m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT05778				[1]
m⁶A modification HULC HULC IGF2BP1 : m⁶A sites Direct Enhancement Non-coding RNA HULC PDCD4 lncRNA miRNA circRNA
m6A Regulator	Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)			READER	Regulator Info
m6A Target	hepatocellular carcinoma up-regulated long non-coding RNA (HULC)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	Non-coding RNA (ncRNA)
Epigenetic Regulator	Hepatocellular carcinoma up-regulated long non-coding RNA (HULC)			LncRNA	View Details
Regulated Target	Programmed cell death 4 (PDCD4)				View Details
Crosstalk Relationship	m6A → ncRNA			Enhancement
Crosstalk Mechanism	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary	Posttranscriptional destabilization of the liver-specific long noncoding RNA hepatocellular carcinoma up-regulated long non-coding RNA (HULC), which affects Programmed cell death 4 (PDCD4) expression, by the IGF2 mRNA-binding protein 1 (IGF2BP1).
Cell Process	RNA degradation (hsa03018)
In-vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens		CVCL_0027

References

Ref 1	Posttranscriptional destabilization of the liver-specific long noncoding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1). Hepatology. 2013 Nov;58(5):1703-12. doi: 10.1002/hep.26537. Epub 2013 Aug 7.