m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0150)
Name
Haemorrhoids
ICD
ICD-11: DB60
Full List of Target Gene(s) of This m6A-centered Disease Response
Tyrosine-protein kinase receptor Tie-1 (TIE1)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary The overexpression of miR-4729 in vascular endothelial cells decreased the global mRNA methylation and TIE1 mRNA 3'UTR-specific site methylation by silencing METTL14 expression, reducing Tyrosine-protein kinase receptor Tie-1 (TIE1) mRNA stability, down-regulating the TIE1/VEGFA signal molecular loop expression, and weakening angiogenesis ability. MiR-4729 regulates TIE1 mRNA m6A modification and angiogenesis in hemorrhoids by targeting METTL14.
Responsed Disease Haemorrhoids [ICD-11: DB60]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response VEGF signaling pathway hsa04370
Cell Process Cell proliferation
In-vitro Model HUVEC-C Normal Homo sapiens CVCL_2959
References
Ref 1 MiR-4729 regulates TIE1 mRNA m6A modification and angiogenesis in hemorrhoids by targeting METTL14. Ann Transl Med. 2021 Feb;9(3):232. doi: 10.21037/atm-20-3399.