m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05671
 [1]
m6A modification hsa-miR-29b-3p hsa-miR-29b-3p WTAP Methylation : m6A sites Direct Enhancement Non-coding RNA miR-29b-3p HDAC4  lncRNA       miRNA   circRNA
m6A Modification:
m6A Regulator Wilms tumor 1-associating protein (WTAP) WRITER
 Regulator Info 
m6A Target hsa-miR-29b-3p
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator hsa-miR-29b-3p microRNA View Details
Regulated Target Histone deacetylase 4 (HDAC4) View Details
Crosstalk Relationship m6A  →  ncRNA Enhancement
Crosstalk Mechanism m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary WTAP-mediated m6A modification promoted osteogenic differentiation and inhibited adipogenic differentiation of BMMSCs through the hsa-miR-29b-3p/Histone deacetylase 4 (HDAC4) axis.
Responsed Disease Osteoporosis ICD-11: FB83.1
 Disease Info 
Cell Process Cell differentiation
In-vitro Model
 RAW 264.7 Mouse leukemia Mus musculus CVCL_0493
In-vivo Model 15 L of an empty vector-carrying lentivirus (5 × 107 copies/mL) was administered to the control group. The lentivirus as an in vivo delivery system can carry a luciferase transgene. The delivery system was injected into the marrow cavity of the femur 4 times at week 1, and luciferase expression in live mice was followed with a whole-animal fluorescence imaging system (IVIS Spectrum, USA) at 3 weeks post-injection.
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Histone deacetylase 4 (HDAC4) 104 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name PMID29671355-Compound-52 Patented [2]
MOA Inhibitor
Activity IC50 = 55 nM
External Link
CID: 117603070
TTD: D02YLT
 Compound Name PMID29671355-Compound-72a Patented [2]
MOA Inhibitor
Activity IC50 = 3 nM
External Link
TTD: D03KOH
 Compound Name PMID29671355-Compound-47c Patented [2]
MOA Inhibitor
Activity IC50 = 40 nM
External Link
CID: 72948227
TTD: D07KQB
 Compound Name PMID29671355-Compound-70 Patented [2]
MOA Inhibitor
Activity IC50 = 3 nM
External Link
CID: 122669618
TTD: D08CYC
 Compound Name PMID29671355-Compound-71b Patented [2]
MOA Inhibitor
Activity IC50 = 8 nM
External Link
TTD: D0BV4M
 Compound Name PMID29671355-Compound-72b Patented [2]
MOA Inhibitor
Activity IC50 = 21 nM
External Link
TTD: D0E7TU
 Compound Name PMID29671355-Compound-47a Patented [2]
MOA Inhibitor
Activity IC50 = 10 nM
External Link
CID: 72722126
TTD: D0L1NO
 Compound Name PMID29671355-Compound-50 Patented [2]
MOA Inhibitor
Activity IC50 = 12 nM
External Link
TTD: D0M7GG
 Compound Name PMID29671355-Compound-47b Patented [2]
MOA Inhibitor
Activity IC50 = 20 nM
External Link
CID: 72950863
TTD: D0NG9V
 Compound Name PMID29671355-Compound-71a Patented [2]
MOA Inhibitor
Activity IC50 = 3 nM
External Link
TTD: D0O1LX
 Compound Name PMID29671355-Compound-47d Patented [2]
MOA Inhibitor
Activity IC50 = 40 nM
External Link
CID: 72948224
TTD: D0SP7T
 Compound Name PMID29671355-Compound-12 Patented [2]
MOA Inhibitor
Activity IC50 = 120 nM
External Link
CID: 78425879
TTD: D0UE9B
 Compound Name PMID29671355-Compound-68b Patented [2]
MOA Inhibitor
Activity IC50 = 2.74 nM
External Link
TTD: D0GD6R
 Compound Name PMID29671355-Compound-45a Patented [2]
MOA Inhibitor
Activity IC50 = 49 nM
External Link
CID: 86302836
TTD: D0YN2T
 Compound Name PMID29671355-Compound-61 Patented [2]
MOA Inhibitor
Activity IC50 > 1000000 nM
External Link
TTD: D0JB4S
 Compound Name PMID29671355-Compound-23 Patented [2]
MOA Inhibitor
Activity IC50 = 3820 nM
External Link
CID: 118884610
TTD: D00HXJ
 Compound Name PMID29671355-Compound-56 Patented [2]
MOA Inhibitor
Activity IC50 = 9220 nM
External Link
CID: 56965342
TTD: D0CH8Q
 Compound Name PMID29671355-Compound-67 Patented [2]
MOA Inhibitor
Activity IC50 = 2840 nM
External Link
CID: 60201048
TTD: D0M0RE
 Compound Name PMID29671355-Compound-31 Patented [2]
MOA Inhibitor
Activity IC50 = 1970 nM
External Link
CID: 90479372
TTD: D0DI9S
DrugBank: DB14979
 Compound Name PMID29671355-Compound-21 Patented [2]
MOA Inhibitor
Activity IC50 = 16400 nM
External Link
CID: 86295624
TTD: D0LP1K
 Compound Name PMID29671355-Compound-62 Patented [2]
MOA Inhibitor
Activity IC50 = 100 to 500 nM
External Link
TTD: D07WAT
 Compound Name PMID29671355-Compound-43 Patented [2]
MOA Inhibitor
Activity IC50 > 100000 nM
External Link
CID: 118515590
TTD: D0BP8I
 Compound Name PMID29671355-Compound-25 Patented [2]
MOA Inhibitor
Activity IC50 = 3310 nM
External Link
CID: 126569528
TTD: D0RA0D
 Compound Name N-hydroxy-9,10-dihydroanthracene-9-carboxamide Investigative [3]
Synonyms
CHEMBL575482; SCHEMBL4541357
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2320 nM
External Link
CID: 45482666
TTD: D03BQS
 Compound Name N-hydroxy-2,2-diphenylacetamide Investigative [3]
Synonyms
Diphenylacetohydroxamic acid; 4099-51-8; N-Hydroxy diphenylacetamide; CHEMBL396097; NSC44620; benzeneacetamide, n-hydroxy-; A-phenyl-; N-Hydroxydiphenylacetamide; BENZENEACETAMIDE,N-HYDROXY-A-PHENYL-; AC1Q5QC3; SCHEMBL2839032; CTK8I6435; DTXSID10286297; AC1L6390; ZINC4522248; NSC-44620; BDBM50207561; MFCD16314231; AKOS022308585; Diphenylacetohydroxamic acid, &gt
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 250 nM
External Link
CID: 239512
TTD: D03QOD
 Compound Name N-hydroxy-9H-xanthene-9-carboxamide Investigative [3]
Synonyms
CHEMBL583490; 9H-Xanthene-9-carboxamide,N-hydroxy-; SCHEMBL2843958; BDBM50300446
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 250 nM
External Link
CID: 44626296
TTD: D06IMY
 Compound Name 2,2-bis(3-fluorophenyl)-N-hydroxyacetamide Investigative [3]
Synonyms
CHEMBL574594; SCHEMBL4536216
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 700 nM
External Link
CID: 45482630
TTD: D0A4HF
 Compound Name AZUMAMIDE E Investigative [4]
Synonyms
CHEMBL402363
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2280 nM
External Link
CID: 16095101
TTD: D0E9DD
 Compound Name 2,2-bis(4-fluorophenyl)-N-hydroxyacetamide Investigative [3]
Synonyms
CHEMBL573190; SCHEMBL2841871
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1100 nM
External Link
CID: 45482672
TTD: D0FN5D
 Compound Name N-hydroxy-2,2-diphenylpropanamide Investigative [3]
Synonyms
CHEMBL585365; SCHEMBL2844474
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4500 nM
External Link
CID: 45482660
TTD: D0I4RK
 Compound Name AZUMAMIDE B Investigative [4]
Synonyms
CHEMBL402727
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3660 nM
External Link
CID: 16095112
TTD: D0M1ZI
 Compound Name 2,2-bis(4-chlorophenyl)-N-hydroxyacetamide Investigative [3]
Synonyms
CHEMBL572805; SCHEMBL2848402
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 960 nM
External Link
CID: 45482643
TTD: D0PK9V
 Compound Name AZUMAMIDE C Investigative [4]
Synonyms
CHEMBL257972
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3160 nM
External Link
CID: 16095114
TTD: D0Q9PO
 Compound Name LARGAZOLE Investigative [5]
Synonyms
CHEMBL1173445; (+)-Largazole; SCHEMBL71330; ZINC56861395
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3000 nM
External Link
CID: 24757913
TTD: D0Z8PX
 Compound Name Cyclo(-L-Am7(S2Py)-L-A1in-L-Ala-D-Pro-) Investigative [6]
Synonyms
CHEMBL393260
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 25 nM
External Link
CID: 44437872
TTD: D00XTC
 Compound Name 7-mercapto-N-(4-phenylthiazol-2-yl)heptanamide Investigative [7]
Synonyms
CHEMBL419758; NCH-31; JMC505425 Compound 7; BDBM19131; 7-mercapto-N-(4-phenyl-2-thiazolyl)heptanamide; N-(4-phenyl-1,3-thiazol-2-yl)-7-sulfanylheptanamide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 32 nM
External Link
CID: 11427204
TTD: D02HVH
 Compound Name Cyclo(-L-Am7(S2Py)-D-A1in-L-Ala-D-Pro-) Investigative [6]
Synonyms
CHEMBL390991
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2.4 nM
External Link
CID: 44437870
TTD: D02NAF
 Compound Name Cyclo(-L-Am7(S2Py)-A2in-L-Ala-D-Pro-) Investigative [6]
Synonyms
CHEMBL394261
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1.6 nM
External Link
CID: 44437869
TTD: D02NVY
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ph5-D-Pro-) Investigative [6]
Synonyms
CHEMBL391384
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2.7 nM
External Link
CID: 44437878
TTD: D03PRG
 Compound Name Cyclo(-L-Am7(S2Py)-D-2MePhe-L-Ala-D-Pro-) Investigative [6]
Synonyms
CHEMBL393261
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 70 nM
External Link
CID: 44437873
TTD: D04CDZ
 Compound Name santacruzamate A Investigative [8]
Synonyms
CAY10683
    Click to Show/Hide
MOA Inhibitor
Activity IC50 > 1000 nM
External Link
CID: 72946782
TTD: D09RKA
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ser(Bzl)-D-Pro-) Investigative [6]
Synonyms
CHEMBL241555
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1.6 nM
External Link
CID: 44437879
TTD: D0E8UH
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Phg-D-Pro-) Investigative [6]
Synonyms
CHEMBL428737
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 56 nM
External Link
CID: 44437876
TTD: D0G1EX
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Tic-) Investigative [6]
Synonyms
CHEMBL238587
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4.2 nM
External Link
CID: 44437875
TTD: D0N5RV
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Pro-) Investigative [6]
Synonyms
CHEMBL238596; BDBM50222727
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 5.2 nM
External Link
CID: 44437883
TTD: D0R3XO
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ser-D-Pro-) Investigative [6]
Synonyms
CHEMBL393961
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4 nM
External Link
CID: 44437880
TTD: D0U0EZ
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ph4-D-Pro-) Investigative [6]
Synonyms
CHEMBL391383
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3.2 nM
External Link
CID: 44437877
TTD: D0X4QC
 Compound Name Cyclo(-L-Am7(S2Py)-L-2MePhe-L-Ala-D-Pro-) Investigative [6]
Synonyms
CHEMBL393464
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2.2 nM
External Link
CID: 44437874
TTD: D0Z6HR
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Phe-D-Pro-) Investigative [6]
Synonyms
CHEMBL238829; BDBM50222732
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1.8 nM
External Link
CID: 44437868
TTD: D0Z6MI
 Compound Name TMP269 Investigative [9]
Synonyms
TMFO1; compound 1 [PMID: 23524983]; TMP-269; TMP 269
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 90.5 nM
External Link
CID: 53344908
TTD: D0R7JA
 Compound Name 8-Oxo-8-phenyl-octanoic acid hydroxyamide Investigative [10]
Synonyms
CHEMBL95959; SCHEMBL3383197; N-hydroxy-8-oxo-8-phenyloctanamide
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11075845
TTD: D0S0WK
 Compound Name ST-3050 Investigative [11]
Synonyms
CHEMBL472631; SCHEMBL3445133; SCHEMBL3445139; BDBM50278222
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 16100 nM
External Link
CID: 44591988
TTD: D01YBR
 Compound Name Octanedioic acid bis-hydroxyamide Investigative [12]
Synonyms
Suberohydroxamic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 5173
TTD: D07YZZ
 Compound Name 9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide Investigative [10]
Synonyms
9,9,9-Trifluoro-8-Oxo-N-Phenylnonanamide; CHEMBL113537; 2gh6; SCHEMBL2702892; KRCXZGYVOZSCSF-UHFFFAOYSA-N; BDBM50121062; DB07553
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 5.1 nM
External Link
CID: 9882812
TTD: D00KFF
DrugBank: DB07553
 Compound Name 7-Mercapto-heptanoic acid phenylamide Investigative [13]
Synonyms
Thiol-SAHA (t-SAHA); CHEMBL325676; SCHEMBL14821761; BDBM152692
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11379392
TTD: D00SEE
 Compound Name 6-benzenesulfinylhexanoic acid hydroxamide Investigative [14]
Synonyms
6-(benzenesulfinyl)hexanoic acid hydroxyamide; 875737-03-4
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11694528
TTD: D00ZSD
 Compound Name N-(2-Mercapto-ethyl)-N'-phenyl-succinamide Investigative [15]
Synonyms
CHEMBL193959
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44401339
TTD: D01MFV
 Compound Name 7-Mercapto-heptanoic acid biphenyl-4-ylamide Investigative [13]
Synonyms
CHEMBL112311
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11220728
TTD: D01XWZ
 Compound Name N-Hydroxy-4-phenylacetylamino-benzamide Investigative [16]
Synonyms
CHEMBL356824; 656261-23-3; SCHEMBL675578; CTK1J6158; DTXSID40458440; ZINC13533297; AKOS030583151; Benzeneacetamide, N-[4-[(hydroxyamino)carbonyl]phenyl]-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11196500
TTD: D01XXN
 Compound Name 6-(2-Bromo-acetylamino)-hexanoic acid phenylamide Investigative [13]
Synonyms
CHEMBL344920; 651767-99-6; SCHEMBL3736839; CTK1J8444; DTXSID50432973; HWYLREOMBVUGJQ-UHFFFAOYSA-N; BDBM50222416; ZINC13587789; AKOS030603042; N-Phenyl-6-(bromoacetylamino)hexanamide; Hexanamide, 6-[(bromoacetyl)amino]-N-phenyl-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9927379
TTD: D02MQM
 Compound Name N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide Investigative [17]
Synonyms
CHEMBL143674; SCHEMBL673760
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11323577
TTD: D02UTC
 Compound Name 7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one Investigative [18]
Synonyms
CHEMBL126355; BDBM50222394
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44350626
TTD: D02WZK
 Compound Name Octanedioic acid hydroxyamide pyridin-4-ylamide Investigative [19]
Synonyms
SCHEMBL8082656; CHEMBL165162; ZINC13472304
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10967421
TTD: D04GGW
 Compound Name N-(6-Mercapto-hexyl)-benzamide Investigative [13]
Synonyms
CHEMBL112364; BDBM50223650
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11447748
TTD: D04HSS
 Compound Name 4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide Investigative [19]
Synonyms
CHEMBL167455
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11086699
TTD: D04NSP
 Compound Name N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide Investigative [16]
Synonyms
SCHEMBL675474
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11231829
TTD: D04ZDI
 Compound Name 6-benzenesulfonylhexanoic acid hydroxamide Investigative [14]
Synonyms
CHEMBL203207
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11572583
TTD: D05AHZ
 Compound Name 9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one Investigative [10]
Synonyms
SCHEMBL7373122; CHEMBL116578
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44342872
TTD: D05FEJ
 Compound Name Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester Investigative [13]
Synonyms
CHEMBL111806; SCHEMBL14812153
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11254470
TTD: D05GVY
 Compound Name 4-Butyrylamino-N-hydroxy-benzamide Investigative [17]
Synonyms
CHEMBL142254; 656261-22-2; Benzamide, N-hydroxy-4-[(1-oxobutyl)amino]-; SCHEMBL675234; CTK1J6159; DTXSID90461262
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11287488
TTD: D05LLX
 Compound Name 7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one Investigative [18]
Synonyms
CHEMBL127328
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44350703
TTD: D05VFP
 Compound Name 7-Mercapto-heptanoic acid biphenyl-3-ylamide Investigative [13]
Synonyms
CHEMBL320323
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11449823
TTD: D05XAN
 Compound Name 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione Investigative [20]
MOA Inhibitor
External Link
CID: 3082127
TTD: D06IQB
 Compound Name N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide Investigative [16]
Synonyms
SCHEMBL676079
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11347053
TTD: D06VBN
 Compound Name 4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide Investigative [13]
Synonyms
CHEMBL324126
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11277483
TTD: D06XNP
 Compound Name 7-Mercapto-heptanoic acid pyridin-3-ylamide Investigative [13]
Synonyms
CHEMBL332246; Heptanamide, 7-mercapto-N-3-pyridinyl-; BDBM50223653
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11345433
TTD: D07FJU
 Compound Name 6-Phenoxy-hexane-1-thiol Investigative [13]
Synonyms
CHEMBL109796; 6-phenoxyhexane-1-thiol; 1-Hexanethiol, 6-phenoxy-; SCHEMBL5679745; MolPort-020-180-823; BDBM50223652; AKOS018584222; MCULE-9521857089
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11298778
TTD: D09YBN
 Compound Name 4-Benzoylamino-N-hydroxy-benzamide Investigative [16]
Synonyms
SCHEMBL673678; CHEMBL191227
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11817702
TTD: D09ZNU
 Compound Name 4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide Investigative [10]
Synonyms
CHEMBL143734; NSC718168; AC1L8L82; SCHEMBL13039735; ZINC5579677; BDBM50082664; NSC-718168; NCI60_040737; 6-(4-Chlorobenzoylamino)hexanehydroxamic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 403373
TTD: D0A5LS
 Compound Name 8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one Investigative [18]
Synonyms
CHEMBL112148; SCHEMBL7364383; BDBM50218532
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44341053
TTD: D0AX7B
 Compound Name 7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one Investigative [18]
Synonyms
CHEMBL127351; SCHEMBL7365180; HWZHDGRMABBYOV-UHFFFAOYSA-N; BDBM50222367; 7-((1,1'-biphenyl)-3-yloxy)-1-(1 ,3-oxazol-2-yl)-1-heptanone
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44350718
TTD: D0B2ZJ
 Compound Name 6-Mercapto-hexanoic acid phenylamide Investigative [13]
Synonyms
CHEMBL109654; Hexanamide, 6-mercapto-N-phenyl-; SCHEMBL14254925; BDBM50027600
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11436024
TTD: D0B3ZM
 Compound Name Cyclostellettamine derivative Investigative [21]
Synonyms
CHEMBL88332
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MOA Inhibitor
External Link
CID: 23327627
TTD: D0C0VP
 Compound Name N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide Investigative [10]
Synonyms
CHEMBL139999; SCHEMBL1232700; BDBM50082661; ZINC13472309
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9943996
TTD: D0C2KD
 Compound Name 5-Mercapto-pentanoic acid phenylamide Investigative [13]
Synonyms
N-Phenyl-5-mercaptovaleramide; CHEMBL114344; Pentanamide, 5-mercapto-N-phenyl-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11608171
TTD: D0D2KE
 Compound Name Octanedioic acid hydroxyamide pyridin-2-ylamide Investigative [19]
Synonyms
SCHEMBL8090513; CHEMBL164872; ZINC13472303
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11747496
TTD: D0E8KR
 Compound Name N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide Investigative [15]
Synonyms
CHEMBL193979
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44401305
TTD: D0F0KS
 Compound Name 2-(methylsulfonylthio)ethyl 2-propylpentanoate Investigative [20]
Synonyms
CHEMBL271677; SCHEMBL4156413
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MOA Inhibitor
External Link
CID: 24759251
TTD: D0H1FZ
 Compound Name (E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one Investigative [18]
Synonyms
CHEMBL126465; SCHEMBL7368197; SCHEMBL7368201
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MOA Inhibitor
External Link
CID: 44350655
TTD: D0KE3I
 Compound Name N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide Investigative [16]
Synonyms
SCHEMBL676080
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MOA Inhibitor
External Link
CID: 11312563
TTD: D0QO0L
 Compound Name N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide Investigative [16]
Synonyms
N-hydroxy-4-(3-phenylpropanamido)benzamide
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MOA Inhibitor
External Link
TTD: D0R4BS
 Compound Name N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide Investigative [16]
Synonyms
SCHEMBL7311087
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MOA Inhibitor
External Link
CID: 11472431
TTD: D0R5VG
 Compound Name 8-Oxo-8-phenyl-octanoic acid Investigative [19]
Synonyms
8-Oxo-8-phenyloctanoic acid; 7-Benzoylheptanoic acid; 24314-23-6; Benzeneoctanoic acid, h-oxo-; 7-BENZOYL HEPTANOIC ACID; AC1L6TSB; SCHEMBL3381106; 8-keto-8-phenyl-caprylic acid; CHEMBL162423; 8-Oxo-8-phenyloctanoic acid #; CTK4F3363; DTXSID40305602; UMCSRRHQLAVYRS-UHFFFAOYSA-N; ZINC2168376; 7009f; NSC171230; AKOS016022495; NSC-171230; MCULE-7202530747; ACM24314236; ST50825837
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MOA Inhibitor
External Link
CID: 298878
TTD: D0RU1X
 Compound Name N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide Investigative [16]
Synonyms
CHEMBL143336; 656261-24-4; SCHEMBL674421; CTK1J6157; DTXSID30433908; ZINC13533300; AKOS030583673; n-hydroxy-4-(4-phenylbutyryl-amino)benzamide; Benzenebutanamide, N-[4-[(hydroxyamino)carbonyl]phenyl]-
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MOA Inhibitor
External Link
CID: 9994848
TTD: D0S7WQ
 Compound Name 6-phenylsulfanylhexanoic acid hydroxamide Investigative [14]
Synonyms
Hexanamide, N-hydroxy-6-(phenylthio)-; CHEMBL203028; SCHEMBL7317658
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MOA Inhibitor
External Link
CID: 11637291
TTD: D0S9JF
 Compound Name ST-2987 Investigative [11]
Synonyms
CHEMBL471042; SCHEMBL3444989; SCHEMBL3444984; BDBM50278220
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MOA Inhibitor
Activity IC50 = 2040 nM
External Link
CID: 44138032
TTD: D0T0SK
 Compound Name 7-Mercapto-heptanoic acid quinolin-3-ylamide Investigative [13]
Synonyms
CHEMBL112234
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MOA Inhibitor
External Link
CID: 10379373
TTD: D0T4IY
 Compound Name 5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide Investigative [22]
Synonyms
CHEMBL84288
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MOA Inhibitor
External Link
CID: 11528707
TTD: D0V2ZO
 Compound Name 8-Mercapto-octanoic acid phenylamide Investigative [13]
Synonyms
8-mercapto-N-phenyloctanamide; CHEMBL326433; ZINC13609343
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MOA Inhibitor
External Link
CID: 11149404
TTD: D0XZ9Q
 Compound Name N-(6-Hydroxycarbamoyl-hexyl)-benzamide Investigative [19]
Synonyms
CHEMBL57107; 174664-71-2; SCHEMBL573254; CTK0A7470; DTXSID00433435; BDBM50220823; ZINC13490043; 7-(Benzoylamino)heptanehydroxamic acid; AKOS030580013; Benzamide, N-[7-(hydroxyamino)-7-oxoheptyl]-
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MOA Inhibitor
External Link
CID: 9965141
TTD: D0YY9M
 Compound Name 7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one Investigative [10]
Synonyms
CHEMBL326529; SCHEMBL7365237; BDBM50217957
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MOA Inhibitor
External Link
CID: 44342825
TTD: D0Z3BM
 Compound Name 7-Mercapto-heptanoic acid benzothiazol-2-ylamide Investigative [13]
Synonyms
CHEMBL178779
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MOA Inhibitor
External Link
CID: 11346934
TTD: D0Z5KX
 Compound Name N-Hydroxy-4-(pentanoylamino-methyl)-benzamide Investigative [17]
Synonyms
CHEMBL143102
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MOA Inhibitor
External Link
CID: 44361923
TTD: D0Z7YS
 Compound Name PSAMMAPLIN A Investigative [10]
Synonyms
110659-91-1; Bisprasin; NSC614495; AC1O46WI; SCHEMBL364511; ZINC150352860; NSC-614495; B723735K022; J-002461; Benzenepropanamide, N,N'-(dithiodi-2,1-ethanediyl)bis(3-bromo-4-hydroxy-alpha-(hydroxyimino)-
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MOA Inhibitor
External Link
CID: 6400741
TTD: D0N0TS
References
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Ref 2 HDAC inhibitors: a 2013-2017 patent survey. Expert Opin Ther Pat. 2018 Apr 19:1-17. doi: 10.1080/13543776.2018.1459568. Online ahead of print.
Ref 3 Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8.
Ref 4 Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. Bioorg Med Chem Lett. 2008 May 1;18(9):2982-4.
Ref 5 Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues. J Med Chem. 2010 Jun 24;53(12):4654-67.
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Ref 7 Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhib... J Med Chem. 2007 Nov 1;50(22):5425-38.
Ref 8 Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod. 2013 Nov 22;76(11):2026-33. doi: 10.1021/np400198r. Epub 2013 Oct 28.
Ref 9 Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol. 2013 May;9(5):319-25. doi: 10.1038/nchembio.1223. Epub 2013 Mar 24.
Ref 10 Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. doi: 10.1021/jm0303094.
Ref 11 N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. doi: 10.1016/j.bmcl.2009.02.029. Epub 2009 Feb 12.
Ref 12 Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells. J Med Chem. 2002 Jul 18;45(15):3296-309. doi: 10.1021/jm0208119.
Ref 13 Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J Med Chem. 2005 Feb 24;48(4):1019-32. doi: 10.1021/jm049207j.
Ref 14 Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. doi: 10.1021/jm051010j.
Ref 15 Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72. doi: 10.1016/j.bmcl.2005.02.075.
Ref 16 Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. doi: 10.1021/jm0503749.
Ref 17 Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. doi: 10.1021/jm0303655.
Ref 18 Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. doi: 10.1016/j.bmcl.2003.09.007.
Ref 19 Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. doi: 10.1021/jm015568c.
Ref 20 New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. doi: 10.1016/j.bmcl.2008.02.007. Epub 2008 Feb 8.
Ref 21 Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. Bioorg Med Chem Lett. 2004 May 17;14(10):2617-20. doi: 10.1016/j.bmcl.2004.02.062.
Ref 22 Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. Bioorg Med Chem Lett. 2004 May 17;14(10):2477-81. doi: 10.1016/j.bmcl.2004.03.012.