Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05769
[1]
m6A modification Circ_PRKAR1B Circ_PRKAR1B METTL3 Methylation : m6A sites Direct Enhancement Non-coding RNA circPRKAR1B SPTBN1  lncRNA       miRNA   circRNA
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
m6A Target Circ_PRKAR1B
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator Circ_PRKAR1B circRNA View Details
Regulated Target Spectrin beta, non-erythrocytic 1 (SPTBN1) View Details
Crosstalk Relationship m6A  →  ncRNA Enhancement
Crosstalk Mechanism m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary METTL3-mediated m6 A modification of Circ_PRKAR1B promotes Crohn's colitis by by interacting with Spectrin beta, non-erythrocytic 1 (SPTBN1).
Responsed Disease Crohn disease ICD-11: DD70.3
Pathway Response Autophagy hsa04140
Cell Process Pyroptosis
Cell autophagy
In-vitro Model
NCM460 Normal Homo sapiens CVCL_0460
HCoEpiC (Healthy colon epithelial HCoEpiC cells)
In-vivo Model Twelve-week-old wild-type (WT) and IL-10-KO mice were allocated randomly to four groups (n = 5 per group): (1) the WT group; (2) the IL-10 KO + si-control group (administrated saline as a placebo via enema once); (3) the IL-10 KO + si-circPRKAR1B group (administrated 200 μL of 1e11 vg adeno-associated virus (AAV) vector carrying si-circPRKAR1B via enema once); and (4) the IL-10 KO + si-METTL3 group (administrated 200 μL of 1e11 vg AAV vector carrying si-METTL3 via enema once).
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Spectrin beta, non-erythrocytic 1 (SPTBN1) 1 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name ABT-413 Phase 1 [2]
External Link
DD70: Crohn disease 265 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Natalizumab Approved [3]
External Link
 Compound Name Clofazimine Approved [4]
Synonyms
2030-63-9; Lamprene; Lampren; Chlofazimine; Clofazimina; Clofaziminum; Clofaziminum [INN-Latin]; B 663 (Pharmaceutical); Clofazimina [INN-Spanish]; B-663; NSC-141046; G 30320; UNII-D959AE5USF; B 663 (VAN); C27H22Cl2N4; 3-(p-Chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin; B 663; 3-(p-Chloroanilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)phenazine; 3-(p-Chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine; EINECS 217-980-2; CFZ; SMP2_000339; B 663, pharmaceutical; G-30320; Lamprene (TN); Liposome-encapsulated clofazimine; Clofazimine [USAN:INN:BAN]; G-30,320; Clofazimine (JAN/USP/INN); N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine; N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine; N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(1-methylethyl)imino)-2-phenazinamine; N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-[(1-methylethyl)imino]-2-phenazinamine; N,5-bis(4-chlorophenyl)-3-(propan-2-ylimino)-3,5-dihydrophenazin-2-amine; (3Z)-N,5-bis(4-chlorophenyl)-3-[(1-methylethyl)imino]-3,5-dihydrophenazin-2-amine; 3-(p-Chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)phenazine; 3-(p-Chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin [German]; Riminophenazine
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 Compound Name MLN0002 Approved [5]
Synonyms
Vedolizumab
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External Link
 Compound Name Vedolizmab Approved [6]
Synonyms
4168-17-6
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External Link
 Compound Name Metronidazole Phase 3 [7]
Synonyms
APMN; Acromona; Anagiardil; Arilin; Atrivyl; Bexon; CONT; Clont; Danizol; Deflamon; Efloran; Elyzol; Entizol; Eumin; Flagemona; Flagesol; Flagil; Flagyl; Flegyl; Florazole; Fossyol; Giatricol; Gineflavir; Giniflavir; Klion; Klont; Meronidal; Methronidazole; Metric; MetroCream; MetroGel; MetroLotion; Metrodzhil; Metrogyl; Metrolag; Metrolyl; Metromidol; Metronidaz; Metronidazol; Metronidazolo; Metronidazolum; Metrotop; Metrozine; Metryl; Mexibol; Monagyl; Monasin; NIDA; Nalox; Nidagel; Noritate; Novonidazol; Orvagil; Protostat; Rathimed; Rosased; Sanatrichom; Satric; Takimetol; Trichazol; Trichex; Trichocide; Trichomol; Trichopal; Trichopol; Tricocet; Tricom; Trikacide; Trikamon; Trikojol; Trikozol; Trimeks; Trivazol; Vagilen; Vagimid; Vandazole; Vertisal; Wagitran; Zadstat; Zidoval; Flagyl Er; Ginefla vir; METRONIDAZOLE USP; Metro Cream; Metro Gel; Metronidazole Monohydrochloride; Metronidazole Phosphoester; Metronidazole in Plastic Container; Metronidazolo [DCIT]; Tricho cordes; Trichomonacid pharmachim; Tricowas B; Bayer 5360; Flagyl 375; M0924; Metric 21; RP 8823; SC 10295; Anabact (TN); Apo-Metronidazole; Deflamon-wirkstoff; Flagyl (TN); IDR-90105; METRO I.V; MetroGel (TN); MetroGel-Vaginal; Metronidazol [INN-Spanish]; Metronidazolum [INN-Latin]; Mexibol (silanes); Neo-Tric; Noritate (TN); RP-8823; Rozex (TN); Tricho-gynaedron; ZERO/004064; CB-01-14 MMX; FLAGYL I.V. RTU IN PLASTIC CONTAINER; Flagyl I.V.; Flagyl I.V. RTU; Metro I.V.; Metro I.V. In Plastic Container; Metrogel-vaginal (TN); Metronidazole (JP15/USP/INN); Metronidazole [USAN:INN:BAN:JAN]; Methyl-5-nitroimidazole-1-ethanol; 1-Hydroxyethyl-2-methyl-5-nitroimidazole; 2-(2-methyl-5-nitroimidazol-1-yl)ethanol; 2-Methyl-5-nitro-1-imidazoleethanol; 2-Methyl-5-nitroimidazole-1-ethanol; MNZ
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External Link
 Compound Name Mercaptopurine Phase 4 [8]
Synonyms
6-mercaptopurine; Ismipur; Leukerin; Leupurin; Mercaleukim; Mercaleukin; Mercaptopurin; Mercaptopurina; Mercaptopurinum; Mercapurin; Merkaptopuryna; Mern; Purimethol; Purinethiol; Purinethol; Thiopurine; Leupu rin; Mercaptopurin [German]; Mercaptopurina Wellcome; Mercaptopurine anhydrous; Merkaptopuryna [Polish]; Puri Nethol; BW 57 323H; Glaxo Wellcome Brand of 6 Mercaptopurine; GlaxoSmithKline Brand of 6 Mercaptopurine; M0063; NCIMech_000025; PM6; Wellcome Brand of 6 Mercaptopurine; Glaxo Wellcome Brand of 6-Mercaptopurine; GlaxoSmithKline Brand of 6-Mercaptopurine; Mercaptopurina [INN-Spanish]; Mercaptopurine (INN); Mercaptopurine (VAN); Mercaptopurine (anhydrous); Mercaptopurinum [INN-Latin]; Puri-Nethol; Purineantimetabolite: inhibits nucleic acid replication; Purinethol (TN); U-4748; Wellcome Brand of 6-Mercaptopurine; AG-670/31547064; Purine-6-thiol; Leukerin, 99%-Carc; Purine-6(1H)-thione; Purinethol, 6-mercaptopurine, 6-MP, Mercaptopurine; 6 MP; 6 Mercaptopurine Monohydrate; 6 Thiohypoxanthine; 6 Thiopurine; 6-MERCAPTOPURINE MONOHYDRATE; 6-MP; 6-Mercaptopurin; 6-Merkaptopurin; 6-Merkaptopurin [Czech]; 6-Purinethiol; 6-Thiohypoxanthine; 6-Thiopurine; 6-Thioxopurine; Mercaptopurine (Purine analog)
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External Link
 Compound Name Upadacitinib Approved [9]
Synonyms
ABT-494
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External Link
 Compound Name Plecanatide Phase 3 [10]
Synonyms
Trulance
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External Link
 Compound Name Ozanimod Phase 3 [9]
Synonyms
1306760-87-1; Ozanimod (RPC1063); UNII-Z80293URPV; Z80293URPV; (S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile; Ozanimod [USAN:INN]; Ozanimod (USAN/INN); SCHEMBL2195490; GTPL8709; CHEMBL3707247; 5-[3-[(1S)-1-(2-hydroxyethylamino)-2,3-dihydro-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-propan-2-yloxybenzonitrile; EX-A1316; s7952; ZINC116109867; AKOS026674086; DB12612; CS-5070; HY-12288; AC-29883; Benzonitrile, 5-(3-((1
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External Link
 Compound Name Ritlecitinib Approved [9]
Synonyms
CBRJPFGIXUFMTM-WDEREUQCSA-N; 1792180-81-4; UNII-2OYE00PC25; 2OYE00PC25; PF06651600; 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one; GTPL9559; SCHEMBL16764638; BCP24778; EX-A2613; ZINC526061581; example 5 [WO2015083028]; ACN-040697; compound 11 [PMID: 28139931]; HY-100754; CS-0020243; 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malonate; 1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]prop-2-en-1-one
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External Link
 Compound Name Citric acid, magnesium oxide, sodium picosulfate Approved [11]
Synonyms
Prepopik (TN)
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 Compound Name PB006 Phase 3 [12]
Synonyms
Natalizumab Biosimilar
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External Link
 Compound Name Alofisel Phase 3 [13]
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 Compound Name Brazikumab Phase 3 [14]
External Link
 Compound Name SHR0302 Phase 3 [15]
Synonyms
(3AR,5S,6AS)-N-(3-METHOXY-1,2,4-THIADIAZOL-5-YL)-5-(METHYL (7H-PYRROLO(2,3- D)PYRIMIDIN-4-YL)AMINO) HEXAHYDROCYCLOPENTA(C)PYRROLE-2(1H)-CARBOXAMIDE; (3aR,5s,6aS)-N-(3-methoxy-1,2,4-thiadiazol-5-yl)-5-(methyl (7H-pyrrolo(2,3-d)pyrimidin-4-yl)amino) hexahydrocyclopenta(c)pyrrole-2(1H)-carboxamide; (3aR,6aS)-N-(3-methoxy-1,2,4-thiadiazol-5-yl)-5-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxamide; (3aS,6aR)-N-(3-methoxy-1,2,4-thiadiazol-5-yl)-5-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxamide; 1445987-21-2; AC-36766; AKOS040759719; CHEMBL5095398; CS-0062969; CYCLOPENTA(C)PYRROLE-2(1H)-CARBOXAMIDE, HEXAHYDRO-N-(3-METHOXY-1,2,4- THIADIAZOL-5-YL)-5-(METHYL-7H-PYRROLO(2,3-D)PYRIMIDIN-4-YLAMINO)-, (3A.ALPHA.,5.ALPHA.,6A.ALPHA.)-; Cyclopenta(c)pyrrole-2(1H)-carboxamide, hexahydro-N-(3-methoxy-1,2,4-thiadiazol-5-yl)-5-(methyl-7H-pyrrolo(2,3-d)pyrimidin-4-ylamino)-, (3aalpha,5alpha,6aalpha)-; EX-A5101; example 34 [WO2013091539A1]; F82248; GTPL11878; HY-112724; Ivarmacitinib; IVARMACITINIB [INN]; Ivarmacitinib [USAN]; K6K4B9Z5TV; MS-27180; NCGC00687790-01; rel-(3aR,5s,6aS)-N-(3-Methoxy-1,2,4-thiadiazol-5-yl)-5-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxamide; SCHEMBL15077696; SCHEMBL15077710; SCHEMBL16191633; SHR0302; SHR-0302; SHR0302 base; SHR0302 FREE BASE; SHR-0302 FREE BASE; UNII-K6K4B9Z5TV; US9527851, 34; US9527851, 74; WHO 11823
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External Link
 Compound Name Remestemcel-L Phase 3 [16]
Synonyms
MSC-100-IV
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External Link
 Compound Name Entyvio Phase 3 [9]
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 Compound Name GS-5745 Phase 3 [9]
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 Compound Name RHB-104 Phase 3 [9]
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 Compound Name Etrolizumab Phase 3 [9]
External Link
 Compound Name Alicaforsen Phase 3 [17]
Synonyms
Alicaforsen [INN]; ISIS 2302; ISIS-2302; Intercellular adhesion molecule-1 antisense oligodeoxynucleotide; DNA, d((R)-P-thio)(G-C-C-A-A-G-C-T-G-G-C-A-T-C-C-G-T-C-A); Deoxyribonucleic acid, d((R)-P-thio)(G-C-C-C-A-A-G-C-T-G-G-C-A-T-C-C-G-T-C-A)
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External Link
 Compound Name AJM-300 Phase 3 [18]
Synonyms
Alpha-4 integrin antagonist (inflammatory bowel disease), Ajinomoto
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External Link
 Compound Name Vercirnon Phase 3 [19]
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 Compound Name ABT-874 Discontinued in Phase 2 [20]
External Link
 Compound Name Sivelestat Application submitted [9]
Synonyms
127373-66-4; UNII-DWI62G0P59; 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid; Elastase Inhibitor IV; C20H22N2O7S; N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid; Sivelestat (ONO-5046); LY544349; CHEMBL76688; LY 544349; DWI62G0P59; Glycine, N-(2-(((4-(2,2-dimethyl-1-oxopropoxy)phenyl)sulfonyl)amino)benzoyl)-; N-(o-(p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine
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External Link
 Compound Name SB2 Application submitted [9]
Synonyms
Antimony; 7440-36-0; Stibium metallicum; Antimony, metallic; UNII-9IT35J3UV3; Antymonowodor [Polish]; UNII-0VKZ97K3UB; 0VKZ97K3UB; Antimonwasserstoffes [German]; HSDB 785; 9IT35J3UV3; UN2676; Antymon; Antimonio; Antimoine; Antimony powder; MFCD00011211; Antimonyl citrate; Antimony, ion(Sb2+); Sb2+; stibanylidyne; Antimonide; Antymonowodor; Antimon; antimony atom; Antimony, citric acid complexes; antimony(0); Antimonwasserstoffes; EINECS 270-130-2; ANTIMONOUS HYDRIDE; ACMC-1BKT5; 51Sb; EC 231-146-5; AC1NS5Q0; Sb(0); ANT
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 Compound Name Rifaximin DR Phase 3 [9]
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 Compound Name BI 655066 Phase 2 [9]
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 Compound Name GED-0301 Phase 3 [9]
Synonyms
SMAD-7 inhibitor (oligonucleotide, Crohn's disease), Giuliani
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 Compound Name MSC-100-IV Phase 3 [9]
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 Compound Name Prochymal Phase 3 [21]
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 Compound Name SHP647 Phase 3 [9]
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 Compound Name MORF-057 Phase 2 [22]
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 Compound Name BI 706321 Phase 2 [23]
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 Compound Name TEV-48574 Phase 2 [24]
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 Compound Name EB8018 Phase 2 [25]
Synonyms
Sibofimloc; 1616113-45-1; Antibiotic-202; VRT-1353385; UNII-00OF00QZC4; 1-[2,7-Bis[2-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]ethynyl]spiro[fluorene-9,4'-piperidine]-1'-yl]ethanone; 1-[2,7-bis({2-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]ethynyl})spiro[fluorene-9,4'-piperidine]-1'-yl]ethan-1-one; 1-[2,7-bis[2-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]ethynyl]spiro[fluorene-9,4'-piperidine]-1'-yl]ethanone; Sibofimloc [INN]; Sibofimloc [USAN]; Sibofimloc (USAN/INN); CHEMBL4594305; SCHEMBL15836795; EX-A750; Antibiotic-202;VRT-1353385; MFCD28144726; WHO 10950; ZINC209678340; ACN-052475; CS-5487; DA-43714; HY-12820; B5896; D11825; J-690221; 1-(2,7-Bis(2,6-anhydro-7,8-dideoxy-D-glycero-D-manno-oct-7-ynitol-8-yl)spiro(fluorene-9,4'-piperidin)-1'-yl)ethan-1-one; 1-[2,7-bis[2-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]ethynyl]spiro[fluorene-9,4a?piperidine]-1a?yl]ethanone; 8,8'-(1'-Acetylspiro(9H-fluorene-9,4'-piperidine)-2,7-diyl)bis(2,6-anhydro-7,8-dideoxy-D-glycero-D-manno-oct-7-ynitol); D-Glycero-D-manno-oct-7-ynitol, 8,8'-(1'-acetylspiro(9H-fluorene-9,4'-piperidine)-2,7-diyl)bis(2,6-anhydro-7,8-dideoxy-
    Click to Show/Hide
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 Compound Name PRA023 Phase 2 [26]
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 Compound Name ABBV-154 Phase 2 [27]
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 Compound Name Alequel Phase 2 [9]
Synonyms
Antigens (colitis), Enzo; Antigen-specific immune regulation therapy (Crohn`s), Enzo
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External Link
 Compound Name YSIL6 Phase 2 [28]
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 Compound Name CC-1088 Phase 2 [29]
Synonyms
CDC801; CHEMBL88153; SCHEMBL185853; CDC-801; DDYUBCCTNHWSQM-UHFFFAOYSA-N; BDBM50216298; HY-U00179; CS-7247; 192819-27-5
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 Compound Name GLPG-0634 Phase 2 [9]
Synonyms
Small molecule, JAK1/JAK2 inhibitor (rheumatoid arthritis), Galapagos/GSK
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External Link
 Compound Name Anti-IP10 Phase 2 [30]
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 Compound Name APD371 Phase 2 [31]
Synonyms
Olorinab; UNII-581F7DFA9B; 581F7DFA9B; Olorinab [USAN]; SCHEMBL11995430; 1268881-20-4; (4aS,5aS)-N-((2S)-1-hydroxy-3,3-dimethylbutan-2-yl)-1-(4-oxidopyrazin-2-yl)-4,4a,5,5a-tetrahydro-1H-cyclopropa(4,5)cyclopenta(1,2-c)pyrazole-3-carboxamide; 1H-Cyclopropa(4,5)cyclopenta(1,2-c)pyrazole-3-carboxamide, 4,4a,5,5a-tetrahydro-N-((1S)-1-(hydroxymethyl)-2,2-dimethylpropyl)-1-(4-oxido-2-pyrazinyl)-, (4aS,5aS)-; (1aS,5aS)-2-(4-Oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa(a)pentalene-4-carboxylic aci
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 Compound Name OPS-2071 Phase 2 [32]
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 Compound Name MEDI2070 Phase 2 [33]
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 Compound Name EGS-21 Phase 2 [34]
Synonyms
Glucocerebroside, Enzo; Glucosylceramide, Enzo Biochem
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 Compound Name GSK2330811 Phase 2 [35]
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 Compound Name STA-5326 Phase 2 [36]
Synonyms
Apilimod; STA 5326; STA5326; N-[(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine
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 Compound Name MDX-1100 Phase 2 [37]
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 Compound Name PF-04236921 Phase 2 [9]
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 Compound Name NN8555 Phase 2 [9]
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 Compound Name AMG-181 Phase 2 [38]
Synonyms
Inflammatory bowel disease therapeutics, Amgen
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 Compound Name SGX203 Phase 2 [9]
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 Compound Name Clazakizumab Phase 2 [39]
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 Compound Name MT-1303 Phase 2 [9]
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 Compound Name EcoActive Phase 1/2 [40]
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 Compound Name AZD7798 Phase 1 [41]
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 Compound Name OSSM-001 Phase 1 [42]
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 Compound Name ONS-3010 Phase 1 [9]
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 Compound Name ATR-107 Phase 1 [43]
Synonyms
PF-05230900
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External Link
 Compound Name ChronsVax Phase 1 [9]
Synonyms
Crohn's disease vaccine; IR-777
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 Compound Name C326 Phase 1 [44]
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 Compound Name AMG-139 Phase 1 [45]
Synonyms
Anti-inflammatory agent (psoriasis, IBD), Amgen
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 Compound Name TAK-828 Phase 1 [9]
Synonyms
ICMFYVOUDGRBLG-NJMNTPMDSA-N; TAK828F; GTPL9867; TAK-828F; SCHEMBL17390967; SCHEMBL17390969; SCHEMBL17391123; ICMFYVOUDGRBLG-VFHHBZAHSA-N; ICMFYVOUDGRBLG-XVNUGVHUSA-N; compound 10 [PMID: 29510038]; E3V; {cis-3-[(5R)-5-[(7-fluoro-1,1-dimethyl-1H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridine-6(5H)-carbonyl]cyclobutyl}acetic acid; (cis-3-(((5R)-5-((7-fluoro-1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)carbamoyl)-2-methoxy-7,8-dihydro-1,6-naphthyridin-6 (5H)-yl)carbonyl)cyclobutyl)acetic acid; (cis-3-(((5R)-5-((7-fluoro-1,1-dimethyl-2
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 Compound Name CrohnsVax Phase 1 [46]
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 Compound Name ETX201 Phase 1 [9]
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 Compound Name VBY-129 Phase 1 [9]
Synonyms
Cathepsin S inhibitor (oral, psoriasis), Virobay
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 Compound Name SAR252067 Phase 1 [47]
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 Compound Name PF-06480605 Phase 1 [48]
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 Compound Name ABBV-323 Phase 1 [9]
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 Compound Name CCX-025 Phase 1 [49]
Synonyms
CCX-807; CCR9 chemokine receptor-targeting therapeutic (gastrointestinal diseases), ChemoCentryx
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External Link
 Compound Name Biaryl mannoside derivative 6 Patented [50]
Synonyms
PMID26651364-Compound-2f
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 Compound Name Biaryl mannoside derivative 3 Patented [50]
Synonyms
PMID26651364-Compound-2c
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 Compound Name Alkyl mannoside derivative 2 Patented [50]
Synonyms
PMID26651364-Compound-1b
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 Compound Name Mannoside derivative 2 Patented [50]
Synonyms
PMID26651364-Compound-101
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 Compound Name Biphenyl mannoside derivative 16 Patented [50]
Synonyms
PMID26651364-Compound-51
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 Compound Name PMID26651364-Compound-126b Patented [50]
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 Compound Name PMID26651364-Compound-7d Patented [50]
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 Compound Name Aryl mannoside derivative 7 Patented [50]
Synonyms
PMID26651364-Compound-18
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External Link
 Compound Name Biaryl mannoside derivative 28 Patented [50]
Synonyms
PMID26651364-Compound-64
    Click to Show/Hide
External Link
 Compound Name Mannoside derivative 5 Patented [50]
Synonyms
PMID26651364-Compound-104
    Click to Show/Hide
External Link
 Compound Name C-linked disaccharide biphenyl mannoside derivative 3 Patented [50]
Synonyms
PMID26651364-Compound-88
    Click to Show/Hide
External Link
 Compound Name Mannoside derivative 4 Patented [50]
Synonyms
PMID26651364-Compound-103
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-50 Patented [50]
External Link
 Compound Name PMID26651364-Compound-118 Patented [50]
External Link
 Compound Name Aryl mannoside derivative 18 Patented [50]
Synonyms
PMID26651364-Compound-80
    Click to Show/Hide
External Link
 Compound Name Beta-cyclodextrin conjugate derivative 5 Patented [50]
Synonyms
PMID26651364-Compound-133
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-49 Patented [50]
External Link
 Compound Name PMID26651364-Compound-111 Patented [50]
External Link
 Compound Name Biphenyl mannoside derivative 20 Patented [50]
Synonyms
PMID26651364-Compound-55
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-5b Patented [50]
External Link
 Compound Name Biphenyl mannoside derivative 23 Patented [50]
Synonyms
PMID26651364-Compound-68b
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-107 Patented [50]
External Link
 Compound Name Aryl mannoside derivative 9 Patented [50]
Synonyms
PMID26651364-Compound-20
    Click to Show/Hide
External Link
 Compound Name Alkyl mannoside derivative 1 Patented [50]
Synonyms
PMID26651364-Compound-1a
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External Link
 Compound Name PMID26651364-Compound-6d Patented [50]
External Link
 Compound Name C-linked disaccharide biphenyl mannoside derivative 2 Patented [50]
Synonyms
PMID26651364-Compound-87
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-126a Patented [50]
External Link
 Compound Name Biphenyl mannoside derivative 7 Patented [50]
Synonyms
PMID26651364-Compound-31
    Click to Show/Hide
External Link
 Compound Name Biphenyl mannoside derivative 28 Patented [50]
Synonyms
PMID26651364-Compound-73
    Click to Show/Hide
External Link
 Compound Name Alkyl mannoside derivative 6 Patented [50]
Synonyms
PMID26651364-Compound-Table2R1=n-alkyl04
    Click to Show/Hide
External Link
 Compound Name Mannoside derivative 9 Patented [50]
Synonyms
PMID26651364-Compound-95
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-113 Patented [50]
External Link
 Compound Name Aryl mannoside derivative 20 Patented [50]
Synonyms
PMID26651364-Compound-82
    Click to Show/Hide
External Link
 Compound Name Biphenyl mannoside derivative 29 Patented [50]
Synonyms
PMID26651364-Compound-74
    Click to Show/Hide
External Link
 Compound Name Biphenyl mannoside derivative 1 Patented [50]
Synonyms
PMID26651364-Compound-25
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-124 Patented [50]
External Link
 Compound Name Alkyl mannoside derivative 3 Patented [50]
Synonyms
PMID26651364-Compound-Table2R1=n-alkyl01
    Click to Show/Hide
External Link
 Compound Name Aryl mannoside derivative 11 Patented [50]
Synonyms
PMID26651364-Compound-22
    Click to Show/Hide
External Link
 Compound Name Biphenyl mannoside derivative 17 Patented [50]
Synonyms
PMID26651364-Compound-52
    Click to Show/Hide
External Link
 Compound Name Biaryl mannoside derivative 22 Patented [50]
Synonyms
PMID26651364-Compound-44
    Click to Show/Hide
External Link
 Compound Name Biphenyl mannoside derivative 13 Patented [50]
Synonyms
PMID26651364-Compound-37
    Click to Show/Hide
External Link
 Compound Name Mannoside derivative 3 Patented [50]
Synonyms
PMID26651364-Compound-102
    Click to Show/Hide
External Link
 Compound Name Aryl mannoside derivative 10 Patented [50]
Synonyms
PMID26651364-Compound-21
    Click to Show/Hide
External Link
 Compound Name Biaryl mannoside derivative 29 Patented [50]
Synonyms
PMID26651364-Compound-65
    Click to Show/Hide
External Link
 Compound Name Biaryl mannoside derivative 1 Patented [50]
Synonyms
PMID26651364-Compound-2a
    Click to Show/Hide
External Link
 Compound Name Aryl mannoside derivative 16 Patented [50]
Synonyms
PMID26651364-Compound-78
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-47 Patented [50]
External Link
 Compound Name Beta-cyclodextrin conjugate derivative 2 Patented [50]
Synonyms
PMID26651364-Compound-130
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-5f Patented [50]
External Link
 Compound Name Biaryl mannoside derivative 23 Patented [50]
Synonyms
PMID26651364-Compound-59
    Click to Show/Hide
External Link
 Compound Name Mannoside derivative 13 Patented [50]
Synonyms
PMID26651364-Compound-99
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-7e Patented [50]
External Link
 Compound Name PMID26651364-Compound-9c Patented [50]
External Link
 Compound Name PMID26651364-Compound-8d Patented [50]
External Link
 Compound Name PMID26651364-Compound-11c Patented [50]
External Link
 Compound Name Biaryl mannoside derivative 25 Patented [50]
Synonyms
PMID26651364-Compound-61
    Click to Show/Hide
External Link
 Compound Name Mannoside derivative 1 Patented [50]
Synonyms
PMID26651364-Compound-100
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External Link
 Compound Name PMID26651364-Compound-8c Patented [50]
External Link
 Compound Name PMID26651364-Compound-10b Patented [50]
External Link
 Compound Name Biphenyl mannoside derivative 8 Patented [50]
Synonyms
PMID26651364-Compound-32
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-106 Patented [50]
External Link
 Compound Name Biphenyl mannoside derivative 11 Patented [50]
Synonyms
PMID26651364-Compound-35
    Click to Show/Hide
External Link
 Compound Name Biphenyl mannoside derivative 19 Patented [50]
Synonyms
PMID26651364-Compound-54
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External Link
 Compound Name PMID26651364-Compound-10d Patented [50]
External Link
 Compound Name Alkyl mannoside derivative 5 Patented [50]
Synonyms
PMID26651364-Compound-Table2R1=n-alkyl03
    Click to Show/Hide
External Link
 Compound Name Beta-cyclodextrin conjugate derivative 1 Patented [50]
Synonyms
PMID26651364-Compound-129
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-122 Patented [50]
External Link
 Compound Name PMID26651364-Compound-6c Patented [50]
External Link
 Compound Name Aryl mannoside derivative 8 Patented [50]
Synonyms
PMID26651364-Compound-19
    Click to Show/Hide
External Link
 Compound Name Biphenyl mannoside derivative 27 Patented [50]
Synonyms
PMID26651364-Compound-72
    Click to Show/Hide
External Link
 Compound Name Alkyl mannoside derivative 4 Patented [50]
Synonyms
PMID26651364-Compound-Table2R1=n-alkyl02
    Click to Show/Hide
External Link
 Compound Name Aryl mannoside derivative 6 Patented [50]
Synonyms
PMID26651364-Compound-17
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External Link
 Compound Name PMID26651364-Compound-9b Patented [50]
External Link
 Compound Name PMID26651364-Compound-46 Patented [50]
External Link
 Compound Name Biaryl mannoside derivative 27 Patented [50]
Synonyms
PMID26651364-Compound-63
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-112 Patented [50]
External Link
 Compound Name Biaryl mannoside derivative 11 Patented [50]
Synonyms
PMID26651364-Compound-3c
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-127 Patented [50]
External Link
 Compound Name PMID26651364-Compound-4 Patented [50]
External Link
 Compound Name PMID26651364-Compound-110 Patented [50]
External Link
 Compound Name PMID26651364-Compound-117a Patented [50]
External Link
 Compound Name PMID26651364-Compound-9f Patented [50]
External Link
 Compound Name Biphenyl mannoside derivative 18 Patented [50]
Synonyms
PMID26651364-Compound-53
    Click to Show/Hide
External Link
 Compound Name Mannoside derivative 11 Patented [50]
Synonyms
PMID26651364-Compound-97
    Click to Show/Hide
External Link
 Compound Name C-linked disaccharide biphenyl mannoside derivative 1 Patented [50]
Synonyms
PMID26651364-Compound-86
    Click to Show/Hide
External Link
 Compound Name Biaryl mannoside derivative 19 Patented [50]
Synonyms
PMID26651364-Compound-41
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External Link
 Compound Name Biaryl mannoside derivative 2 Patented [50]
Synonyms
PMID26651364-Compound-2b
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External Link
 Compound Name Biphenyl mannoside derivative 22 Patented [50]
Synonyms
PMID26651364-Compound-68a
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External Link
 Compound Name PMID26651364-Compound-115 Patented [50]
External Link
 Compound Name Biphenyl mannoside derivative 9 Patented [50]
Synonyms
PMID26651364-Compound-33
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-10a Patented [50]
External Link
 Compound Name Aryl mannoside derivative 2 Patented [50]
Synonyms
PMID26651364-Compound-13
    Click to Show/Hide
External Link
 Compound Name Aryl mannoside derivative 3 Patented [50]
Synonyms
PMID26651364-Compound-14
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External Link
 Compound Name PMID26651364-Compound-120 Patented [50]
External Link
 Compound Name PMID26651364-Compound-6a Patented [50]
External Link
 Compound Name Biaryl mannoside derivative 13 Patented [50]
Synonyms
PMID26651364-Compound-3e
    Click to Show/Hide
External Link
 Compound Name Mannoside derivative 6 Patented [50]
Synonyms
PMID26651364-Compound-92
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External Link
 Compound Name Biaryl mannoside derivative 30 Patented [50]
Synonyms
PMID26651364-Compound-66
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External Link
 Compound Name Biaryl mannoside derivative 14 Patented [50]
Synonyms
PMID26651364-Compound-3f
    Click to Show/Hide
External Link
 Compound Name Biphenyl mannoside derivative 15 Patented [50]
Synonyms
PMID26651364-Compound-39
    Click to Show/Hide
External Link
 Compound Name Alkyl mannoside derivative 11 Patented [50]
Synonyms
PMID26651364-Compound-Table2R1=n-aryl02
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External Link
 Compound Name PMID26651364-Compound-5g Patented [50]
External Link
 Compound Name PMID26651364-Compound-6b Patented [50]
External Link
 Compound Name Alkyl mannoside derivative 10 Patented [50]
Synonyms
PMID26651364-Compound-Table2R1=n-aryl01
    Click to Show/Hide
External Link
 Compound Name Biaryl mannoside derivative 16 Patented [50]
Synonyms
PMID26651364-Compound-3h
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External Link
 Compound Name Aryl mannoside derivative 12 Patented [50]
Synonyms
PMID26651364-Compound-23
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External Link
 Compound Name Aryl mannoside derivative 17 Patented [50]
Synonyms
PMID26651364-Compound-79
    Click to Show/Hide
External Link
 Compound Name Alkyl mannoside derivative 7 Patented [50]
Synonyms
PMID26651364-Compound-Table2R1=n-alkyl05
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External Link
 Compound Name Mannoside derivative 12 Patented [50]
Synonyms
PMID26651364-Compound-98
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External Link
 Compound Name PMID26651364-Compound-117b Patented [50]
External Link
 Compound Name Biphenyl mannoside derivative 26 Patented [50]
Synonyms
PMID26651364-Compound-71
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-7c Patented [50]
External Link
 Compound Name PMID26651364-Compound-5c Patented [50]
External Link
 Compound Name Beta-cyclodextrin conjugate derivative 4 Patented [50]
Synonyms
PMID26651364-Compound-132
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-45 Patented [50]
External Link
 Compound Name Biphenyl mannoside derivative 21 Patented [50]
Synonyms
PMID26651364-Compound-56
    Click to Show/Hide
External Link
 Compound Name Biphenyl mannoside derivative 2 Patented [50]
Synonyms
PMID26651364-Compound-26
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External Link
 Compound Name PMID26651364-Compound-8b Patented [50]
External Link
 Compound Name Aryl mannoside derivative 14 Patented [50]
Synonyms
PMID26651364-Compound-76
    Click to Show/Hide
External Link
 Compound Name C-linked disaccharide biphenyl mannoside derivative 5 Patented [50]
Synonyms
PMID26651364-Compound-90
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External Link
 Compound Name Biaryl mannoside derivative 20 Patented [50]
Synonyms
PMID26651364-Compound-42
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-10c Patented [50]
External Link
 Compound Name Aryl mannoside derivative 15 Patented [50]
Synonyms
PMID26651364-Compound-77
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-7b Patented [50]
External Link
 Compound Name Biaryl mannoside derivative 4 Patented [50]
Synonyms
PMID26651364-Compound-2d
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External Link
 Compound Name PMID26651364-Compound-9e Patented [50]
External Link
 Compound Name Biphenyl mannoside derivative 4 Patented [50]
Synonyms
PMID26651364-Compound-28
    Click to Show/Hide
External Link
 Compound Name Biphenyl mannoside derivative 24 Patented [50]
Synonyms
PMID26651364-Compound-69
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External Link
 Compound Name Biaryl mannoside derivative 7 Patented [50]
Synonyms
PMID26651364-Compound-2g
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External Link
 Compound Name Aryl mannoside derivative 13 Patented [50]
Synonyms
PMID26651364-Compound-24
    Click to Show/Hide
External Link
 Compound Name Mannoside derivative 7 Patented [50]
Synonyms
PMID26651364-Compound-93
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-105 Patented [50]
External Link
 Compound Name PMID26651364-Compound-5a Patented [50]
External Link
 Compound Name PMID26651364-Compound-8a Patented [50]
External Link
 Compound Name Biaryl mannoside derivative 18 Patented [50]
Synonyms
PMID26651364-Compound-40
    Click to Show/Hide
External Link
 Compound Name Aryl mannoside derivative 1 Patented [50]
Synonyms
PMID26651364-Compound-12
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External Link
 Compound Name PMID26651364-Compound-48 Patented [50]
External Link
 Compound Name Mannoside derivative 8 Patented [50]
Synonyms
PMID26651364-Compound-94
    Click to Show/Hide
External Link
 Compound Name Biaryl mannoside derivative 5 Patented [50]
Synonyms
PMID26651364-Compound-2e
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External Link
 Compound Name Aryl mannoside derivative 23 Patented [50]
Synonyms
PMID26651364-Compound-85
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External Link
 Compound Name Alkyl mannoside derivative 8 Patented [50]
Synonyms
PMID26651364-Compound-Table2R1=n-alkyl06
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-119 Patented [50]
External Link
 Compound Name Biaryl mannoside derivative 17 Patented [50]
Synonyms
PMID26651364-Compound-3i
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External Link
 Compound Name Aryl mannoside derivative 21 Patented [50]
Synonyms
PMID26651364-Compound-83
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External Link
 Compound Name Alkyl mannoside derivative 12 Patented [50]
Synonyms
PMID26651364-Compound-Table2R1=n-aryl03
    Click to Show/Hide
External Link
 Compound Name Aryl mannoside derivative 22 Patented [50]
Synonyms
PMID26651364-Compound-84
    Click to Show/Hide
External Link
 Compound Name Alkyl mannoside derivative 9 Patented [50]
Synonyms
PMID26651364-Compound-Table2R1=n-alkyl07
    Click to Show/Hide
External Link
 Compound Name Biaryl mannoside derivative 12 Patented [50]
Synonyms
PMID26651364-Compound-3d
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External Link
 Compound Name Aryl mannoside derivative 5 Patented [50]
Synonyms
PMID26651364-Compound-16
    Click to Show/Hide
External Link
 Compound Name Biaryl mannoside derivative 26 Patented [50]
Synonyms
PMID26651364-Compound-62
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-5e Patented [50]
External Link
 Compound Name PMID26651364-Compound-6e Patented [50]
External Link
 Compound Name Biphenyl mannoside derivative 14 Patented [50]
Synonyms
PMID26651364-Compound-38
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-11b Patented [50]
External Link
 Compound Name Biphenyl mannoside derivative 5 Patented [50]
Synonyms
PMID26651364-Compound-29
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-123 Patented [50]
External Link
 Compound Name PMID26651364-Compound-9a Patented [50]
External Link
 Compound Name Mannoside derivative 10 Patented [50]
Synonyms
PMID26651364-Compound-96
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-126c Patented [50]
External Link
 Compound Name Biphenyl mannoside derivative 30 Patented [50]
Synonyms
PMID26651364-Compound-75
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-125 Patented [50]
External Link
 Compound Name PMID26651364-Compound-128 Patented [50]
External Link
 Compound Name C-linked disaccharide biphenyl mannoside derivative 4 Patented [50]
Synonyms
PMID26651364-Compound-89
    Click to Show/Hide
External Link
 Compound Name Biphenyl mannoside derivative 25 Patented [50]
Synonyms
PMID26651364-Compound-70
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External Link
 Compound Name Biphenyl mannoside derivative 3 Patented [50]
Synonyms
PMID26651364-Compound-27
    Click to Show/Hide
External Link
 Compound Name Biphenyl mannoside derivative 12 Patented [50]
Synonyms
PMID26651364-Compound-36
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-108 Patented [50]
External Link
 Compound Name Aryl mannoside derivative 4 Patented [50]
Synonyms
PMID26651364-Compound-15
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-121 Patented [50]
External Link
 Compound Name Biphenyl mannoside derivative 10 Patented [50]
Synonyms
PMID26651364-Compound-34
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External Link
 Compound Name Biaryl mannoside derivative 15 Patented [50]
Synonyms
PMID26651364-Compound-3g
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External Link
 Compound Name C-linked disaccharide biphenyl mannoside derivative 6 Patented [50]
Synonyms
PMID26651364-Compound-91
    Click to Show/Hide
External Link
 Compound Name Aryl mannoside derivative 19 Patented [50]
Synonyms
PMID26651364-Compound-81
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External Link
 Compound Name PMID26651364-Compound-9d Patented [50]
External Link
 Compound Name PMID26651364-Compound-7a Patented [50]
External Link
 Compound Name Biaryl mannoside derivative 9 Patented [50]
Synonyms
PMID26651364-Compound-3a
    Click to Show/Hide
External Link
 Compound Name Biaryl mannoside derivative 10 Patented [50]
Synonyms
PMID26651364-Compound-3b
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External Link
 Compound Name Biaryl mannoside derivative 31 Patented [50]
Synonyms
PMID26651364-Compound-67
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External Link
 Compound Name Biaryl mannoside derivative 21 Patented [50]
Synonyms
PMID26651364-Compound-43
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External Link
 Compound Name PMID26651364-Compound-5d Patented [50]
External Link
 Compound Name Biphenyl mannoside derivative 6 Patented [50]
Synonyms
PMID26651364-Compound-30
    Click to Show/Hide
External Link
 Compound Name PMID26651364-Compound-114 Patented [50]
External Link
 Compound Name PMID26651364-Compound-109 Patented [50]
External Link
 Compound Name Beta-cyclodextrin conjugate derivative 3 Patented [50]
Synonyms
PMID26651364-Compound-131
    Click to Show/Hide
External Link
 Compound Name Biaryl mannoside derivative 8 Patented [50]
Synonyms
PMID26651364-Compound-2h
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External Link
 Compound Name PMID26651364-Compound-116 Patented [50]
External Link
 Compound Name PMID26651364-Compound-5 Patented [50]
External Link
 Compound Name Biaryl mannoside derivative 24 Patented [50]
Synonyms
PMID26651364-Compound-60
    Click to Show/Hide
External Link
 Compound Name CDP571 Discontinued in Phase 3 [51]
External Link
 Compound Name ISIS 104838 Discontinued in Phase 2 [52]
External Link
 Compound Name TNFQb therapeutic vaccines Terminated [53]
Synonyms
TNFQb; CYT-020-TNFQb; TNF-targeted vaccine (inflammation, Immunodrug), Cytos Biotechnology; TNFQb therapeutic vaccines (rheumatoid arthritis/psoriasis/Crohn's disease); TNFQb therapeutic vaccines (rheumatoid arthritis/psoriasis/Crohn's disease), Cytos; Immunodrug vaccines (TNF) (rheumatoid arthritis/psoriasis/Crohn's disease), Cytos
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External Link
 Compound Name Mycophenolic acid Approved [6]
External Link
 Compound Name STP-432 Investigative [54]
Synonyms
Multi-targeted siRNA therapeutic (nanoparticle, Crohns disease), Sirnaomics
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External Link
References
Ref 1 METTL3-mediated m(6) A modification of circPRKAR1B promotes Crohn's colitis by inducing pyroptosis via autophagy inhibition. Clin Transl Med. 2023 Sep;13(9):e1405. doi: 10.1002/ctm2.1405.
Ref 2 The Discovery of Novel Selective D1 Dopaminergic Agonists: A-68930, A-77636, A-86929, and ABT-413. International Journal of Medicinal Chemistry Volume 2011 (2011), Article ID 424535, Page(8).
Ref 3 FDA Approved Drug Products from FDA Official Website.
Ref 4 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 019500.
Ref 5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7437).
Ref 6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 7 ClinicalTrials.gov (NCT00509639) Evaluation of Topical 10% Metronidazole Ointment for the Treatment of Active Perianal Crohn's Disease. U.S. National Institutes of Health.
Ref 8 ClinicalTrials.gov (NCT00846703) The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia. U.S. National Institutes of Health.
Ref 9 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 10 The druggable genome: Evaluation of drug targets in clinical trials suggests major shifts in molecular class and indication. Annu Rev Pharmacol Toxicol. 2014;54:9-26.
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