m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05587
|
[1] | |||
m6A modification
MIR182
MIR182
METTL3
Methylation
 : m6A sites
Direct
Enhancement
Non-coding RNA
miR-182
Regulated Target
lncRNA miRNA circRNA
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | miR-182 | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | MiR-182 | microRNA | View Details | ||
| Crosstalk Relationship | m6A → ncRNA | Enhancement | |||
| Crosstalk Mechanism | m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA | ||||
| Crosstalk Summary | METTL3 promoted cell proliferation, migration, invasion and tumorigenesis in PCa. METTL3 upregulating the level of m6A, and interacted with DGCR8 to recognize the m6A modification of pre-miR-182 to regulate its splicing and maturation and promote the high expression of miRNA. | ||||
| Responsed Disease | Prostate cancer | ICD-11: 2C82 | |||
| Cell Process | Cell proliferation | ||||
| Cell invasion | |||||
| Cell migration | |||||
In-vitro Model |
DU145 | Prostate carcinoma | Homo sapiens | CVCL_0105 | |
| LNCaP | Prostate carcinoma | Homo sapiens | CVCL_0395 | ||
| VCaP | Prostate carcinoma | Homo sapiens | CVCL_2235 | ||
| PC-3 | Prostate carcinoma | Homo sapiens | CVCL_0035 | ||
| WPMY-1 | Normal | Homo sapiens | CVCL_3814 | ||
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
| 2C82: Prostate cancer | 1 Compound(s) Regulating the Disease | Click to Show/Hide the Full List | ||
 Compound Name |
CC-94676 | Phase 1 | [2] | |
|---|---|---|---|---|
| External Link | ||||
References