m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05651
|
[1] | |||
m6A modification
MIR155
MIR155
FTO
Demethylation
 : m6A sites
Direct
Inhibition
Non-coding RNA
pri-miR-155
Regulated Target
lncRNA miRNA circRNA
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Fat mass and obesity-associated protein (FTO) | ERASER | |||
| m6A Target | microRNA 155 (MIR155) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | MicroRNA 155 (MIR155) | microRNA | View Details | ||
| Crosstalk Relationship | m6A → ncRNA | Inhibition | |||
| Crosstalk Mechanism | m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA | ||||
| Crosstalk Summary | Downregulation of FTO expression contributes to increased m6A RNA modification of microRNA 155 (MIR155) in cerebral I/R injury. | ||||
| Responsed Disease | Traumatic brain injury induced by controlled cortical impact injury | ICD-11: NA07 | |||
| Pathway Response | MAPK signaling pathway | hsa04010 | |||
| Cell Process | Cell proliferation | ||||
| Cell differentiation | |||||
| Cell invasion | |||||
| Cell apoptosis | |||||