m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT05725				[1]
m⁶A modification THRIL THRIL METTL14 Methylation : m⁶A sites Direct Enhancement Non-coding RNA THRIL Regulated Target lncRNA miRNA circRNA
m6A Regulator	Methyltransferase-like 14 (METTL14)			WRITER	Regulator Info
m6A Target	TNF and HNRNPL related immunoregulatory long non-coding RNA (THRIL)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	Non-coding RNA (ncRNA)
Epigenetic Regulator	TNF and HNRNPL related immunoregulatory long non-coding RNA (THRIL)			LncRNA	View Details
Crosstalk Relationship	m6A → ncRNA			Enhancement
Crosstalk Mechanism	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary	LncRNA TNF and HNRNPL related immunoregulatory long non-coding RNA (THRIL), transcriptionally activated by AP-1 and stabilized by METTL14-mediated m6A modification, accelerates LPS-evoked acute injury in alveolar epithelial cells.
Responsed Disease	Injury of other or unspecified intrathoracic organs		ICD-11: NB32.3		Disease Info
Responsed Drug	LPS				Drug Info
Cell Process	mRNA stability
Cell Process	Cell autophagy
In-vitro Model	A-549	Lung adenocarcinoma	Homo sapiens		CVCL_0023

References

Ref 1	LncRNA THRIL, transcriptionally activated by AP-1 and stabilized by METTL14-mediated m6A modification, accelerates LPS-evoked acute injury in alveolar epithelial cells. Int Immunopharmacol. 2023 Oct;123:110740. doi: 10.1016/j.intimp.2023.110740. Epub 2023 Aug 3.