m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05781
|
[1] | |||
m6A modification
MIRLET7E
MIRLET7E
FTO
Demethylation
 : m6A sites
Direct
Enhancement
Non-coding RNA
MIRLET7E
Regulated Target
lncRNA miRNA circRNA
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Fat mass and obesity-associated protein (FTO) | ERASER | |||
| m6A Target | MIRLET7E | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | MIRLET7E | microRNA | View Details | ||
| Crosstalk Relationship | m6A → ncRNA | Enhancement | |||
| Crosstalk Mechanism | m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA | ||||
| Crosstalk Summary | Knockdown of FTO reduced levels of MIRLET7E miRNAs | ||||
In-vitro Model |
HEK293 | Normal | Homo sapiens | CVCL_0045 | |