m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05815
|
[1] | |||
m6A modification
UCA1
UCA1
METTL3
Methylation
 : m6A sites
Direct
Enhancement
Non-coding RNA
UCA1
Regulated Target
lncRNA miRNA circRNA
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | Urothelial cancer associated 1 (UCA1) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | Urothelial cancer associated 1 (UCA1) | LncRNA | View Details | ||
| Crosstalk Relationship | m6A → ncRNA | Enhancement | |||
| Crosstalk Mechanism | m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA | ||||
| Crosstalk Summary | m6A writers, METTL3 and WTAP positively regulate Urothelial cancer associated 1 (UCA1) expression in an IGF2BP2 dependent manner. | ||||
| Cell Process | Cell proliferation | ||||
| Cell growth | |||||
In-vitro Model |
HCT 116 | Colon carcinoma | Homo sapiens | CVCL_0291 | |
| DLD-1 | Colon adenocarcinoma | Homo sapiens | CVCL_0248 | ||
| In-vivo Model | BALB/c nude mice (4-6 weeks old) were purchased from Hunan SLAC Jingda Experimental Animal Company (Changsha, China). All animal experiments were approved by the Ethical Committee of the First People's Hospital of Chenzhou City, University of South China. Six mice in each group were subcutaneously injected with 5.0 × 106 stable HCT-116 UCA1-KD cells or control cells in 0.2 mL PBS with 50% matrigel as described previously | ||||