m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0132)
Name
Keloid
ICD
ICD-11: EE60
Full List of Target Gene(s) of This m6A-centered Disease Response
Transforming growth factor beta-1 proprotein (TGFB1)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [2]
Response Summary Pregulation of eIF3a mRNA and protein and in human keloid tissues compared with in normal tissues. Knockdown of eIF3a inhibited KF proliferation induced by Transforming growth factor beta-1 proprotein (TGFB1).
Responsed Disease Keloid [ICD-11: EE60.0]
Target Regulator Eukaryotic initiation factor 3 (EIF3A) READER
 Regulator Info 
Pathway Response TGF-beta signaling pathway hsa04350
In-vitro Model Responsive keloid fibroblasts (Isolated from skin keloid tissue)
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
In total 8 item(s) under this disease
Crosstalk ID: M6ACROT00050
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Collagen alpha-1 (COL1A1)
 Target Gene 
Epigenetic Regulator Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (ALKBH3)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship m1A → m6A
Crosstalk ID: M6ACROT00051
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Fibronectin (FN1)
 Target Gene 
Epigenetic Regulator Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (ALKBH3)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship m1A → m6A
Drug Ocriplasmin
 Drug Info 
Crosstalk ID: M6ACROT00052
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Collagen alpha-1 (COL1A1)
 Target Gene 
Epigenetic Regulator YTH domain-containing family protein 2 (YTHDF2)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship m1A → m6A
Crosstalk ID: M6ACROT00053
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Fibronectin (FN1)
 Target Gene 
Epigenetic Regulator YTH domain-containing family protein 2 (YTHDF2)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship m1A → m6A
Drug Ocriplasmin
 Drug Info 
Crosstalk ID: M6ACROT00054
 Crosstalk Info 
m6A Regulator YTH domain-containing family protein 1 (YTHDF1)
 Regulator Info 
m6A Target Collagen alpha-1 (COL1A1)
 Target Gene 
Epigenetic Regulator Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (ALKBH3)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship m1A → m6A
Crosstalk ID: M6ACROT00055
 Crosstalk Info 
m6A Regulator YTH domain-containing family protein 1 (YTHDF1)
 Regulator Info 
m6A Target Fibronectin (FN1)
 Target Gene 
Epigenetic Regulator Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (ALKBH3)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship m1A → m6A
Drug Ocriplasmin
 Drug Info 
Crosstalk ID: M6ACROT00056
 Crosstalk Info 
m6A Regulator YTH domain-containing family protein 1 (YTHDF1)
 Regulator Info 
m6A Target Collagen alpha-1 (COL1A1)
 Target Gene 
Epigenetic Regulator YTH domain-containing family protein 2 (YTHDF2)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship m1A → m6A
Crosstalk ID: M6ACROT00057
 Crosstalk Info 
m6A Regulator YTH domain-containing family protein 1 (YTHDF1)
 Regulator Info 
m6A Target Fibronectin (FN1)
 Target Gene 
Epigenetic Regulator YTH domain-containing family protein 2 (YTHDF2)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship m1A → m6A
Drug Ocriplasmin
 Drug Info 
References
Ref 1 CN patent application no. 101094684, With the combination of chemokine activation progenitor cells/stem cells.
Ref 2 Knockdown of elF3a inhibits TGF?Beta1?induced extracellular matrix protein expression in keloid fibroblasts. Mol Med Rep. 2018 Mar;17(3):4057-4061. doi: 10.3892/mmr.2017.8365. Epub 2017 Dec 29.
Ref 3 ClinicalTrials.gov (NCT03267173) Evaluate the Safety and Efficacy of CAR-T in the Treatment of Pancreatic Cancer.
Ref 4 Targeted therapies in myelodysplastic syndromes: ASH 2003 review. Semin Hematol. 2004 Apr;41(2 Suppl 4):13-20. doi: 10.1053/j.seminhematol.2004.02.003.