m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0134)
| Name |
Acute respiratory distress syndrome
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|---|---|---|---|---|---|
| ICD |
ICD-11: CB00
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Full List of Target Gene(s) of This m6A-centered Disease Response
hsa-miR-29a-3p
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | The knockout of methyltransferase 3 (N6-adenosine-methyltransferase complex catalytic subunit) removed the m6A modification of hsa-miR-29a-3p and reduced miR-29a-3p expression. These findings suggest that miR-29a-3p is a potential target that can be manipulated for ALI/ARDS. | |||
| Responsed Disease | Acute respiratory distress syndrome [ICD-11: CB00] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| In-vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens | CVCL_0023 |
| In-vivo Model | All the mice were randomly divided into three groups: the normal saline group (NS), the lipopolysaccharide + negative control group (LPS + NC), and the LPS + miR-29a-3p agomir group (LPS + Agomir). | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
| In total 1 item(s) under this disease | ||
| Crosstalk ID: M6ACROT05580 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | hsa-miR-29a-3p | |
| Epigenetic Regulator | hsa-miR-29a-3p | |
| Regulated Target | Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) | |
| Crosstalk relationship | m6A → ncRNA | |