68]
Baricitinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Baricitinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Baricitinib through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [69]
Bicalutamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Bicalutamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Bicalutamide through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [70]
Binimetinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Binimetinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Binimetinib through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [71]
Brigatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Brigatinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Brigatinib through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [72]
Bupropion [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Bupropion. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Bupropion through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [73]
Canagliflozin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Canagliflozin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Canagliflozin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [74]
Cephalothin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Cephalothin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cephalothin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [75]
Cerivastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Cerivastatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cerivastatin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [76]
Chlorothiazide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Chlorothiazide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Chlorothiazide through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [77]
Cholic acid [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Cholic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cholic acid through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [78]
Cimetidine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Cimetidine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cimetidine through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [79]
Ciprofloxacin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Ciprofloxacin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ciprofloxacin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [80]
Cisplatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Cisplatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cisplatin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [81]
Cladribine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Cladribine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cladribine through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [82]
Clofarabine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Clofarabine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Clofarabine through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [82]
Cyclosporine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Cyclosporine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cyclosporine through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [76]
Dabrafenib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Dabrafenib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dabrafenib through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [83]
Dactinomycin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Dactinomycin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dactinomycin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [84]
Daidzein [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Daidzein. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Daidzein through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [85]
Dehydroepiandrosterone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Dehydroepiandrosterone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dehydroepiandrosterone through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [86]
Dehydroepiandrosterone sulfate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Dehydroepiandrosterone sulfate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dehydroepiandrosterone sulfate through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [87]
Delavirdine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Delavirdine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Delavirdine through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [76]
Deoxycholic acid [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Deoxycholic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Deoxycholic acid through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [75]
Diclofenac [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Diclofenac. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Diclofenac through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [88]
Dipyridamole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Dipyridamole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dipyridamole through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [89]
Dirithromycin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Dirithromycin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dirithromycin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [75]
Docetaxel [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Docetaxel. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Docetaxel through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [90]
Eltrombopag [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Eltrombopag. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Eltrombopag through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [91]
Empagliflozin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Empagliflozin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Empagliflozin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [92]
Entacapone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Entacapone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Entacapone through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [93]
Entecavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Entecavir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Entecavir through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [94]
Epirubicin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Epirubicin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Epirubicin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [76]
Erythromycin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Erythromycin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Erythromycin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [89]
Estradiol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Estradiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Estradiol through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [95]
Estrone sulfate [Approved]
In total 2 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Estrone sulfate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Estrone sulfate through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [96]
Breast cancer resistance protein (ABCG2) is a therapeutic target for Estrone sulfate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Estrone sulfate through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [97]
Etoposide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Etoposide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Etoposide through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [98]
Ezetimibe [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Ezetimibe. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ezetimibe through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [99]
Fluvastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Fluvastatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fluvastatin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [100]
Folic acid [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Folic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Folic acid through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [101]
Ganciclovir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Ganciclovir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ganciclovir through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [102]
Glibenclamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Glibenclamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Glibenclamide through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [103]
Glutathione [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Glutathione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Glutathione through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [104]
Grepafloxacin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Grepafloxacin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Grepafloxacin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [105]
Hesperetin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Hesperetin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Hesperetin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [106]
Hydroxychloroquine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Hydroxychloroquine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Hydroxychloroquine through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [107]
Hypericin [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Hypericin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Hypericin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [108]
Idarubicin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Idarubicin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Idarubicin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [109]
Idelalisib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Idelalisib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Idelalisib through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [110]
Imatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Imatinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Imatinib through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [111]
Irinotecan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Irinotecan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Irinotecan through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [112]
Lamivudine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Lamivudine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lamivudine through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [113]
Lapatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Lapatinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lapatinib through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [114]
Leflunomide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Leflunomide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Leflunomide through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [115]
Lopinavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Lopinavir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lopinavir through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [76]
Menadione [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Menadione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Menadione through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [116]
Mercaptopurine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Mercaptopurine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Mercaptopurine through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [64]
Methotrexate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Methotrexate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Methotrexate through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [117]
Mitoxantrone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Mitoxantrone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Mitoxantrone through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [118]
Moxidectin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Moxidectin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Moxidectin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [119]
Mycophenolate mofetil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Mycophenolate mofetil. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Mycophenolate mofetil through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [120]
Nelfinavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Nelfinavir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nelfinavir through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [76]
Nicardipine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Nicardipine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nicardipine through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [76]
Nifurtimox [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Nifurtimox. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nifurtimox through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [121]
Nilotinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Nilotinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nilotinib through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [122]
Nitrofurantoin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Nitrofurantoin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nitrofurantoin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [123]
Norfloxacin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Norfloxacin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Norfloxacin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [124]
Ofloxacin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Ofloxacin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ofloxacin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [76]
Olmesartan medoxomil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Olmesartan medoxomil. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Olmesartan medoxomil through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [92]
Oxaliplatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Oxaliplatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Oxaliplatin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [125]
Palbociclib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Palbociclib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Palbociclib through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [126]
Pantoprazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Pantoprazole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pantoprazole through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [127]
Pazopanib hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Pazopanib hydrochloride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pazopanib hydrochloride through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [128]
Pemetrexed [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Pemetrexed. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pemetrexed through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [129]
Pirarubicin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Pirarubicin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pirarubicin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [130]
Pitavastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Pitavastatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pitavastatin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [89]
Pitavastatin calcium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Pitavastatin calcium. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pitavastatin calcium through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [131]
Ponatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Ponatinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ponatinib through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [132]
Pravastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Pravastatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pravastatin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [76]
Prazosin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Prazosin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Prazosin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [133]
Progesterone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Progesterone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Progesterone through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [95]
Pyrimethamine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Pyrimethamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pyrimethamine through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [134]
Quercetin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Quercetin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Quercetin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [76]
Rabeprazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Rabeprazole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Rabeprazole through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [135]
Raltitrexed [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Raltitrexed. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Raltitrexed through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [136]
Regorafenib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Regorafenib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Regorafenib through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [92]
Reserpine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Reserpine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Reserpine through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [76]
Riboflavin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Riboflavin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Riboflavin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [137]
Rifampicin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Rifampicin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Rifampicin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [75]
Riluzole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Riluzole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Riluzole through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [138]
Riociguat [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Riociguat. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Riociguat through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [92]
Rivaroxaban [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Rivaroxaban. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Rivaroxaban through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [139]
Rosiglitazone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Rosiglitazone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Rosiglitazone through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [140]
Rosuvastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Rosuvastatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Rosuvastatin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [141]
Saquinavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Saquinavir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Saquinavir through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [142]
Simvastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Simvastatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Simvastatin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [86]
Sofosbuvir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Sofosbuvir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sofosbuvir through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [92]
Sulfasalazine [Approved]
In total 2 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Sulfasalazine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sulfasalazine through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [143]
Breast cancer resistance protein (ABCG2) is a therapeutic target for Sulfasalazine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sulfasalazine through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [144]
Talazoparib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Talazoparib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Talazoparib through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [145]
Tenofovir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Tenofovir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tenofovir through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [92]
Teriflunomide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Teriflunomide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Teriflunomide through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [107]
Testosterone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Testosterone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Testosterone through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [146]
Tetracycline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Tetracycline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tetracycline through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [75]
Thioguanine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Thioguanine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Thioguanine through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [64]
Topotecan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Topotecan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Topotecan through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [147]
Trimetrexate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Trimetrexate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Trimetrexate through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [134]
Vandetanib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Vandetanib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Vandetanib through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [148]
Verteporfin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Verteporfin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Verteporfin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [149]
Vinblastine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Vinblastine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Vinblastine through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [90]
Vincristine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Vincristine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Vincristine through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [134]
Zidovudine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Zidovudine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Zidovudine through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [76]
AG 337 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for AG 337. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AG 337 through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [134]
Belotecan [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Belotecan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Belotecan through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [150]
BNP-1350 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for BNP-1350. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BNP-1350 through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [136]
Butyrate [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Butyrate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Butyrate through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [151]
Camptothecin [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Camptothecin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Camptothecin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [152]
Exatecan mesylate [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Exatecan mesylate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Exatecan mesylate through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [136]
Glycocholic acid [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Glycocholic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Glycocholic acid through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [78]
J-107088 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for J-107088. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of J-107088 through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [136]
Phenethyl isothiocyanate [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Phenethyl isothiocyanate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Phenethyl isothiocyanate through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [87]
Tenofovir alafenamide [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Tenofovir alafenamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tenofovir alafenamide through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [153]
Uric acid [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Uric acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Uric acid through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [154]
9-Aminocamptothecin [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for 9-Aminocamptothecin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 9-Aminocamptothecin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [136]
Bisantrene [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Bisantrene. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Bisantrene through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [136]
BN-80915 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for BN-80915. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BN-80915 through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [136]
C-1311 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for C-1311. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C-1311 through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [155]
Cholesterol [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Cholesterol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cholesterol through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [95]
Flavopiridol [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Flavopiridol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Flavopiridol through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [156]
Genistein [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Genistein. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Genistein through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [97]
Gimatecan [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Gimatecan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Gimatecan through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [136]
HPPH [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for HPPH. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HPPH through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [157]
Ortataxel [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Ortataxel. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ortataxel through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [76]
Oxfendazole [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Oxfendazole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Oxfendazole through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [158]
Phosphatidylserine [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Phosphatidylserine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Phosphatidylserine through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [159]
Piritrexim [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Piritrexim. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Piritrexim through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [134]
Quinacrine [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Quinacrine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Quinacrine through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [75]
SJG-136 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for SJG-136. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SJG-136 through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [160]
SN-38 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for SN-38. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SN-38 through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [161]
UCN-01 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for UCN-01. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of UCN-01 through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [136]
Benzo(a)pyrene [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Benzo(a)pyrene. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Benzo(a)pyrene through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [87]
Benzoylphenylurea [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Benzoylphenylurea. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Benzoylphenylurea through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [162]
CP-724714 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for CP-724714. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CP-724714 through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [163]
Mycophenolic acid glucuronide [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Mycophenolic acid glucuronide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Mycophenolic acid glucuronide through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [120]
YP-005 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for YP-005. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of YP-005 through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [164]
AG1478 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for AG1478. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AG1478 through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [81]
AZD-1152-HQPA [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for AZD-1152-HQPA. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AZD-1152-HQPA through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [165]
Azidothymidine monophosphate [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Azidothymidine monophosphate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Azidothymidine monophosphate through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [166]
BMS 536924 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for BMS 536924. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BMS 536924 through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [167]
Coumestrol [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Coumestrol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Coumestrol through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [85]
Enrofloxacin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Enrofloxacin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Enrofloxacin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [168]
Homocamptothecin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Homocamptothecin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Homocamptothecin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [169]
JNJ 7706621 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for JNJ 7706621. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of JNJ 7706621 through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [170]
N-desethyl sunitinib [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for N-desethyl sunitinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-desethyl sunitinib through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [171]
Pancratistatin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Pancratistatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pancratistatin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [172]
Protoporphyrin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Protoporphyrin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Protoporphyrin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [136]
Puromycin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Puromycin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Puromycin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [87]
Scutellarin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Scutellarin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Scutellarin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [173]
Chrysin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Chrysin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Chrysin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [76]
Estradiol-17beta-glucuronide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Estradiol-17beta-glucuronide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Estradiol-17beta-glucuronide through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [174]
Hematoporphyrin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Hematoporphyrin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Hematoporphyrin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [175]
Becatecarin [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Becatecarin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Becatecarin through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [176]
Befloxatone [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Befloxatone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Befloxatone through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [177]
E3040 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for E3040. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of E3040 through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [166]
Lurtotecan [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Lurtotecan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lurtotecan through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [87]
NB-506 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for NB-506. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NB-506 through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [136]
Parabis [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Parabis. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Parabis through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [178]
Rhodamine 123 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Rhodamine 123. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Rhodamine 123 through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [179]
Taurocholic acid [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Breast cancer resistance protein (ABCG2) is a therapeutic target for Taurocholic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Taurocholic acid through regulating the expression of Breast cancer resistance protein (ABCG2). [61], [78]
Bromodomain-containing protein 4 (BRD4)
CPI-0610 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Bromodomain-containing protein 4 (BRD4) is a therapeutic target for CPI-0610. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CPI-0610 through regulating the expression of Bromodomain-containing protein 4 (BRD4). [180], [181]
INCB57643 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Bromodomain-containing protein 4 (BRD4) is a therapeutic target for INCB57643. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of INCB57643 through regulating the expression of Bromodomain-containing protein 4 (BRD4). [180], [182]
OTX-015 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Bromodomain-containing protein 4 (BRD4) is a therapeutic target for OTX-015. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of OTX-015 through regulating the expression of Bromodomain-containing protein 4 (BRD4). [5], [180]
PLX2853 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Bromodomain-containing protein 4 (BRD4) is a therapeutic target for PLX2853. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PLX2853 through regulating the expression of Bromodomain-containing protein 4 (BRD4). [180], [182]
ABBV-744 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Bromodomain-containing protein 4 (BRD4) is a therapeutic target for ABBV-744. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ABBV-744 through regulating the expression of Bromodomain-containing protein 4 (BRD4). [5], [180]
AZD5153 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Bromodomain-containing protein 4 (BRD4) is a therapeutic target for AZD5153. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AZD5153 through regulating the expression of Bromodomain-containing protein 4 (BRD4). [180], [182]
GSK525762 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Bromodomain-containing protein 4 (BRD4) is a therapeutic target for GSK525762. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GSK525762 through regulating the expression of Bromodomain-containing protein 4 (BRD4). [180], [182]
TEN010 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Bromodomain-containing protein 4 (BRD4) is a therapeutic target for TEN010. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TEN010 through regulating the expression of Bromodomain-containing protein 4 (BRD4). [5], [180]
BzT-7 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Bromodomain-containing protein 4 (BRD4) is a therapeutic target for BzT-7. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BzT-7 through regulating the expression of Bromodomain-containing protein 4 (BRD4). [180], [183]
CPI-203 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Bromodomain-containing protein 4 (BRD4) is a therapeutic target for CPI-203. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CPI-203 through regulating the expression of Bromodomain-containing protein 4 (BRD4). [180], [184]
GW841819X [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Bromodomain-containing protein 4 (BRD4) is a therapeutic target for GW841819X. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GW841819X through regulating the expression of Bromodomain-containing protein 4 (BRD4). [180], [185]
I-BET151 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Bromodomain-containing protein 4 (BRD4) is a therapeutic target for I-BET151. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of I-BET151 through regulating the expression of Bromodomain-containing protein 4 (BRD4). [180], [186]
isoxazole azepine compound 3 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Bromodomain-containing protein 4 (BRD4) is a therapeutic target for isoxazole azepine compound 3. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of isoxazole azepine compound 3 through regulating the expression of Bromodomain-containing protein 4 (BRD4). [180], [187]
MS417 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Bromodomain-containing protein 4 (BRD4) is a therapeutic target for MS417. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MS417 through regulating the expression of Bromodomain-containing protein 4 (BRD4). [180], [188]
MS436 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Bromodomain-containing protein 4 (BRD4) is a therapeutic target for MS436. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MS436 through regulating the expression of Bromodomain-containing protein 4 (BRD4). [180], [189]
PFI-1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Bromodomain-containing protein 4 (BRD4) is a therapeutic target for PFI-1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PFI-1 through regulating the expression of Bromodomain-containing protein 4 (BRD4). [180], [190]
XD1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Bromodomain-containing protein 4 (BRD4) is a therapeutic target for XD1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of XD1 through regulating the expression of Bromodomain-containing protein 4 (BRD4). [180], [190]
XD14 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Bromodomain-containing protein 4 (BRD4) is a therapeutic target for XD14. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of XD14 through regulating the expression of Bromodomain-containing protein 4 (BRD4). [180], [184]
C-X-C motif chemokine 10 (CXCL10)
Anti-IP10 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C motif chemokine 10 (CXCL10) is a therapeutic target for Anti-IP10. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Anti-IP10 through regulating the expression of C-X-C motif chemokine 10 (CXCL10). [60], [191]
BMS-936557 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C motif chemokine 10 (CXCL10) is a therapeutic target for BMS-936557. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BMS-936557 through regulating the expression of C-X-C motif chemokine 10 (CXCL10). [191], [192]
JT02 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C motif chemokine 10 (CXCL10) is a therapeutic target for JT02. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of JT02 through regulating the expression of C-X-C motif chemokine 10 (CXCL10). [191], [193]
MDX-1100 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C motif chemokine 10 (CXCL10) is a therapeutic target for MDX-1100. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MDX-1100 through regulating the expression of C-X-C motif chemokine 10 (CXCL10). [191], [194]
NI-0801 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C motif chemokine 10 (CXCL10) is a therapeutic target for NI-0801. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NI-0801 through regulating the expression of C-X-C motif chemokine 10 (CXCL10). [191], [195]
NG-641 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C motif chemokine 10 (CXCL10) is a therapeutic target for NG-641. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NG-641 through regulating the expression of C-X-C motif chemokine 10 (CXCL10). [191], [194]
N-Methylleucine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C motif chemokine 10 (CXCL10) is a therapeutic target for N-Methylleucine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Methylleucine through regulating the expression of C-X-C motif chemokine 10 (CXCL10). [191], [196]
C-X-C motif chemokine 9 (CXCL9)
NG-641 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary C-X-C motif chemokine 9 (CXCL9) is a therapeutic target for NG-641. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NG-641 through regulating the expression of C-X-C motif chemokine 9 (CXCL9). [191], [197]
Caspase-3 (CASP3)
PAC1 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Caspase-3 (CASP3) is a therapeutic target for PAC1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PAC1 through regulating the expression of Caspase-3 (CASP3). [198], [199]
2-(4-fluoro-benzyl)isoquinoline-1,3,4-trione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Caspase-3 (CASP3) is a therapeutic target for 2-(4-fluoro-benzyl)isoquinoline-1,3,4-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(4-fluoro-benzyl)isoquinoline-1,3,4-trione through regulating the expression of Caspase-3 (CASP3). [198], [200]
2-(4-methoxy-benzyl)isoquinoline-1,3,4-trione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Caspase-3 (CASP3) is a therapeutic target for 2-(4-methoxy-benzyl)isoquinoline-1,3,4-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(4-methoxy-benzyl)isoquinoline-1,3,4-trione through regulating the expression of Caspase-3 (CASP3). [198], [200]
2-allylisoquinoline-1,3,4-trione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Caspase-3 (CASP3) is a therapeutic target for 2-allylisoquinoline-1,3,4-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-allylisoquinoline-1,3,4-trione through regulating the expression of Caspase-3 (CASP3). [198], [200]
2-benzylisoquinoline-1,3,4-trione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Caspase-3 (CASP3) is a therapeutic target for 2-benzylisoquinoline-1,3,4-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-benzylisoquinoline-1,3,4-trione through regulating the expression of Caspase-3 (CASP3). [198], [200]
2-methylisoquinoline-1,3,4-trione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Caspase-3 (CASP3) is a therapeutic target for 2-methylisoquinoline-1,3,4-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-methylisoquinoline-1,3,4-trione through regulating the expression of Caspase-3 (CASP3). [198], [201]
2-phenethylisoquinoline-1,3,4-trione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Caspase-3 (CASP3) is a therapeutic target for 2-phenethylisoquinoline-1,3,4-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-phenethylisoquinoline-1,3,4-trione through regulating the expression of Caspase-3 (CASP3). [198], [200]
5-(azepan-1-ylsulfonyl)indoline-2,3-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Caspase-3 (CASP3) is a therapeutic target for 5-(azepan-1-ylsulfonyl)indoline-2,3-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-(azepan-1-ylsulfonyl)indoline-2,3-dione through regulating the expression of Caspase-3 (CASP3). [198], [201]
5-(azetidin-1-ylsulfonyl)indoline-2,3-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Caspase-3 (CASP3) is a therapeutic target for 5-(azetidin-1-ylsulfonyl)indoline-2,3-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-(azetidin-1-ylsulfonyl)indoline-2,3-dione through regulating the expression of Caspase-3 (CASP3). [198], [201]
5-(piperidin-1-ylsulfonyl)indoline-2,3-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Caspase-3 (CASP3) is a therapeutic target for 5-(piperidin-1-ylsulfonyl)indoline-2,3-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-(piperidin-1-ylsulfonyl)indoline-2,3-dione through regulating the expression of Caspase-3 (CASP3). [198], [201]
5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Caspase-3 (CASP3) is a therapeutic target for 5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-dione through regulating the expression of Caspase-3 (CASP3). [198], [202]
Ac-Asp-Glu-Val-Asp-CHO [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Caspase-3 (CASP3) is a therapeutic target for Ac-Asp-Glu-Val-Asp-CHO. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ac-Asp-Glu-Val-Asp-CHO through regulating the expression of Caspase-3 (CASP3). [198], [200]
Ac-DEVD-CHO [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Caspase-3 (CASP3) is a therapeutic target for Ac-DEVD-CHO. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ac-DEVD-CHO through regulating the expression of Caspase-3 (CASP3). [198], [203]
AZ10417808 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Caspase-3 (CASP3) is a therapeutic target for AZ10417808. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AZ10417808 through regulating the expression of Caspase-3 (CASP3). [198], [204]
Glionitrin A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Caspase-3 (CASP3) is a therapeutic target for Glionitrin A. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Glionitrin A through regulating the expression of Caspase-3 (CASP3). [198], [205]
Isoquinoline-1,3,4(2H)-trione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Caspase-3 (CASP3) is a therapeutic target for Isoquinoline-1,3,4(2H)-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Isoquinoline-1,3,4(2H)-trione through regulating the expression of Caspase-3 (CASP3). [198], [200]
M826 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Caspase-3 (CASP3) is a therapeutic target for M826. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of M826 through regulating the expression of Caspase-3 (CASP3). [198], [206]
PETCM [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Caspase-3 (CASP3) is a therapeutic target for PETCM. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PETCM through regulating the expression of Caspase-3 (CASP3). [198], [207]
SJ-8002 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Caspase-3 (CASP3) is a therapeutic target for SJ-8002. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SJ-8002 through regulating the expression of Caspase-3 (CASP3). [198], [208]
Caterpiller protein 1.1 (NLRP3)
Dapansutrile [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Caterpiller protein 1.1 (NLRP3) is a therapeutic target for Dapansutrile. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dapansutrile through regulating the expression of Caterpiller protein 1.1 (NLRP3). [209], [210]
BMS-986299 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Caterpiller protein 1.1 (NLRP3) is a therapeutic target for BMS-986299. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BMS-986299 through regulating the expression of Caterpiller protein 1.1 (NLRP3). [209], [211]
MCC950 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Caterpiller protein 1.1 (NLRP3) is a therapeutic target for MCC950. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MCC950 through regulating the expression of Caterpiller protein 1.1 (NLRP3). [209], [212]
Cellular tumor antigen p53 (TP53)
Contusugene ladenovec [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for Contusugene ladenovec. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Contusugene ladenovec through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [214]
QPI-1002 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for QPI-1002. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of QPI-1002 through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [215]
Thymoquinone [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for Thymoquinone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Thymoquinone through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [216]
Ad-p53 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for Ad-p53. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ad-p53 through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [217]
ALT-801 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for ALT-801. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ALT-801 through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [218]
APG-115 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for APG-115. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of APG-115 through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [219]
APR-246 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for APR-246. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of APR-246 through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [220]
Cenersen [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for Cenersen. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cenersen through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [221]
INGN-225 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for INGN-225. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of INGN-225 through regulating the expression of Cellular tumor antigen p53 (TP53). [5], [213]
ISA-P53-01 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for ISA-P53-01. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISA-P53-01 through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [222]
Kevetrin [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for Kevetrin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Kevetrin through regulating the expression of Cellular tumor antigen p53 (TP53). [18], [213]
OPI-1002 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for OPI-1002. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of OPI-1002 through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [223]
SGT-53 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for SGT-53. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SGT-53 through regulating the expression of Cellular tumor antigen p53 (TP53). [5], [213]
CGM097 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for CGM097. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CGM097 through regulating the expression of Cellular tumor antigen p53 (TP53). [5], [213]
COTI-2 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for COTI-2. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of COTI-2 through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [224]
Dendritic cell vaccine [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for Dendritic cell vaccine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dendritic cell vaccine through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [225]
HDM201 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for HDM201. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HDM201 through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [226]
ONYX-015 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for ONYX-015. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ONYX-015 through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [227]
SAR-405838 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for SAR-405838. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SAR-405838 through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [214]
1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [228]
AHL [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for AHL. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AHL through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [229]
NU-8231 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for NU-8231. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NU-8231 through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [230]
NUTLIN-3 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for NUTLIN-3. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NUTLIN-3 through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [231]
INGN-234 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for INGN-234. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of INGN-234 through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [232]
Pifithrin-alpha [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for Pifithrin-alpha. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pifithrin-alpha through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [233]
TAR-1 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Cellular tumor antigen p53 (TP53) is a therapeutic target for TAR-1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TAR-1 through regulating the expression of Cellular tumor antigen p53 (TP53). [213], [234]
Clusterin messenger RNA (Clusterin mRNA)
Custirsen [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Clusterin messenger RNA (Clusterin mRNA) is a therapeutic target for Custirsen. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Custirsen through regulating the expression of Clusterin messenger RNA (Clusterin mRNA). [235], [236]
Cyclin-dependent kinase 1 (CDK1)
P-276 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for P-276. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of P-276 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [238]
P276-00 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for P276-00. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of P276-00 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [239]
Ro 31-7453 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for Ro 31-7453. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ro 31-7453 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [240]
Roscovitine [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for Roscovitine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Roscovitine through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [241]
AG-024322 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for AG-024322. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AG-024322 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [242]
PHA-793887 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for PHA-793887. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PHA-793887 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [239]
RGB-286638 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for RGB-286638. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RGB-286638 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [239]
L-751250 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for L-751250. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of L-751250 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [239]
ON-01135 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for ON-01135. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ON-01135 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [243]
(2,6-Diamino-pyridin-3-yl)-phenyl-methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for (2,6-Diamino-pyridin-3-yl)-phenyl-methanone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (2,6-Diamino-pyridin-3-yl)-phenyl-methanone through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [244]
10Z-Hymenialdisine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for 10Z-Hymenialdisine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 10Z-Hymenialdisine through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [245]
2-(p-toluidino)-4-phenylpyrimidine-5-carbonitrile [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for 2-(p-toluidino)-4-phenylpyrimidine-5-carbonitrile. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(p-toluidino)-4-phenylpyrimidine-5-carbonitrile through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [246]
3,4-bis(indol-3-yl)maleimide derivative [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for 3,4-bis(indol-3-yl)maleimide derivative. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3,4-bis(indol-3-yl)maleimide derivative through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [244]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [7], [237]
3,4-diphenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for 3,4-diphenyl-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3,4-diphenyl-1H-pyrrole-2,5-dione through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [7], [237]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [247]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [7], [237]
4-(Quinolin-3-yl)-N-p-tolylpyrimidin-2-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for 4-(Quinolin-3-yl)-N-p-tolylpyrimidin-2-amine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(Quinolin-3-yl)-N-p-tolylpyrimidin-2-amine through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [248]
4-(Quinolin-4-yl)-N-p-tolylpyrimidin-2-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for 4-(Quinolin-4-yl)-N-p-tolylpyrimidin-2-amine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(Quinolin-4-yl)-N-p-tolylpyrimidin-2-amine through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [249]
4-phenyl-2-(phenylamino)pyrimidine-5-carbonitrile [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for 4-phenyl-2-(phenylamino)pyrimidine-5-carbonitrile. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-phenyl-2-(phenylamino)pyrimidine-5-carbonitrile through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [250]
9-Nitropaullone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for 9-Nitropaullone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 9-Nitropaullone through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [251]
aloisine A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for aloisine A. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of aloisine A through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [22], [237]
alsterpaullone 2-cyanoethyl [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for alsterpaullone 2-cyanoethyl. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of alsterpaullone 2-cyanoethyl through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [22], [237]
aminopurvalanol A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for aminopurvalanol A. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of aminopurvalanol A through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [252]
AZAKENPAULLONE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for AZAKENPAULLONE. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AZAKENPAULLONE through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [253]
Bisindolylmaleimide-I [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for Bisindolylmaleimide-I. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Bisindolylmaleimide-I through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [253]
BMS-265246 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for BMS-265246. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BMS-265246 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [22], [237]
Cdk1 inhibitor [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for Cdk1 inhibitor. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cdk1 inhibitor through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [254]
CGP74514A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for CGP74514A. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CGP74514A through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [243]
CVT-313 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for CVT-313. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CVT-313 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [255]
IN1535 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for IN1535. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of IN1535 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [256]
Indirubin-3'-monoxime [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for Indirubin-3'-monoxime. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Indirubin-3'-monoxime through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [210], [237]
Indirubin-5-sulfonate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for Indirubin-5-sulfonate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Indirubin-5-sulfonate through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [257]
JNJ 7706621 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for JNJ 7706621. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of JNJ 7706621 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [7], [237]
K00024 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for K00024. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of K00024 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [258]
Microxine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for Microxine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Microxine through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [259]
NU6140 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for NU6140. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NU6140 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [260]
PF-228 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for PF-228. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PF-228 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [249]
Purvalanol A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for Purvalanol A. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Purvalanol A through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [243]
Quinoxaline1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for Quinoxaline1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Quinoxaline1 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [22], [237]
RO-316233 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for RO-316233. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RO-316233 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [244]
SU9516 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for SU9516. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SU9516 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [261]
Thieno analogue of kenpaullone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for Thieno analogue of kenpaullone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Thieno analogue of kenpaullone through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [250]
BAY 10-00394 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for BAY 10-00394. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BAY 10-00394 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [262]
CGP-60474 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for CGP-60474. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CGP-60474 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [263]
Olomoucine [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for Olomoucine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Olomoucine through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [264]
R547 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for R547. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of R547 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [239]
SCH 727965 [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for SCH 727965. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SCH 727965 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [265]
ZK 304709 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cyclin-dependent kinase 1 (CDK1) is a therapeutic target for ZK 304709. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ZK 304709 through regulating the expression of Cyclin-dependent kinase 1 (CDK1). [237], [239]
Cysteines of Keap1 (KEAP1 Cysteines)
CXA10 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cysteines of Keap1 (KEAP1 Cysteines) is a therapeutic target for CXA10. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CXA10 through regulating the expression of Cysteines of Keap1 (KEAP1 Cysteines). [266], [267]
VCB101 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Cysteines of Keap1 (KEAP1 Cysteines) is a therapeutic target for VCB101. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of VCB101 through regulating the expression of Cysteines of Keap1 (KEAP1 Cysteines). [266], [268]
VCB102 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Cysteines of Keap1 (KEAP1 Cysteines) is a therapeutic target for VCB102. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of VCB102 through regulating the expression of Cysteines of Keap1 (KEAP1 Cysteines). [266], [269]
Cystine/glutamate transporter (SLC7A11)
L-glutamic acid [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cystine/glutamate transporter (SLC7A11) is a therapeutic target for L-glutamic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of L-glutamic acid through regulating the expression of Cystine/glutamate transporter (SLC7A11). [270], [271]
SXC-2023 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cystine/glutamate transporter (SLC7A11) is a therapeutic target for SXC-2023. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SXC-2023 through regulating the expression of Cystine/glutamate transporter (SLC7A11). [270], [272]
Cytochrome P450 1B1 (CYP1B1)
Amodiaquine [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Amodiaquine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Amodiaquine through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [274]
Caffeine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Caffeine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Caffeine through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [275]
Erythromycin stearate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Erythromycin stearate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Erythromycin stearate through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [276]
Estrone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Estrone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Estrone through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [277]
Flutamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Flutamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Flutamide through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [278]
Hydrogen peroxide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Hydrogen peroxide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Hydrogen peroxide through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [279]
Melatonin [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Melatonin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Melatonin through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [280]
Oxaliplatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Oxaliplatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Oxaliplatin through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [281]
Procarbazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Procarbazine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Procarbazine through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [282]
Progesterone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Progesterone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Progesterone through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [283]
Rosuvastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Rosuvastatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Rosuvastatin through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [284]
Testosterone cypionate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Testosterone cypionate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Testosterone cypionate through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [283]
Theophylline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Theophylline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Theophylline through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [275]
Estradiol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Estradiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Estradiol through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [285]
HSDB-3466 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for HSDB-3466. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HSDB-3466 through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [286]
NSC-122758 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for NSC-122758. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NSC-122758 through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [287]
PINOCEMBRIN [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for PINOCEMBRIN. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PINOCEMBRIN through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [288]
Naringenin [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Naringenin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Naringenin through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [289]
2-[2-(3,5-Dimethoxy-phenyl)-vinyl]-thiophene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for 2-[2-(3,5-Dimethoxy-phenyl)-vinyl]-thiophene. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-[2-(3,5-Dimethoxy-phenyl)-vinyl]-thiophene through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [290]
3-[2-(3,5-Dimethoxy-phenyl)-vinyl]-furan [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for 3-[2-(3,5-Dimethoxy-phenyl)-vinyl]-furan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-[2-(3,5-Dimethoxy-phenyl)-vinyl]-furan through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [290]
4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-pyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for 4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-pyridine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-pyridine through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [290]
ACACETIN [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for ACACETIN. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ACACETIN through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [289]
APIGENIN [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for APIGENIN. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of APIGENIN through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [289]
Chrysin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Chrysin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Chrysin through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [289]
CHRYSOERIOL [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for CHRYSOERIOL. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CHRYSOERIOL through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [289]
Dibutylphthalate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Dibutylphthalate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dibutylphthalate through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [291]
DIOSMETIN [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for DIOSMETIN. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of DIOSMETIN through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [289]
ERIODICTYOL [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for ERIODICTYOL. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ERIODICTYOL through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [289]
Galangin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Galangin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Galangin through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [290]
HOMOERIODICTYOL [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for HOMOERIODICTYOL. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HOMOERIODICTYOL through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [289]
ISORHAMNETIN [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for ISORHAMNETIN. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISORHAMNETIN through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [289]
ISOSAKUTANETIN [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for ISOSAKUTANETIN. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISOSAKUTANETIN through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [289]
KAEMPFERIDE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for KAEMPFERIDE. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of KAEMPFERIDE through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [289]
KAEMPFEROL [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for KAEMPFEROL. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of KAEMPFEROL through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [289]
N-(2,4-Dimethoxy-phenyl)-3,5-dimethoxy-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for N-(2,4-Dimethoxy-phenyl)-3,5-dimethoxy-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(2,4-Dimethoxy-phenyl)-3,5-dimethoxy-benzamide through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [289]
TAMARIXETIN [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for TAMARIXETIN. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TAMARIXETIN through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [289]
TRISMETHOXYRESVERATROL [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for TRISMETHOXYRESVERATROL. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TRISMETHOXYRESVERATROL through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [273], [290]
Cytochrome P450 2C8 (CYP2C8)
Almotriptan malate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Almotriptan malate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Almotriptan malate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [293]
Aminophenazone [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Aminophenazone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Aminophenazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [294]
Amiodarone hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Amiodarone hydrochloride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Amiodarone hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [295]
Amitriptyline hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Amitriptyline hydrochloride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Amitriptyline hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [296]
Amodiaquine [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Amodiaquine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Amodiaquine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [297]
Anastrozole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Anastrozole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Anastrozole through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [298]
Apalutamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Apalutamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Apalutamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [299]
Apixaban [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Apixaban. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Apixaban through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [300]
Atorvastatin calcium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Atorvastatin calcium. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Atorvastatin calcium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [301]
Azelastine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Azelastine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Azelastine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [302]
Benzyl alcohol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Benzyl alcohol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Benzyl alcohol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [303]
Beraprost [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Beraprost. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Beraprost through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [304]
Brigatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Brigatinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Brigatinib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [305]
Bromfenac [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Bromfenac. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Bromfenac through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [306]
Buprenorphine hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Buprenorphine hydrochloride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Buprenorphine hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [307]
Cabazitaxel [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cabazitaxel. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cabazitaxel through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [308]
Caffeine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Caffeine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Caffeine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [309]
Capsaicin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Capsaicin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Capsaicin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [310]
Carbamazepine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Carbamazepine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Carbamazepine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [311]
Cefaloridine [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cefaloridine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cefaloridine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [312]
Celecoxib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Celecoxib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Celecoxib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [313]
Cerivastatin sodium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cerivastatin sodium. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cerivastatin sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [301]
Cisapride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cisapride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cisapride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [314]
Clozapine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Clozapine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Clozapine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [315]
Cyclophosphamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cyclophosphamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cyclophosphamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [316]
Dabrafenib mesylate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Dabrafenib mesylate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dabrafenib mesylate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [301]
Dapsone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Dapsone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dapsone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [317]
Desloratadine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Desloratadine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Desloratadine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [318]
Dexibuprofen [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Dexibuprofen. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dexibuprofen through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [319]
Diazepam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diazepam. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Diazepam through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [320]
Diclofenac sodium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diclofenac sodium. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Diclofenac sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [321]
Diethylstilbestrol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diethylstilbestrol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Diethylstilbestrol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [322]
Diltiazem hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diltiazem hydrochloride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Diltiazem hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [323]
Eltrombopag olamine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Eltrombopag olamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Eltrombopag olamine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [324]
Enasidenib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Enasidenib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Enasidenib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [325]
Enzalutamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Enzalutamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Enzalutamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [301]
Estradiol acetate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol acetate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Estradiol acetate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [301]
Estradiol cypionate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol cypionate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Estradiol cypionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [326]
Estradiol valerate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol valerate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Estradiol valerate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [326]
Eszopiclone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Eszopiclone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Eszopiclone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [327]
Ethinyl estradiol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ethinyl estradiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ethinyl estradiol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [328]
Fluvastatin sodium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Fluvastatin sodium. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fluvastatin sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [329]
Glasdegib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Glasdegib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Glasdegib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [330]
Halofantrine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Halofantrine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Halofantrine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [331]
Ibuprofen [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ibuprofen. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ibuprofen through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [319]
Ifosfamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ifosfamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ifosfamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [316]
Imatinib mesylate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Imatinib mesylate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Imatinib mesylate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [301]
Irbesartan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Irbesartan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Irbesartan through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [328]
Istradefylline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Istradefylline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Istradefylline through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [332]
Ixazomib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ixazomib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ixazomib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [333]
Ketobemidone [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ketobemidone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ketobemidone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [334]
Ketorolac [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ketorolac. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ketorolac through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [335]
Lansoprazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lansoprazole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lansoprazole through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [336]
Lapatinib ditosylate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lapatinib ditosylate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lapatinib ditosylate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [337]
Levomilnacipran [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Levomilnacipran. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Levomilnacipran through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [338]
Lidocaine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lidocaine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lidocaine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [339]
Loperamide hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Loperamide hydrochloride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Loperamide hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [340]
Loratadine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Loratadine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Loratadine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [301]
Lorlatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lorlatinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lorlatinib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [341]
Losartan potassium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Losartan potassium. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Losartan potassium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [342]
Lovastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lovastatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lovastatin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [343]
Mefenamic acid [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mefenamic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Mefenamic acid through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [301]
Meloxicam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Meloxicam. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Meloxicam through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [344]
Mephenytoin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mephenytoin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Mephenytoin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [345]
Mestranol [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mestranol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Mestranol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [346]
Methadone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Methadone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Methadone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [347]
Mirtazapine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mirtazapine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Mirtazapine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [339]
Montelukast sodium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Montelukast sodium. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Montelukast sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [348]
Morphine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Morphine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Morphine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [349]
Mycophenolate mofetil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mycophenolate mofetil. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Mycophenolate mofetil through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [350]
Naloxone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Naloxone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Naloxone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [307]
Naproxen [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Naproxen. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Naproxen through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [351]
Nicardipine hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Nicardipine hydrochloride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nicardipine hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [339]
Nicotine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Nicotine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nicotine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [352]
Nilotinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Nilotinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nilotinib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [301]
Ombitasvir [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ombitasvir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ombitasvir through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [353]
Omeprazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Omeprazole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Omeprazole through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [354]
Pazopanib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pazopanib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pazopanib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [355]
Pentamidine isethionate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pentamidine isethionate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pentamidine isethionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [356]
Perphenazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Perphenazine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Perphenazine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [357]
Phenobarbital [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Phenobarbital. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Phenobarbital through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [358]
Phenprocoumon [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Phenprocoumon. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Phenprocoumon through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [359]
Phenytoin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Phenytoin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Phenytoin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [339]
Pioglitazone hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pioglitazone hydrochloride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pioglitazone hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [360]
Piroxicam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Piroxicam. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Piroxicam through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [361]
Pitavastatin calcium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pitavastatin calcium. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pitavastatin calcium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [362]
Propofol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Propofol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Propofol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [363]
Quinidine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Quinidine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Quinidine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [301]
Quinine sulfate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Quinine sulfate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Quinine sulfate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [301]
Repaglinide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Repaglinide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Repaglinide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [364]
Riociguat [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Riociguat. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Riociguat through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [365]
Rofecoxib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Rofecoxib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Rofecoxib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [301]
Rosiglitazone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Rosiglitazone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Rosiglitazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [366]
Selegiline hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Selegiline hydrochloride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Selegiline hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [367]
Selexipag [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Selexipag. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Selexipag through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [368]
Simvastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Simvastatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Simvastatin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [369]
Sitagliptin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Sitagliptin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sitagliptin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [370]
Sulfadiazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Sulfadiazine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sulfadiazine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [371]
Sulfamethoxazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Sulfamethoxazole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sulfamethoxazole through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [372]
Sulfinpyrazone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Sulfinpyrazone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sulfinpyrazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [339]
Tazarotene [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Tazarotene. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tazarotene through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [373]
Tegafur [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Tegafur. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tegafur through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [374]
Temazepam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Temazepam. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Temazepam through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [375]
Terbinafine hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Terbinafine hydrochloride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Terbinafine hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [327]
Testosterone cypionate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Testosterone cypionate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Testosterone cypionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [301]
Testosterone enanthate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Testosterone enanthate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Testosterone enanthate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [301]
Testosterone undecanoate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Testosterone undecanoate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Testosterone undecanoate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [301]
Thalidomide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Thalidomide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Thalidomide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [376]
Tolbutamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Tolbutamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tolbutamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [377]
Torasemide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Torasemide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Torasemide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [378]
Treprostinil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Treprostinil. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Treprostinil through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [379]
Trifarotene [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Trifarotene. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Trifarotene through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [380]
Trimethadione [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Trimethadione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Trimethadione through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [381]
Trimethoprim [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Trimethoprim. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Trimethoprim through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [382]
Troglitazone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Troglitazone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Troglitazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [383]
Velpatasvir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Velpatasvir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Velpatasvir through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [384]
Verapamil hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Verapamil hydrochloride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Verapamil hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [385]
Vortioxetine hydrobromide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Vortioxetine hydrobromide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Vortioxetine hydrobromide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [386]
Voxilaprevir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Voxilaprevir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Voxilaprevir through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [384]
Warfarin sodium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Warfarin sodium. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Warfarin sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [351]
Zafirlukast [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Zafirlukast. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Zafirlukast through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [382]
Zidovudine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Zidovudine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Zidovudine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [339]
Zopiclone [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Zopiclone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Zopiclone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [387]
BMS-298585 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for BMS-298585. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BMS-298585 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [388]
BNP-1350 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for BNP-1350. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BNP-1350 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [389]
CKD-501 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for CKD-501. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CKD-501 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [390]
CYT-387 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for CYT-387. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CYT-387 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [391]
Dasabuvir [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Dasabuvir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dasabuvir through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [392]
Domperidone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Domperidone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Domperidone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [393]
DRF-2593 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for DRF-2593. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of DRF-2593 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [390]
EMD-128130 [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for EMD-128130. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of EMD-128130 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [394]
Estradiol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Estradiol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [301]
LAS-17177 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for LAS-17177. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of LAS-17177 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [395]
LAU-7b [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for LAU-7b. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of LAU-7b through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [396]
LY-2484595 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for LY-2484595. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of LY-2484595 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [397]
NSC-122758 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for NSC-122758. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NSC-122758 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [398]
QLT-091001 [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for QLT-091001. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of QLT-091001 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [398]
Rivoglitazone [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Rivoglitazone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Rivoglitazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [399]
AZD-2014 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for AZD-2014. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AZD-2014 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [400]
GSK-1278863 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for GSK-1278863. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GSK-1278863 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [401]
TAK-652 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for TAK-652. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TAK-652 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [402]
AG-1549 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for AG-1549. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AG-1549 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [403]
AZD-9496 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for AZD-9496. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AZD-9496 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [404]
H3B-6545 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for H3B-6545. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of H3B-6545 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [405]
M-813 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for M-813. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of M-813 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [406]
MK-0822 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for MK-0822. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MK-0822 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [407]
Antipyrine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Antipyrine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Antipyrine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [327]
Cyamemazine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cyamemazine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cyamemazine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [408]
Paraoxon [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Paraoxon. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Paraoxon through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [409]
ABT-001 [Discontinued]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for ABT-001. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ABT-001 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [410]
ADD-3878 [Discontinued]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for ADD-3878. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ADD-3878 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [390]
Aleglitazar [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Aleglitazar. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Aleglitazar through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [411]
ML-3000 [Discontinued]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for ML-3000. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ML-3000 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [292], [327]
Delta-like protein 3 (DLL3)
Rova-T [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Delta-like protein 3 (DLL3) is a therapeutic target for Rova-T. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Rova-T through regulating the expression of Delta-like protein 3 (DLL3). [412], [413]
HPN328 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Delta-like protein 3 (DLL3) is a therapeutic target for HPN328. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HPN328 through regulating the expression of Delta-like protein 3 (DLL3). [412], [414]
AMG 119 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Delta-like protein 3 (DLL3) is a therapeutic target for AMG 119. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AMG 119 through regulating the expression of Delta-like protein 3 (DLL3). [412], [415]
AMG 757 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Delta-like protein 3 (DLL3) is a therapeutic target for AMG 757. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AMG 757 through regulating the expression of Delta-like protein 3 (DLL3). [412], [416]
Diacylglycerol O-acyltransferase 2 (DGAT2)
Vitamin B3 [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Diacylglycerol O-acyltransferase 2 (DGAT2) is a therapeutic target for Vitamin B3. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Vitamin B3 through regulating the expression of Diacylglycerol O-acyltransferase 2 (DGAT2). [53], [417]
ARI-3037MO [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Diacylglycerol O-acyltransferase 2 (DGAT2) is a therapeutic target for ARI-3037MO. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ARI-3037MO through regulating the expression of Diacylglycerol O-acyltransferase 2 (DGAT2). [53], [418]
ION 224 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Diacylglycerol O-acyltransferase 2 (DGAT2) is a therapeutic target for ION 224. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ION 224 through regulating the expression of Diacylglycerol O-acyltransferase 2 (DGAT2). [53], [419]
PF-06427878 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Diacylglycerol O-acyltransferase 2 (DGAT2) is a therapeutic target for PF-06427878. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PF-06427878 through regulating the expression of Diacylglycerol O-acyltransferase 2 (DGAT2). [53], [420]
DNA repair protein RAD51 homolog 1 (RAD51)
CYT-0851 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary DNA repair protein RAD51 homolog 1 (RAD51) is a therapeutic target for CYT-0851. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CYT-0851 through regulating the expression of DNA repair protein RAD51 homolog 1 (RAD51). [210], [421]
AMP-PNP [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary DNA repair protein RAD51 homolog 1 (RAD51) is a therapeutic target for AMP-PNP. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AMP-PNP through regulating the expression of DNA repair protein RAD51 homolog 1 (RAD51). [421], [422]
DNA-binding factor KBF1 (p105)
CAT 1004 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary DNA-binding factor KBF1 (p105) is a therapeutic target for CAT 1004. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CAT 1004 through regulating the expression of DNA-binding factor KBF1 (p105). [423], [424]
P54 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary DNA-binding factor KBF1 (p105) is a therapeutic target for P54. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of P54 through regulating the expression of DNA-binding factor KBF1 (p105). [423], [425]
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A)
KH-CB19 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) is a therapeutic target for KH-CB19. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of KH-CB19 through regulating the expression of Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A). [426], [427]
leucettine L41 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) is a therapeutic target for leucettine L41. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of leucettine L41 through regulating the expression of Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A). [426], [428]
ML315 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) is a therapeutic target for ML315. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ML315 through regulating the expression of Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A). [426], [429]
WO2013026806C72 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) is a therapeutic target for WO2013026806C72 . The Methyltransferase-like 3 (METTL3) has potential in affecting the response of WO2013026806C72 through regulating the expression of Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A). [426], [428]
DUSP5 messenger RNA (DUSP5 mRNA)
ISIS 133206 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary DUSP5 messenger RNA (DUSP5 mRNA) is a therapeutic target for ISIS 133206. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 133206 through regulating the expression of DUSP5 messenger RNA (DUSP5 mRNA). [430], [431]
ISIS 133207 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary DUSP5 messenger RNA (DUSP5 mRNA) is a therapeutic target for ISIS 133207. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 133207 through regulating the expression of DUSP5 messenger RNA (DUSP5 mRNA). [430], [431]
ISIS 133208 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary DUSP5 messenger RNA (DUSP5 mRNA) is a therapeutic target for ISIS 133208. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 133208 through regulating the expression of DUSP5 messenger RNA (DUSP5 mRNA). [430], [431]
ISIS 133211 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary DUSP5 messenger RNA (DUSP5 mRNA) is a therapeutic target for ISIS 133211. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 133211 through regulating the expression of DUSP5 messenger RNA (DUSP5 mRNA). [430], [431]
ISIS 133242 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary DUSP5 messenger RNA (DUSP5 mRNA) is a therapeutic target for ISIS 133242. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 133242 through regulating the expression of DUSP5 messenger RNA (DUSP5 mRNA). [430], [431]
ISIS 133243 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary DUSP5 messenger RNA (DUSP5 mRNA) is a therapeutic target for ISIS 133243. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 133243 through regulating the expression of DUSP5 messenger RNA (DUSP5 mRNA). [430], [431]
ISIS 133244 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary DUSP5 messenger RNA (DUSP5 mRNA) is a therapeutic target for ISIS 133244. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 133244 through regulating the expression of DUSP5 messenger RNA (DUSP5 mRNA). [430], [431]
ISIS 133245 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary DUSP5 messenger RNA (DUSP5 mRNA) is a therapeutic target for ISIS 133245. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 133245 through regulating the expression of DUSP5 messenger RNA (DUSP5 mRNA). [430], [432]
E2F transcription factor 1 (E2F1)
ARQ-171 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary E2F transcription factor 1 (E2F1) is a therapeutic target for ARQ-171. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ARQ-171 through regulating the expression of E2F transcription factor 1 (E2F1). [433], [434]
ISIS 113019 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary E2F transcription factor 1 (E2F1) is a therapeutic target for ISIS 113019. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 113019 through regulating the expression of E2F transcription factor 1 (E2F1). [433], [435]
ISIS 113020 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary E2F transcription factor 1 (E2F1) is a therapeutic target for ISIS 113020. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 113020 through regulating the expression of E2F transcription factor 1 (E2F1). [433], [435]
ISIS 113021 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary E2F transcription factor 1 (E2F1) is a therapeutic target for ISIS 113021. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 113021 through regulating the expression of E2F transcription factor 1 (E2F1). [433], [435]
ISIS 113022 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary E2F transcription factor 1 (E2F1) is a therapeutic target for ISIS 113022. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 113022 through regulating the expression of E2F transcription factor 1 (E2F1). [433], [435]
ISIS 113048 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary E2F transcription factor 1 (E2F1) is a therapeutic target for ISIS 113048. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 113048 through regulating the expression of E2F transcription factor 1 (E2F1). [433], [436]
EIF4E messenger RNA (EIF4E mRNA)
7-Methyl-Gpppa [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary EIF4E messenger RNA (EIF4E mRNA) is a therapeutic target for 7-Methyl-Gpppa. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-Methyl-Gpppa through regulating the expression of EIF4E messenger RNA (EIF4E mRNA). [210], [437]
7-Methyl-Guanosine-5'-Triphosphate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary EIF4E messenger RNA (EIF4E mRNA) is a therapeutic target for 7-Methyl-Guanosine-5'-Triphosphate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-Methyl-Guanosine-5'-Triphosphate through regulating the expression of EIF4E messenger RNA (EIF4E mRNA). [210], [437]
7n-Methyl-8-Hydroguanosine-5'-Diphosphate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary EIF4E messenger RNA (EIF4E mRNA) is a therapeutic target for 7n-Methyl-8-Hydroguanosine-5'-Diphosphate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7n-Methyl-8-Hydroguanosine-5'-Diphosphate through regulating the expression of EIF4E messenger RNA (EIF4E mRNA). [437], [438]
Endoplasmic reticulum chaperone BiP (HSPA5)
IT-139 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Endoplasmic reticulum chaperone BiP (HSPA5) is a therapeutic target for IT-139. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of IT-139 through regulating the expression of Endoplasmic reticulum chaperone BiP (HSPA5). [439], [440]
NKP-1339 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Endoplasmic reticulum chaperone BiP (HSPA5) is a therapeutic target for NKP-1339. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NKP-1339 through regulating the expression of Endoplasmic reticulum chaperone BiP (HSPA5). [439], [441]
SAM-6 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Endoplasmic reticulum chaperone BiP (HSPA5) is a therapeutic target for SAM-6. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SAM-6 through regulating the expression of Endoplasmic reticulum chaperone BiP (HSPA5). [439], [442]
Enhancer of zeste homolog 2 (EZH2)
Tazemetostat [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Enhancer of zeste homolog 2 (EZH2) is a therapeutic target for Tazemetostat. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tazemetostat through regulating the expression of Enhancer of zeste homolog 2 (EZH2). [443], [444]
CPI-0209 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Enhancer of zeste homolog 2 (EZH2) is a therapeutic target for CPI-0209. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CPI-0209 through regulating the expression of Enhancer of zeste homolog 2 (EZH2). [443], [445]
CPI-1205 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Enhancer of zeste homolog 2 (EZH2) is a therapeutic target for CPI-1205. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CPI-1205 through regulating the expression of Enhancer of zeste homolog 2 (EZH2). [443], [446]
DS-3201b [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Enhancer of zeste homolog 2 (EZH2) is a therapeutic target for DS-3201b. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of DS-3201b through regulating the expression of Enhancer of zeste homolog 2 (EZH2). [443], [447]
SHR2554 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Enhancer of zeste homolog 2 (EZH2) is a therapeutic target for SHR2554. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SHR2554 through regulating the expression of Enhancer of zeste homolog 2 (EZH2). [443], [448]
DS-3201 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Enhancer of zeste homolog 2 (EZH2) is a therapeutic target for DS-3201. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of DS-3201 through regulating the expression of Enhancer of zeste homolog 2 (EZH2). [443], [449]
GSK2816126 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Enhancer of zeste homolog 2 (EZH2) is a therapeutic target for GSK2816126. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GSK2816126 through regulating the expression of Enhancer of zeste homolog 2 (EZH2). [5], [443]
HH2853 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Enhancer of zeste homolog 2 (EZH2) is a therapeutic target for HH2853. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HH2853 through regulating the expression of Enhancer of zeste homolog 2 (EZH2). [5], [443]
PF-06821497 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Enhancer of zeste homolog 2 (EZH2) is a therapeutic target for PF-06821497. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PF-06821497 through regulating the expression of Enhancer of zeste homolog 2 (EZH2). [443], [450]
EI1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Enhancer of zeste homolog 2 (EZH2) is a therapeutic target for EI1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of EI1 through regulating the expression of Enhancer of zeste homolog 2 (EZH2). [443], [451]
EPZ005687 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Enhancer of zeste homolog 2 (EZH2) is a therapeutic target for EPZ005687. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of EPZ005687 through regulating the expression of Enhancer of zeste homolog 2 (EZH2). [443], [452]
GSK343 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Enhancer of zeste homolog 2 (EZH2) is a therapeutic target for GSK343. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GSK343 through regulating the expression of Enhancer of zeste homolog 2 (EZH2). [443], [453]
MS1943 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Enhancer of zeste homolog 2 (EZH2) is a therapeutic target for MS1943. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MS1943 through regulating the expression of Enhancer of zeste homolog 2 (EZH2). [443], [454]
UNC1999 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Enhancer of zeste homolog 2 (EZH2) is a therapeutic target for UNC1999. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of UNC1999 through regulating the expression of Enhancer of zeste homolog 2 (EZH2). [443], [455]
Ephrin type-A receptor 2 (EPHA2)
BT5528 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-A receptor 2 (EPHA2) is a therapeutic target for BT5528. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BT5528 through regulating the expression of Ephrin type-A receptor 2 (EPHA2). [456], [457]
CAR-T cells targeting EphA2 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-A receptor 2 (EPHA2) is a therapeutic target for CAR-T cells targeting EphA2. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CAR-T cells targeting EphA2 through regulating the expression of Ephrin type-A receptor 2 (EPHA2). [456], [458]
DS-8895 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-A receptor 2 (EPHA2) is a therapeutic target for DS-8895. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of DS-8895 through regulating the expression of Ephrin type-A receptor 2 (EPHA2). [456], [459]
MEDI-547 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-A receptor 2 (EPHA2) is a therapeutic target for MEDI-547. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MEDI-547 through regulating the expression of Ephrin type-A receptor 2 (EPHA2). [456], [460]
MEDI-543 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-A receptor 2 (EPHA2) is a therapeutic target for MEDI-543. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MEDI-543 through regulating the expression of Ephrin type-A receptor 2 (EPHA2). [456], [461]
AMP-PNP [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-A receptor 2 (EPHA2) is a therapeutic target for AMP-PNP. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AMP-PNP through regulating the expression of Ephrin type-A receptor 2 (EPHA2). [456], [462]
Ephrin type-A receptor 3 (EPHA3)
Ifabotuzumab [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-A receptor 3 (EPHA3) is a therapeutic target for Ifabotuzumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ifabotuzumab through regulating the expression of Ephrin type-A receptor 3 (EPHA3). [434], [463]
KB-004 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-A receptor 3 (EPHA3) is a therapeutic target for KB-004. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of KB-004 through regulating the expression of Ephrin type-A receptor 3 (EPHA3). [435], [463]
Ephrin type-B receptor 2 (EPHB2)
BVD-523 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-B receptor 2 (EPHB2) is a therapeutic target for BVD-523. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BVD-523 through regulating the expression of Ephrin type-B receptor 2 (EPHB2). [464], [465]
SEphB4-HSA [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-B receptor 2 (EPHB2) is a therapeutic target for SEphB4-HSA. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SEphB4-HSA through regulating the expression of Ephrin type-B receptor 2 (EPHB2). [464], [466]
KO-947 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-B receptor 2 (EPHB2) is a therapeutic target for KO-947. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of KO-947 through regulating the expression of Ephrin type-B receptor 2 (EPHB2). [5], [464]
MK-8353 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-B receptor 2 (EPHB2) is a therapeutic target for MK-8353. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MK-8353 through regulating the expression of Ephrin type-B receptor 2 (EPHB2). [5], [464]
AMP-PNP [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-B receptor 2 (EPHB2) is a therapeutic target for AMP-PNP. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AMP-PNP through regulating the expression of Ephrin type-B receptor 2 (EPHB2). [464], [467]
SNEWIQPRLPQH [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-B receptor 2 (EPHB2) is a therapeutic target for SNEWIQPRLPQH. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SNEWIQPRLPQH through regulating the expression of Ephrin type-B receptor 2 (EPHB2). [5], [464]
Epidermal growth factor (EGF)
Epidermal growth factor [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor (EGF) is a therapeutic target for Epidermal growth factor. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Epidermal growth factor through regulating the expression of Epidermal growth factor (EGF). [421], [468]
Hebervis [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor (EGF) is a therapeutic target for Hebervis. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Hebervis through regulating the expression of Epidermal growth factor (EGF). [421], [469]
Epidermal growth factor receptor (EGFR)
Afatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Afatinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Afatinib through regulating the expression of Epidermal growth factor receptor (EGFR). [241], [470]
Cetuximab [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Cetuximab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cetuximab through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [471]
Dacomitinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Dacomitinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dacomitinib through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [472]
Epidermal growth factor [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Epidermal growth factor. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Epidermal growth factor through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [473]
HEGF [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for HEGF. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HEGF through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [474]
Icotinib hydrochloride [Registered]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Icotinib hydrochloride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Icotinib hydrochloride through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [475]
Lapatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Lapatinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lapatinib through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [476]
Merimepodib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Merimepodib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Merimepodib through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [477]
Necitumumab [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Necitumumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Necitumumab through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [478]
NERATINIB MALEATE [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for NERATINIB MALEATE. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NERATINIB MALEATE through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [479]
Nitroglycerin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Nitroglycerin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nitroglycerin through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [477]
Panitumumab [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Panitumumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Panitumumab through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [480]
SKI-758 [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for SKI-758. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SKI-758 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
Vandetanib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Vandetanib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Vandetanib through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [482]
AC0010 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for AC0010. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AC0010 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [483]
Almonertinib [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Almonertinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Almonertinib through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [484]
Amivantamab [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Amivantamab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Amivantamab through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [485]
ASP1929 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for ASP1929. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ASP1929 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [486]
CO-1686 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for CO-1686. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CO-1686 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
DE-766 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for DE-766. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of DE-766 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [487]
EGF816 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for EGF816. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of EGF816 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
HKI-272 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for HKI-272. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HKI-272 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [488]
Indium-111 [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Indium-111. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Indium-111 through regulating the expression of Epidermal growth factor receptor (EGFR). [214], [470]
Rindopepimut [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Rindopepimut. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Rindopepimut through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [489]
SYM-004 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for SYM-004. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SYM-004 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [490]
Varlitinib [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Varlitinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Varlitinib through regulating the expression of Epidermal growth factor receptor (EGFR). [29], [470]
Zalutumumab [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Zalutumumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Zalutumumab through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [472]
ABT-414 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for ABT-414. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ABT-414 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [471]
ABX-EGF [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for ABX-EGF. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ABX-EGF through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [491]
AFM24 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for AFM24. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AFM24 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [492]
ASP8273 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for ASP8273. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ASP8273 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [493]
BDTX-189 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for BDTX-189. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BDTX-189 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [494]
BMS-599626 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for BMS-599626. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BMS-599626 through regulating the expression of Epidermal growth factor receptor (EGFR). [241], [470]
BMS-690514 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for BMS-690514. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BMS-690514 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [489]
CART-EGFR [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for CART-EGFR. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CART-EGFR through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [495]
CetuGEX [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for CetuGEX. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CetuGEX through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [496]
CI-1033 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for CI-1033. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CI-1033 through regulating the expression of Epidermal growth factor receptor (EGFR). [5], [470]
CK-101 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for CK-101. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CK-101 through regulating the expression of Epidermal growth factor receptor (EGFR). [5], [470]
Depatuxizumab [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Depatuxizumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Depatuxizumab through regulating the expression of Epidermal growth factor receptor (EGFR). [5], [470]
EGFR antisense DNA [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for EGFR antisense DNA. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of EGFR antisense DNA through regulating the expression of Epidermal growth factor receptor (EGFR). [5], [470]
EGFR CART [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for EGFR CART. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of EGFR CART through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [497]
EMB-01 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for EMB-01. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of EMB-01 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [498]
EMD 55900 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for EMD 55900. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of EMD 55900 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [499]
HER1-VSSP vaccine [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for HER1-VSSP vaccine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HER1-VSSP vaccine through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [500]
HM-78136B [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for HM-78136B. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HM-78136B through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [501]
Matuzumab [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Matuzumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Matuzumab through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [502]
MEHD-7945A [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for MEHD-7945A. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MEHD-7945A through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [503]
Pelitinib [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Pelitinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pelitinib through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [504]
RM-1929 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for RM-1929. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RM-1929 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [505]
SN-32793 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for SN-32793. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SN-32793 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [506]
Sym013 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Sym013. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sym013 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [507]
Sym015 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Sym015. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sym015 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [497]
Tarloxotinib [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Tarloxotinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tarloxotinib through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [508]
TT-100 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for TT-100. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TT-100 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [509]
VATALANIB [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for VATALANIB. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of VATALANIB through regulating the expression of Epidermal growth factor receptor (EGFR). [214], [470]
ZN-e4 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for ZN-e4. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ZN-e4 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [510]
AMG 595 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for AMG 595. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AMG 595 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [511]
Anti-EGFR CAR T [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Anti-EGFR CAR T. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Anti-EGFR CAR T through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [512]
AP32788 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for AP32788. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AP32788 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [513]
AST-1306 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for AST-1306. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AST-1306 through regulating the expression of Epidermal growth factor receptor (EGFR). [214], [470]
BCA101 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for BCA101. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BCA101 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [514]
BIBX-1382 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for BIBX-1382. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BIBX-1382 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [515]
Cipatinib [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Cipatinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cipatinib through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [516]
CLN-081 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for CLN-081. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CLN-081 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [517]
CUDC-101 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for CUDC-101. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CUDC-101 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [518]
D2C7 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for D2C7. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of D2C7 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [519]
EGFR806-specific CAR T cell [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for EGFR806-specific CAR T cell. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of EGFR806-specific CAR T cell through regulating the expression of Epidermal growth factor receptor (EGFR). [414], [470]
IMGN289 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for IMGN289. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of IMGN289 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
JNJ-26483327 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for JNJ-26483327. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of JNJ-26483327 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [520]
LY3164530 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for LY3164530. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of LY3164530 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [521]
MCLA-158 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for MCLA-158. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MCLA-158 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [522]
MM-151 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for MM-151. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MM-151 through regulating the expression of Epidermal growth factor receptor (EGFR). [5], [470]
MR1-1 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for MR1-1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MR1-1 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [523]
PF-05230907 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for PF-05230907. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PF-05230907 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [497]
Pyrotinib [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Pyrotinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pyrotinib through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [524]
S-222611 [Phase 1b]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for S-222611. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of S-222611 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
SI-B001 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for SI-B001. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SI-B001 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [525]
SYN004 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for SYN004. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SYN004 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [497]
111In-hEGF [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 111In-hEGF. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 111In-hEGF through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [526]
(3-Bromo-phenyl)-(5-nitro-quinazolin-4-yl)-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for (3-Bromo-phenyl)-(5-nitro-quinazolin-4-yl)-amine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (3-Bromo-phenyl)-(5-nitro-quinazolin-4-yl)-amine through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [527]
(3-Bromo-phenyl)-quinazolin-4-yl-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for (3-Bromo-phenyl)-quinazolin-4-yl-amine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (3-Bromo-phenyl)-quinazolin-4-yl-amine through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [528]
(E)-5-(4-Hydroxybenzylidene)-1-phenethylhydantoin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for (E)-5-(4-Hydroxybenzylidene)-1-phenethylhydantoin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (E)-5-(4-Hydroxybenzylidene)-1-phenethylhydantoin through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [529]
(S)-benzyl 4-chloro-3-oxobutan-2-ylcarbamate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for (S)-benzyl 4-chloro-3-oxobutan-2-ylcarbamate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (S)-benzyl 4-chloro-3-oxobutan-2-ylcarbamate through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [527]
10-hydroxy-18-methoxybetaenone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 10-hydroxy-18-methoxybetaenone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 10-hydroxy-18-methoxybetaenone through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [527]
2-(4,5-Dihydroxy-indan-1-ylidene)-malononitrile [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 2-(4,5-Dihydroxy-indan-1-ylidene)-malononitrile. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(4,5-Dihydroxy-indan-1-ylidene)-malononitrile through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [530]
2-(5,6-Dihydroxy-indan-1-ylidene)-malononitrile [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 2-(5,6-Dihydroxy-indan-1-ylidene)-malononitrile. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(5,6-Dihydroxy-indan-1-ylidene)-malononitrile through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [531]
2-benzoyl-3-(3,4-dihydroxyphenyl)acrylonitrile [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 2-benzoyl-3-(3,4-dihydroxyphenyl)acrylonitrile. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-benzoyl-3-(3,4-dihydroxyphenyl)acrylonitrile through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [527]
2-cyano-3-(3,4-dihydroxyphenyl)acrylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 2-cyano-3-(3,4-dihydroxyphenyl)acrylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-cyano-3-(3,4-dihydroxyphenyl)acrylamide through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [527]
2-methoxy-4-(2-nitrovinyl)phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 2-methoxy-4-(2-nitrovinyl)phenol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-methoxy-4-(2-nitrovinyl)phenol through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [527]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione through regulating the expression of Epidermal growth factor receptor (EGFR). [7], [470]
3,4-diphenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 3,4-diphenyl-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3,4-diphenyl-1H-pyrrole-2,5-dione through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [532]
3-(3-Chloro-phenyl)-5,7-dihydroxy-chromen-4-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 3-(3-Chloro-phenyl)-5,7-dihydroxy-chromen-4-one. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(3-Chloro-phenyl)-5,7-dihydroxy-chromen-4-one through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [533]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [534]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [535]
3-Pyridin-4-yl-quinoline-6,7-diol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 3-Pyridin-4-yl-quinoline-6,7-diol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-Pyridin-4-yl-quinoline-6,7-diol through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [536]
4-(2-nitroprop-1-enyl)benzene-1,2-diol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 4-(2-nitroprop-1-enyl)benzene-1,2-diol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(2-nitroprop-1-enyl)benzene-1,2-diol through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [527]
4-(2-nitrovinyl)benzene-1,2-diol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 4-(2-nitrovinyl)benzene-1,2-diol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(2-nitrovinyl)benzene-1,2-diol through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [537]
4-(2-nitrovinyl)phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 4-(2-nitrovinyl)phenol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(2-nitrovinyl)phenol through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [527]
4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinazoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinazoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinazoline through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [538]
4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinoline through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [528]
4-(4-(2-nitrovinyl)phenoxysulfonyl)benzoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 4-(4-(2-nitrovinyl)phenoxysulfonyl)benzoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(4-(2-nitrovinyl)phenoxysulfonyl)benzoic acid through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [527]
4-(5-Bromoindole-3-yl)-6,7-dimethoxyquinazoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 4-(5-Bromoindole-3-yl)-6,7-dimethoxyquinazoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(5-Bromoindole-3-yl)-6,7-dimethoxyquinazoline through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [539]
4-acrylamido-N-(3-bromophenyl)-2-hydroxybenzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 4-acrylamido-N-(3-bromophenyl)-2-hydroxybenzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-acrylamido-N-(3-bromophenyl)-2-hydroxybenzamide through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [540]
4-biphenyl-2-ylethynyl-6,7-dimethoxy-quinazoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 4-biphenyl-2-ylethynyl-6,7-dimethoxy-quinazoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-biphenyl-2-ylethynyl-6,7-dimethoxy-quinazoline through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [541]
4557W [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 4557W. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4557W through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [542]
5,6-Bis-p-tolylamino-isoindole-1,3-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 5,6-Bis-p-tolylamino-isoindole-1,3-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5,6-Bis-p-tolylamino-isoindole-1,3-dione through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [543]
5-acrylamido-N-(3-bromophenyl)-2-hydroxybenzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 5-acrylamido-N-(3-bromophenyl)-2-hydroxybenzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-acrylamido-N-(3-bromophenyl)-2-hydroxybenzamide through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [544]
6,7-diethoxy-4-(4-phenylbut-1-enyl)quinazoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 6,7-diethoxy-4-(4-phenylbut-1-enyl)quinazoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-diethoxy-4-(4-phenylbut-1-enyl)quinazoline through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [541]
6,7-diethoxy-4-(5-phenylpent-1-enyl)quinazoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 6,7-diethoxy-4-(5-phenylpent-1-enyl)quinazoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-diethoxy-4-(5-phenylpent-1-enyl)quinazoline through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [541]
6,7-diethoxy-4-styrylquinazoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 6,7-diethoxy-4-styrylquinazoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-diethoxy-4-styrylquinazoline through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [541]
6,7-dimethoxy-4-(2-phenylethynyl)quinazoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 6,7-dimethoxy-4-(2-phenylethynyl)quinazoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-dimethoxy-4-(2-phenylethynyl)quinazoline through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [541]
6,7-dimethoxy-4-(3-phenoxyprop-1-ynyl)quinazoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 6,7-dimethoxy-4-(3-phenoxyprop-1-ynyl)quinazoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-dimethoxy-4-(3-phenoxyprop-1-ynyl)quinazoline through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [541]
6,7-dimethoxy-4-(4-phenylbut-1-ynyl)quinazoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 6,7-dimethoxy-4-(4-phenylbut-1-ynyl)quinazoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-dimethoxy-4-(4-phenylbut-1-ynyl)quinazoline through regulating the expression of Epidermal growth factor receptor (EGFR). [22], [470]
6,7-dimethoxy-N-m-tolylquinazolin-4-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 6,7-dimethoxy-N-m-tolylquinazolin-4-amine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-dimethoxy-N-m-tolylquinazolin-4-amine through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [534]
6-chloro-N-(3-chlorophenyl)quinazolin-4-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for 6-chloro-N-(3-chlorophenyl)quinazolin-4-amine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6-chloro-N-(3-chlorophenyl)quinazolin-4-amine through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [534]
AFM-21 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for AFM-21. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AFM-21 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
AG 112 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for AG 112. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AG 112 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [545]
AG 9 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for AG 9. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AG 9 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
AG-213 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for AG-213. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AG-213 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [527]
AG-538 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for AG-538. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AG-538 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [546]
AG1478 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for AG1478. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AG1478 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [547]
AGT-2000 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for AGT-2000. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AGT-2000 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
AL-6802 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for AL-6802. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AL-6802 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
Anti-EGFR humanized mabs [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Anti-EGFR humanized mabs. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Anti-EGFR humanized mabs through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
Anti-EGFR mab [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Anti-EGFR mab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Anti-EGFR mab through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
ARX-AHD [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for ARX-AHD. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ARX-AHD through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
Benzo[g]quinazolin-4-yl-(3-bromo-phenyl)-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Benzo[g]quinazolin-4-yl-(3-bromo-phenyl)-amine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Benzo[g]quinazolin-4-yl-(3-bromo-phenyl)-amine through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [538]
Benzyl-quinazolin-4-yl-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Benzyl-quinazolin-4-yl-amine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Benzyl-quinazolin-4-yl-amine through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [539]
Bmab-200 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Bmab-200. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Bmab-200 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
BPIQ-I [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for BPIQ-I. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BPIQ-I through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [548]
CL-387785 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for CL-387785. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CL-387785 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [540]
Cochliobolic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Cochliobolic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cochliobolic acid through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [549]
EDP-13 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for EDP-13. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of EDP-13 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
EGFR inhibitor [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for EGFR inhibitor. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of EGFR inhibitor through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [550]
Epitinib [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Epitinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Epitinib through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
FHT-2107 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for FHT-2107. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of FHT-2107 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
GI-3000 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for GI-3000. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GI-3000 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
HDS-029 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for HDS-029. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HDS-029 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [551]
HKI-9924129 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for HKI-9924129. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HKI-9924129 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [552]
HM-61713B [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for HM-61713B. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HM-61713B through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
HTS-00213 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for HTS-00213. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HTS-00213 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [534]
HTS-02876 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for HTS-02876. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HTS-02876 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [553]
HTS-05058 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for HTS-05058. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HTS-05058 through regulating the expression of Epidermal growth factor receptor (EGFR). [7], [470]
ICR 62 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for ICR 62. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ICR 62 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [554]
IPS-01003 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for IPS-01003. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of IPS-01003 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
LA22-radioimmunoconjugates [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for LA22-radioimmunoconjugates. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of LA22-radioimmunoconjugates through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
LAVENDUSTIN A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for LAVENDUSTIN A. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of LAVENDUSTIN A through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [541]
mabionHER2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for mabionHER2. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of mabionHER2 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
MDP-01 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for MDP-01. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MDP-01 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
MG-111 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for MG-111. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MG-111 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [555]
MT-062 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for MT-062. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MT-062 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
N*4*-(3-Bromo-phenyl)-quinazoline-4,6,7-triamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for N*4*-(3-Bromo-phenyl)-quinazoline-4,6,7-triamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N*4*-(3-Bromo-phenyl)-quinazoline-4,6,7-triamine through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [556]
N*4*-(3-Bromo-phenyl)-quinazoline-4,6-diamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for N*4*-(3-Bromo-phenyl)-quinazoline-4,6-diamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N*4*-(3-Bromo-phenyl)-quinazoline-4,6-diamine through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [557]
N*4*-(3-Bromo-phenyl)-quinazoline-4,7-diamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for N*4*-(3-Bromo-phenyl)-quinazoline-4,7-diamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N*4*-(3-Bromo-phenyl)-quinazoline-4,7-diamine through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [558]
N*4*-Benzyl-pyrido[4,3-d]pyrimidine-4,7-diamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for N*4*-Benzyl-pyrido[4,3-d]pyrimidine-4,7-diamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N*4*-Benzyl-pyrido[4,3-d]pyrimidine-4,7-diamine through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [546]
N-(4-(phenylamino)quinazolin-6-yl)acrylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for N-(4-(phenylamino)quinazolin-6-yl)acrylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(4-(phenylamino)quinazolin-6-yl)acrylamide through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [554]
N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [530]
N-(4-m-Tolylamino-quinazolin-7-yl)-acrylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for N-(4-m-Tolylamino-quinazolin-7-yl)-acrylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(4-m-Tolylamino-quinazolin-7-yl)-acrylamide through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [528]
N4-(3-chlorophenyl)quinazoline-4,6-diamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for N4-(3-chlorophenyl)quinazoline-4,6-diamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N4-(3-chlorophenyl)quinazoline-4,6-diamine through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [556]
N4-(3-methylphenyl)-4,6-quinazolinediamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for N4-(3-methylphenyl)-4,6-quinazolinediamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N4-(3-methylphenyl)-4,6-quinazolinediamine through regulating the expression of Epidermal growth factor receptor (EGFR). [7], [470]
NRC-2694 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for NRC-2694. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NRC-2694 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
ON-128 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for ON-128. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ON-128 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [528]
OSI-75 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for OSI-75. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of OSI-75 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [559]
PD-0166326 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for PD-0166326. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PD-0166326 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [529]
PD-0173956 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for PD-0173956. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PD-0173956 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [529]
PD-158780 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for PD-158780. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PD-158780 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [528]
PD-168393 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for PD-168393. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PD-168393 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [558]
PD182905 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for PD182905. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PD182905 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [506]
PF 5208766 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for PF 5208766. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PF 5208766 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [560]
PP121 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for PP121. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PP121 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [561]
RG-50810 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for RG-50810. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RG-50810 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [553]
RM-6427 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for RM-6427. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RM-6427 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
Ro-4396686 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Ro-4396686. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ro-4396686 through regulating the expression of Epidermal growth factor receptor (EGFR). [7], [470]
RX-1792 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for RX-1792. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RX-1792 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
SYM-011 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for SYM-011. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SYM-011 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
TGF alpha [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for TGF alpha. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TGF alpha through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
Theliatinib [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Theliatinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Theliatinib through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [562]
WHI-P154 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for WHI-P154. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of WHI-P154 through regulating the expression of Epidermal growth factor receptor (EGFR). [22], [470]
WZ-3146 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for WZ-3146. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of WZ-3146 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [481]
AZD-9935 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for AZD-9935. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AZD-9935 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [563]
AZD4769 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for AZD4769. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AZD4769 through regulating the expression of Epidermal growth factor receptor (EGFR). [241], [470]
CGP-52411 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for CGP-52411. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CGP-52411 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [564]
CGP-53353 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for CGP-53353. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CGP-53353 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [506]
Heparin-EGF-like factor [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for Heparin-EGF-like factor. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Heparin-EGF-like factor through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [565]
PD-153035 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for PD-153035. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PD-153035 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [566]
PKI166 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for PKI166. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PKI166 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [567]
RG7160 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for RG7160. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RG7160 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [568]
TAK165 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Epidermal growth factor receptor (EGFR) is a therapeutic target for TAK165. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TAK165 through regulating the expression of Epidermal growth factor receptor (EGFR). [470], [569]
Extracellular matrix receptor III (CD44)
A-6 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Extracellular matrix receptor III (CD44) is a therapeutic target for A-6. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of A-6 through regulating the expression of Extracellular matrix receptor III (CD44). [570], [571]
SPL-108 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Extracellular matrix receptor III (CD44) is a therapeutic target for SPL-108. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SPL-108 through regulating the expression of Extracellular matrix receptor III (CD44). [570], [572]
BIWA 4 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Extracellular matrix receptor III (CD44) is a therapeutic target for BIWA 4. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BIWA 4 through regulating the expression of Extracellular matrix receptor III (CD44). [570], [573]
Bivatuzumab mertansine [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Extracellular matrix receptor III (CD44) is a therapeutic target for Bivatuzumab mertansine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Bivatuzumab mertansine through regulating the expression of Extracellular matrix receptor III (CD44). [570], [574]
Fatty acid synthase (FASN)
Cerulenin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for Cerulenin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cerulenin through regulating the expression of Fatty acid synthase (FASN). [53], [575]
TVB-2640 [Phase 2]
In total 2 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for TVB-2640. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TVB-2640 through regulating the expression of Fatty acid synthase (FASN). [53], [576]
Fatty acid synthase (FASN) is a therapeutic target for TVB-2640. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TVB-2640 through regulating the expression of Fatty acid synthase (FASN). [53], [577]
FAS1 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for FAS1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of FAS1 through regulating the expression of Fatty acid synthase (FASN). [53], [575]
FSA2 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for FSA2. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of FSA2 through regulating the expression of Fatty acid synthase (FASN). [53], [578]
(-)-CATECHINGALLATE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for (-)-CATECHINGALLATE. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (-)-CATECHINGALLATE through regulating the expression of Fatty acid synthase (FASN). [53], [579]
2-Hexadecynoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for 2-Hexadecynoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-Hexadecynoic acid through regulating the expression of Fatty acid synthase (FASN). [53], [575]
3,7,3',4'-TETRAHYDROXYFLAVONE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for 3,7,3',4'-TETRAHYDROXYFLAVONE. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3,7,3',4'-TETRAHYDROXYFLAVONE through regulating the expression of Fatty acid synthase (FASN). [53], [577]
4-hydroxy-6-nitro-3-phenylquinolin-2(1H)-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for 4-hydroxy-6-nitro-3-phenylquinolin-2(1H)-one. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-hydroxy-6-nitro-3-phenylquinolin-2(1H)-one through regulating the expression of Fatty acid synthase (FASN). [53], [577]
4-hydroxy-8-nitro-3-phenylquinolin-2(1H)-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for 4-hydroxy-8-nitro-3-phenylquinolin-2(1H)-one. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-hydroxy-8-nitro-3-phenylquinolin-2(1H)-one through regulating the expression of Fatty acid synthase (FASN). [53], [580]
Anti-Fas mabs [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for Anti-Fas mabs. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Anti-Fas mabs through regulating the expression of Fatty acid synthase (FASN). [53], [581]
biochanin A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for biochanin A. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of biochanin A through regulating the expression of Fatty acid synthase (FASN). [53], [577]
C75 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for C75. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C75 through regulating the expression of Fatty acid synthase (FASN). [53], [577]
FAS-031 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for FAS-031. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of FAS-031 through regulating the expression of Fatty acid synthase (FASN). [53], [581]
GALLOCATECHIN GALLATE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for GALLOCATECHIN GALLATE. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GALLOCATECHIN GALLATE through regulating the expression of Fatty acid synthase (FASN). [53], [579]
GSK2194069 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for GSK2194069. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GSK2194069 through regulating the expression of Fatty acid synthase (FASN). [53], [582]
MG-28 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for MG-28. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MG-28 through regulating the expression of Fatty acid synthase (FASN). [53], [583]
MORIN [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for MORIN. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MORIN through regulating the expression of Fatty acid synthase (FASN). [53], [577]
MT-061 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Fatty acid synthase (FASN) is a therapeutic target for MT-061. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MT-061 through regulating the expression of Fatty acid synthase (FASN). [53], [581]
Forkhead box protein O1A (FOXO1)
AS-1708727 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for AS-1708727. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AS-1708727 through regulating the expression of Forkhead box protein O1A (FOXO1). [53], [584]
ISIS 188755 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for ISIS 188755. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 188755 through regulating the expression of Forkhead box protein O1A (FOXO1). [53], [585]
ISIS 188757 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for ISIS 188757. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 188757 through regulating the expression of Forkhead box protein O1A (FOXO1). [53], [585]
ISIS 188759 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for ISIS 188759. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 188759 through regulating the expression of Forkhead box protein O1A (FOXO1). [53], [585]
ISIS 188761 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for ISIS 188761. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 188761 through regulating the expression of Forkhead box protein O1A (FOXO1). [53], [585]
ISIS 188763 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for ISIS 188763. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 188763 through regulating the expression of Forkhead box protein O1A (FOXO1). [53], [585]
ISIS 188778 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for ISIS 188778. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 188778 through regulating the expression of Forkhead box protein O1A (FOXO1). [53], [585]
ISIS 188780 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for ISIS 188780. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 188780 through regulating the expression of Forkhead box protein O1A (FOXO1). [53], [585]
ISIS 188781 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for ISIS 188781. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 188781 through regulating the expression of Forkhead box protein O1A (FOXO1). [53], [585]
ISIS 188782 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Forkhead box protein O1A (FOXO1) is a therapeutic target for ISIS 188782. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 188782 through regulating the expression of Forkhead box protein O1A (FOXO1). [53], [586]
G1/S-specific cyclin-D1 (CCND1)
ABT-263 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-D1 (CCND1) is a therapeutic target for ABT-263. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ABT-263 through regulating the expression of G1/S-specific cyclin-D1 (CCND1). [587], [588]
Briciclib [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-D1 (CCND1) is a therapeutic target for Briciclib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Briciclib through regulating the expression of G1/S-specific cyclin-D1 (CCND1). [5], [587]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-D1 (CCND1) is a therapeutic target for 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione through regulating the expression of G1/S-specific cyclin-D1 (CCND1). [7], [587]
3,4-diphenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-D1 (CCND1) is a therapeutic target for 3,4-diphenyl-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3,4-diphenyl-1H-pyrrole-2,5-dione through regulating the expression of G1/S-specific cyclin-D1 (CCND1). [7], [587]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-D1 (CCND1) is a therapeutic target for 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione through regulating the expression of G1/S-specific cyclin-D1 (CCND1). [587], [589]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-D1 (CCND1) is a therapeutic target for 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione through regulating the expression of G1/S-specific cyclin-D1 (CCND1). [7], [587]
7-hydroxycoumarin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-D1 (CCND1) is a therapeutic target for 7-hydroxycoumarin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-hydroxycoumarin through regulating the expression of G1/S-specific cyclin-D1 (CCND1). [587], [590]
G1/S-specific cyclin-E1 (CCNE1)
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-E1 (CCNE1) is a therapeutic target for 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione through regulating the expression of G1/S-specific cyclin-E1 (CCNE1). [7], [591]
3,4-diphenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-E1 (CCNE1) is a therapeutic target for 3,4-diphenyl-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3,4-diphenyl-1H-pyrrole-2,5-dione through regulating the expression of G1/S-specific cyclin-E1 (CCNE1). [7], [591]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-E1 (CCNE1) is a therapeutic target for 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione through regulating the expression of G1/S-specific cyclin-E1 (CCNE1). [591], [592]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-E1 (CCNE1) is a therapeutic target for 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione through regulating the expression of G1/S-specific cyclin-E1 (CCNE1). [7], [591]
aloisine A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-E1 (CCNE1) is a therapeutic target for aloisine A. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of aloisine A through regulating the expression of G1/S-specific cyclin-E1 (CCNE1). [590], [591]
BMS 536924 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-E1 (CCNE1) is a therapeutic target for BMS 536924. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BMS 536924 through regulating the expression of G1/S-specific cyclin-E1 (CCNE1). [591], [593]
PD-0183812 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary G1/S-specific cyclin-E1 (CCNE1) is a therapeutic target for PD-0183812. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PD-0183812 through regulating the expression of G1/S-specific cyclin-E1 (CCNE1). [591], [594]
Glucose transporter type 1 (SLC2A1)
D-glucose [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Glucose transporter type 1 (SLC2A1) is a therapeutic target for D-glucose. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of D-glucose through regulating the expression of Glucose transporter type 1 (SLC2A1). [595], [596]
Quercetin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Glucose transporter type 1 (SLC2A1) is a therapeutic target for Quercetin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Quercetin through regulating the expression of Glucose transporter type 1 (SLC2A1). [595], [597]
2-Deoxyglucose [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Glucose transporter type 1 (SLC2A1) is a therapeutic target for 2-Deoxyglucose. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-Deoxyglucose through regulating the expression of Glucose transporter type 1 (SLC2A1). [595], [598]
WZB-117 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Glucose transporter type 1 (SLC2A1) is a therapeutic target for WZB-117. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of WZB-117 through regulating the expression of Glucose transporter type 1 (SLC2A1). [595], [599]
Arsenite [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glucose transporter type 1 (SLC2A1) is a therapeutic target for Arsenite. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Arsenite through regulating the expression of Glucose transporter type 1 (SLC2A1). [595], [600]
Dehydroascorbic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glucose transporter type 1 (SLC2A1) is a therapeutic target for Dehydroascorbic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dehydroascorbic acid through regulating the expression of Glucose transporter type 1 (SLC2A1). [595], [601]
Heat shock protein 90 alpha (HSP90A)
Amlexanox [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Amlexanox. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Amlexanox through regulating the expression of Heat shock protein 90 alpha (HSP90A). [220], [602]
Cromoglicate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Cromoglicate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cromoglicate through regulating the expression of Heat shock protein 90 alpha (HSP90A). [220], [602]
BIIB-021 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for BIIB-021. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BIIB-021 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [603]
Efungumab [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Efungumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Efungumab through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [604]
KW-2478 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for KW-2478. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of KW-2478 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [605]
NVP-AUY922 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for NVP-AUY922. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NVP-AUY922 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [606]
SNX-5422 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for SNX-5422. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SNX-5422 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [604]
Tanespimycin [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Tanespimycin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tanespimycin through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [607]
VER 50589 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for VER 50589. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of VER 50589 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [608]
Alvespimycin hydrochloride [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Alvespimycin hydrochloride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Alvespimycin hydrochloride through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [609]
AT13387 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for AT13387. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AT13387 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [604]
BIIB 028 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for BIIB 028. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BIIB 028 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [211], [602]
Debio 0932 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Debio 0932. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Debio 0932 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [610]
PU-AD [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for PU-AD. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PU-AD through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [605]
PU3 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for PU3. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PU3 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [611]
RTA-901 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for RTA-901. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RTA-901 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [612]
CCT-018159 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for CCT-018159. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CCT-018159 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [613]
KOS-2484 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for KOS-2484. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of KOS-2484 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [604]
17-desmethoxy-17-aminogeldanamycin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for 17-desmethoxy-17-aminogeldanamycin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 17-desmethoxy-17-aminogeldanamycin through regulating the expression of Heat shock protein 90 alpha (HSP90A). [436], [602]
2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for 2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol through regulating the expression of Heat shock protein 90 alpha (HSP90A). [220], [602]
2-Methyl-2,4-Pentanediol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for 2-Methyl-2,4-Pentanediol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-Methyl-2,4-Pentanediol through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [604]
4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for 4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [604]
6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE through regulating the expression of Heat shock protein 90 alpha (HSP90A). [220], [602]
8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H- [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H-. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H- through regulating the expression of Heat shock protein 90 alpha (HSP90A). [220], [602]
9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for 9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine through regulating the expression of Heat shock protein 90 alpha (HSP90A). [220], [602]
9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for 9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine through regulating the expression of Heat shock protein 90 alpha (HSP90A). [220], [602]
Geldanamycin-estradiol hybrid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Geldanamycin-estradiol hybrid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Geldanamycin-estradiol hybrid through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [614]
GNF-PF-67 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for GNF-PF-67. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GNF-PF-67 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [436], [602]
KOSN1559 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for KOSN1559. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of KOSN1559 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [604]
Macbecin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Macbecin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Macbecin through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [615]
PU24S [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for PU24S. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PU24S through regulating the expression of Heat shock protein 90 alpha (HSP90A). [210], [602]
Radicicol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Radicicol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Radicicol through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [616]
RHEIN [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for RHEIN. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RHEIN through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [617]
SNX-2112 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for SNX-2112. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SNX-2112 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [614]
VER-49009 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for VER-49009. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of VER-49009 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [618]
ZEARALANONE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for ZEARALANONE. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ZEARALANONE through regulating the expression of Heat shock protein 90 alpha (HSP90A). [436], [602]
EC-154 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for EC-154. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of EC-154 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [619]
Geldanamycin [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for Geldanamycin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Geldanamycin through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [620]
HBP-347 [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for HBP-347. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HBP-347 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [621]
IPI-493 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for IPI-493. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of IPI-493 through regulating the expression of Heat shock protein 90 alpha (HSP90A). [602], [622]
Heat shock protein beta-1 (HSPB1)
AZX-100 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein beta-1 (HSPB1) is a therapeutic target for AZX-100. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AZX-100 through regulating the expression of Heat shock protein beta-1 (HSPB1). [623], [624]
SB-242235 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Heat shock protein beta-1 (HSPB1) is a therapeutic target for SB-242235. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SB-242235 through regulating the expression of Heat shock protein beta-1 (HSPB1). [623], [625]
Hepatocyte nuclear factor 1-alpha (HNF1A)
Norleucine [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Hepatocyte nuclear factor 1-alpha (HNF1A) is a therapeutic target for Norleucine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Norleucine through regulating the expression of Hepatocyte nuclear factor 1-alpha (HNF1A). [626], [627]
Herpesvirus ubiquitin-specific protease (HAUSP)
ADC-01 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Herpesvirus ubiquitin-specific protease (HAUSP) is a therapeutic target for ADC-01. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ADC-01 through regulating the expression of Herpesvirus ubiquitin-specific protease (HAUSP). [628], [629]
ADC-03 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Herpesvirus ubiquitin-specific protease (HAUSP) is a therapeutic target for ADC-03. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ADC-03 through regulating the expression of Herpesvirus ubiquitin-specific protease (HAUSP). [628], [630]
HBX19818 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Herpesvirus ubiquitin-specific protease (HAUSP) is a therapeutic target for HBX19818. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HBX19818 through regulating the expression of Herpesvirus ubiquitin-specific protease (HAUSP). [628], [631]
P22077 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Herpesvirus ubiquitin-specific protease (HAUSP) is a therapeutic target for P22077. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of P22077 through regulating the expression of Herpesvirus ubiquitin-specific protease (HAUSP). [628], [632]
Hexokinase-2 (HK2)
VDA-1102 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Hexokinase-2 (HK2) is a therapeutic target for VDA-1102. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of VDA-1102 through regulating the expression of Hexokinase-2 (HK2). [595], [633]
HIF-1 responsive protein RTP801 (DDIT4)
PF-04523655 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary HIF-1 responsive protein RTP801 (DDIT4) is a therapeutic target for PF-04523655. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PF-04523655 through regulating the expression of HIF-1 responsive protein RTP801 (DDIT4). [423], [634]
PF-4523655 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary HIF-1 responsive protein RTP801 (DDIT4) is a therapeutic target for PF-4523655. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PF-4523655 through regulating the expression of HIF-1 responsive protein RTP801 (DDIT4). [423], [635]
Histone deacetylase 2 (HDAC2)
CHR-3996 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for CHR-3996. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CHR-3996 through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [636]
(E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for (E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [637]
1,1,1-Trifluoro-8-(4-phenoxy-phenoxy)-octan-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 1,1,1-Trifluoro-8-(4-phenoxy-phenoxy)-octan-2-one. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 1,1,1-Trifluoro-8-(4-phenoxy-phenoxy)-octan-2-one through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [637]
1,1,1-Trifluoro-8-phenoxy-octan-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 1,1,1-Trifluoro-8-phenoxy-octan-2-one. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 1,1,1-Trifluoro-8-phenoxy-octan-2-one through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [638]
2-(allyloxy)-N8-hydroxy-N1-phenyloctanediamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 2-(allyloxy)-N8-hydroxy-N1-phenyloctanediamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(allyloxy)-N8-hydroxy-N1-phenyloctanediamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [639]
2-(benzyloxy)-N7-hydroxy-N1-phenylheptanediamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 2-(benzyloxy)-N7-hydroxy-N1-phenylheptanediamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(benzyloxy)-N7-hydroxy-N1-phenylheptanediamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [639]
2-(methylsulfonylthio)ethyl 2-propylpentanoate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 2-(methylsulfonylthio)ethyl 2-propylpentanoate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(methylsulfonylthio)ethyl 2-propylpentanoate through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [640]
4-Benzoylamino-N-hydroxy-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 4-Benzoylamino-N-hydroxy-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-Benzoylamino-N-hydroxy-benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [641]
4-Butyrylamino-N-hydroxy-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 4-Butyrylamino-N-hydroxy-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-Butyrylamino-N-hydroxy-benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [642]
4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [643]
4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [642]
4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [644]
4-Phenylbutyrohydroxamic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 4-Phenylbutyrohydroxamic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-Phenylbutyrohydroxamic acid through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [645]
5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [644]
5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [646]
5-(Biphenyl-4-yl)-pentanoic acid N-hydroxyamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 5-(Biphenyl-4-yl)-pentanoic acid N-hydroxyamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-(Biphenyl-4-yl)-pentanoic acid N-hydroxyamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [647]
5-Mercapto-pentanoic acid phenylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 5-Mercapto-pentanoic acid phenylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-Mercapto-pentanoic acid phenylamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [648]
6-(2-Bromo-acetylamino)-hexanoic acid phenylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 6-(2-Bromo-acetylamino)-hexanoic acid phenylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6-(2-Bromo-acetylamino)-hexanoic acid phenylamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [649]
6-benzenesulfinylhexanoic acid hydroxamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 6-benzenesulfinylhexanoic acid hydroxamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6-benzenesulfinylhexanoic acid hydroxamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [650]
6-benzenesulfonylhexanoic acid hydroxamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 6-benzenesulfonylhexanoic acid hydroxamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6-benzenesulfonylhexanoic acid hydroxamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [646]
6-Mercapto-hexanoic acid phenylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 6-Mercapto-hexanoic acid phenylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6-Mercapto-hexanoic acid phenylamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [648]
6-Phenoxy-hexane-1-thiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 6-Phenoxy-hexane-1-thiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6-Phenoxy-hexane-1-thiol through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [648]
6-phenylsulfanylhexanoic acid hydroxamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 6-phenylsulfanylhexanoic acid hydroxamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6-phenylsulfanylhexanoic acid hydroxamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [646]
7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [637]
7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [638]
7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [651]
7-(Biphenyl-4-yloxy)-heptanoic acid hydroxyamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 7-(Biphenyl-4-yloxy)-heptanoic acid hydroxyamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-(Biphenyl-4-yloxy)-heptanoic acid hydroxyamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [638]
7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [637]
7-Biphenyl-4-yl-heptanoic acid hydroxyamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 7-Biphenyl-4-yl-heptanoic acid hydroxyamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-Biphenyl-4-yl-heptanoic acid hydroxyamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [652]
7-Mercapto-heptanoic acid benzothiazol-2-ylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 7-Mercapto-heptanoic acid benzothiazol-2-ylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-Mercapto-heptanoic acid benzothiazol-2-ylamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [648]
7-Mercapto-heptanoic acid biphenyl-3-ylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 7-Mercapto-heptanoic acid biphenyl-3-ylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-Mercapto-heptanoic acid biphenyl-3-ylamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [642]
7-Mercapto-heptanoic acid biphenyl-4-ylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 7-Mercapto-heptanoic acid biphenyl-4-ylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-Mercapto-heptanoic acid biphenyl-4-ylamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [648]
7-Mercapto-heptanoic acid phenylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 7-Mercapto-heptanoic acid phenylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-Mercapto-heptanoic acid phenylamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [648]
7-Mercapto-heptanoic acid pyridin-3-ylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 7-Mercapto-heptanoic acid pyridin-3-ylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-Mercapto-heptanoic acid pyridin-3-ylamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [648]
7-Mercapto-heptanoic acid quinolin-3-ylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 7-Mercapto-heptanoic acid quinolin-3-ylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-Mercapto-heptanoic acid quinolin-3-ylamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [648]
7-Phenoxy-heptanoic acid hydroxyamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 7-Phenoxy-heptanoic acid hydroxyamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-Phenoxy-heptanoic acid hydroxyamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [653]
8-(Biphenyl-3-yloxy)-1,1,1-trifluoro-octan-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 8-(Biphenyl-3-yloxy)-1,1,1-trifluoro-octan-2-one. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 8-(Biphenyl-3-yloxy)-1,1,1-trifluoro-octan-2-one through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [638]
8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [653]
8-(Biphenyl-4-yloxy)-2-oxo-octanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 8-(Biphenyl-4-yloxy)-2-oxo-octanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 8-(Biphenyl-4-yloxy)-2-oxo-octanoic acid through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [654]
8-Mercapto-octanoic acid phenylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 8-Mercapto-octanoic acid phenylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 8-Mercapto-octanoic acid phenylamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [648]
8-Oxo-8-phenyl-octanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 8-Oxo-8-phenyl-octanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 8-Oxo-8-phenyl-octanoic acid through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [644]
8-Oxo-8-phenyl-octanoic acid hydroxyamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 8-Oxo-8-phenyl-octanoic acid hydroxyamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 8-Oxo-8-phenyl-octanoic acid hydroxyamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [655]
8-Phenyl-octanoic acid hydroxyamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 8-Phenyl-octanoic acid hydroxyamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 8-Phenyl-octanoic acid hydroxyamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [653]
9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [644]
9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for 9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [648]
Cyclostellettamine derivative [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for Cyclostellettamine derivative. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cyclostellettamine derivative through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [654]
KAR-1880 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for KAR-1880. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of KAR-1880 through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [656]
N-(2-amino-5-(benzofuran-2-yl)phenyl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(2-amino-5-(benzofuran-2-yl)phenyl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(2-amino-5-(benzofuran-2-yl)phenyl)benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [657]
N-(2-amino-5-(furan-2-yl)phenyl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(2-amino-5-(furan-2-yl)phenyl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(2-amino-5-(furan-2-yl)phenyl)benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [657]
N-(2-amino-5-(furan-3-yl)phenyl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(2-amino-5-(furan-3-yl)phenyl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(2-amino-5-(furan-3-yl)phenyl)benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [657]
N-(2-amino-5-(pyridin-4-yl)phenyl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(2-amino-5-(pyridin-4-yl)phenyl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(2-amino-5-(pyridin-4-yl)phenyl)benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [657]
N-(2-amino-5-(thiazol-2-yl)phenyl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(2-amino-5-(thiazol-2-yl)phenyl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(2-amino-5-(thiazol-2-yl)phenyl)benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [657]
N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [655]
N-(2-aminophenyl)-4-methoxybenzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(2-aminophenyl)-4-methoxybenzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(2-aminophenyl)-4-methoxybenzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [658]
N-(2-aminophenyl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(2-aminophenyl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(2-aminophenyl)benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [647]
N-(2-aminophenyl)nicotinamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(2-aminophenyl)nicotinamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(2-aminophenyl)nicotinamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [659]
N-(2-aminophenyl)quinoxaline-6-carboxamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(2-aminophenyl)quinoxaline-6-carboxamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(2-aminophenyl)quinoxaline-6-carboxamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [640]
N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [649]
N-(2-Mercapto-ethyl)-N'-phenyl-succinamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(2-Mercapto-ethyl)-N'-phenyl-succinamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(2-Mercapto-ethyl)-N'-phenyl-succinamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [648]
N-(3'-acetyl-4-aminobiphenyl-3-yl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(3'-acetyl-4-aminobiphenyl-3-yl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(3'-acetyl-4-aminobiphenyl-3-yl)benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [657]
N-(4'-acetyl-4-aminobiphenyl-3-yl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(4'-acetyl-4-aminobiphenyl-3-yl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(4'-acetyl-4-aminobiphenyl-3-yl)benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [657]
N-(4-amino-3'-methoxybiphenyl-3-yl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(4-amino-3'-methoxybiphenyl-3-yl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(4-amino-3'-methoxybiphenyl-3-yl)benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [657]
N-(4-amino-3'-methylbiphenyl-3-yl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(4-amino-3'-methylbiphenyl-3-yl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(4-amino-3'-methylbiphenyl-3-yl)benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [657]
N-(4-amino-4'-bromobiphenyl-3-yl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(4-amino-4'-bromobiphenyl-3-yl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(4-amino-4'-bromobiphenyl-3-yl)benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [657]
N-(4-amino-4'-fluorobiphenyl-3-yl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(4-amino-4'-fluorobiphenyl-3-yl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(4-amino-4'-fluorobiphenyl-3-yl)benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [657]
N-(4-amino-4'-methoxybiphenyl-3-yl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(4-amino-4'-methoxybiphenyl-3-yl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(4-amino-4'-methoxybiphenyl-3-yl)benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [657]
N-(4-amino-4'-vinylbiphenyl-3-yl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(4-amino-4'-vinylbiphenyl-3-yl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(4-amino-4'-vinylbiphenyl-3-yl)benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [657]
N-(4-aminobiphenyl-3-yl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(4-aminobiphenyl-3-yl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(4-aminobiphenyl-3-yl)benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [657]
N-(4-aminobiphenyl-3-yl)nicotinamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(4-aminobiphenyl-3-yl)nicotinamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(4-aminobiphenyl-3-yl)nicotinamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [659]
N-(4-hydroxybiphenyl-3-yl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(4-hydroxybiphenyl-3-yl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(4-hydroxybiphenyl-3-yl)benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [659]
N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [643]
N-(6-Hydroxycarbamoyl-hexyl)-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(6-Hydroxycarbamoyl-hexyl)-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(6-Hydroxycarbamoyl-hexyl)-benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [638]
N-(6-Mercapto-hexyl)-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-(6-Mercapto-hexyl)-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(6-Mercapto-hexyl)-benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [648]
N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [648]
N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [642]
N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [652]
N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [642]
N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [660]
N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [642]
N-Hydroxy-4-(pentanoylamino-methyl)-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-Hydroxy-4-(pentanoylamino-methyl)-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-4-(pentanoylamino-methyl)-benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [642]
N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [652]
N-Hydroxy-4-phenylacetylamino-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-Hydroxy-4-phenylacetylamino-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-4-phenylacetylamino-benzamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [639]
N-Hydroxy-E-3-(4'-chlorobiphenyl-4-yl)-acrylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-Hydroxy-E-3-(4'-chlorobiphenyl-4-yl)-acrylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-E-3-(4'-chlorobiphenyl-4-yl)-acrylamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [659]
N-Hydroxy-E-3-(4'-cyanobiphenyl-4-yl)-acrylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-Hydroxy-E-3-(4'-cyanobiphenyl-4-yl)-acrylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-E-3-(4'-cyanobiphenyl-4-yl)-acrylamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [647]
N-Hydroxy-E-3-(biphenyl-4-yl)-acrylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-Hydroxy-E-3-(biphenyl-4-yl)-acrylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-E-3-(biphenyl-4-yl)-acrylamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [647]
N7-hydroxy-2-methoxy-N1-phenylheptanediamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N7-hydroxy-2-methoxy-N1-phenylheptanediamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N7-hydroxy-2-methoxy-N1-phenylheptanediamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [658]
N7-hydroxy-N1-phenyl-2-propoxyheptanediamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N7-hydroxy-N1-phenyl-2-propoxyheptanediamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N7-hydroxy-N1-phenyl-2-propoxyheptanediamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [639]
N8,2-dihydroxy-N1-phenyloctanediamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N8,2-dihydroxy-N1-phenyloctanediamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N8,2-dihydroxy-N1-phenyloctanediamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [639]
N8-hydroxy-2-methoxy-N1-phenyloctanediamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N8-hydroxy-2-methoxy-N1-phenyloctanediamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N8-hydroxy-2-methoxy-N1-phenyloctanediamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [639]
Octanedioic acid bis-hydroxyamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for Octanedioic acid bis-hydroxyamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Octanedioic acid bis-hydroxyamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [657]
Octanedioic acid hydroxyamide pyridin-2-ylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for Octanedioic acid hydroxyamide pyridin-2-ylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Octanedioic acid hydroxyamide pyridin-2-ylamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [643]
Octanedioic acid hydroxyamide pyridin-4-ylamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for Octanedioic acid hydroxyamide pyridin-4-ylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Octanedioic acid hydroxyamide pyridin-4-ylamide through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [644]
PSAMMAPLIN A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for PSAMMAPLIN A. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PSAMMAPLIN A through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [638]
santacruzamate A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for santacruzamate A. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of santacruzamate A through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [638]
ST-2986 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for ST-2986. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ST-2986 through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [653]
ST-2987 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for ST-2987. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ST-2987 through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [661]
Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester through regulating the expression of Histone deacetylase 2 (HDAC2). [235], [648]
Histone deacetylase 5 (HDAC5)
TMP269 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 5 (HDAC5) is a therapeutic target for TMP269. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TMP269 through regulating the expression of Histone deacetylase 5 (HDAC5). [636], [662]
Histone-lysine N-methyltransferase SETD7 (SETD7)
(R)-PFI-2 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Histone-lysine N-methyltransferase SETD7 (SETD7) is a therapeutic target for (R)-PFI-2. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (R)-PFI-2 through regulating the expression of Histone-lysine N-methyltransferase SETD7 (SETD7). [434], [663]
Hypoxia-inducible factor 1 alpha (HIF-1A)
HIF-1alpha [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for HIF-1alpha. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HIF-1alpha through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [664], [665]
IT-101 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for IT-101. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of IT-101 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [664], [666]
2-Methoxyestradiol [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for 2-Methoxyestradiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-Methoxyestradiol through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [664], [667]
PT2385 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for PT2385. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PT2385 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [664], [668]
ENMD-1198 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ENMD-1198. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ENMD-1198 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [664], [669]
EZN-2968 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for EZN-2968. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of EZN-2968 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [664], [670]
PX-478 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for PX-478. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PX-478 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [664], [671]
(5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for (5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [5], [664]
ISIS 175510 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 175510. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 175510 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [664], [672]
ISIS 298697 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298697. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 298697 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [664], [672]
ISIS 298699 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298699. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 298699 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [664], [672]
ISIS 298700 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298700. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 298700 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [664], [672]
ISIS 298701 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298701. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 298701 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [664], [672]
ISIS 298702 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298702. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 298702 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [664], [672]
ISIS 298711 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298711. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 298711 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [664], [672]
ISIS 298712 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298712. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 298712 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [664], [672]
ISIS 298743 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298743. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 298743 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [664], [672]
ISIS 298744 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298744. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 298744 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [664], [672]
ISIS 298745 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298745. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 298745 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [664], [672]
ISIS 298746 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298746. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 298746 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [664], [673]
Inhibitor of nuclear factor kappa-B kinase alpha (IKKA)
5-Bromo-6-methoxy-9H-beta-carboline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) is a therapeutic target for 5-Bromo-6-methoxy-9H-beta-carboline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-Bromo-6-methoxy-9H-beta-carboline through regulating the expression of Inhibitor of nuclear factor kappa-B kinase alpha (IKKA). [674], [675]
IKI-1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) is a therapeutic target for IKI-1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of IKI-1 through regulating the expression of Inhibitor of nuclear factor kappa-B kinase alpha (IKKA). [674], [676]
ISIS 23544 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) is a therapeutic target for ISIS 23544. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 23544 through regulating the expression of Inhibitor of nuclear factor kappa-B kinase alpha (IKKA). [674], [677]
ISIS 23559 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) is a therapeutic target for ISIS 23559. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 23559 through regulating the expression of Inhibitor of nuclear factor kappa-B kinase alpha (IKKA). [674], [678]
N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) is a therapeutic target for N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide through regulating the expression of Inhibitor of nuclear factor kappa-B kinase alpha (IKKA). [674], [679]
Inhibitor of nuclear factor kappa-B kinase beta (IKKB)
Arsenic trioxide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase beta (IKKB) is a therapeutic target for Arsenic trioxide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Arsenic trioxide through regulating the expression of Inhibitor of nuclear factor kappa-B kinase beta (IKKB). [680], [681]
IMD-1041 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase beta (IKKB) is a therapeutic target for IMD-1041. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of IMD-1041 through regulating the expression of Inhibitor of nuclear factor kappa-B kinase beta (IKKB). [680], [682]
Parthenolide [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase beta (IKKB) is a therapeutic target for Parthenolide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Parthenolide through regulating the expression of Inhibitor of nuclear factor kappa-B kinase beta (IKKB). [680], [683]
SAR-113945 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase beta (IKKB) is a therapeutic target for SAR-113945. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SAR-113945 through regulating the expression of Inhibitor of nuclear factor kappa-B kinase beta (IKKB). [680], [684]
IMD-0354 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase beta (IKKB) is a therapeutic target for IMD-0354. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of IMD-0354 through regulating the expression of Inhibitor of nuclear factor kappa-B kinase beta (IKKB). [680], [685]
2-amino-5-phenylthiophene-3-carboxamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase beta (IKKB) is a therapeutic target for 2-amino-5-phenylthiophene-3-carboxamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-amino-5-phenylthiophene-3-carboxamide through regulating the expression of Inhibitor of nuclear factor kappa-B kinase beta (IKKB). [680], [686]
2-amino-quinoline-3-carboxylic acid amide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase beta (IKKB) is a therapeutic target for 2-amino-quinoline-3-carboxylic acid amide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-amino-quinoline-3-carboxylic acid amide through regulating the expression of Inhibitor of nuclear factor kappa-B kinase beta (IKKB). [680], [686]
3-amino-5-(4-chlorophenyl)thiophene-2-carboxamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase beta (IKKB) is a therapeutic target for 3-amino-5-(4-chlorophenyl)thiophene-2-carboxamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-amino-5-(4-chlorophenyl)thiophene-2-carboxamide through regulating the expression of Inhibitor of nuclear factor kappa-B kinase beta (IKKB). [247], [680]
3-amino-benzo[b]thiophene-2-carboxylic acid amide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase beta (IKKB) is a therapeutic target for 3-amino-benzo[b]thiophene-2-carboxylic acid amide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-amino-benzo[b]thiophene-2-carboxylic acid amide through regulating the expression of Inhibitor of nuclear factor kappa-B kinase beta (IKKB). [680], [686]
4-amino-biphenyl-3-carboxylic acid amide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase beta (IKKB) is a therapeutic target for 4-amino-biphenyl-3-carboxylic acid amide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-amino-biphenyl-3-carboxylic acid amide through regulating the expression of Inhibitor of nuclear factor kappa-B kinase beta (IKKB). [680], [686]
5-amino-2-p-tolyl-oxazole-4-carboxylic acid amide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase beta (IKKB) is a therapeutic target for 5-amino-2-p-tolyl-oxazole-4-carboxylic acid amide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-amino-2-p-tolyl-oxazole-4-carboxylic acid amide through regulating the expression of Inhibitor of nuclear factor kappa-B kinase beta (IKKB). [680], [686]
5-amino-2-phenyl-oxazole-4-carboxylic acid amide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase beta (IKKB) is a therapeutic target for 5-amino-2-phenyl-oxazole-4-carboxylic acid amide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-amino-2-phenyl-oxazole-4-carboxylic acid amide through regulating the expression of Inhibitor of nuclear factor kappa-B kinase beta (IKKB). [680], [686]
5-Bromo-6-methoxy-9H-beta-carboline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase beta (IKKB) is a therapeutic target for 5-Bromo-6-methoxy-9H-beta-carboline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-Bromo-6-methoxy-9H-beta-carboline through regulating the expression of Inhibitor of nuclear factor kappa-B kinase beta (IKKB). [680], [686]
6-phenyl-thieno[3,2-d]pyrimidin-4-ylamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase beta (IKKB) is a therapeutic target for 6-phenyl-thieno[3,2-d]pyrimidin-4-ylamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6-phenyl-thieno[3,2-d]pyrimidin-4-ylamine through regulating the expression of Inhibitor of nuclear factor kappa-B kinase beta (IKKB). [680], [686]
PF-228 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase beta (IKKB) is a therapeutic target for PF-228. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PF-228 through regulating the expression of Inhibitor of nuclear factor kappa-B kinase beta (IKKB). [680], [687]
SC-514 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase beta (IKKB) is a therapeutic target for SC-514. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SC-514 through regulating the expression of Inhibitor of nuclear factor kappa-B kinase beta (IKKB). [677], [680]
Staurosporine [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase beta (IKKB) is a therapeutic target for Staurosporine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Staurosporine through regulating the expression of Inhibitor of nuclear factor kappa-B kinase beta (IKKB). [680], [688]
MLN0415 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Inhibitor of nuclear factor kappa-B kinase beta (IKKB) is a therapeutic target for MLN0415. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MLN0415 through regulating the expression of Inhibitor of nuclear factor kappa-B kinase beta (IKKB). [680], [689]
Insulin-like growth factor I receptor (IGF1R)
Mecasermin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Mecasermin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Mecasermin through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [691]
Somatomedin-1 [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Somatomedin-1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Somatomedin-1 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [5], [690]
Teprotumumab [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Teprotumumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Teprotumumab through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [692]
Rinfabate [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Rinfabate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Rinfabate through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [693]
AMG 479 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AMG 479. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AMG 479 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [29], [690]
AXL-1717 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AXL-1717. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AXL-1717 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [500], [690]
Cixutumumab [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Cixutumumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cixutumumab through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [694]
MM-141 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for MM-141. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MM-141 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [3], [690]
R1507 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for R1507. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of R1507 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [695]
TT-100 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for TT-100. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TT-100 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [696]
VPI-2690B [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for VPI-2690B. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of VPI-2690B through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [697]
AEW-541 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AEW-541. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AEW-541 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [698]
BIIB 022 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for BIIB 022. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BIIB 022 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [699]
Cyclolignan picropodophyllin [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Cyclolignan picropodophyllin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cyclolignan picropodophyllin through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [241], [690]
FPI-1434 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for FPI-1434. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of FPI-1434 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [700]
HF-0299 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for HF-0299. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HF-0299 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [701]
RG-7010 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for RG-7010. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RG-7010 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [702]
ATL-1101 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for ATL-1101. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ATL-1101 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [703]
BMS-695735 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for BMS-695735. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BMS-695735 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [526], [690]
4-((1H-indazol-6-ylamino)methyl)benzene-1,2-diol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for 4-((1H-indazol-6-ylamino)methyl)benzene-1,2-diol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-((1H-indazol-6-ylamino)methyl)benzene-1,2-diol through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [704]
4-((naphthalen-2-ylamino)methyl)benzene-1,2-diol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for 4-((naphthalen-2-ylamino)methyl)benzene-1,2-diol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-((naphthalen-2-ylamino)methyl)benzene-1,2-diol through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [705]
AG 1024 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AG 1024. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AG 1024 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [706]
Alpha-D-Mannose [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Alpha-D-Mannose. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Alpha-D-Mannose through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [210], [690]
AMP-PNP [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AMP-PNP. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AMP-PNP through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [210], [690]
AZD3463 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AZD3463. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AZD3463 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [707]
BMS 536924 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for BMS 536924. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BMS 536924 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [704]
Fucose [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Fucose. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fucose through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [26], [690]
GSK-1838705A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for GSK-1838705A. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GSK-1838705A through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [708]
GSK1511931 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for GSK1511931. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GSK1511931 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [709]
JB-1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for JB-1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of JB-1 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [710]
NVP-ADW742 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for NVP-ADW742. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NVP-ADW742 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [26], [690]
PQ401 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for PQ401. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PQ401 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [711]
AVE-1642 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AVE-1642. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AVE-1642 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [712]
Figitumumab [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Figitumumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Figitumumab through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [214], [690]
KW-2450 [Discontinued in Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for KW-2450. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of KW-2450 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [690], [713]
Insulin-like growth factor-I (IGF1)
Xentuzumab [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor-I (IGF1) is a therapeutic target for Xentuzumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Xentuzumab through regulating the expression of Insulin-like growth factor-I (IGF1). [714], [715]
BI-836845 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor-I (IGF1) is a therapeutic target for BI-836845. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BI-836845 through regulating the expression of Insulin-like growth factor-I (IGF1). [497], [714]
MEDI-573 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor-I (IGF1) is a therapeutic target for MEDI-573. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MEDI-573 through regulating the expression of Insulin-like growth factor-I (IGF1). [714], [716]
Insulin-like growth factor-II (IGF2)
Dusigitumab [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor-II (IGF2) is a therapeutic target for Dusigitumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dusigitumab through regulating the expression of Insulin-like growth factor-II (IGF2). [235], [717]
Xentuzumab [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor-II (IGF2) is a therapeutic target for Xentuzumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Xentuzumab through regulating the expression of Insulin-like growth factor-II (IGF2). [235], [497]
Integrin beta-1 (ITGB1)
131I-radretumab [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Integrin beta-1 (ITGB1) is a therapeutic target for 131I-radretumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 131I-radretumab through regulating the expression of Integrin beta-1 (ITGB1). [718], [719]
JSM 6427 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Integrin beta-1 (ITGB1) is a therapeutic target for JSM 6427. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of JSM 6427 through regulating the expression of Integrin beta-1 (ITGB1). [718], [720]
OS2966 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Integrin beta-1 (ITGB1) is a therapeutic target for OS2966. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of OS2966 through regulating the expression of Integrin beta-1 (ITGB1). [718], [721]
C(-GRGDfL-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Integrin beta-1 (ITGB1) is a therapeutic target for C(-GRGDfL-). The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C(-GRGDfL-) through regulating the expression of Integrin beta-1 (ITGB1). [718], [722]
MK-0668 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Integrin beta-1 (ITGB1) is a therapeutic target for MK-0668. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MK-0668 through regulating the expression of Integrin beta-1 (ITGB1). [718], [723]
SB-265123 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Integrin beta-1 (ITGB1) is a therapeutic target for SB-265123. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SB-265123 through regulating the expression of Integrin beta-1 (ITGB1). [718], [724]
Intercellular adhesion molecule ICAM-1 (ICAM1)
ISIS 1570 [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for ISIS 1570. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 1570 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [726]
lifitegrast [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for lifitegrast. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of lifitegrast through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [727]
Alicaforsen [Phase 3]
In total 2 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for Alicaforsen. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Alicaforsen through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [728]
Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for Alicaforsen. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Alicaforsen through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [729]
APC-8015F [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for APC-8015F. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of APC-8015F through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [730]
BI-505 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for BI-505. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BI-505 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [731]
AIC100 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for AIC100. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AIC100 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [732]
A-286982 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for A-286982. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of A-286982 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [733]
Dehydropipernonaline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for Dehydropipernonaline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dehydropipernonaline through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [733]
ISIS 11158 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for ISIS 11158. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 11158 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [734]
ISIS 11159 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for ISIS 11159. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 11159 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [735]
ISIS 11665 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for ISIS 11665. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 11665 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [735]
ISIS 1931 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for ISIS 1931. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 1931 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [728]
ISIS 2974 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for ISIS 2974. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 2974 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [735]
ISIS 3067 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for ISIS 3067. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 3067 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [735]
ISIS 3224 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for ISIS 3224. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 3224 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [735]
ISIS-1939 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for ISIS-1939. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS-1939 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [736]
Pellitorin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for Pellitorin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pellitorin through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [733]
PIPERNONALINE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for PIPERNONALINE. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PIPERNONALINE through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [737]
PIPERROLEIN B [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for PIPERROLEIN B. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PIPERROLEIN B through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [733]
A-252444.0 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for A-252444.0. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of A-252444.0 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [738]
GI-270384X [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for GI-270384X. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GI-270384X through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [739]
INXC-ICAM1 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for INXC-ICAM1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of INXC-ICAM1 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [728]
MOR-102 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for MOR-102. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MOR-102 through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [725], [740]
Interferon-gamma (IFNG)
Emapalumab [Approved]
In total 2 mechanisms lead to this potential drug response
Response Summary Interferon-gamma (IFNG) is a therapeutic target for Emapalumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Emapalumab through regulating the expression of Interferon-gamma (IFNG). [191], [741]
Interferon-gamma (IFNG) is a therapeutic target for Emapalumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Emapalumab through regulating the expression of Interferon-gamma (IFNG). [191], [624]
Fumaric acid [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Interferon-gamma (IFNG) is a therapeutic target for Fumaric acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fumaric acid through regulating the expression of Interferon-gamma (IFNG). [191], [742]
VIR-201 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Interferon-gamma (IFNG) is a therapeutic target for VIR-201. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of VIR-201 through regulating the expression of Interferon-gamma (IFNG). [191], [743]
AMG 811 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Interferon-gamma (IFNG) is a therapeutic target for AMG 811. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AMG 811 through regulating the expression of Interferon-gamma (IFNG). [191], [744]
CIGB-128 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Interferon-gamma (IFNG) is a therapeutic target for CIGB-128. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CIGB-128 through regulating the expression of Interferon-gamma (IFNG). [191], [745]
VPM-4-001 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Interferon-gamma (IFNG) is a therapeutic target for VPM-4-001. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of VPM-4-001 through regulating the expression of Interferon-gamma (IFNG). [191], [746]
CRx-191 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Interferon-gamma (IFNG) is a therapeutic target for CRx-191. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CRx-191 through regulating the expression of Interferon-gamma (IFNG). [191], [747]
Fontolizumab [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Interferon-gamma (IFNG) is a therapeutic target for Fontolizumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fontolizumab through regulating the expression of Interferon-gamma (IFNG). [191], [748]
TAK-603 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Interferon-gamma (IFNG) is a therapeutic target for TAK-603. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TAK-603 through regulating the expression of Interferon-gamma (IFNG). [191], [749]
TG-1042 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Interferon-gamma (IFNG) is a therapeutic target for TG-1042. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TG-1042 through regulating the expression of Interferon-gamma (IFNG). [191], [750]
Interleukin-6 (IL6)
Siltuximab [Approved]
In total 2 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for Siltuximab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Siltuximab through regulating the expression of Interleukin-6 (IL6). [751], [752]
Interleukin-6 (IL6) is a therapeutic target for Siltuximab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Siltuximab through regulating the expression of Interleukin-6 (IL6). [751], [754]
Olokizumab [Phase 3]
In total 2 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for Olokizumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Olokizumab through regulating the expression of Interleukin-6 (IL6). [60], [751]
Interleukin-6 (IL6) is a therapeutic target for Olokizumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Olokizumab through regulating the expression of Interleukin-6 (IL6). [751], [753]
Sirukumab [Phase 3]
In total 2 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for Sirukumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sirukumab through regulating the expression of Interleukin-6 (IL6). [751], [755]
Interleukin-6 (IL6) is a therapeutic target for Sirukumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sirukumab through regulating the expression of Interleukin-6 (IL6). [751], [758]
ALD-518 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for ALD-518. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ALD-518 through regulating the expression of Interleukin-6 (IL6). [60], [751]
CDP-6038 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for CDP-6038. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CDP-6038 through regulating the expression of Interleukin-6 (IL6). [214], [751]
Clazakizumab [Phase 2]
In total 2 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for Clazakizumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Clazakizumab through regulating the expression of Interleukin-6 (IL6). [60], [751]
Interleukin-6 (IL6) is a therapeutic target for Clazakizumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Clazakizumab through regulating the expression of Interleukin-6 (IL6). [751], [756]
PF-04236921 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for PF-04236921. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PF-04236921 through regulating the expression of Interleukin-6 (IL6). [751], [757]
YSIL6 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for YSIL6. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of YSIL6 through regulating the expression of Interleukin-6 (IL6). [214], [751]
C326 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for C326. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C326 through regulating the expression of Interleukin-6 (IL6). [751], [759]
Gerilimzumab [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for Gerilimzumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Gerilimzumab through regulating the expression of Interleukin-6 (IL6). [751], [760]
MEDI5117 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for MEDI5117. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MEDI5117 through regulating the expression of Interleukin-6 (IL6). [751], [761]
OP-R003 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for OP-R003. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of OP-R003 through regulating the expression of Interleukin-6 (IL6). [60], [751]
ITGB3 messenger RNA (ITGB3 mRNA)
3-(3-(benzamido)-5-nitrobenzamido)propanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for 3-(3-(benzamido)-5-nitrobenzamido)propanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(3-(benzamido)-5-nitrobenzamido)propanoic acid through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [763]
3-(3-(carbamoyl)benzamido)-3-phenylpropanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for 3-(3-(carbamoyl)benzamido)-3-phenylpropanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(3-(carbamoyl)benzamido)-3-phenylpropanoic acid through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [763]
3-(3-(carbamoyl)benzamido)propanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for 3-(3-(carbamoyl)benzamido)propanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(3-(carbamoyl)benzamido)propanoic acid through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [764]
Ac-Asp-Arg-Leu-Asp-Ser-OH [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Ac-Asp-Arg-Leu-Asp-Ser-OH. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ac-Asp-Arg-Leu-Asp-Ser-OH through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [724], [762]
AcDRGDS [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for AcDRGDS. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AcDRGDS through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [765]
C(-GRGDfL-) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C(-GRGDfL-). The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C(-GRGDfL-) through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [766]
C(Arg-Gly-Asp-D-Phe-Val) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C(Arg-Gly-Asp-D-Phe-Val). The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C(Arg-Gly-Asp-D-Phe-Val) through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [767]
C(RGDfF) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C(RGDfF). The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C(RGDfF) through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [767]
C(RGDfMeF) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C(RGDfMeF). The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C(RGDfMeF) through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [768]
C-[-Arg-Gly-Asp-Acpca30-] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C-[-Arg-Gly-Asp-Acpca30-]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C-[-Arg-Gly-Asp-Acpca30-] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [769]
C-[-Arg-Gly-Asp-Acpca31-] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C-[-Arg-Gly-Asp-Acpca31-]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C-[-Arg-Gly-Asp-Acpca31-] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [769]
C-[-Arg-Gly-Asp-Acpca32-] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C-[-Arg-Gly-Asp-Acpca32-]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C-[-Arg-Gly-Asp-Acpca32-] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [769]
C-[-Arg-Gly-Asp-Acpca33-] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C-[-Arg-Gly-Asp-Acpca33-]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C-[-Arg-Gly-Asp-Acpca33-] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [765]
Cyclo(RGDfV) (control) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Cyclo(RGDfV) (control). The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cyclo(RGDfV) (control) through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [764]
Cyclo-[-Arg-Gly-Asp-Amp21-] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Cyclo-[-Arg-Gly-Asp-Amp21-]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cyclo-[-Arg-Gly-Asp-Amp21-] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [765]
Cyclo-[-Arg-Gly-Asp-Amp22-] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Cyclo-[-Arg-Gly-Asp-Amp22-]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cyclo-[-Arg-Gly-Asp-Amp22-] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [768]
Cyclo-[-Arg-Gly-Asp-Amp23-] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Cyclo-[-Arg-Gly-Asp-Amp23-]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cyclo-[-Arg-Gly-Asp-Amp23-] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [765]
Cyclo-[-Arg-Gly-Asp-Amp24-] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Cyclo-[-Arg-Gly-Asp-Amp24-]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cyclo-[-Arg-Gly-Asp-Amp24-] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [765]
Cyclo-[-Arg-Gly-Asp-Amp25-] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Cyclo-[-Arg-Gly-Asp-Amp25-]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cyclo-[-Arg-Gly-Asp-Amp25-] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [770]
Cyclo-[-Arg-Gly-Asp-Amp26-] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Cyclo-[-Arg-Gly-Asp-Amp26-]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cyclo-[-Arg-Gly-Asp-Amp26-] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [765]
Cyclo-[-Arg-Gly-Asp-Amp27-] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Cyclo-[-Arg-Gly-Asp-Amp27-]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cyclo-[-Arg-Gly-Asp-Amp27-] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [765]
Cyclo-[-Arg-Gly-Asp-Amp28-] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Cyclo-[-Arg-Gly-Asp-Amp28-]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cyclo-[-Arg-Gly-Asp-Amp28-] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [765]
CYCLORGDFV [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for CYCLORGDFV. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CYCLORGDFV through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [771]
Cyclo[RGDfK(cypate)] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Cyclo[RGDfK(cypate)]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cyclo[RGDfK(cypate)] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [772]
Cypate-[(RGD)2-NH2]1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Cypate-[(RGD)2-NH2]1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cypate-[(RGD)2-NH2]1 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [764]
Cypate-[(RGD)2-NH2]2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Cypate-[(RGD)2-NH2]2. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cypate-[(RGD)2-NH2]2 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [764]
Cypate-[(RGD)3-NH2]1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Cypate-[(RGD)3-NH2]1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cypate-[(RGD)3-NH2]1 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [764]
Cypate-[(RGD)3-NH2]2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Cypate-[(RGD)3-NH2]2. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cypate-[(RGD)3-NH2]2 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [764]
Cypate-[(RGD)4-NH2]1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Cypate-[(RGD)4-NH2]1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cypate-[(RGD)4-NH2]1 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [764]
Cypate-[(RGD)4-NH2]2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Cypate-[(RGD)4-NH2]2. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cypate-[(RGD)4-NH2]2 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [764]
C[-Arg-Gly-Asp-Acpca19-] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C[-Arg-Gly-Asp-Acpca19-]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C[-Arg-Gly-Asp-Acpca19-] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [769]
C[-Arg-Gly-Asp-Acpca20-] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C[-Arg-Gly-Asp-Acpca20-]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C[-Arg-Gly-Asp-Acpca20-] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [769]
C[-Arg-Gly-Asp-Acpca21-] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C[-Arg-Gly-Asp-Acpca21-]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C[-Arg-Gly-Asp-Acpca21-] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [769]
C[-Arg-Gly-Asp-Acpca22-] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C[-Arg-Gly-Asp-Acpca22-]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C[-Arg-Gly-Asp-Acpca22-] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [769]
C[-Arg-Gly-Asp-Acpca34-] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C[-Arg-Gly-Asp-Acpca34-]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C[-Arg-Gly-Asp-Acpca34-] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [769]
C[-Arg-Gly-Asp-Acpca35-] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C[-Arg-Gly-Asp-Acpca35-]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C[-Arg-Gly-Asp-Acpca35-] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [769]
C[-Arg-Gly-Asp-Acpca36-] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C[-Arg-Gly-Asp-Acpca36-]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C[-Arg-Gly-Asp-Acpca36-] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [769]
C[RGD-(R)-alpha-TfmfV] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C[RGD-(R)-alpha-TfmfV]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C[RGD-(R)-alpha-TfmfV] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [768]
C[RGD-(S)-alpha-TfmfV] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C[RGD-(S)-alpha-TfmfV]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C[RGD-(S)-alpha-TfmfV] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [768]
C[RGDf-(R)-alpha-TfmF] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C[RGDf-(R)-alpha-TfmF]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C[RGDf-(R)-alpha-TfmF] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [768]
C[RGDf-(R)-alpha-TfmV] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C[RGDf-(R)-alpha-TfmV]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C[RGDf-(R)-alpha-TfmV] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [768]
C[RGDf-(R)-N-Me-alpha-TfmF] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C[RGDf-(R)-N-Me-alpha-TfmF]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C[RGDf-(R)-N-Me-alpha-TfmF] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [768]
C[RGDf-(S)-alpha-TfmF] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C[RGDf-(S)-alpha-TfmF]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C[RGDf-(S)-alpha-TfmF] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [768]
C[RGDf-(S)-alpha-TfmV] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C[RGDf-(S)-alpha-TfmV]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C[RGDf-(S)-alpha-TfmV] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [768]
C[RGDf-(S)-N-Me-alpha-TfmF] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C[RGDf-(S)-N-Me-alpha-TfmF]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C[RGDf-(S)-N-Me-alpha-TfmF] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [768]
C[RGDf-(S,R)-alpha-Dfm-F] [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for C[RGDf-(S,R)-alpha-Dfm-F]. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of C[RGDf-(S,R)-alpha-Dfm-F] through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [768]
E[c(RGDyK)]2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for E[c(RGDyK)]2. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of E[c(RGDyK)]2 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [773]
E[c(RGDyK)]2-PTX conjugate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for E[c(RGDyK)]2-PTX conjugate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of E[c(RGDyK)]2-PTX conjugate through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [774]
Gly-Arg-Gly-Asp-Ser [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Gly-Arg-Gly-Asp-Ser. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Gly-Arg-Gly-Asp-Ser through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [775]
Gly-Arg-Gly-Asp-Ser-Pro-Lys [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Gly-Arg-Gly-Asp-Ser-Pro-Lys. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Gly-Arg-Gly-Asp-Ser-Pro-Lys through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [776]
ISIS 196103 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for ISIS 196103. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 196103 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [769]
ISIS 25237 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for ISIS 25237. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 25237 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [777]
ISONIPECOTAMIDE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for ISONIPECOTAMIDE. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISONIPECOTAMIDE through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [778]
L-734115 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for L-734115. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of L-734115 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [776]
L-739758 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for L-739758. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of L-739758 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [776]
L-746233 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for L-746233. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of L-746233 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [776]
L-750034 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for L-750034. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of L-750034 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [776]
L-756568 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for L-756568. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of L-756568 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [779]
L-767679 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for L-767679. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of L-767679 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [780]
N-(3,5-dichlorophenyl)imidodicarbonimidic diamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for N-(3,5-dichlorophenyl)imidodicarbonimidic diamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(3,5-dichlorophenyl)imidodicarbonimidic diamide through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [781]
RGDechi [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for RGDechi. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RGDechi through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [763]
ROXIFIBAN [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for ROXIFIBAN. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ROXIFIBAN through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [782]
RWJ-53419 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for RWJ-53419. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RWJ-53419 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [776]
SB-207043 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for SB-207043. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SB-207043 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [765]
SB-265123 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for SB-265123. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SB-265123 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [783]
SC-54701A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for SC-54701A. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SC-54701A through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [784]
ST-1646 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for ST-1646. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ST-1646 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [773]
DMP-757 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for DMP-757. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of DMP-757 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [776]
DMP-802 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for DMP-802. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of DMP-802 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [776]
L-709780 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for L-709780. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of L-709780 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [785]
L-738167 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for L-738167. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of L-738167 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [786]
Ro-43-5054 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Ro-43-5054. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ro-43-5054 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [776]
Ro-43-8857 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for Ro-43-8857. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ro-43-8857 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [783]
SB-223245 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for SB-223245. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SB-223245 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [776]
SC-47643 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for SC-47643. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SC-47643 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [787]
SKF-107260 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for SKF-107260. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SKF-107260 through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [210], [762]
XEMILOFIBAN [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary ITGB3 messenger RNA (ITGB3 mRNA) is a therapeutic target for XEMILOFIBAN. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of XEMILOFIBAN through regulating the expression of ITGB3 messenger RNA (ITGB3 mRNA). [762], [788]
Jagged2 messenger RNA (JAG2 mRNA)
ISIS 148715 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Jagged2 messenger RNA (JAG2 mRNA) is a therapeutic target for ISIS 148715. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 148715 through regulating the expression of Jagged2 messenger RNA (JAG2 mRNA). [412], [789]
Janus kinase 2 (JAK-2)
Baricitinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for Baricitinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Baricitinib through regulating the expression of Janus kinase 2 (JAK-2). [790], [791]
Fedratinib [Approved]
In total 2 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for Fedratinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fedratinib through regulating the expression of Janus kinase 2 (JAK-2). [790], [792]
Janus kinase 2 (JAK-2) is a therapeutic target for Fedratinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fedratinib through regulating the expression of Janus kinase 2 (JAK-2). [790], [809]
Ruxolitinib [Approved]
In total 2 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for Ruxolitinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ruxolitinib through regulating the expression of Janus kinase 2 (JAK-2). [790], [793]
Janus kinase 2 (JAK-2) is a therapeutic target for Ruxolitinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ruxolitinib through regulating the expression of Janus kinase 2 (JAK-2). [60], [790]
CYT-387 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for CYT-387. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CYT-387 through regulating the expression of Janus kinase 2 (JAK-2). [790], [794]
ITF2357 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for ITF2357. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ITF2357 through regulating the expression of Janus kinase 2 (JAK-2). [790], [795]
Pacritinib [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for Pacritinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pacritinib through regulating the expression of Janus kinase 2 (JAK-2). [790], [796]
XL019 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for XL019. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of XL019 through regulating the expression of Janus kinase 2 (JAK-2). [790], [797]
AZD1480 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for AZD1480. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AZD1480 through regulating the expression of Janus kinase 2 (JAK-2). [790], [798]
BMS-911543 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for BMS-911543. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BMS-911543 through regulating the expression of Janus kinase 2 (JAK-2). [790], [799]
Cerdulatinib [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for Cerdulatinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cerdulatinib through regulating the expression of Janus kinase 2 (JAK-2). [790], [800]
CTP-543 [Phase 2]
In total 2 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for CTP-543. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CTP-543 through regulating the expression of Janus kinase 2 (JAK-2). [790], [801]
Janus kinase 2 (JAK-2) is a therapeutic target for CTP-543. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CTP-543 through regulating the expression of Janus kinase 2 (JAK-2). [790], [797]
INCB039110 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for INCB039110. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of INCB039110 through regulating the expression of Janus kinase 2 (JAK-2). [790], [802]
LY2784544 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for LY2784544. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of LY2784544 through regulating the expression of Janus kinase 2 (JAK-2). [790], [803]
NS-018 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for NS-018. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NS-018 through regulating the expression of Janus kinase 2 (JAK-2). [790], [801]
AC430 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for AC430. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AC430 through regulating the expression of Janus kinase 2 (JAK-2). [790], [804]
Peginterferon beta [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for Peginterferon beta. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Peginterferon beta through regulating the expression of Janus kinase 2 (JAK-2). [790], [793]
SB-1578 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for SB-1578. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SB-1578 through regulating the expression of Janus kinase 2 (JAK-2). [790], [805]
1,2,3,4,5,6-hexabromocyclohexane [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for 1,2,3,4,5,6-hexabromocyclohexane. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 1,2,3,4,5,6-hexabromocyclohexane through regulating the expression of Janus kinase 2 (JAK-2). [790], [806]
5-phenyl-1H-indazol-3-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for 5-phenyl-1H-indazol-3-amine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-phenyl-1H-indazol-3-amine through regulating the expression of Janus kinase 2 (JAK-2). [790], [807]
AMG-JAK2-01 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for AMG-JAK2-01. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AMG-JAK2-01 through regulating the expression of Janus kinase 2 (JAK-2). [790], [801]
Atropisomer 1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for Atropisomer 1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Atropisomer 1 through regulating the expression of Janus kinase 2 (JAK-2). [436], [790]
AZ960 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for AZ960. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AZ960 through regulating the expression of Janus kinase 2 (JAK-2). [220], [790]
BVB-808 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for BVB-808. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BVB-808 through regulating the expression of Janus kinase 2 (JAK-2). [790], [808]
CMP-6 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for CMP-6. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CMP-6 through regulating the expression of Janus kinase 2 (JAK-2). [562], [790]
K-454 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for K-454. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of K-454 through regulating the expression of Janus kinase 2 (JAK-2). [790], [810]
NSC-1771 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for NSC-1771. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NSC-1771 through regulating the expression of Janus kinase 2 (JAK-2). [790], [811]
ON-044580 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for ON-044580. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ON-044580 through regulating the expression of Janus kinase 2 (JAK-2). [790], [801]
SGI-1252 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for SGI-1252. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SGI-1252 through regulating the expression of Janus kinase 2 (JAK-2). [790], [812]
WHI-P154 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for WHI-P154. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of WHI-P154 through regulating the expression of Janus kinase 2 (JAK-2). [790], [813]
AG490 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Janus kinase 2 (JAK-2) is a therapeutic target for AG490. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AG490 through regulating the expression of Janus kinase 2 (JAK-2). [790], [793]
Kruppel like factor 4 (KLF4)
APTO-253 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Kruppel like factor 4 (KLF4) is a therapeutic target for APTO-253. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of APTO-253 through regulating the expression of Kruppel like factor 4 (KLF4). [223], [663]
Leukocyte surface antigen CD47 (CD47)
Hu5F9-G4 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Leukocyte surface antigen CD47 (CD47) is a therapeutic target for Hu5F9-G4. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Hu5F9-G4 through regulating the expression of Leukocyte surface antigen CD47 (CD47). [814], [815]
ALX148 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Leukocyte surface antigen CD47 (CD47) is a therapeutic target for ALX148. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ALX148 through regulating the expression of Leukocyte surface antigen CD47 (CD47). [814], [816]
AO-176 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Leukocyte surface antigen CD47 (CD47) is a therapeutic target for AO-176. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AO-176 through regulating the expression of Leukocyte surface antigen CD47 (CD47). [5], [814]
DSP-107 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Leukocyte surface antigen CD47 (CD47) is a therapeutic target for DSP-107. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of DSP-107 through regulating the expression of Leukocyte surface antigen CD47 (CD47). [814], [817]
CC-90002 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Leukocyte surface antigen CD47 (CD47) is a therapeutic target for CC-90002. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CC-90002 through regulating the expression of Leukocyte surface antigen CD47 (CD47). [814], [818]
IBI188 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Leukocyte surface antigen CD47 (CD47) is a therapeutic target for IBI188. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of IBI188 through regulating the expression of Leukocyte surface antigen CD47 (CD47). [814], [819]
IMC-002 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Leukocyte surface antigen CD47 (CD47) is a therapeutic target for IMC-002. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of IMC-002 through regulating the expression of Leukocyte surface antigen CD47 (CD47). [814], [820]
SL-172154 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Leukocyte surface antigen CD47 (CD47) is a therapeutic target for SL-172154. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SL-172154 through regulating the expression of Leukocyte surface antigen CD47 (CD47). [5], [814]
TG-1801 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Leukocyte surface antigen CD47 (CD47) is a therapeutic target for TG-1801. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TG-1801 through regulating the expression of Leukocyte surface antigen CD47 (CD47). [814], [821]
TJC4 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Leukocyte surface antigen CD47 (CD47) is a therapeutic target for TJC4. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TJC4 through regulating the expression of Leukocyte surface antigen CD47 (CD47). [814], [822]
TTI-621 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Leukocyte surface antigen CD47 (CD47) is a therapeutic target for TTI-621. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TTI-621 through regulating the expression of Leukocyte surface antigen CD47 (CD47). [814], [823]
TTI-622 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Leukocyte surface antigen CD47 (CD47) is a therapeutic target for TTI-622. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TTI-622 through regulating the expression of Leukocyte surface antigen CD47 (CD47). [814], [824]
ZL-1201 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Leukocyte surface antigen CD47 (CD47) is a therapeutic target for ZL-1201. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ZL-1201 through regulating the expression of Leukocyte surface antigen CD47 (CD47). [814], [825]
M-phase inducer phosphatase 2 (MPIP2)
2-Sulfhydryl-Ethanol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary M-phase inducer phosphatase 2 (MPIP2) is a therapeutic target for 2-Sulfhydryl-Ethanol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-Sulfhydryl-Ethanol through regulating the expression of M-phase inducer phosphatase 2 (MPIP2). [826], [827]
3-isopropyl-4-(phenylamino)naphthalene-1,2-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary M-phase inducer phosphatase 2 (MPIP2) is a therapeutic target for 3-isopropyl-4-(phenylamino)naphthalene-1,2-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-isopropyl-4-(phenylamino)naphthalene-1,2-dione through regulating the expression of M-phase inducer phosphatase 2 (MPIP2). [826], [828]
3-isopropyl-4-(phenylthio)naphthalene-1,2-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary M-phase inducer phosphatase 2 (MPIP2) is a therapeutic target for 3-isopropyl-4-(phenylthio)naphthalene-1,2-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-isopropyl-4-(phenylthio)naphthalene-1,2-dione through regulating the expression of M-phase inducer phosphatase 2 (MPIP2). [826], [827]
3-isopropyl-4-phenylnaphthalene-1,2-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary M-phase inducer phosphatase 2 (MPIP2) is a therapeutic target for 3-isopropyl-4-phenylnaphthalene-1,2-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-isopropyl-4-phenylnaphthalene-1,2-dione through regulating the expression of M-phase inducer phosphatase 2 (MPIP2). [826], [828]
4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary M-phase inducer phosphatase 2 (MPIP2) is a therapeutic target for 4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione through regulating the expression of M-phase inducer phosphatase 2 (MPIP2). [826], [828]
4-ethoxynaphthalene-1,2-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary M-phase inducer phosphatase 2 (MPIP2) is a therapeutic target for 4-ethoxynaphthalene-1,2-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-ethoxynaphthalene-1,2-dione through regulating the expression of M-phase inducer phosphatase 2 (MPIP2). [826], [829]
5,6,7,8-tetrahydroanthracene-1,4-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary M-phase inducer phosphatase 2 (MPIP2) is a therapeutic target for 5,6,7,8-tetrahydroanthracene-1,4-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5,6,7,8-tetrahydroanthracene-1,4-dione through regulating the expression of M-phase inducer phosphatase 2 (MPIP2). [826], [830]
6,7-dibromoquinoline-5,8-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary M-phase inducer phosphatase 2 (MPIP2) is a therapeutic target for 6,7-dibromoquinoline-5,8-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-dibromoquinoline-5,8-dione through regulating the expression of M-phase inducer phosphatase 2 (MPIP2). [826], [827]
ADOCIAQUINONE B [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary M-phase inducer phosphatase 2 (MPIP2) is a therapeutic target for ADOCIAQUINONE B. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ADOCIAQUINONE B through regulating the expression of M-phase inducer phosphatase 2 (MPIP2). [826], [829]
ANTHRAQUINONE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary M-phase inducer phosphatase 2 (MPIP2) is a therapeutic target for ANTHRAQUINONE. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ANTHRAQUINONE through regulating the expression of M-phase inducer phosphatase 2 (MPIP2). [826], [829]
Cysteine Sulfenic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary M-phase inducer phosphatase 2 (MPIP2) is a therapeutic target for Cysteine Sulfenic Acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cysteine Sulfenic Acid through regulating the expression of M-phase inducer phosphatase 2 (MPIP2). [210], [826]
Cysteinesulfonic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary M-phase inducer phosphatase 2 (MPIP2) is a therapeutic target for Cysteinesulfonic Acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cysteinesulfonic Acid through regulating the expression of M-phase inducer phosphatase 2 (MPIP2). [210], [826]
Double Oxidized Cysteine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary M-phase inducer phosphatase 2 (MPIP2) is a therapeutic target for Double Oxidized Cysteine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Double Oxidized Cysteine through regulating the expression of M-phase inducer phosphatase 2 (MPIP2). [826], [831]
Methyl Mercury Ion [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary M-phase inducer phosphatase 2 (MPIP2) is a therapeutic target for Methyl Mercury Ion. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Methyl Mercury Ion through regulating the expression of M-phase inducer phosphatase 2 (MPIP2). [210], [826]
NSC-95397 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary M-phase inducer phosphatase 2 (MPIP2) is a therapeutic target for NSC-95397. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NSC-95397 through regulating the expression of M-phase inducer phosphatase 2 (MPIP2). [826], [828]
MX-7065 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary M-phase inducer phosphatase 2 (MPIP2) is a therapeutic target for MX-7065. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MX-7065 through regulating the expression of M-phase inducer phosphatase 2 (MPIP2). [826], [829]
Mammalian target of rapamycin complex 1 (mTORC1)
RBT-101 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for RBT-101. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RBT-101 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [832], [833]
AZD-2014 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for AZD-2014. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AZD-2014 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [832], [834]
ME-344 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for ME-344. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ME-344 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [5], [832]
NV-5138 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for NV-5138. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NV-5138 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [832], [835]
Palomid-529 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for Palomid-529. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Palomid-529 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [5], [832]
VS-5584 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for VS-5584. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of VS-5584 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [832], [836]
MAP kinase signal-integrating kinase 2 (MKNK2)
EFT508 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary MAP kinase signal-integrating kinase 2 (MKNK2) is a therapeutic target for EFT508. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of EFT508 through regulating the expression of MAP kinase signal-integrating kinase 2 (MKNK2). [464], [837]
MAPK-activated protein kinase 2 (MAPKAPK2)
CBP-501 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary MAPK-activated protein kinase 2 (MAPKAPK2) is a therapeutic target for CBP-501. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CBP-501 through regulating the expression of MAPK-activated protein kinase 2 (MAPKAPK2). [235], [838]
MMI-0100 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary MAPK-activated protein kinase 2 (MAPKAPK2) is a therapeutic target for MMI-0100. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MMI-0100 through regulating the expression of MAPK-activated protein kinase 2 (MAPKAPK2). [235], [839]
CMPD1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary MAPK-activated protein kinase 2 (MAPKAPK2) is a therapeutic target for CMPD1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CMPD1 through regulating the expression of MAPK-activated protein kinase 2 (MAPKAPK2). [235], [840]
PF-3644022 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary MAPK-activated protein kinase 2 (MAPKAPK2) is a therapeutic target for PF-3644022. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PF-3644022 through regulating the expression of MAPK-activated protein kinase 2 (MAPKAPK2). [235], [841]
MAPK/ERK kinase kinase 3 (MAP3K3)
ISIS 122970 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary MAPK/ERK kinase kinase 3 (MAP3K3) is a therapeutic target for ISIS 122970. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 122970 through regulating the expression of MAPK/ERK kinase kinase 3 (MAP3K3). [272], [426]
ISIS 122971 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary MAPK/ERK kinase kinase 3 (MAP3K3) is a therapeutic target for ISIS 122971. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 122971 through regulating the expression of MAPK/ERK kinase kinase 3 (MAP3K3). [272], [426]
ISIS 122974 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary MAPK/ERK kinase kinase 3 (MAP3K3) is a therapeutic target for ISIS 122974. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 122974 through regulating the expression of MAPK/ERK kinase kinase 3 (MAP3K3). [272], [426]
ISIS 122975 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary MAPK/ERK kinase kinase 3 (MAP3K3) is a therapeutic target for ISIS 122975. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 122975 through regulating the expression of MAPK/ERK kinase kinase 3 (MAP3K3). [272], [426]
ISIS 122976 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary MAPK/ERK kinase kinase 3 (MAP3K3) is a therapeutic target for ISIS 122976. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 122976 through regulating the expression of MAPK/ERK kinase kinase 3 (MAP3K3). [272], [426]
ISIS 122984 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary MAPK/ERK kinase kinase 3 (MAP3K3) is a therapeutic target for ISIS 122984. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 122984 through regulating the expression of MAPK/ERK kinase kinase 3 (MAP3K3). [272], [426]
ISIS 122985 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary MAPK/ERK kinase kinase 3 (MAP3K3) is a therapeutic target for ISIS 122985. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 122985 through regulating the expression of MAPK/ERK kinase kinase 3 (MAP3K3). [272], [426]
ISIS 122986 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary MAPK/ERK kinase kinase 3 (MAP3K3) is a therapeutic target for ISIS 122986. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 122986 through regulating the expression of MAPK/ERK kinase kinase 3 (MAP3K3). [272], [426]
ISIS 122990 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary MAPK/ERK kinase kinase 3 (MAP3K3) is a therapeutic target for ISIS 122990. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 122990 through regulating the expression of MAPK/ERK kinase kinase 3 (MAP3K3). [272], [426]
ISIS 122991 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary MAPK/ERK kinase kinase 3 (MAP3K3) is a therapeutic target for ISIS 122991. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 122991 through regulating the expression of MAPK/ERK kinase kinase 3 (MAP3K3). [426], [842]
Matrix metalloproteinase-1 (MMP-1)
Prinomastat [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for Prinomastat. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Prinomastat through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [844]
CIPEMASTAT [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for CIPEMASTAT. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CIPEMASTAT through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [845]
Marimastat [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for Marimastat. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Marimastat through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [846]
Apratastat [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for Apratastat. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Apratastat through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [847]
3-(4-Methoxy-benzenesulfonyl)-cyclohexanethiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for 3-(4-Methoxy-benzenesulfonyl)-cyclohexanethiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-Methoxy-benzenesulfonyl)-cyclohexanethiol through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [848]
3-(4-Methoxy-benzenesulfonyl)-hexane-1-thiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for 3-(4-Methoxy-benzenesulfonyl)-hexane-1-thiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-Methoxy-benzenesulfonyl)-hexane-1-thiol through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [849]
3-(4-Methoxy-benzenesulfonyl)-pentane-1-thiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for 3-(4-Methoxy-benzenesulfonyl)-pentane-1-thiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-Methoxy-benzenesulfonyl)-pentane-1-thiol through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [850]
3-(4-Phenoxy-benzenesulfonyl)-cyclohexanethiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for 3-(4-Phenoxy-benzenesulfonyl)-cyclohexanethiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-Phenoxy-benzenesulfonyl)-cyclohexanethiol through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [850]
3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for 3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiol through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [851]
3-Benzenesulfinyl-heptanoic acid hydroxyamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for 3-Benzenesulfinyl-heptanoic acid hydroxyamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-Benzenesulfinyl-heptanoic acid hydroxyamide through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [852]
3-Benzenesulfonyl-heptanoic acid hydroxyamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for 3-Benzenesulfonyl-heptanoic acid hydroxyamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-Benzenesulfonyl-heptanoic acid hydroxyamide through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [852]
3-Cyclohexanesulfonyl-heptanoic acid hydroxyamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for 3-Cyclohexanesulfonyl-heptanoic acid hydroxyamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-Cyclohexanesulfonyl-heptanoic acid hydroxyamide through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [853]
4-(4-Butoxy-phenyl)-N-hydroxy-4-oxo-butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for 4-(4-Butoxy-phenyl)-N-hydroxy-4-oxo-butyramide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(4-Butoxy-phenyl)-N-hydroxy-4-oxo-butyramide through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [853]
4-(4-Methoxy-benzenesulfonyl)-butane-2-thiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for 4-(4-Methoxy-benzenesulfonyl)-butane-2-thiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(4-Methoxy-benzenesulfonyl)-butane-2-thiol through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [854]
4-Butoxy-N-hydroxycarbamoylmethyl-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for 4-Butoxy-N-hydroxycarbamoylmethyl-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-Butoxy-N-hydroxycarbamoylmethyl-benzamide through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [853]
METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [852]
MMI270 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for MMI270. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MMI270 through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [855]
N-(Ethylphosphoryl)-L-isoleucyl-L-Trp-NHCH3 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for N-(Ethylphosphoryl)-L-isoleucyl-L-Trp-NHCH3. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(Ethylphosphoryl)-L-isoleucyl-L-Trp-NHCH3 through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [856]
N-Hydroxy-4-(4-methoxy-phenyl)-4-oxo-butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for N-Hydroxy-4-(4-methoxy-phenyl)-4-oxo-butyramide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-4-(4-methoxy-phenyl)-4-oxo-butyramide through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [853]
N-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-butyramide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for N-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-butyramide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-butyramide through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [853]
N-Hydroxycarbamoylmethyl-4-methoxy-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for N-Hydroxycarbamoylmethyl-4-methoxy-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxycarbamoylmethyl-4-methoxy-benzamide through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [853]
N-Hydroxycarbamoylmethyl-4-phenoxy-benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for N-Hydroxycarbamoylmethyl-4-phenoxy-benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxycarbamoylmethyl-4-phenoxy-benzamide through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [854]
PKF-242-484 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for PKF-242-484. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PKF-242-484 through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [857]
Ro-37-9790 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for Ro-37-9790. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ro-37-9790 through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [850]
RS-39066 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for RS-39066. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RS-39066 through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [850]
SR-973 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for SR-973. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SR-973 through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [858]
BB-1101 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for BB-1101. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BB-1101 through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [859]
BB-3644 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for BB-3644. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BB-3644 through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [860]
BMS 275291 [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for BMS 275291. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BMS 275291 through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [861]
GM6001 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for GM6001. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GM6001 through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [220], [843]
L-696418 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for L-696418. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of L-696418 through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [862]
Ro-31-4724 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for Ro-31-4724. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ro-31-4724 through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [863]
RO-319790 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for RO-319790. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RO-319790 through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [864]
RS-130830 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for RS-130830. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RS-130830 through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [865]
SC-44463 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for SC-44463. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SC-44463 through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [866]
XL784 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-1 (MMP-1) is a therapeutic target for XL784. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of XL784 through regulating the expression of Matrix metalloproteinase-1 (MMP-1). [843], [867]
Matrix metalloproteinase-12 (MMP-12)
FP-025 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for FP-025. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of FP-025 through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [866], [868]
Neovastat [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for Neovastat. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Neovastat through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [869]
2-(2-(biphenyl-4-yl)ethylsulfinyl)acetic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for 2-(2-(biphenyl-4-yl)ethylsulfinyl)acetic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(2-(biphenyl-4-yl)ethylsulfinyl)acetic acid through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [870]
2-(2-(biphenyl-4-yl)ethylsulfonyl)acetic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for 2-(2-(biphenyl-4-yl)ethylsulfonyl)acetic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(2-(biphenyl-4-yl)ethylsulfonyl)acetic acid through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [870]
2-(2-(biphenyl-4-yl)ethylthio)acetic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for 2-(2-(biphenyl-4-yl)ethylthio)acetic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(2-(biphenyl-4-yl)ethylthio)acetic acid through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [870]
2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [871]
3-(4-(2-phenylethynyl)benzoyl)pentanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [872]
3-(4-Phenylethynylbenzoyl)nonanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for 3-(4-Phenylethynylbenzoyl)nonanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-Phenylethynylbenzoyl)nonanoic acid through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [872]
3-Benzenesulfonyl-heptanoic acid hydroxyamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for 3-Benzenesulfonyl-heptanoic acid hydroxyamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-Benzenesulfonyl-heptanoic acid hydroxyamide through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [852], [868]
3-Cyclohexanesulfonyl-heptanoic acid hydroxyamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for 3-Cyclohexanesulfonyl-heptanoic acid hydroxyamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-Cyclohexanesulfonyl-heptanoic acid hydroxyamide through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [872]
4-(4-(dec-1-ynyl)phenyl)-4-oxobutanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for 4-(4-(dec-1-ynyl)phenyl)-4-oxobutanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(4-(dec-1-ynyl)phenyl)-4-oxobutanoic acid through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [873]
5-(3'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for 5-(3'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-(3'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [874]
5-(4'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for 5-(4'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-(4'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [870]
5-(biphenyl-4-yl)-3-methoxypentanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for 5-(biphenyl-4-yl)-3-methoxypentanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-(biphenyl-4-yl)-3-methoxypentanoic acid through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [870]
5-(biphenyl-4-yl)-3-oxopentanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for 5-(biphenyl-4-yl)-3-oxopentanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-(biphenyl-4-yl)-3-oxopentanoic acid through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [870]
Acetate Ion [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for Acetate Ion. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Acetate Ion through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [210], [868]
AGELADINE A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for AGELADINE A. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AGELADINE A through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [871]
CP-271485 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for CP-271485. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CP-271485 through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [831], [868]
MMP-408 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for MMP-408. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MMP-408 through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [875]
N-(biphenyl-4-ylsulfonyl)-D-leucine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for N-(biphenyl-4-ylsulfonyl)-D-leucine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(biphenyl-4-ylsulfonyl)-D-leucine through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [220], [868]
N-(dibenzo[b,d]thiophen-3-ylsulfonyl)-L-valine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for N-(dibenzo[b,d]thiophen-3-ylsulfonyl)-L-valine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(dibenzo[b,d]thiophen-3-ylsulfonyl)-L-valine through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [220], [868]
N-Hydroxy-2-(4-methoxy-benzenesulfonyl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for N-Hydroxy-2-(4-methoxy-benzenesulfonyl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-2-(4-methoxy-benzenesulfonyl)benzamide through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [870]
N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [871]
N-oxo-2-(phenylsulfonylamino)ethanamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for N-oxo-2-(phenylsulfonylamino)ethanamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-oxo-2-(phenylsulfonylamino)ethanamide through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [220], [868]
N-oxo-2-[(4-phenylphenyl)sulfonylamino]ethanamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for N-oxo-2-[(4-phenylphenyl)sulfonylamino]ethanamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-oxo-2-[(4-phenylphenyl)sulfonylamino]ethanamide through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [220], [868]
N-[(4-methoxyphenyl)sulfonyl]-D-alanine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for N-[(4-methoxyphenyl)sulfonyl]-D-alanine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-[(4-methoxyphenyl)sulfonyl]-D-alanine through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [852], [868]
PF-00356231 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for PF-00356231. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PF-00356231 through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [220], [868]
PUP-1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for PUP-1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PUP-1 through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [869]
RXP-470 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for RXP-470. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RXP-470 through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [869]
RXP470.1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for RXP470.1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RXP470.1 through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [876]
WAY-644 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for WAY-644. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of WAY-644 through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [869]
[2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [871]
AZD1236 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for AZD1236. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AZD1236 through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [877]
GM6001 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for GM6001. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GM6001 through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [868], [878]
V85546 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for V85546. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of V85546 through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [613], [868]
Matrix metalloproteinase-13 (MMP-13)
Curcumin [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for Curcumin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Curcumin through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [866], [879]
Apratastat [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for Apratastat. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Apratastat through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [879], [880]
PMID17935984C1 [Clinical trial]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for PMID17935984C1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PMID17935984C1 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [861], [879]
1-(4-Methoxy-benzenesulfonyl)-heptane-3-thiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 1-(4-Methoxy-benzenesulfonyl)-heptane-3-thiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 1-(4-Methoxy-benzenesulfonyl)-heptane-3-thiol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [850], [879]
1-Methyloxy-4-Sulfone-Benzene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 1-Methyloxy-4-Sulfone-Benzene. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 1-Methyloxy-4-Sulfone-Benzene through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [852], [879]
2-(2-(biphenyl-4-yl)ethylsulfonyl)acetic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 2-(2-(biphenyl-4-yl)ethylsulfonyl)acetic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(2-(biphenyl-4-yl)ethylsulfonyl)acetic acid through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [870], [879]
2-(biphenyl-4-ylsulfonamido)pentanedioic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 2-(biphenyl-4-ylsulfonamido)pentanedioic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(biphenyl-4-ylsulfonamido)pentanedioic acid through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [879], [880]
2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [871], [879]
3-(4-Methoxy-benzenesulfonyl)-cyclohexanethiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-(4-Methoxy-benzenesulfonyl)-cyclohexanethiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-Methoxy-benzenesulfonyl)-cyclohexanethiol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [848], [879]
3-(4-Methoxy-benzenesulfonyl)-cyclopentanethiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-(4-Methoxy-benzenesulfonyl)-cyclopentanethiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-Methoxy-benzenesulfonyl)-cyclopentanethiol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [879], [881]
3-(4-Methoxy-benzenesulfonyl)-hexane-1-thiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-(4-Methoxy-benzenesulfonyl)-hexane-1-thiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-Methoxy-benzenesulfonyl)-hexane-1-thiol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [849], [879]
3-(4-Methoxy-benzenesulfonyl)-pentane-1-thiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-(4-Methoxy-benzenesulfonyl)-pentane-1-thiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-Methoxy-benzenesulfonyl)-pentane-1-thiol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [850], [879]
3-(4-Methoxy-benzenesulfonyl)-propane-1-thiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-(4-Methoxy-benzenesulfonyl)-propane-1-thiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-Methoxy-benzenesulfonyl)-propane-1-thiol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [854], [879]
3-(4-Phenoxy-benzenesulfonyl)-cyclohexanethiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-(4-Phenoxy-benzenesulfonyl)-cyclohexanethiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-Phenoxy-benzenesulfonyl)-cyclohexanethiol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [850], [879]
3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [850], [879]
3-Benzenesulfonyl-heptanoic acid hydroxyamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-Benzenesulfonyl-heptanoic acid hydroxyamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-Benzenesulfonyl-heptanoic acid hydroxyamide through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [852], [879]
3-Cyclohexanesulfonyl-heptanoic acid hydroxyamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-Cyclohexanesulfonyl-heptanoic acid hydroxyamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-Cyclohexanesulfonyl-heptanoic acid hydroxyamide through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [854], [879]
3-Methylpyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 3-Methylpyridine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-Methylpyridine through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [210], [879]
4-(2,2'-bithiophen-5-ylmethyleneamino)phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 4-(2,2'-bithiophen-5-ylmethyleneamino)phenol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(2,2'-bithiophen-5-ylmethyleneamino)phenol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [879], [882]
4-(4-Methoxy-benzenesulfonyl)-butane-2-thiol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 4-(4-Methoxy-benzenesulfonyl)-butane-2-thiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(4-Methoxy-benzenesulfonyl)-butane-2-thiol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [854], [879]
4-(methyl(4-phenylthiazol-2-yl)amino)phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 4-(methyl(4-phenylthiazol-2-yl)amino)phenol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(methyl(4-phenylthiazol-2-yl)amino)phenol through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [879], [883]
4-amino-3-(4-(hexyloxy)phenyl)-4-oxobutanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 4-amino-3-(4-(hexyloxy)phenyl)-4-oxobutanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-amino-3-(4-(hexyloxy)phenyl)-4-oxobutanoic acid through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [879], [880]
5-(4'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for 5-(4'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-(4'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [879], [884]
CL82198 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for CL82198. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CL82198 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [879], [885]
Ethyl 2-cyano-2-(quinoxalin-2(1H)-ylidene)acetate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for Ethyl 2-cyano-2-(quinoxalin-2(1H)-ylidene)acetate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ethyl 2-cyano-2-(quinoxalin-2(1H)-ylidene)acetate through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [879], [883]
Hydroxyaminovaline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for Hydroxyaminovaline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Hydroxyaminovaline through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [210], [879]
IK-862 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for IK-862. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of IK-862 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [850], [879]
MMI270 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for MMI270. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MMI270 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [867], [879]
N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [870], [879]
N1,N3-bis(3-methoxybenzyl)isophthalamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for N1,N3-bis(3-methoxybenzyl)isophthalamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N1,N3-bis(3-methoxybenzyl)isophthalamide through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [879], [886]
N4,N6-dibenzylpyrimidine-4,6-dicarboxamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for N4,N6-dibenzylpyrimidine-4,6-dicarboxamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N4,N6-dibenzylpyrimidine-4,6-dicarboxamide through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [879], [880]
PD-156 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for PD-156. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PD-156 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [879], [887]
PKF-242-484 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for PKF-242-484. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PKF-242-484 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [857], [879]
Ro-37-9790 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for Ro-37-9790. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ro-37-9790 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [850], [879]
SL422 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for SL422. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SL422 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [879], [888]
SR-973 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for SR-973. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SR-973 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [871], [879]
UK-356618 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for UK-356618. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of UK-356618 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [210], [879]
WAY-151693 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for WAY-151693. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of WAY-151693 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [210], [879]
WAY170523 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for WAY170523. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of WAY170523 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [879], [888]
[2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [871], [879]
GM6001 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for GM6001. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GM6001 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [879], [889]
RS-130830 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for RS-130830. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RS-130830 through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [879], [890]
Matrix metalloproteinase-2 (MMP-2)
Amylin [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for Amylin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Amylin through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [892]
Prinomastat [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for Prinomastat. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Prinomastat through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [844], [891]
Marimastat [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for Marimastat. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Marimastat through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [846], [891]
Metastat [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for Metastat. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Metastat through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [893]
Neovastat [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for Neovastat. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Neovastat through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [862], [891]
RO-26-2853 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for RO-26-2853. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RO-26-2853 through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [867], [891]
2-(4'-chloro-biphenyl-4-sulfonyl)-pentanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for 2-(4'-chloro-biphenyl-4-sulfonyl)-pentanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(4'-chloro-biphenyl-4-sulfonyl)-pentanoic acid through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [872], [891]
2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [871], [891]
3-(4-(2-phenylethynyl)benzoyl)pentanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [894]
3-(4-Phenylethynylbenzoyl)nonanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for 3-(4-Phenylethynylbenzoyl)nonanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-Phenylethynylbenzoyl)nonanoic acid through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [872], [891]
4-(4-(dec-1-ynyl)phenyl)-4-oxobutanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for 4-(4-(dec-1-ynyl)phenyl)-4-oxobutanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(4-(dec-1-ynyl)phenyl)-4-oxobutanoic acid through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [895]
5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for 5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [896]
5-Biphenyl-4-yl-5-ethyl-pyrimidine-2,4,6-trione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for 5-Biphenyl-4-yl-5-ethyl-pyrimidine-2,4,6-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-Biphenyl-4-yl-5-ethyl-pyrimidine-2,4,6-trione through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [881], [891]
5-Biphenyl-4-yl-5-hexyl-pyrimidine-2,4,6-trione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for 5-Biphenyl-4-yl-5-hexyl-pyrimidine-2,4,6-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-Biphenyl-4-yl-5-hexyl-pyrimidine-2,4,6-trione through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [897]
5-Hexyl-5-phenyl-pyrimidine-2,4,6-trione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for 5-Hexyl-5-phenyl-pyrimidine-2,4,6-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-Hexyl-5-phenyl-pyrimidine-2,4,6-trione through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [897]
Cis-2-aminocyclohexylcarbamoylphosphonic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for Cis-2-aminocyclohexylcarbamoylphosphonic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cis-2-aminocyclohexylcarbamoylphosphonic acid through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [898]
Clinopodic acid C [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for Clinopodic acid C. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Clinopodic acid C through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [899]
Folate gamma-hydroxamic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for Folate gamma-hydroxamic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Folate gamma-hydroxamic acid through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [872], [891]
Folate gamma-L-proline-hydroxamic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for Folate gamma-L-proline-hydroxamic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Folate gamma-L-proline-hydroxamic acid through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [900]
IK-862 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for IK-862. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of IK-862 through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [849], [891]
Lithospermic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for Lithospermic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lithospermic acid through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [901]
Methotrexate gamma-hydroxamic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for Methotrexate gamma-hydroxamic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Methotrexate gamma-hydroxamic acid through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [898]
Methotrexate gamma-L-proline-hydroxamic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for Methotrexate gamma-L-proline-hydroxamic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Methotrexate gamma-L-proline-hydroxamic acid through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [898]
MMI270 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for MMI270. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MMI270 through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [855], [891]
N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [870], [891]
N-hydroxy-3-(2-oxo-2H-chromen-3-yl)propanamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for N-hydroxy-3-(2-oxo-2H-chromen-3-yl)propanamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-hydroxy-3-(2-oxo-2H-chromen-3-yl)propanamide through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [900]
N-hydroxy-3-(6-methoxy-2-oxo-2H-chromen-3-yl) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for N-hydroxy-3-(6-methoxy-2-oxo-2H-chromen-3-yl). The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-hydroxy-3-(6-methoxy-2-oxo-2H-chromen-3-yl) through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [902]
PD-169469 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for PD-169469. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PD-169469 through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [857], [891]
PNU-107859 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for PNU-107859. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PNU-107859 through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [897]
Ro-37-9790 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for Ro-37-9790. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ro-37-9790 through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [898]
Roche 28-2653 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for Roche 28-2653. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Roche 28-2653 through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [897]
SC-74020 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for SC-74020. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SC-74020 through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [903]
SR-973 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for SR-973. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SR-973 through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [871], [891]
UK-356618 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for UK-356618. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of UK-356618 through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [210], [891]
[2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [871], [891]
BB-1101 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for BB-1101. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BB-1101 through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [28], [891]
BB-3644 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for BB-3644. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BB-3644 through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [904]
BMS 275291 [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for BMS 275291. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BMS 275291 through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [905]
CDP-845 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for CDP-845. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CDP-845 through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [860], [891]
Galarubicin [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for Galarubicin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Galarubicin through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [906]
GM6001 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for GM6001. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GM6001 through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [878], [891]
L-696418 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for L-696418. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of L-696418 through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [862], [891]
RS-130830 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for RS-130830. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RS-130830 through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [891], [907]
SC-44463 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for SC-44463. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SC-44463 through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [866], [891]
Tanomastat [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for Tanomastat. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tanomastat through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [865], [891]
Matrix metalloproteinase-3 (MMP-3)
Batimastat [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for Batimastat. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Batimastat through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [889]
1-Methyloxy-4-Sulfone-Benzene [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for 1-Methyloxy-4-Sulfone-Benzene. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 1-Methyloxy-4-Sulfone-Benzene through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [896]
3-Methylpyridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for 3-Methylpyridine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-Methylpyridine through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [210], [751]
5-Biphenyl-4-yl-5-ethyl-pyrimidine-2,4,6-trione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for 5-Biphenyl-4-yl-5-ethyl-pyrimidine-2,4,6-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-Biphenyl-4-yl-5-ethyl-pyrimidine-2,4,6-trione through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [881]
8-chloro-quinoline-3-carbonitrile [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for 8-chloro-quinoline-3-carbonitrile. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 8-chloro-quinoline-3-carbonitrile through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [908]
AM-2S [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for AM-2S. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AM-2S through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [905]
CM-352 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for CM-352. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CM-352 through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [862]
FUTOENONE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for FUTOENONE. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of FUTOENONE through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [210], [751]
Hydroxyaminovaline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for Hydroxyaminovaline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Hydroxyaminovaline through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [210], [751]
IK-862 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for IK-862. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of IK-862 through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [909]
MMI270 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for MMI270. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MMI270 through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [860]
PD-169469 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for PD-169469. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PD-169469 through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [910]
PKF-242-484 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for PKF-242-484. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PKF-242-484 through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [895]
PNU-107859 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for PNU-107859. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PNU-107859 through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [897]
PNU-142372 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for PNU-142372. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PNU-142372 through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [856]
Ro-37-9790 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for Ro-37-9790. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ro-37-9790 through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [848]
RS-39066 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for RS-39066. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RS-39066 through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [849]
UK-356618 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for UK-356618. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of UK-356618 through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [911]
BB-1101 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for BB-1101. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BB-1101 through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [859]
GM6001 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for GM6001. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GM6001 through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [912]
L-696418 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for L-696418. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of L-696418 through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [913]
PG-530742 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for PG-530742. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PG-530742 through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [867]
RO-319790 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for RO-319790. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RO-319790 through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [914]
RS-130830 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for RS-130830. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RS-130830 through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [844]
SC-44463 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-3 (MMP-3) is a therapeutic target for SC-44463. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SC-44463 through regulating the expression of Matrix metalloproteinase-3 (MMP-3). [751], [866]
Matrix metalloproteinase-9 (MMP-9)
Amylin [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for Amylin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Amylin through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [892]
Andecaliximab [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for Andecaliximab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Andecaliximab through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [915]
Curcumin [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for Curcumin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Curcumin through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [916]
DP-b99 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for DP-b99. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of DP-b99 through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [917]
GS-5745 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for GS-5745. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GS-5745 through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [887]
BLZ-100 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for BLZ-100. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BLZ-100 through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [497], [868]
Neovastat [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for Neovastat. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Neovastat through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [918]
DX-2802 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for DX-2802. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of DX-2802 through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [867], [868]
2-(4'-chloro-biphenyl-4-sulfonyl)-pentanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for 2-(4'-chloro-biphenyl-4-sulfonyl)-pentanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(4'-chloro-biphenyl-4-sulfonyl)-pentanoic acid through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [857], [868]
2-(biphenyl-4-ylsulfonamido)pentanedioic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for 2-(biphenyl-4-ylsulfonamido)pentanedioic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(biphenyl-4-ylsulfonamido)pentanedioic acid through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [883]
2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [871]
2-Amino-N,3,3-Trimethylbutanamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for 2-Amino-N,3,3-Trimethylbutanamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-Amino-N,3,3-Trimethylbutanamide through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [903]
3-(4-(2-phenylethynyl)benzoyl)pentanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [919]
3-(4-Phenylethynylbenzoyl)nonanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for 3-(4-Phenylethynylbenzoyl)nonanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-Phenylethynylbenzoyl)nonanoic acid through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [872]
4-amino-3-(4-(hexyloxy)phenyl)-4-oxobutanoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for 4-amino-3-(4-(hexyloxy)phenyl)-4-oxobutanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-amino-3-(4-(hexyloxy)phenyl)-4-oxobutanoic acid through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [899]
5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for 5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [897]
5-Biphenyl-4-yl-5-ethyl-pyrimidine-2,4,6-trione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for 5-Biphenyl-4-yl-5-ethyl-pyrimidine-2,4,6-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-Biphenyl-4-yl-5-ethyl-pyrimidine-2,4,6-trione through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [881]
5-Biphenyl-4-yl-5-hexyl-pyrimidine-2,4,6-trione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for 5-Biphenyl-4-yl-5-hexyl-pyrimidine-2,4,6-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-Biphenyl-4-yl-5-hexyl-pyrimidine-2,4,6-trione through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [897]
5-Hexyl-5-phenyl-pyrimidine-2,4,6-trione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for 5-Hexyl-5-phenyl-pyrimidine-2,4,6-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-Hexyl-5-phenyl-pyrimidine-2,4,6-trione through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [897]
5-Methyl-5-phenyl-pyrimidine-2,4,6-trione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for 5-Methyl-5-phenyl-pyrimidine-2,4,6-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-Methyl-5-phenyl-pyrimidine-2,4,6-trione through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [897]
ARP100 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for ARP100. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ARP100 through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [920]
Carboxylated glucosamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for Carboxylated glucosamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Carboxylated glucosamine through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [894]
Folate gamma-hydroxamic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for Folate gamma-hydroxamic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Folate gamma-hydroxamic acid through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [898]
IK-862 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for IK-862. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of IK-862 through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [849], [868]
Methotrexate gamma-hydroxamic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for Methotrexate gamma-hydroxamic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Methotrexate gamma-hydroxamic acid through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [900]
Methotrexate gamma-L-phenylalaninehydroxamic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for Methotrexate gamma-L-phenylalaninehydroxamic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Methotrexate gamma-L-phenylalaninehydroxamic acid through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [872]
Methotrexate gamma-L-proline-hydroxamic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for Methotrexate gamma-L-proline-hydroxamic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Methotrexate gamma-L-proline-hydroxamic acid through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [898]
MMI270 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for MMI270. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MMI270 through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [904]
N-hydroxy-2,3-bis(phenylsulfonamido)propanamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for N-hydroxy-2,3-bis(phenylsulfonamido)propanamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-hydroxy-2,3-bis(phenylsulfonamido)propanamide through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [871]
N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [870]
N-hydroxy-3-(2-oxo-2H-chromen-3-yl)propanamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for N-hydroxy-3-(2-oxo-2H-chromen-3-yl)propanamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-hydroxy-3-(2-oxo-2H-chromen-3-yl)propanamide through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [900]
N-hydroxy-3-(6-methoxy-2-oxo-2H-chromen-3-yl) [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for N-hydroxy-3-(6-methoxy-2-oxo-2H-chromen-3-yl). The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-hydroxy-3-(6-methoxy-2-oxo-2H-chromen-3-yl) through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [898]
Ro 28-2653 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for Ro 28-2653. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ro 28-2653 through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [903]
Ro-37-9790 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for Ro-37-9790. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ro-37-9790 through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [898]
Roche 28-2653 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for Roche 28-2653. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Roche 28-2653 through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [897]
SL422 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for SL422. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SL422 through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [921]
SR-973 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for SR-973. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SR-973 through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [871]
UK-356618 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for UK-356618. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of UK-356618 through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [210], [868]
[2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [922]
CDP-845 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for CDP-845. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CDP-845 through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [923]
CT-1746 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for CT-1746. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CT-1746 through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [859], [868]
Galarubicin [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for Galarubicin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Galarubicin through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [924]
GM6001 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for GM6001. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GM6001 through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [878]
RO-319790 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for RO-319790. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RO-319790 through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [925]
RS-130830 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for RS-130830. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RS-130830 through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [868], [907]
SC-44463 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for SC-44463. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SC-44463 through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [866], [868]
microRNA hsa-miR-17 (MIR17)
RGLS4326 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary microRNA hsa-miR-17 (MIR17) is a therapeutic target for RGLS4326. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RGLS4326 through regulating the expression of microRNA hsa-miR-17 (MIR17). [268], [926]
microRNA hsa-miR-191 (MIR191)
Anti-miR-191 modified oligonucleotide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary microRNA hsa-miR-191 (MIR191) is a therapeutic target for Anti-miR-191 modified oligonucleotide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Anti-miR-191 modified oligonucleotide through regulating the expression of microRNA hsa-miR-191 (MIR191). [926], [927]
Mitochondrial matrix protein P1 (HSPD1)
DiaPep-277 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Mitochondrial matrix protein P1 (HSPD1) is a therapeutic target for DiaPep-277. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of DiaPep-277 through regulating the expression of Mitochondrial matrix protein P1 (HSPD1). [623], [928]
Mothers against decapentaplegic homolog 3 (SMAD3)
FLUORESCEIN [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Mothers against decapentaplegic homolog 3 (SMAD3) is a therapeutic target for FLUORESCEIN. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of FLUORESCEIN through regulating the expression of Mothers against decapentaplegic homolog 3 (SMAD3). [929], [930]
SIS-3 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Mothers against decapentaplegic homolog 3 (SMAD3) is a therapeutic target for SIS-3. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SIS-3 through regulating the expression of Mothers against decapentaplegic homolog 3 (SMAD3). [436], [929]
ELLAGIC ACID [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Mothers against decapentaplegic homolog 3 (SMAD3) is a therapeutic target for ELLAGIC ACID. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ELLAGIC ACID through regulating the expression of Mothers against decapentaplegic homolog 3 (SMAD3). [436], [929]
GNF-PF-2272 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Mothers against decapentaplegic homolog 3 (SMAD3) is a therapeutic target for GNF-PF-2272. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GNF-PF-2272 through regulating the expression of Mothers against decapentaplegic homolog 3 (SMAD3). [929], [931]
Mothers against decapentaplegic homolog 7 (SMAD7)
GED-0301 [Phase 3]
In total 2 mechanisms lead to this potential drug response
Response Summary Mothers against decapentaplegic homolog 7 (SMAD7) is a therapeutic target for GED-0301. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GED-0301 through regulating the expression of Mothers against decapentaplegic homolog 7 (SMAD7). [932], [933]
Mothers against decapentaplegic homolog 7 (SMAD7) is a therapeutic target for GED-0301. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GED-0301 through regulating the expression of Mothers against decapentaplegic homolog 7 (SMAD7). [932], [934]
ISIS 28465 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Mothers against decapentaplegic homolog 7 (SMAD7) is a therapeutic target for ISIS 28465. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 28465 through regulating the expression of Mothers against decapentaplegic homolog 7 (SMAD7). [932], [935]
ISIS 28466 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Mothers against decapentaplegic homolog 7 (SMAD7) is a therapeutic target for ISIS 28466. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 28466 through regulating the expression of Mothers against decapentaplegic homolog 7 (SMAD7). [932], [935]
ISIS 28472 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Mothers against decapentaplegic homolog 7 (SMAD7) is a therapeutic target for ISIS 28472. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 28472 through regulating the expression of Mothers against decapentaplegic homolog 7 (SMAD7). [932], [935]
ISIS 28477 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Mothers against decapentaplegic homolog 7 (SMAD7) is a therapeutic target for ISIS 28477. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 28477 through regulating the expression of Mothers against decapentaplegic homolog 7 (SMAD7). [932], [936]
MST-1 protein kinase (STK4)
TAT-120 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary MST-1 protein kinase (STK4) is a therapeutic target for TAT-120. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TAT-120 through regulating the expression of MST-1 protein kinase (STK4). [937], [938]
NAD-dependent deacetylase sirtuin-1 (SIRT1)
GSK2245840 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for GSK2245840. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GSK2245840 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [53], [939]
MB-12066 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for MB-12066. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MB-12066 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [53], [940]
SEN-196 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for SEN-196. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SEN-196 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [53], [941]
SRT2379 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for SRT2379. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SRT2379 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [53], [942]
SRT3025 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for SRT3025. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SRT3025 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [53], [943]
(R)-sirtinol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for (R)-sirtinol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (R)-sirtinol through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [53], [944]
(S)-sirtinol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for (S)-sirtinol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (S)-sirtinol through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [53], [944]
2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for 2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [53], [945]
2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for 2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [53], [471]
Meta-sirtinol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for Meta-sirtinol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Meta-sirtinol through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [53], [946]
Para-sirtinol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for Para-sirtinol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Para-sirtinol through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [53], [944]
RO-316233 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for RO-316233. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RO-316233 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [53], [945]
Ro31-8220 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for Ro31-8220. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ro31-8220 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [53], [947]
splitomicin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for splitomicin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of splitomicin through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [53], [948]
SRT1720 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for SRT1720. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SRT1720 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [53], [944]
YK-3237 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for YK-3237. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of YK-3237 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [53], [947]
GSK184072 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary NAD-dependent deacetylase sirtuin-1 (SIRT1) is a therapeutic target for GSK184072. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GSK184072 through regulating the expression of NAD-dependent deacetylase sirtuin-1 (SIRT1). [53], [949]
Neural cadherin (CDH2)
Exherin [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Neural cadherin (CDH2) is a therapeutic target for Exherin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Exherin through regulating the expression of Neural cadherin (CDH2). [950], [951]
NF-kappa-B inhibitor alpha (NFKBIA)
I3C [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary NF-kappa-B inhibitor alpha (NFKBIA) is a therapeutic target for I3C. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of I3C through regulating the expression of NF-kappa-B inhibitor alpha (NFKBIA). [672], [674]
Fucoxanthin [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary NF-kappa-B inhibitor alpha (NFKBIA) is a therapeutic target for Fucoxanthin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fucoxanthin through regulating the expression of NF-kappa-B inhibitor alpha (NFKBIA). [674], [952]
NLR pyrin domain containing 1 (NLRP1)
muramyl dipeptide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary NLR pyrin domain containing 1 (NLRP1) is a therapeutic target for muramyl dipeptide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of muramyl dipeptide through regulating the expression of NLR pyrin domain containing 1 (NLRP1). [953], [954]
Notch-1 receptor (NOTCH1)
LY3039478 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Notch-1 receptor (NOTCH1) is a therapeutic target for LY3039478. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of LY3039478 through regulating the expression of Notch-1 receptor (NOTCH1). [955], [956]
OMP-52M51 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Notch-1 receptor (NOTCH1) is a therapeutic target for OMP-52M51. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of OMP-52M51 through regulating the expression of Notch-1 receptor (NOTCH1). [5], [955]
Notch-2 receptor (NOTCH2)
Tarextumab [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Notch-2 receptor (NOTCH2) is a therapeutic target for Tarextumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tarextumab through regulating the expression of Notch-2 receptor (NOTCH2). [957], [958]
Notch-3 receptor (NOTCH3)
Tarextumab [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Notch-3 receptor (NOTCH3) is a therapeutic target for Tarextumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tarextumab through regulating the expression of Notch-3 receptor (NOTCH3). [412], [959]
Notch-4 receptor (NOTCH4)
LY3039478 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Notch-4 receptor (NOTCH4) is a therapeutic target for LY3039478. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of LY3039478 through regulating the expression of Notch-4 receptor (NOTCH4). [412], [960]
Nuclear factor erythroid 2-related factor 2 (Nrf2)
ABT-RTA-408 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for ABT-RTA-408. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ABT-RTA-408 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [266], [961]
CXA10 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for CXA10. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CXA10 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [266], [267]
Omaveloxolone [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for Omaveloxolone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Omaveloxolone through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [266], [962]
OT-551 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for OT-551. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of OT-551 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [266], [963]
OT551 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for OT551. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of OT551 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [266], [269]
SFX-01 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for SFX-01. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SFX-01 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [266], [964]
HPP971 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for HPP971. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HPP971 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [266], [965]
CAT4001 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for CAT4001. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CAT4001 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [266], [966]
M102 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for M102. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of M102 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [266], [967]
TFM735 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for TFM735. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TFM735 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [266], [962]
Nucleobindin-1 (NUCB1)
KML110 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nucleobindin-1 (NUCB1) is a therapeutic target for KML110. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of KML110 through regulating the expression of Nucleobindin-1 (NUCB1). [815], [968]
MJN228 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Nucleobindin-1 (NUCB1) is a therapeutic target for MJN228. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MJN228 through regulating the expression of Nucleobindin-1 (NUCB1). [968], [969]
O-6-methylguanine-DNA-alkyltransferase (MGMT)
O6-Benzylguanine alkylade [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary O-6-methylguanine-DNA-alkyltransferase (MGMT) is a therapeutic target for O6-Benzylguanine alkylade. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of O6-Benzylguanine alkylade through regulating the expression of O-6-methylguanine-DNA-alkyltransferase (MGMT). [970], [971]
6-Allyloxy-9H-purin-2-ylamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary O-6-methylguanine-DNA-alkyltransferase (MGMT) is a therapeutic target for 6-Allyloxy-9H-purin-2-ylamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6-Allyloxy-9H-purin-2-ylamine through regulating the expression of O-6-methylguanine-DNA-alkyltransferase (MGMT). [970], [972]
6-Benzyloxy-5-nitro-pyrimidine-2,4-diamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary O-6-methylguanine-DNA-alkyltransferase (MGMT) is a therapeutic target for 6-Benzyloxy-5-nitro-pyrimidine-2,4-diamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6-Benzyloxy-5-nitro-pyrimidine-2,4-diamine through regulating the expression of O-6-methylguanine-DNA-alkyltransferase (MGMT). [970], [972]
6-Benzyloxy-5-nitroso-pyrimidine-2,4-diamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary O-6-methylguanine-DNA-alkyltransferase (MGMT) is a therapeutic target for 6-Benzyloxy-5-nitroso-pyrimidine-2,4-diamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6-Benzyloxy-5-nitroso-pyrimidine-2,4-diamine through regulating the expression of O-6-methylguanine-DNA-alkyltransferase (MGMT). [970], [973]
6-Benzyloxy-9H-purin-2-ylamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary O-6-methylguanine-DNA-alkyltransferase (MGMT) is a therapeutic target for 6-Benzyloxy-9H-purin-2-ylamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6-Benzyloxy-9H-purin-2-ylamine through regulating the expression of O-6-methylguanine-DNA-alkyltransferase (MGMT). [210], [970]
Benzylcysteine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary O-6-methylguanine-DNA-alkyltransferase (MGMT) is a therapeutic target for Benzylcysteine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Benzylcysteine through regulating the expression of O-6-methylguanine-DNA-alkyltransferase (MGMT). [970], [972]
S-Methylcysteine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary O-6-methylguanine-DNA-alkyltransferase (MGMT) is a therapeutic target for S-Methylcysteine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of S-Methylcysteine through regulating the expression of O-6-methylguanine-DNA-alkyltransferase (MGMT). [970], [974]
P-glycoprotein 1 (ABCB1)
Abacavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Abacavir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Abacavir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [975]
Acebutolol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Acebutolol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Acebutolol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Acrivastine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Acrivastine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Acrivastine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [976]
Actinomycin D [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Actinomycin D. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Actinomycin D through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Afatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Afatinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Afatinib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [65]
Ajmaline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ajmaline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ajmaline through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [977]
Albendazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Albendazole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Albendazole through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [978]
Aldosterone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Aldosterone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Aldosterone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [979]
Aliskiren fumarate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Aliskiren fumarate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Aliskiren fumarate through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [980]
Ambrisentan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ambrisentan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ambrisentan through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [981]
Amiodarone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Amiodarone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Amiodarone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Amisulpride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Amisulpride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Amisulpride through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [982]
Amitriptyline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Amitriptyline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Amitriptyline through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [983]
Amoxicillin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Amoxicillin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Amoxicillin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Amphotericin B [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Amphotericin B. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Amphotericin B through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [984]
Amprenavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Amprenavir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Amprenavir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Apixaban [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Apixaban. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Apixaban through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [985]
Apremilast [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Apremilast. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Apremilast through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Aprepitant [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Aprepitant. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Aprepitant through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [987]
Arsenic trioxide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Arsenic trioxide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Arsenic trioxide through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [988]
Aspirin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Aspirin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Aspirin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [983]
Atenolol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Atenolol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Atenolol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [989]
Atomoxetine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Atomoxetine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Atomoxetine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [987]
Axitinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Axitinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Axitinib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [990]
Azasetron [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Azasetron. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Azasetron through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Azathioprine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Azathioprine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Azathioprine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [983]
Azithromycin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Azithromycin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Azithromycin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [991]
Baloxavir marboxil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Baloxavir marboxil. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Baloxavir marboxil through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [992]
Baricitinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Baricitinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Baricitinib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [993]
Beclomethasone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Beclomethasone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Beclomethasone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [994]
Beclomethasone dipropionate [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Beclomethasone dipropionate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Beclomethasone dipropionate through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [994]
Bepridil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Bepridil. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Bepridil through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
beta-Acetyldigoxin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for beta-Acetyldigoxin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of beta-Acetyldigoxin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [995]
beta-Carotene [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for beta-Carotene. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of beta-Carotene through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [984]
Betamethasone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Betamethasone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Betamethasone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [996]
Betrixaban [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Betrixaban. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Betrixaban through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [997]
Bicalutamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Bicalutamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Bicalutamide through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [70]
Binimetinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Binimetinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Binimetinib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [71]
Biotin [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Biotin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Biotin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [998]
Boceprevir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Boceprevir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Boceprevir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [999]
Bosutinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Bosutinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Bosutinib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1000]
Brilinta [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Brilinta. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Brilinta through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1001]
Bromocriptine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Bromocriptine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Bromocriptine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [987]
Bupropion [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Bupropion. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Bupropion through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1002]
Cabergoline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cabergoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cabergoline through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1003]
Canagliflozin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Canagliflozin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Canagliflozin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [74]
Cannabidiol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cannabidiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cannabidiol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1001]
Carfilzomib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Carfilzomib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Carfilzomib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1004]
Carvedilol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Carvedilol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Carvedilol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Cefoperazone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cefoperazone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cefoperazone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Cefotetan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cefotetan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cefotetan through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Ceftriaxone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ceftriaxone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ceftriaxone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Celiprolol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Celiprolol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Celiprolol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1005]
Cepharanthine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cepharanthine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cepharanthine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1006]
Ceritinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ceritinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ceritinib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1007]
Cerivastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cerivastatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cerivastatin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1008]
Cetirizine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cetirizine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cetirizine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1009]
Chlorambucil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Chlorambucil. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Chlorambucil through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Chloramphenicol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Chloramphenicol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Chloramphenicol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1010]
Chlorpromazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Chlorpromazine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Chlorpromazine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Ciclesonide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ciclesonide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ciclesonide through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [994]
Cimetidine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cimetidine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cimetidine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Cinchonidine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cinchonidine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cinchonidine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Cisplatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cisplatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cisplatin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Citalopram [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Citalopram. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Citalopram through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1011]
Clarithromycin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Clarithromycin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Clarithromycin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Clobazam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Clobazam. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Clobazam through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Clofazimine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Clofazimine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Clofazimine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1012]
Clomifene [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Clomifene. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Clomifene through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1013]
Clomiphene citrate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Clomiphene citrate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Clomiphene citrate through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1013]
Clomipramine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Clomipramine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Clomipramine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [987]
Clonidine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Clonidine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Clonidine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [983]
Clopidogrel [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Clopidogrel. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Clopidogrel through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1014]
Clozapine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Clozapine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Clozapine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [982]
Colchicine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Colchicine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Colchicine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1015]
Cortisone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cortisone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cortisone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [996]
Cyclosporine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cyclosporine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cyclosporine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1016]
Cytarabine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cytarabine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cytarabine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Dabigatran [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dabigatran. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dabigatran through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1017]
Dabrafenib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dabrafenib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dabrafenib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [83]
Daclatasvir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Daclatasvir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Daclatasvir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1017]
Dactinomycin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dactinomycin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dactinomycin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1018]
Darunavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Darunavir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Darunavir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1019]
Debrisoquine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Debrisoquine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Debrisoquine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1020]
Deflazacort [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Deflazacort. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Deflazacort through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1001]
Delavirdine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Delavirdine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Delavirdine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [975]
Desipramine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Desipramine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Desipramine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1021]
Desloratadine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Desloratadine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Desloratadine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1022]
Diazepam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Diazepam. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Diazepam through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1023]
Dicloxacillin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dicloxacillin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dicloxacillin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1024]
Diethylstilbestrol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Diethylstilbestrol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Diethylstilbestrol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1013]
Digitoxin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Digitoxin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Digitoxin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1025]
Digoxin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Digoxin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Digoxin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1026]
Dihydroergocristine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dihydroergocristine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dihydroergocristine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1027]
Diltiazem [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Diltiazem. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Diltiazem through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Dipyridamole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dipyridamole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dipyridamole through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [987]
Docetaxel [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Docetaxel. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Docetaxel through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1028]
Dolutegravir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dolutegravir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dolutegravir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Domperidone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Domperidone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Domperidone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [982]
Doxycycline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Doxycycline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Doxycycline through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Ebastine [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ebastine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ebastine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Edoxaban [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Edoxaban. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Edoxaban through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1029]
Efavirenz [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Efavirenz. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Efavirenz through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Eletriptan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Eletriptan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Eletriptan through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [987]
Eliglustat tartrate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Eliglustat tartrate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Eliglustat tartrate through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1001]
Emetine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Emetine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Emetine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1018]
Empagliflozin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Empagliflozin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Empagliflozin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1001]
Epinastine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Epinastine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Epinastine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1030]
Epirubicin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Epirubicin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Epirubicin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Ergotamine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ergotamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ergotamine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [987]
Erythromycin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Erythromycin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Erythromycin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1031]
Eslicarbazepine acetate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Eslicarbazepine acetate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Eslicarbazepine acetate through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1032]
Estradiol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Estradiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Estradiol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1013]
Estriol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Estriol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Estriol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1033]
Estrone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Estrone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Estrone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1033]
Estrone sulfate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Estrone sulfate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Estrone sulfate through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1008]
Ethinyl estradiol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ethinyl estradiol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ethinyl estradiol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1033]
Etoposide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Etoposide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Etoposide through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1034]
Ezetimibe [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ezetimibe. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ezetimibe through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1035]
Famciclovir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Famciclovir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Famciclovir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [976]
Felodipine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Felodipine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Felodipine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1036]
Fentanyl [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fentanyl. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fentanyl through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Fesoterodine fumarate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fesoterodine fumarate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fesoterodine fumarate through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1037]
Fexofenadine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fexofenadine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fexofenadine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1038]
Fluoxetine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fluoxetine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fluoxetine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1039]
Flupentixol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Flupentixol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Flupentixol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [982]
Fluphenazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fluphenazine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fluphenazine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [982]
Fluticasone propionate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fluticasone propionate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fluticasone propionate through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [994]
Fluvastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fluvastatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fluvastatin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1021]
Fluvoxamine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fluvoxamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fluvoxamine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [982]
Folic acid [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Folic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Folic acid through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1040]
Fosamprenavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fosamprenavir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fosamprenavir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Gatifloxacin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Gatifloxacin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Gatifloxacin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1041]
Gilteritinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Gilteritinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Gilteritinib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1001]
Glutathione [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Glutathione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Glutathione through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1042]
Gramicidin D [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Gramicidin D. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Gramicidin D through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Grepafloxacin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Grepafloxacin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Grepafloxacin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Guanabenz [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Guanabenz. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Guanabenz through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1021]
Guanfacine [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Guanfacine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Guanfacine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1043]
Haloperidol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Haloperidol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Haloperidol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [982]
Hydrocortisone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Hydrocortisone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Hydrocortisone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [994]
Hydroxyurea [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Hydroxyurea. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Hydroxyurea through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Ibrutinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ibrutinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ibrutinib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1044]
Idarubicin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Idarubicin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Idarubicin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [109]
Imatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Imatinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Imatinib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1045]
Imipramine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Imipramine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Imipramine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [983]
Indacaterol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Indacaterol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Indacaterol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1001]
Indinavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Indinavir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Indinavir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1046]
Indomethacin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Indomethacin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Indomethacin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1047]
Ingenol-3-angelate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ingenol-3-angelate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ingenol-3-angelate through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1048]
Irinotecan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Irinotecan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Irinotecan through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1049]
Itraconazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Itraconazole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Itraconazole through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Ivacaftor [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ivacaftor. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ivacaftor through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1050]
Ivermectin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ivermectin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ivermectin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1051]
Ivosidenib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ivosidenib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ivosidenib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1052]
Ixabepilone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ixabepilone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ixabepilone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [90]
Ketoconazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ketoconazole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ketoconazole through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
L-tryptophan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for L-tryptophan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of L-tryptophan through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1053]
Labetalol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Labetalol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Labetalol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Lamotrigine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Lamotrigine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lamotrigine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1054]
Lansoprazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Lansoprazole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lansoprazole through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1021]
Lapatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Lapatinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lapatinib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Ledipasvir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ledipasvir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ledipasvir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Lenalidomide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Lenalidomide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lenalidomide through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1055]
Lenvatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Lenvatinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lenvatinib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1056]
Levetiracetam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Levetiracetam. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Levetiracetam through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1057]
Levodopa [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Levodopa. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Levodopa through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Levofloxacin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Levofloxacin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Levofloxacin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Levomepromazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Levomepromazine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Levomepromazine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [982]
Levomilnacipran [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Levomilnacipran. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Levomilnacipran through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1058]
Lidocaine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Lidocaine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lidocaine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Linagliptin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Linagliptin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Linagliptin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Loperamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Loperamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Loperamide through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1059]
Lopinavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Lopinavir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lopinavir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1060]
Loratadine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Loratadine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Loratadine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1022]
Losartan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Losartan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Losartan through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1061]
Lovastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Lovastatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lovastatin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Lovastatin acid [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Lovastatin acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lovastatin acid through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Maraviroc [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Maraviroc. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Maraviroc through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Mefloquine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Mefloquine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Mefloquine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1062]
Melphalan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Melphalan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Melphalan through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1063]
Meperidine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Meperidine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Meperidine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1064]
Mequitazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Mequitazine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Mequitazine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [976]
Methadone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Methadone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Methadone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1065]
Methotrexate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Methotrexate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Methotrexate through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Methylprednisolone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Methylprednisolone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Methylprednisolone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1066]
Methysergide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Methysergide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Methysergide through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [976]
Midazolam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Midazolam. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Midazolam through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1021]
Midostaurin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Midostaurin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Midostaurin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Mitomycin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Mitomycin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Mitomycin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1067]
Mitoxantrone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Mitoxantrone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Mitoxantrone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Morphine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Morphine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Morphine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1068]
Moxidectin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Moxidectin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Moxidectin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [119]
Mycophenolate mofetil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Mycophenolate mofetil. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Mycophenolate mofetil through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [120]
Nadolol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nadolol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nadolol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Nalbuphine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nalbuphine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nalbuphine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [976]
Naloxegol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Naloxegol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Naloxegol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Nelfinavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nelfinavir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nelfinavir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1069]
Neostigmine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Neostigmine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Neostigmine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [987]
Nevirapine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nevirapine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nevirapine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Nicardipine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nicardipine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nicardipine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1070]
Nifedipine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nifedipine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nifedipine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Nilotinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nilotinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nilotinib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1001]
Nimodipine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nimodipine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nimodipine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Nintedanib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nintedanib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nintedanib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1071]
Nisoldipine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nisoldipine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nisoldipine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Nitrendipine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nitrendipine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nitrendipine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Nizatidine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nizatidine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nizatidine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1072]
Norfloxacin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Norfloxacin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Norfloxacin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Olanzapine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Olanzapine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Olanzapine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [982]
Olmesartan medoxomil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Olmesartan medoxomil. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Olmesartan medoxomil through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1001]
Olopatadine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Olopatadine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Olopatadine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Omadacycline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Omadacycline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Omadacycline through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1073]
Ombitasvir [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ombitasvir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ombitasvir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Omeprazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Omeprazole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Omeprazole through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1021]
Ondansetron [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ondansetron. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ondansetron through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1062]
Oseltamivir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Oseltamivir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Oseltamivir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1074]
Oxcarbazepine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Oxcarbazepine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Oxcarbazepine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1075]
Palbociclib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Palbociclib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Palbociclib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [126]
Paliperidone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Paliperidone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Paliperidone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1076]
Panobinostat [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Panobinostat. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Panobinostat through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1077]
Pantoprazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pantoprazole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pantoprazole through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1021]
Paroxetine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Paroxetine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Paroxetine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [987]
Pazopanib hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pazopanib hydrochloride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pazopanib hydrochloride through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [128]
Pemirolast [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pemirolast. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pemirolast through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Pentazocine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pentazocine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pentazocine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Perazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Perazine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Perazine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [982]
Perphenazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Perphenazine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Perphenazine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [982]
Phenobarbital [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Phenobarbital. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Phenobarbital through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1075]
Phenprocoumon [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Phenprocoumon. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Phenprocoumon through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1078]
Phenytoin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Phenytoin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Phenytoin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1075]
Pibrentasvir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pibrentasvir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pibrentasvir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Pimozide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pimozide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pimozide through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Pirarubicin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pirarubicin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pirarubicin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Pirenzepine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pirenzepine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pirenzepine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [976]
Pomalidomide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pomalidomide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pomalidomide through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1079]
Ponatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ponatinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ponatinib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [132]
Posaconazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Posaconazole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Posaconazole through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1001]
Pravastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pravastatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pravastatin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Prazosin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Prazosin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Prazosin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1080]
Prednisolone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Prednisolone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Prednisolone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1081]
Prednisone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Prednisone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Prednisone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [996]
Progesterone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Progesterone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Progesterone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1023]
Propafenone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Propafenone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Propafenone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Propranolol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Propranolol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Propranolol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Protriptyline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Protriptyline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Protriptyline through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [976]
Prucalopride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Prucalopride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Prucalopride through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1082]
Quercetin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Quercetin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Quercetin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1083]
Quetiapine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Quetiapine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Quetiapine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [982]
Quinine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Quinine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Quinine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Raloxifene [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Raloxifene. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Raloxifene through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1084]
Ramosetron [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ramosetron. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ramosetron through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1085]
Ranitidine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ranitidine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ranitidine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Ranolazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ranolazine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ranolazine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1086]
Regorafenib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Regorafenib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Regorafenib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1087]
Reserpine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Reserpine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Reserpine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [987]
Rifampicin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Rifampicin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Rifampicin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Rifaximin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Rifaximin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Rifaximin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1088]
Riociguat [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Riociguat. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Riociguat through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1089]
Risperidone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Risperidone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Risperidone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1090]
Ritonavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ritonavir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ritonavir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1091]
Rivaroxaban [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Rivaroxaban. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Rivaroxaban through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1092]
Romidepsin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Romidepsin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Romidepsin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1093]
Rosuvastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Rosuvastatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Rosuvastatin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [141]
S-licarbazepine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for S-licarbazepine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of S-licarbazepine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1032]
Saphris [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Saphris. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Saphris through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Saquinavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Saquinavir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Saquinavir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1094]
Saxagliptin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Saxagliptin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Saxagliptin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Sertraline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Sertraline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sertraline through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [987]
Silodosin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Silodosin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Silodosin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1095]
Simeprevir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Simeprevir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Simeprevir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1001]
Simvastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Simvastatin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Simvastatin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Sitagliptin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Sitagliptin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sitagliptin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Sofosbuvir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Sofosbuvir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sofosbuvir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1096]
Sparfloxacin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Sparfloxacin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sparfloxacin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Spiperone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Spiperone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Spiperone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Sumatriptan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Sumatriptan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sumatriptan through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1097]
Sunitinib malate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Sunitinib malate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sunitinib malate through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1098]
Tacrine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tacrine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tacrine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1099]
Tacrolimus [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tacrolimus. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tacrolimus through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Tadalafil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tadalafil. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tadalafil through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1100]
Talazoparib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Talazoparib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Talazoparib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [145]
Telaprevir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Telaprevir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Telaprevir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [999]
Telithromycin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Telithromycin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Telithromycin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1101]
Temsirolimus [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Temsirolimus. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Temsirolimus through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1102]
Tenofovir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tenofovir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tenofovir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1001]
Tenofovir disoproxil [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tenofovir disoproxil. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tenofovir disoproxil through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Tenoxicam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tenoxicam. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tenoxicam through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Testosterone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Testosterone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Testosterone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1021]
Tetracycline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tetracycline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tetracycline through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Thiamphenicol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Thiamphenicol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Thiamphenicol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1010]
Thioridazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Thioridazine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Thioridazine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [987]
Timolol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Timolol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Timolol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1005]
Tolvaptan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tolvaptan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tolvaptan through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1103]
Topiramate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Topiramate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Topiramate through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1104]
Topotecan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Topotecan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Topotecan through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [150]
Toremifene [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Toremifene. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Toremifene through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1013]
Tramadol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tramadol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tramadol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1105]
Trifluoperazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Trifluoperazine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Trifluoperazine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Triflupromazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Triflupromazine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Triflupromazine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Trimethoprim [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Trimethoprim. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Trimethoprim through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [987]
Triprolidine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Triprolidine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Triprolidine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1106]
Trospium chloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Trospium chloride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Trospium chloride through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1107]
Vecuronium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Vecuronium. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Vecuronium through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1062]
Venetoclax [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Venetoclax. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Venetoclax through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1108]
Verapamil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Verapamil. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Verapamil through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1109]
vildagliptin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for vildagliptin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of vildagliptin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1110]
Vinblastine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Vinblastine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Vinblastine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1111]
Vincristine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Vincristine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Vincristine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1112]
Vindesine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Vindesine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Vindesine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Vinorelbine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Vinorelbine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Vinorelbine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1113]
Zidovudine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Zidovudine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Zidovudine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [975]
Ziprasidone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ziprasidone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ziprasidone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [987]
Zolmitriptan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Zolmitriptan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Zolmitriptan through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [987]
4-Hydroxytamoxifen [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for 4-Hydroxytamoxifen. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-Hydroxytamoxifen through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1013]
Asimadoline [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Asimadoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Asimadoline through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Asunaprevir [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Asunaprevir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Asunaprevir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1001]
Belotecan [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Belotecan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Belotecan through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
CBT-1 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for CBT-1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CBT-1 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [453]
Corticosterone [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Corticosterone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Corticosterone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1013]
Dasabuvir [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dasabuvir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dasabuvir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Morphine-6-glucuronide [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Morphine-6-glucuronide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Morphine-6-glucuronide through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Pazufloxacin [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pazufloxacin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pazufloxacin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1114]
Relugolix [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Relugolix. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Relugolix through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1001]
Simvastatin acid [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Simvastatin acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Simvastatin acid through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1115]
Sitafloxacin [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Sitafloxacin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sitafloxacin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Tenofovir alafenamide [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tenofovir alafenamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tenofovir alafenamide through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [153]
Vibegron [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Vibegron. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Vibegron through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1001]
(Z)-endoxifen [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for (Z)-endoxifen. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (Z)-endoxifen through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1116]
ABT-263 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for ABT-263. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ABT-263 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1117]
Bisantrene [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Bisantrene. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Bisantrene through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Cholesterol [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cholesterol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cholesterol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1118]
CP-122721 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for CP-122721. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CP-122721 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1119]
Curcumin [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Curcumin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Curcumin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Dihydrotestosterone [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dihydrotestosterone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dihydrotestosterone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1120]
Dolastatin 10 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dolastatin 10. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dolastatin 10 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1121]
Fucoxanthin [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fucoxanthin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fucoxanthin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [984]
Gallopamil [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Gallopamil. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Gallopamil through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Gepirone [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Gepirone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Gepirone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Glecaprevir [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Glecaprevir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Glecaprevir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Norverapamil [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Norverapamil. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Norverapamil through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1122]
NSC325663 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for NSC325663. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NSC325663 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1123]
Paritaprevir [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Paritaprevir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Paritaprevir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Roscovitine [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Roscovitine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Roscovitine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1124]
Staurosporine [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Staurosporine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Staurosporine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
EDP-322 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for EDP-322. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of EDP-322 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1125]
Genz 644282 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Genz 644282. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Genz 644282 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1126]
Naringenin [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Naringenin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Naringenin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1083]
Norbuprenorphine [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Norbuprenorphine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Norbuprenorphine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1127]
Prostaglandin A2 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Prostaglandin A2. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Prostaglandin A2 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1128]
Substance P [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Substance P. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Substance P through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1129]
Talinolol [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Talinolol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Talinolol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1130]
Velpatasvir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Velpatasvir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Velpatasvir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
Voxilaprevir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Voxilaprevir. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Voxilaprevir through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [986]
W-198 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for W-198. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of W-198 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1131]
YP-005 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for YP-005. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of YP-005 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1132]
Abamectin B1A [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Abamectin B1A. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Abamectin B1A through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1133]
AG1478 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for AG1478. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AG1478 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [81]
Bouvardin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Bouvardin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Bouvardin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1123]
Bunitrolol [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Bunitrolol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Bunitrolol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1134]
Cephaeline [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cephaeline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cephaeline through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1123]
Coelenterazine [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Coelenterazine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Coelenterazine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1135]
Cycloheximide [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cycloheximide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Cycloheximide through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [984]
Desmethylsertraline [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Desmethylsertraline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Desmethylsertraline through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1002]
E-guggulsterone [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for E-guggulsterone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of E-guggulsterone through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1136]
Epothilone A [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Epothilone A. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Epothilone A through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Geneticin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Geneticin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Geneticin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1137]
Metildigoxin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Metildigoxin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Metildigoxin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1001]
Metkephamid [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Metkephamid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Metkephamid through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1123]
MG-132 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for MG-132. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MG-132 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1138]
N-desethyl sunitinib [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for N-desethyl sunitinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-desethyl sunitinib through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [171]
Nafoxidine [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nafoxidine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nafoxidine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1013]
Nogalamycin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nogalamycin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nogalamycin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1123]
Nonactin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nonactin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nonactin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1018]
Okadaic acid [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Okadaic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Okadaic acid through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1123]
Pepstatin A [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pepstatin A. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pepstatin A through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Puromycin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Puromycin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Puromycin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1137]
Selamectin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Selamectin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Selamectin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1133]
Silvestrol [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Silvestrol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Silvestrol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1139]
SNS-032 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for SNS-032. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SNS-032 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
4,3'',5''-trimethoxy-[1,1':2',1'']-terphenyl [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for 4,3'',5''-trimethoxy-[1,1':2',1'']-terphenyl. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4,3'',5''-trimethoxy-[1,1':2',1'']-terphenyl through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1140]
6-(3,5-dimethoxy-phenyl)-naphthalen-2-ol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for 6-(3,5-dimethoxy-phenyl)-naphthalen-2-ol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6-(3,5-dimethoxy-phenyl)-naphthalen-2-ol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1141]
Azidopine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Azidopine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Azidopine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Bcecf-Am [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Bcecf-Am. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Bcecf-Am through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Hoechst 33342 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Hoechst 33342. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Hoechst 33342 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Leupeptin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Leupeptin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Leupeptin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Paraquat [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Paraquat. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Paraquat through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Tiapamil [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tiapamil. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tiapamil through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
TRISMETHOXYRESVERATROL [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for TRISMETHOXYRESVERATROL. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TRISMETHOXYRESVERATROL through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1140]
Valinomycin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Valinomycin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Valinomycin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1070]
XR-9456 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for XR-9456. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of XR-9456 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1141]
XR-9504 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for XR-9504. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of XR-9504 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1141]
XR-9544 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for XR-9544. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of XR-9544 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1142]
XR-9577 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for XR-9577. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of XR-9577 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1141]
[1,1':2',1'']-terphenyl-4,3'',5''-triol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for [1,1':2',1'']-terphenyl-4,3'',5''-triol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of [1,1':2',1'']-terphenyl-4,3'',5''-triol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1140]
ABT-737 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for ABT-737. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ABT-737 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1117]
Alprenolol [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Alprenolol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Alprenolol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1021]
Apafant [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Apafant. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Apafant through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1143]
Astemizole [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Astemizole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Astemizole through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [987]
Biricodar [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Biricodar. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Biricodar through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1140]
Calphostin C [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Calphostin C. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Calphostin C through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Dexniguldipine [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dexniguldipine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Dexniguldipine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1123]
Droloxifene [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Droloxifene. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Droloxifene through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
ELACRIDAR [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for ELACRIDAR. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ELACRIDAR through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1144]
Flesinoxan [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Flesinoxan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Flesinoxan through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1145]
Hydroxybupropion [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Hydroxybupropion. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Hydroxybupropion through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1002]
Isoxicam [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Isoxicam. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Isoxicam through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
LY335979 [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for LY335979. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of LY335979 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1146]
Melagatran [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Melagatran. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Melagatran through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Mibefradil [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Mibefradil. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Mibefradil through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Mithramycin [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Mithramycin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Mithramycin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Niguldipine [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Niguldipine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Niguldipine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
ONT-093 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for ONT-093. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ONT-093 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1147]
Pafenolol [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pafenolol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pafenolol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Rhodamine 123 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Rhodamine 123. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Rhodamine 123 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1070]
Roxithromycin [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Roxithromycin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Roxithromycin through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1101]
S9788 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for S9788. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of S9788 through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
Tariquidar [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tariquidar. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tariquidar through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1148]
Terfenadine [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Terfenadine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Terfenadine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Tolafentrine [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tolafentrine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Tolafentrine through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [1021]
Trans-flupentixol [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Trans-flupentixol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Trans-flupentixol through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Valspodar [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Valspodar. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Valspodar through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [76]
Ximelagatran [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ximelagatran. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ximelagatran through regulating the expression of P-glycoprotein 1 (ABCB1). [61], [86]
p53-binding protein Mdm4 (MDM4)
ALRN-6924 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary p53-binding protein Mdm4 (MDM4) is a therapeutic target for ALRN-6924. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ALRN-6924 through regulating the expression of p53-binding protein Mdm4 (MDM4). [12], [1149]
NSC-207895 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary p53-binding protein Mdm4 (MDM4) is a therapeutic target for NSC-207895. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NSC-207895 through regulating the expression of p53-binding protein Mdm4 (MDM4). [12], [1150]
Parathyroid hormone 1 receptor (PTH1R)
Abaloparatide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Parathyroid hormone 1 receptor (PTH1R) is a therapeutic target for Abaloparatide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Abaloparatide through regulating the expression of Parathyroid hormone 1 receptor (PTH1R). [1151], [1152]
PCO371 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Parathyroid hormone 1 receptor (PTH1R) is a therapeutic target for PCO371. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PCO371 through regulating the expression of Parathyroid hormone 1 receptor (PTH1R). [1151], [1153]
Peroxisome proliferator-activated receptor alpha (PPARA)
Bezafibrate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Bezafibrate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Bezafibrate through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1155]
Ciprofibrate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Ciprofibrate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ciprofibrate through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1156]
Fenofibrate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Fenofibrate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fenofibrate through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1157]
Lobeglitazone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Lobeglitazone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Lobeglitazone through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1158]
Pemafibrate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Pemafibrate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pemafibrate through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1155]
BMS-298585 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for BMS-298585. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BMS-298585 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [833], [1154]
CS-038 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for CS-038. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CS-038 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1159]
GFT-505 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for GFT-505. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GFT-505 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1160]
Imiglitazar [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Imiglitazar. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Imiglitazar through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1161]
Ragaglitazar [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Ragaglitazar. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ragaglitazar through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1162]
TESAGLITAZAR [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for TESAGLITAZAR. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TESAGLITAZAR through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1163]
ZYH-1 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for ZYH-1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ZYH-1 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1164]
GFT14 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for GFT14. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GFT14 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1165]
LY-518674 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for LY-518674. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of LY-518674 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1166]
Naveglitazar [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Naveglitazar. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Naveglitazar through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [214], [1154]
ONO-5129 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for ONO-5129. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ONO-5129 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1167]
ZYH7 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for ZYH7. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ZYH7 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1168]
AVE0897 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for AVE0897. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AVE0897 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1169]
CDT-fenofibrate [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for CDT-fenofibrate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CDT-fenofibrate through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1170]
GW-409544 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for GW-409544. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GW-409544 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1171]
Oxeglitazar [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Oxeglitazar. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Oxeglitazar through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1172]
TPST-1120 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for TPST-1120. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TPST-1120 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1173]
MC-3001 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for MC-3001. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MC-3001 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1174]
MC-3002 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for MC-3002. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MC-3002 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1175]
PIRINIXIC ACID [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for PIRINIXIC ACID. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PIRINIXIC ACID through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1176]
Romazarit [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Romazarit. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Romazarit through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [214], [1154]
(9Z,12E)-12-nitrooctadeca-9,12-dienoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for (9Z,12E)-12-nitrooctadeca-9,12-dienoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (9Z,12E)-12-nitrooctadeca-9,12-dienoic acid through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1177]
(E)-12-Nitrooctadec-12-enoic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for (E)-12-Nitrooctadec-12-enoic Acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (E)-12-Nitrooctadec-12-enoic Acid through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1178]
(E)-13-Nitrooctadec-12-enoic Acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for (E)-13-Nitrooctadec-12-enoic Acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (E)-13-Nitrooctadec-12-enoic Acid through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1178]
(E)-4-(3,5-dimethoxystyryl)phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for (E)-4-(3,5-dimethoxystyryl)phenol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (E)-4-(3,5-dimethoxystyryl)phenol through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1179]
8S-HETE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for 8S-HETE. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 8S-HETE through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1164]
AD-5061 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for AD-5061. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AD-5061 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1180]
BMS-687453 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for BMS-687453. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BMS-687453 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1181]
CP-775146 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for CP-775146. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CP-775146 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [210], [1154]
DB-900 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for DB-900. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of DB-900 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1182]
Deoxy-Bigchap [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Deoxy-Bigchap. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Deoxy-Bigchap through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1183]
DRF 2519 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for DRF 2519. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of DRF 2519 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1184]
eicosatetranoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for eicosatetranoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of eicosatetranoic acid through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1185]
Fibrates [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Fibrates. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Fibrates through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1186]
GSK-9578 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for GSK-9578. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GSK-9578 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1178]
GW-2331 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for GW-2331. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GW-2331 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1187]
GW7647 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for GW7647. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GW7647 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1188]
L-165461 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for L-165461. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of L-165461 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1186]
L-796449 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for L-796449. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of L-796449 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1155]
LL-6531 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for LL-6531. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of LL-6531 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1189]
LY-465608 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for LY-465608. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of LY-465608 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1190]
N-oleoylethanolamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for N-oleoylethanolamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-oleoylethanolamide through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1191]
pristanic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for pristanic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of pristanic acid through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1192]
reglitazar [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for reglitazar. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of reglitazar through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1193]
TZD18 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for TZD18. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TZD18 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1194]
ZY H2 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for ZY H2. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ZY H2 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1195]
Aleglitazar [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Aleglitazar. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Aleglitazar through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1196]
AR-H049020 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for AR-H049020. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AR-H049020 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1192]
AVE-0847 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for AVE-0847. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AVE-0847 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1197]
AVE-8134 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for AVE-8134. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AVE-8134 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1198]
BM-17.0744 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for BM-17.0744. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BM-17.0744 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [214], [1154]
BVT-142 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for BVT-142. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BVT-142 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1199]
CS-204 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for CS-204. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CS-204 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1200]
CS-207 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for CS-207. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CS-207 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1201]
DRF 10945 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for DRF 10945. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of DRF 10945 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1202]
E-3030 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for E-3030. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of E-3030 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1203]
GSK-677954 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for GSK-677954. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GSK-677954 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1204]
Indeglitazar [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Indeglitazar. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Indeglitazar through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [29], [1154]
KRP-101 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for KRP-101. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of KRP-101 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1205]
KRP-105 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for KRP-105. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of KRP-105 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1163]
KRP-297 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for KRP-297. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of KRP-297 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1192]
LG-101280 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for LG-101280. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of LG-101280 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1206]
LY-929 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for LY-929. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of LY-929 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1207]
MP-136 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for MP-136. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MP-136 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1208]
NS-220 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for NS-220. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NS-220 through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1209]
Reglixane [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Reglixane. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Reglixane through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1210]
Sipoglitazar [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Sipoglitazar. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sipoglitazar through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1211]
Sodelglitazar [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Peroxisome proliferator-activated receptor alpha (PPARA) is a therapeutic target for Sodelglitazar. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sodelglitazar through regulating the expression of Peroxisome proliferator-activated receptor alpha (PPARA). [1154], [1212]
PI3-kinase alpha (PIK3CA)
Alpelisib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary PI3-kinase alpha (PIK3CA) is a therapeutic target for Alpelisib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Alpelisib through regulating the expression of PI3-kinase alpha (PIK3CA). [482], [1213]
BAY 80-6946 [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary PI3-kinase alpha (PIK3CA) is a therapeutic target for BAY 80-6946. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BAY 80-6946 through regulating the expression of PI3-kinase alpha (PIK3CA). [665], [1213]
Buparlisib [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary PI3-kinase alpha (PIK3CA) is a therapeutic target for Buparlisib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Buparlisib through regulating the expression of PI3-kinase alpha (PIK3CA). [1213], [1214]
GDC-0032 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary PI3-kinase alpha (PIK3CA) is a therapeutic target for GDC-0032. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GDC-0032 through regulating the expression of PI3-kinase alpha (PIK3CA). [1213], [1215]
LY3023414 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary PI3-kinase alpha (PIK3CA) is a therapeutic target for LY3023414. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of LY3023414 through regulating the expression of PI3-kinase alpha (PIK3CA). [1213], [1216]
MLN1117 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary PI3-kinase alpha (PIK3CA) is a therapeutic target for MLN1117. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MLN1117 through regulating the expression of PI3-kinase alpha (PIK3CA). [1213], [1217]
PA-799 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary PI3-kinase alpha (PIK3CA) is a therapeutic target for PA-799. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PA-799 through regulating the expression of PI3-kinase alpha (PIK3CA). [1213], [1218]
BLY719 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary PI3-kinase alpha (PIK3CA) is a therapeutic target for BLY719. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BLY719 through regulating the expression of PI3-kinase alpha (PIK3CA). [214], [1213]
HHCYH33 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary PI3-kinase alpha (PIK3CA) is a therapeutic target for HHCYH33. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HHCYH33 through regulating the expression of PI3-kinase alpha (PIK3CA). [1213], [1219]
PWT-33597 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary PI3-kinase alpha (PIK3CA) is a therapeutic target for PWT-33597. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PWT-33597 through regulating the expression of PI3-kinase alpha (PIK3CA). [1213], [1220]
ETP-46321 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary PI3-kinase alpha (PIK3CA) is a therapeutic target for ETP-46321. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ETP-46321 through regulating the expression of PI3-kinase alpha (PIK3CA). [1213], [1221]
Pigment epithelium-derived factor (SERPINF1)
AdPEDR [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Pigment epithelium-derived factor (SERPINF1) is a therapeutic target for AdPEDR. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AdPEDR through regulating the expression of Pigment epithelium-derived factor (SERPINF1). [963], [1222]
PEDF gene therapy [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Pigment epithelium-derived factor (SERPINF1) is a therapeutic target for PEDF gene therapy. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PEDF gene therapy through regulating the expression of Pigment epithelium-derived factor (SERPINF1). [1222], [1223]
PKC-eta messenger RNA (PRKCH mRNA)
8-Octyl-benzolactam-V9 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary PKC-eta messenger RNA (PRKCH mRNA) is a therapeutic target for 8-Octyl-benzolactam-V9. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 8-Octyl-benzolactam-V9 through regulating the expression of PKC-eta messenger RNA (PRKCH mRNA). [1224], [1225]
ISIS 6431 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary PKC-eta messenger RNA (PRKCH mRNA) is a therapeutic target for ISIS 6431. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 6431 through regulating the expression of PKC-eta messenger RNA (PRKCH mRNA). [1224], [1226]
ISIS 6432 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary PKC-eta messenger RNA (PRKCH mRNA) is a therapeutic target for ISIS 6432. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 6432 through regulating the expression of PKC-eta messenger RNA (PRKCH mRNA). [1224], [1226]
ISIS 6434 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary PKC-eta messenger RNA (PRKCH mRNA) is a therapeutic target for ISIS 6434. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 6434 through regulating the expression of PKC-eta messenger RNA (PRKCH mRNA). [1224], [1226]
ISIS 6435 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary PKC-eta messenger RNA (PRKCH mRNA) is a therapeutic target for ISIS 6435. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 6435 through regulating the expression of PKC-eta messenger RNA (PRKCH mRNA). [1224], [1226]
ISIS 6442 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary PKC-eta messenger RNA (PRKCH mRNA) is a therapeutic target for ISIS 6442. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 6442 through regulating the expression of PKC-eta messenger RNA (PRKCH mRNA). [1224], [1226]
ISIS 6443 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary PKC-eta messenger RNA (PRKCH mRNA) is a therapeutic target for ISIS 6443. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 6443 through regulating the expression of PKC-eta messenger RNA (PRKCH mRNA). [1224], [1226]
ISIS 6445 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary PKC-eta messenger RNA (PRKCH mRNA) is a therapeutic target for ISIS 6445. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 6445 through regulating the expression of PKC-eta messenger RNA (PRKCH mRNA). [1224], [1226]
ISIS 6553 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary PKC-eta messenger RNA (PRKCH mRNA) is a therapeutic target for ISIS 6553. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 6553 through regulating the expression of PKC-eta messenger RNA (PRKCH mRNA). [1224], [1226]
ISIS 6581 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary PKC-eta messenger RNA (PRKCH mRNA) is a therapeutic target for ISIS 6581. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 6581 through regulating the expression of PKC-eta messenger RNA (PRKCH mRNA). [1224], [1226]
ISIS 6603 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary PKC-eta messenger RNA (PRKCH mRNA) is a therapeutic target for ISIS 6603. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ISIS 6603 through regulating the expression of PKC-eta messenger RNA (PRKCH mRNA). [1224], [1227]
LY-326449 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary PKC-eta messenger RNA (PRKCH mRNA) is a therapeutic target for LY-326449. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of LY-326449 through regulating the expression of PKC-eta messenger RNA (PRKCH mRNA). [1224], [1228]
PROSTRATIN [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary PKC-eta messenger RNA (PRKCH mRNA) is a therapeutic target for PROSTRATIN. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PROSTRATIN through regulating the expression of PKC-eta messenger RNA (PRKCH mRNA). [1224], [1229]
BALANOL [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary PKC-eta messenger RNA (PRKCH mRNA) is a therapeutic target for BALANOL. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BALANOL through regulating the expression of PKC-eta messenger RNA (PRKCH mRNA). [1224], [1230]
Platelet-derived growth factor receptor alpha (PDGFRA)
Avapritinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for Avapritinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Avapritinib through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1231]
Olaratumab [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for Olaratumab. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Olaratumab through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
Ripretinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for Ripretinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ripretinib through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1233]
Romiplostim [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for Romiplostim. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Romiplostim through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1234]
CP-868596 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for CP-868596. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CP-868596 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1235]
E-3810 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for E-3810. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of E-3810 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1236]
Famitinib [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for Famitinib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Famitinib through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1237]
MEDI-575 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for MEDI-575. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MEDI-575 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1238]
MP470 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for MP470. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MP470 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1239]
XL-820 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for XL-820. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of XL-820 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1240]
(1H-indol-2-yl)(5-methoxy-1H-indol-2-yl)methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for (1H-indol-2-yl)(5-methoxy-1H-indol-2-yl)methanone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (1H-indol-2-yl)(5-methoxy-1H-indol-2-yl)methanone through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1241]
(1H-indol-2-yl)(5-phenoxy-1H-indol-2-yl)methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for (1H-indol-2-yl)(5-phenoxy-1H-indol-2-yl)methanone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (1H-indol-2-yl)(5-phenoxy-1H-indol-2-yl)methanone through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1241]
(1H-indol-2-yl)(6-methoxy-1H-indol-2-yl)methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for (1H-indol-2-yl)(6-methoxy-1H-indol-2-yl)methanone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (1H-indol-2-yl)(6-methoxy-1H-indol-2-yl)methanone through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1241]
(5-fluoro-1H-indol-2-yl)-(1H-indol-2-yl)methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for (5-fluoro-1H-indol-2-yl)-(1H-indol-2-yl)methanone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (5-fluoro-1H-indol-2-yl)-(1H-indol-2-yl)methanone through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1241]
(5-hydroxy-1H-indol-2-yl)(1H-indol-2-yl)methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for (5-hydroxy-1H-indol-2-yl)(1H-indol-2-yl)methanone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (5-hydroxy-1H-indol-2-yl)(1H-indol-2-yl)methanone through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1241]
1-Phenyl-1H-benzoimidazol-5-ol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 1-Phenyl-1H-benzoimidazol-5-ol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 1-Phenyl-1H-benzoimidazol-5-ol through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1242]
1-Phenyl-1H-benzoimidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 1-Phenyl-1H-benzoimidazole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 1-Phenyl-1H-benzoimidazole through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1243]
3-((E)-Styryl)-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 3-((E)-Styryl)-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-((E)-Styryl)-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
3-(1H-Indol-3-yl)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 3-(1H-Indol-3-yl)-6,7-dimethoxy-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(1H-Indol-3-yl)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
3-(1H-Indol-3-yl)-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 3-(1H-Indol-3-yl)-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(1H-Indol-3-yl)-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
3-(2-Cyclohexyl-ethyl)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 3-(2-Cyclohexyl-ethyl)-6,7-dimethoxy-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(2-Cyclohexyl-ethyl)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [531], [1224]
3-(3,4-Dichloro-phenyl)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 3-(3,4-Dichloro-phenyl)-6,7-dimethoxy-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(3,4-Dichloro-phenyl)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
3-(3,4-Difluoro-phenyl)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 3-(3,4-Difluoro-phenyl)-6,7-dimethoxy-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(3,4-Difluoro-phenyl)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
3-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 3-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
3-(3-Fluoro-phenyl)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 3-(3-Fluoro-phenyl)-6,7-dimethoxy-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(3-Fluoro-phenyl)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [531], [1224]
3-(4-Fluoro-phenyl)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 3-(4-Fluoro-phenyl)-6,7-dimethoxy-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-Fluoro-phenyl)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
3-Benzyloxy-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 3-Benzyloxy-6,7-dimethoxy-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-Benzyloxy-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
3-Cyclohexylethynyl-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 3-Cyclohexylethynyl-6,7-dimethoxy-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-Cyclohexylethynyl-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
3-Cyclopent-1-enyl-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 3-Cyclopent-1-enyl-6,7-dimethoxy-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-Cyclopent-1-enyl-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
3-Cyclopentyl-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 3-Cyclopentyl-6,7-dimethoxy-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-Cyclopentyl-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
3-Pyridin-3-yl-quinoline-6,7-diol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 3-Pyridin-3-yl-quinoline-6,7-diol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-Pyridin-3-yl-quinoline-6,7-diol through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
3-Pyridin-4-yl-quinolin-7-ol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 3-Pyridin-4-yl-quinolin-7-ol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-Pyridin-4-yl-quinolin-7-ol through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [529], [1224]
3-Pyridin-4-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 3-Pyridin-4-yl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-Pyridin-4-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
3-Pyridin-4-yl-quinoline-5,7-diol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 3-Pyridin-4-yl-quinoline-5,7-diol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-Pyridin-4-yl-quinoline-5,7-diol through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [531], [1224]
3-Thiophen-3-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 3-Thiophen-3-yl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-Thiophen-3-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [531], [1224]
4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1244]
4-(5-Methoxy-benzoimidazol-1-yl)-phenylamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 4-(5-Methoxy-benzoimidazol-1-yl)-phenylamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(5-Methoxy-benzoimidazol-1-yl)-phenylamine through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1245]
4-(6,7-Dimethoxy-quinolin-3-yl)-benzoic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 4-(6,7-Dimethoxy-quinolin-3-yl)-benzoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(6,7-Dimethoxy-quinolin-3-yl)-benzoic acid through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
4-(6,7-Dimethoxy-quinolin-3-yl)-phenol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 4-(6,7-Dimethoxy-quinolin-3-yl)-phenol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-(6,7-Dimethoxy-quinolin-3-yl)-phenol through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
4-Benzoimidazol-1-yl-phenylamine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 4-Benzoimidazol-1-yl-phenylamine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 4-Benzoimidazol-1-yl-phenylamine through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1245]
5,11-Dimethyl-6H-pyrido[4,3-b]carbazol-9-ol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 5,11-Dimethyl-6H-pyrido[4,3-b]carbazol-9-ol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5,11-Dimethyl-6H-pyrido[4,3-b]carbazol-9-ol through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1246]
5,6,7-Trimethoxy-3-pyridin-4-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 5,6,7-Trimethoxy-3-pyridin-4-yl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5,6,7-Trimethoxy-3-pyridin-4-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
5,7-Dimethoxy-3-pyridin-4-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 5,7-Dimethoxy-3-pyridin-4-yl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5,7-Dimethoxy-3-pyridin-4-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [531], [1224]
5,7-Dimethoxy-3-thiophen-3-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 5,7-Dimethoxy-3-thiophen-3-yl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5,7-Dimethoxy-3-thiophen-3-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
5,7-Dimethyl-3-thiophen-3-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 5,7-Dimethyl-3-thiophen-3-yl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5,7-Dimethyl-3-thiophen-3-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
5-(6,7-Dimethoxy-quinolin-3-yl)-1H-pyridin-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 5-(6,7-Dimethoxy-quinolin-3-yl)-1H-pyridin-2-one. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-(6,7-Dimethoxy-quinolin-3-yl)-1H-pyridin-2-one through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
5-Fluoro-3-thiophen-3-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 5-Fluoro-3-thiophen-3-yl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-Fluoro-3-thiophen-3-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
5-Methoxy-1-phenyl-1H-benzoimidazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 5-Methoxy-1-phenyl-1H-benzoimidazole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-Methoxy-1-phenyl-1H-benzoimidazole through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1245]
6,7-Dichloro-3-thiophen-3-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 6,7-Dichloro-3-thiophen-3-yl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-Dichloro-3-thiophen-3-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
6,7-Difluoro-3-thiophen-3-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 6,7-Difluoro-3-thiophen-3-yl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-Difluoro-3-thiophen-3-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
6,7-Dimethoxy-3-((E)-styryl)-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 6,7-Dimethoxy-3-((E)-styryl)-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-Dimethoxy-3-((E)-styryl)-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
6,7-Dimethoxy-3-(2-methoxy-phenyl)-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 6,7-Dimethoxy-3-(2-methoxy-phenyl)-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-Dimethoxy-3-(2-methoxy-phenyl)-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
6,7-Dimethoxy-3-(3-methoxy-phenyl)-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 6,7-Dimethoxy-3-(3-methoxy-phenyl)-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-Dimethoxy-3-(3-methoxy-phenyl)-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
6,7-Dimethoxy-3-(4-methoxy-phenyl)-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 6,7-Dimethoxy-3-(4-methoxy-phenyl)-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-Dimethoxy-3-(4-methoxy-phenyl)-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
6,7-Dimethoxy-3-(4-nitro-phenyl)-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 6,7-Dimethoxy-3-(4-nitro-phenyl)-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-Dimethoxy-3-(4-nitro-phenyl)-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [531], [1224]
6,7-Dimethoxy-3-p-tolyl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 6,7-Dimethoxy-3-p-tolyl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-Dimethoxy-3-p-tolyl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
6,7-Dimethoxy-3-phenyl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 6,7-Dimethoxy-3-phenyl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-Dimethoxy-3-phenyl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
6,7-Dimethoxy-3-phenylethynyl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 6,7-Dimethoxy-3-phenylethynyl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-Dimethoxy-3-phenylethynyl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
6,7-Dimethoxy-3-pyridin-3-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 6,7-Dimethoxy-3-pyridin-3-yl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-Dimethoxy-3-pyridin-3-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
6,7-Dimethoxy-3-pyridin-4-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 6,7-Dimethoxy-3-pyridin-4-yl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-Dimethoxy-3-pyridin-4-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [531], [1224]
6,7-Dimethoxy-3-thiophen-2-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 6,7-Dimethoxy-3-thiophen-2-yl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6,7-Dimethoxy-3-thiophen-2-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
6-Methoxy-3-pyridin-4-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 6-Methoxy-3-pyridin-4-yl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6-Methoxy-3-pyridin-4-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [531], [1224]
6-Methoxy-3-thiophen-3-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 6-Methoxy-3-thiophen-3-yl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 6-Methoxy-3-thiophen-3-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
7-Chloro-3-pyridin-4-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 7-Chloro-3-pyridin-4-yl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-Chloro-3-pyridin-4-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [531], [1224]
7-Fluoro-3-thiophen-3-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 7-Fluoro-3-thiophen-3-yl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-Fluoro-3-thiophen-3-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
7-Methoxy-3-pyridin-4-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 7-Methoxy-3-pyridin-4-yl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-Methoxy-3-pyridin-4-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
7-Methoxy-3-thiophen-3-yl-quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 7-Methoxy-3-thiophen-3-yl-quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-Methoxy-3-thiophen-3-yl-quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
7-Thiophen-3-yl-[1,3]dioxolo[4,5-g]quinoline [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for 7-Thiophen-3-yl-[1,3]dioxolo[4,5-g]quinoline. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-Thiophen-3-yl-[1,3]dioxolo[4,5-g]quinoline through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
Benzyl-(6,7-dimethoxy-quinolin-3-yl)-amine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for Benzyl-(6,7-dimethoxy-quinolin-3-yl)-amine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Benzyl-(6,7-dimethoxy-quinolin-3-yl)-amine through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
Bis-(5-hydroxy-1H-indol-2-yl)-methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for Bis-(5-hydroxy-1H-indol-2-yl)-methanone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Bis-(5-hydroxy-1H-indol-2-yl)-methanone through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1241]
BMS 536924 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for BMS 536924. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BMS 536924 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1247]
CP-673451 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for CP-673451. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CP-673451 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [586], [1224]
D-65476 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for D-65476. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of D-65476 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [551], [1224]
Di(1H-indol-2-yl)methanone [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for Di(1H-indol-2-yl)methanone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Di(1H-indol-2-yl)methanone through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [535], [1224]
HKI-9924129 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for HKI-9924129. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HKI-9924129 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1245]
JNJ-10198409 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for JNJ-10198409. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of JNJ-10198409 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1233]
PD-0166326 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for PD-0166326. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PD-0166326 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [529], [1224]
PD-0173952 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for PD-0173952. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PD-0173952 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [529], [1224]
PD-0173955 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for PD-0173955. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PD-0173955 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1241]
PD-0173956 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for PD-0173956. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PD-0173956 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [529], [1224]
PD-0173958 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for PD-0173958. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PD-0173958 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [529], [1224]
PD-0179483 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for PD-0179483. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PD-0179483 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [529], [1224]
PP121 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for PP121. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PP121 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [10], [1224]
Ro-4396686 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for Ro-4396686. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ro-4396686 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [529], [1224]
RPR-101511 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for RPR-101511. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RPR-101511 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
RPR-108514A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for RPR-108514A. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RPR-108514A through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1232]
SU-11652 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for SU-11652. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SU-11652 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [538], [1224]
AG1295 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for AG1295. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AG1295 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1248]
CEP-2563 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for CEP-2563. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CEP-2563 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1249]
RG-13022 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for RG-13022. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RG-13022 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1241]
SRI-62-834 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Platelet-derived growth factor receptor alpha (PDGFRA) is a therapeutic target for SRI-62-834. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of SRI-62-834 through regulating the expression of Platelet-derived growth factor receptor alpha (PDGFRA). [1224], [1250]
Polo-like kinase 1 (PLK1)
Rigosertib [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Polo-like kinase 1 (PLK1) is a therapeutic target for Rigosertib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Rigosertib through regulating the expression of Polo-like kinase 1 (PLK1). [181], [1251]
Volasertib [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Polo-like kinase 1 (PLK1) is a therapeutic target for Volasertib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Volasertib through regulating the expression of Polo-like kinase 1 (PLK1). [1251], [1252]
BI 2536 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Polo-like kinase 1 (PLK1) is a therapeutic target for BI 2536. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of BI 2536 through regulating the expression of Polo-like kinase 1 (PLK1). [1251], [1253]
PCM-075 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Polo-like kinase 1 (PLK1) is a therapeutic target for PCM-075. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PCM-075 through regulating the expression of Polo-like kinase 1 (PLK1). [1251], [1254]
TKM-PLK1 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Polo-like kinase 1 (PLK1) is a therapeutic target for TKM-PLK1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TKM-PLK1 through regulating the expression of Polo-like kinase 1 (PLK1). [497], [1251]
CYC140 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Polo-like kinase 1 (PLK1) is a therapeutic target for CYC140. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CYC140 through regulating the expression of Polo-like kinase 1 (PLK1). [5], [1251]
GSK461364 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Polo-like kinase 1 (PLK1) is a therapeutic target for GSK461364. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GSK461364 through regulating the expression of Polo-like kinase 1 (PLK1). [1251], [1255]
MK-1496 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Polo-like kinase 1 (PLK1) is a therapeutic target for MK-1496. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MK-1496 through regulating the expression of Polo-like kinase 1 (PLK1). [1251], [1256]
TAK-960 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Polo-like kinase 1 (PLK1) is a therapeutic target for TAK-960. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of TAK-960 through regulating the expression of Polo-like kinase 1 (PLK1). [1251], [1257]
CYC-800 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Polo-like kinase 1 (PLK1) is a therapeutic target for CYC-800. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CYC-800 through regulating the expression of Polo-like kinase 1 (PLK1). [1251], [1254]
DAP-81 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Polo-like kinase 1 (PLK1) is a therapeutic target for DAP-81. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of DAP-81 through regulating the expression of Polo-like kinase 1 (PLK1). [1251], [1254]
ZK-thiazolidinone [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Polo-like kinase 1 (PLK1) is a therapeutic target for ZK-thiazolidinone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ZK-thiazolidinone through regulating the expression of Polo-like kinase 1 (PLK1). [1251], [1254]
CHR-4125 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Polo-like kinase 1 (PLK1) is a therapeutic target for CHR-4125. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CHR-4125 through regulating the expression of Polo-like kinase 1 (PLK1). [1251], [1258]
GSK579289A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Polo-like kinase 1 (PLK1) is a therapeutic target for GSK579289A. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GSK579289A through regulating the expression of Polo-like kinase 1 (PLK1). [1251], [1258]
GW853606 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Polo-like kinase 1 (PLK1) is a therapeutic target for GW853606. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of GW853606 through regulating the expression of Polo-like kinase 1 (PLK1). [1251], [1259]
MLN-0905 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Polo-like kinase 1 (PLK1) is a therapeutic target for MLN-0905. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of MLN-0905 through regulating the expression of Polo-like kinase 1 (PLK1). [1251], [1253]
NMS-1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Polo-like kinase 1 (PLK1) is a therapeutic target for NMS-1. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NMS-1 through regulating the expression of Polo-like kinase 1 (PLK1). [1251], [1253]
Ro5203280 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Polo-like kinase 1 (PLK1) is a therapeutic target for Ro5203280. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ro5203280 through regulating the expression of Polo-like kinase 1 (PLK1). [1251], [1254]
HMN-214 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Polo-like kinase 1 (PLK1) is a therapeutic target for HMN-214. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HMN-214 through regulating the expression of Polo-like kinase 1 (PLK1). [1251], [1254]
Poly [ADP-ribose] polymerase 1 (PARP1)
KU-0058948 [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Poly [ADP-ribose] polymerase 1 (PARP1) is a therapeutic target for KU-0058948. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of KU-0058948 through regulating the expression of Poly [ADP-ribose] polymerase 1 (PARP1). [1153], [1260]
Nicotinamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Poly [ADP-ribose] polymerase 1 (PARP1) is a therapeutic target for Nicotinamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nicotinamide through regulating the expression of Poly [ADP-ribose] polymerase 1 (PARP1). [1260], [1261]
Niraparib Tosylate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Poly [ADP-ribose] polymerase 1 (PARP1) is a therapeutic target for Niraparib Tosylate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Niraparib Tosylate through regulating the expression of Poly [ADP-ribose] polymerase 1 (PARP1). [220], [1260]
CC-486 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Poly [ADP-ribose] polymerase 1 (PARP1) is a therapeutic target for CC-486. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CC-486 through regulating the expression of Poly [ADP-ribose] polymerase 1 (PARP1). [1260], [1262]
Nicaraven [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Poly [ADP-ribose] polymerase 1 (PARP1) is a therapeutic target for Nicaraven. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nicaraven through regulating the expression of Poly [ADP-ribose] polymerase 1 (PARP1). [1260], [1263]
AG140699 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Poly [ADP-ribose] polymerase 1 (PARP1) is a therapeutic target for AG140699. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AG140699 through regulating the expression of Poly [ADP-ribose] polymerase 1 (PARP1). [1260], [1264]
AMXI 5001 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Poly [ADP-ribose] polymerase 1 (PARP1) is a therapeutic target for AMXI 5001. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of AMXI 5001 through regulating the expression of Poly [ADP-ribose] polymerase 1 (PARP1). [1260], [1265]
PMID27841036-Compound-37 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Poly [ADP-ribose] polymerase 1 (PARP1) is a therapeutic target for PMID27841036-Compound-37. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PMID27841036-Compound-37 through regulating the expression of Poly [ADP-ribose] polymerase 1 (PARP1). [1260], [1266]
Stenoparib [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Poly [ADP-ribose] polymerase 1 (PARP1) is a therapeutic target for Stenoparib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Stenoparib through regulating the expression of Poly [ADP-ribose] polymerase 1 (PARP1). [1260], [1267]
NMS-03305293 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Poly [ADP-ribose] polymerase 1 (PARP1) is a therapeutic target for NMS-03305293. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NMS-03305293 through regulating the expression of Poly [ADP-ribose] polymerase 1 (PARP1). [1260], [1268]
CPH-102 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Poly [ADP-ribose] polymerase 1 (PARP1) is a therapeutic target for CPH-102. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of CPH-102 through regulating the expression of Poly [ADP-ribose] polymerase 1 (PARP1). [1260], [1269]
PJ34 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Poly [ADP-ribose] polymerase 1 (PARP1) is a therapeutic target for PJ34. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PJ34 through regulating the expression of Poly [ADP-ribose] polymerase 1 (PARP1). [1260], [1270]
(E)-N-(4-Phenylthiazol-2-yl) cinnamamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Poly [ADP-ribose] polymerase 1 (PARP1) is a therapeutic target for (E)-N-(4-Phenylthiazol-2-yl) cinnamamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of (E)-N-(4-Phenylthiazol-2-yl) cinnamamide through regulating the expression of Poly [ADP-ribose] polymerase 1 (PARP1). [1260], [1271]
1,2,3,4,4a,5-hexahydrophenanthridin-6(10bH)-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Poly [ADP-ribose] polymerase 1 (PARP1) is a therapeutic target for 1,2,3,4,4a,5-hexahydrophenanthridin-6(10bH)-one. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 1,2,3,4,4a,5-hexahydrophenanthridin-6(10bH)-one through regulating the expression of Poly [ADP-ribose] polymerase 1 (PARP1). [1260], [1271]
1,7,8,9-tetrahydro-1,5-diaza-trindene-4,6-dione [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Poly [ADP-ribose] polymerase 1 (PARP1) is a therapeutic target for 1,7,8,9-tetrahydro-1,5-diaza-trindene-4,6-dione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 1,7,8,9-tetrahydro-1,5-diaza-trindene-4,6-dione through regulating the expression of Poly [ADP-ribose] polymerase 1 (PARP1). [1260], [1272]
2,3-dihydro-1H-benzo[de]isoquinolin-1-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Poly [ADP-ribose] polymerase 1 (PARP1) is a therapeutic target for 2,3-dihydro-1H-benzo[de]isoquinolin-1-one. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2,3-dihydro-1H-benzo[de]isoquinolin-1-one through regulating the expression of Poly [ADP-ribose] polymerase 1 (PARP1). [1260], [1273]
2,8-Dimethyl-3H-quinazolin-4-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Poly [ADP-ribose] polymerase 1 (PARP1) is a therapeutic target for 2,8-Dimethyl-3H-quinazolin-4-one. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2,8-Dimethyl-3H-quinazolin-4-one through regulating the expression of Poly [ADP-ribose] polymerase 1 (PARP1). [1260], [1274]
2-(2-Chlorophenyl)-2H-indazole-7-carboxamide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Poly [ADP-ribose] polymerase 1 (PARP1) is a therapeutic target for 2-(2-Chlorophenyl)-2H-indazole-7-carboxamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-(2-Chlorophenyl)-2H-indazole-7-carboxamide through regulating the expression of Poly [ADP-ribose] polymerase 1 (PARP1). [1260], [1275]