m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05807
|
[1] | |||
m6A modification
MIR106B
MIR106B
HNRNPA2B1
 : m6A sites
Direct
Enhancement
Non-coding RNA
MIR106B
Regulated Target
lncRNA miRNA circRNA
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) | READER | |||
| m6A Target | hsa-mir-106b | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | hsa-mir-106b | microRNA | View Details | ||
| Crosstalk Relationship | m6A → ncRNA | Enhancement | |||
| Crosstalk Mechanism | m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA | ||||
| Crosstalk Summary | Knockdown of HNRNPA2B1 significantly decreased the expression of MIR17, MIR18A, MIR20A, MIR93, and hsa-mir-106b and inhibited the proliferation of ESCA cells.. | ||||
| Cell Process | Cell proliferation | ||||
In-vitro Model |
TE1
|
N.A. | Mus musculus | CVCL_C6K3 | |