m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05643
|
[1] | |||
m6A modification
Circ_MPP1
Circ_MPP1
YTHDC1
 : m6A sites
Direct
Inhibition
Non-coding RNA
circMPP1
Regulated Target
lncRNA miRNA circRNA
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | YTH domain-containing protein 1 (YTHDC1) | READER | |||
| m6A Target | Circ_MPP1 | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | Circ_MPP1 | circRNA | View Details | ||
| Crosstalk Relationship | m6A → ncRNA | Inhibition | |||
| Crosstalk Mechanism | m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA | ||||
| Crosstalk Summary | the m6A "reader" protein YTHDC1 was found to reduce Circ_MPP1 expression via m6A modification. In conclusion, this study demonstrates that YTHDC1 maintains trophoblasts function by promoting degradation of m6A-mediated circMPP1. | ||||
| Responsed Disease | Disorders of newborn related to slow fetal growth or fetal malnutrition | ICD-11: KA20.1 | |||
| Pathway Response | AMPK signaling pathway | hsa04152 | |||
| Cell Process | Cell migration | ||||
In-vitro Model |
JEG-3 | Gestational choriocarcinoma | Homo sapiens | CVCL_0363 | |