m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05824
 [1]
m6A modification hsa_circ_0136959 hsa_circ_0136959 METTL3 Methylation : m6A sites Direct Enhancement Non-coding RNA hsa_circ_0136959 Regulated Target  lncRNA       miRNA   circRNA
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target hsa_circ_0136959
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator hsa_circ_0136959 circRNA View Details
Crosstalk Relationship m6A  →  ncRNA Enhancement
Crosstalk Mechanism m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary METTL3 was notably reduced in PTC samples and was positively correlated with hsa_circ_0136959. Mechanistically, METTL3 enhanced hsa_circ_0136959 expression through m6A modification. Our results demonstrate that METTL3-mediated m6A modification elevated hsa_circ_0136959 expression and subsequently restricted the tumor characteristics of PTC by accelerating ferroptosis.
Responsed Disease Papillary thyroid cancer ICD-11: 2D10.1
 Disease Info 
Pathway Response Ferroptosis hsa04216
Cell Process Ferroptosis
In-vitro Model
 TPC-1 Thyroid gland papillary carcinoma Homo sapiens CVCL_6298
Nthy-ori 3-1 Normal Homo sapiens CVCL_2659
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
2D10: Thyroid Cancer 12 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Lenvatinib Approved [2]
Synonyms
E 7080; E-7080, E7080; 4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxy-quinoline-6-carboxamide
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CID: 9823820
TTD: D0R0FO
DrugBank: DB09078
 Compound Name Cabozantinib Approved [3]
Synonyms
Cabometyx; Cometriq
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CID: 25102847
TTD: D0IQ6P
DrugBank: DB08875
 Compound Name Thyrotropin Alfa Approved [4]
External Link
TTD: D0H4TQ
 Compound Name Selpercatinib Approved [5]
Synonyms
MFOVQWYFURMVKU-IWAAJCSBSA-N; 2222755-14-6; LOXO292; ARRY-192; LOXO 292; EX-A2636
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CID: 134823904
TTD: D01KOA
 Compound Name Selumetinib Phase 3 [6]
Synonyms
AZD-6244; ARRY142886; AZD6244; AZD 6244; 6UH91I579U; ARRY 142886; ARRY-142886; AZD6244 (Selumetinib); AZD6244(Selumetinib); CHEBI:90227; CHEMBL1614701; MEK inhibitors; Selumetinib (AZD6244); UNII-6UH91I579U
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CID: 10127622
TTD: D0T5DP
DrugBank: DB11689
 Compound Name QGE-031 Phase 2 [7]
External Link
TTD: D0J7CH
 Compound Name GI-6207 Phase 2 [8]
External Link
TTD: D0L7VC
 Compound Name AIC100 Phase 1 [9]
External Link
TTD: DP0NU9
 Compound Name CYTO-403 Phase 1 [10]
External Link
TTD: DB2R5Y
 Compound Name Demogastrin Phase 1 [11]
Synonyms
Technetium-99m-Demogastrin 2; Cholecystokinin-2 receptor/gastrin-R binding radiolabeled minigastrinanalogue (medullary thyroid cancer), Biomedica Life Science; 99mTc-Demogastrin 2; 99mTc-N4-Gly-(D)Glu-(Glu)5-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2
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TTD: D0QJ6L
 Compound Name Recombinant TSH superagonists Investigative [12]
Synonyms
Recombinant TSH superagonists (thyroid cancer); TR-1401; TR-1402; Recombinant TSH superagonists (thyroid cancer), Trophogen; TSH superagonist (thyroid cancer/goiter), Trophogen; Thyroid stimulating hormone superagonist (thyroid cancer/goiter), Trophogen
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TTD: D0U2DY
 Compound Name ITRI-305 Investigative [13]
Synonyms
RET tyrosine kinase inhibitors, Industrial Technology Research Institute
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TTD: D0N5TB
References
Ref 1 METTL3-Induced m6A Modification Enhances Hsa_Circ_0136959 Expression to Impair the Tumor Characteristics of Papillary Thyroid Carcinoma via Accelerating Ferroptosis. DNA Cell Biol. 2025 Feb;44(2):99-108. doi: 10.1089/dna.2024.0197. Epub 2024 Dec 2.
Ref 2 FDA Approved Drug Products from FDA Official Website. 2018. Application Number: (ANDA) 208627.
Ref 3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5887).
Ref 4 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020898.
Ref 5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
Ref 6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 7 ClinicalTrials.gov (NCT02336425) Efficacy and Safety of QGE031 Compared With Placebo in Patients Aged 18-75 Years With Asthma. U.S. National Institutes of Health.
Ref 8 ClinicalTrials.gov (NCT01856920) A Phase 2 Study of GI-6207 in Patients With Recurrent Medullary Thyroid Cancer. U.S. National Institutes of Health.
Ref 9 ClinicalTrials.gov (NCT04420754) Study of AIC100 in Relapsed/Refractory Thyroid Cancer. U.S. National Institutes of Health.
Ref 10 Clinical pipeline report, company report or official report of Cytocom
Ref 11 99mTc-Demogastrin 2 for CCK 2-receptor scintigraphy in medullary thyroid carcinoma. J Nucl Med. 2008; 49 (Supplement 1):115P.
Ref 12 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 255).
Ref 13 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2185).