m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT06025
|
[1] | |||
m6A modification
XIST
XIST
WTAP
Methylation
 : m6A sites
Direct
Enhancement
Non-coding RNA
XIST
ATRX
lncRNA miRNA circRNA
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Wilms tumor 1-associating protein (WTAP) | WRITER | |||
| m6A Target | X inactive specific transcript (XIST) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | X inactive specific transcript (XIST) | LncRNA | View Details | ||
| Regulated Target | Transcriptional regulator ATRX (ATRX) | View Details | |||
| Crosstalk Relationship | m6A → ncRNA | Enhancement | |||
| Crosstalk Mechanism | m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA | ||||
| Crosstalk Summary | RBM15 and WTAP are required for X inactive specific transcript (XIST)-mediated silencing, are co-localized, and potentially interact with XIST RNA. YTHDC1 is the m6A reader of XIST and is required for XIST function. m6A modification is required for XIST-mediated transcriptional repression of X-linked genes, such as GPC4 and Transcriptional regulator ATRX (ATRX). | ||||