m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT05751				[1]
m⁶A modification miR-196b-5p miR-196b-5p METTL3 Methylation : m⁶A sites Direct Inhibition Non-coding RNA miR-196b-5p Regulated Target lncRNA miRNA circRNA
m6A Regulator	Methyltransferase-like 3 (METTL3)			WRITER	Regulator Info
m6A Target	hsa-miR-196b-5p				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	Non-coding RNA (ncRNA)
Epigenetic Regulator	hsa-miR-196b-5p			microRNA	View Details
Crosstalk Relationship	m6A → ncRNA			Inhibition
Crosstalk Mechanism	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary	METTL3 Promotes Osteo/Odontogenic Differentiation of Stem Cells by Inhibiting hsa-miR-196b-5p Maturation.
Responsed Disease	Structural developmental anomalies of teeth and periodontal tissues		ICD-11: LA30.5		Disease Info
Cell Process	Cell migration
	Cell invasion
	Cell proliferation
In-vitro Model	Ca Ski	Cervical squamous cell carcinoma	Homo sapiens		CVCL_1100
	SiHa	Cervical squamous cell carcinoma	Homo sapiens		CVCL_0032
	End1/E6E7	Normal	Homo sapiens		CVCL_3684
	HUCECs (Human Uterine Cervical Epithelial Cells)
In-vivo Model	A total of 2.0 × 10⁶ SCAPs were mixed with 20 mg HA/tricalcium phosphate (Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China) at 37°C for 2 h, and then, the mixture was subcutaneously transplanted into the back of nude mice (10-week-old female, nu/nu).

References

Ref 1	METTL3 Promotes Osteo/Odontogenic Differentiation of Stem Cells by Inhibiting miR-196b-5p Maturation. Stem Cells Int. 2023 Jun 7;2023:8992284. doi: 10.1155/2023/8992284. eCollection 2023.