m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT05642			[1]
m⁶A modification Circ_RERE Circ_RERE YTHDF2 : m⁶A sites Direct Inhibition Non-coding RNA CircRERE miR-195-5p lncRNA miRNA circRNA
m6A Regulator	YTH domain-containing family protein 2 (YTHDF2)		READER	Regulator Info
m6A Target	Circ_RERE			Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	Non-coding RNA (ncRNA)
Epigenetic Regulator	Circ_RERE		circRNA	View Details
Regulated Target	hsa-miR-195-5p			View Details
Crosstalk Relationship	m6A → ncRNA		Inhibition
Crosstalk Mechanism	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary	Circ_RERE expression is downregulated in human osteoarthritis (OA) cartilage and chondrocytes, and circRERE downregulation is likely attributed to its increased m6A modification prone to endoribonucleolytic cleavage by YTHDF2-HRSP12-RNase P/MRP. Mechanistically, circRERE downregulation leads to aberrant beta-catenin ubiquitin and degradation by targeting hsa-miR-195-5p/IRF2BPL during OA pathogenesis.
Responsed Disease	Osteoarthritis	ICD-11: FA05		Disease Info
Responsed Drug	ICG-001			Drug Info
Cell Process	Cell apoptosis

References

Ref 1	N(6) -methyladenosine-modified circRNA RERE modulates osteoarthritis by regulating beta-catenin ubiquitination and degradation. Cell Prolif. 2023 Jan;56(1):e13297. doi: 10.1111/cpr.13297. Epub 2022 Jun 22.