m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05554
 [1]
m6A modification hsa-miR-143-3p hsa-miR-143-3p METTL3 Methylation : m6A sites Direct Enhancement Non-coding RNA miR-143-3p PRKCE  lncRNA       miRNA   circRNA
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target hsa-miR-143-3p
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator hsa-miR-143-3p microRNA View Details
Regulated Target Protein kinase C epsilon (PRKCE) View Details
Crosstalk Relationship m6A  →  ncRNA Enhancement
Crosstalk Mechanism m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary METTL3 promoted DGCR8 binding to pri-miR-143-3p through m6A modification, thus enhancing hsa-miR-143-3p expression to inhibit Protein kinase C epsilon (PRKCE) transcription and further aggravating cardiomyocyte pyroptosis and MI/R injury.
Responsed Disease Ischemic heart disease ICD-11: BA40-BA6Z
 Disease Info 
Cell Process Pyroptosis
In-vitro Model
 H9c2(2-1) Normal Rattus norvegicus CVCL_0286
In-vivo Model The thoracic cavity of rats was exposed, and the left anterior descending coronary artery was ligated with a 6-0 silk thread. Successfully surgical MI could be observed, with myocardium color fading and pulse weakening. After 30 min of ischemia, the blood flow was restored by releasing the slipknot, and then 120-min perfusion was performed. Afterward, the thoracic cavity of rats was sutured. The rats were assigned into 4 groups, with 12 rats in each group. Lentivirus packaged short hairpin (sh)-negative control (NC) and sh-METTL3 (GenePharma, Shanghai, China) were injected into the rats via tail vein 24 h before operation. The titer of lentivirus was 1 × 109 TU/mL, and the injection rate was 0.2 ul/min for 10 min. Blood samples were collected 24 h after reperfusion.
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Protein kinase C epsilon (PRKCE) 32 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Meprobamate Approved [2]
Synonyms
Meprospan; Meprobamat; Equanil; Miltown; Amepromat; Meprocompren; Meproban; Tranmep; Meprobam; Dapaz; Metractyl; Meprotabs; Meprosin; Meprodil; Mepiosine; Libiolan; Crestanil; Calmiren; Ayeramate; Andaksin; Anatimon; Anathylmon; Holbamate; Despasmol; Cirponyl; Biobamat; Neuramate; Metranquil; Meprocon; Mepantin; Lepetown; Ipsotian; Equilium; Equatrate; Carbaxin; Biobamate; Ansiatan; Anastress; Miltamato; Meprotil; Meprotan; Meprosan; Meproleaf; Meprindon; Mepranil; Mepavlon; Margonil; Harmonin; Dicandiol; Calmadin; Auxietil; Anxietil; Ansiowas; Amosene; Andaxin; Aneural; Aneurol; Aneusral; Aneuxal; Aneuxral; Ansietan; Ansil; Anural; Anzil; Apascil; Apasil; Appetrol; Arcoban; Arpon; Artolon; Ataraxine; Atraxin; Ayermate; Bamate; Brobamate; Calmax; Cirpon; Coprobate; Cypron; Cyrpon; Deprol; Diron; Diurnal; Diurnaldiverondormabrol; Diveron; Dormabrol; Ecuanil; Edenal; Enorden; Epicur; Epikur; Equinil; Equitar; Erina; Estasil; Gadexyl; Gagexyl; Hartol; Kessobamate; Klort; Larten; Lepenil; Letyl; Mendel; Mepamtin; Meposed; Mepriam; Meprin; Meprobamato; Meprobamatum; Meprodiol; Meprol; Meprosa; Meprotanum; Meproten; Meprovan; Meprovanmeprozine; Meprozine; Meptran; Meptranactylmilprem; Micrainin; Milpath; Milprem; Miltann; Miltaun; Miltuan; Miltwon; Misedant; Morbam; Multaun; Nephentine; Nervonus; Oasil; Optarket;Orlevol; Orolevol; Pancalma; Panediol; Pankalma; Pathibamate; Paxin; Pensive; Perequietil; Perequil; Perquietil; Pertranquil; Pimal; Placidon; Placitate; Prequil; Probamato; Probamyl; Probate; Procalmadiol; Procalmadol; Procalmidol; Procarbamide; Promate; Promato; Proquanil; Protran; Quaname; Quanane; Quanil; Quietidon; Quivet; Rastenil; Reostral; Restenil; Restenyl; Restinal; Restinil; Robamate;Sadanyl; Scolazil; Sedabamate; Sedanil; Sedanyl; Sedazil; Sedoquil; Sedoselecta; Selene; Seril; Setran; Shalvaton; Sowell; Spantran; Stensolo; Tamate; Tensol; Tensonal; Trancot; Trankvilan; Tranlisant; Tranquilan; Tranquilate; Tranquilax; Tranquiline; Tranquilsan; Tranquinol; Trelmar; Urbil; Urbilat; Vistabamate; Wardamate; Wyseals; Zirpon; Component of Appetrol; Component of Bamadex; Component of Equalysen; Component of Milpath; Component of Milprem; Component of Miltrate; Equanil suspension; Meprobamat [German]; Meprobamate and Aspirin Tablets; Meprobamato [Italian]; Meprobamic acid; Meprocon CMC; Solevione anastress; Bamd 400; Bamo 400; Canquil 400; Miltown 600; PMB 200; PMB 400; Apo-Meprobamate; Appetrol-Sr; Canquil-400; Component of PMB-400; Equanil (TN); Equazine-M; Fas-Cile; Fas-Cile 200; Kesso-Bamate; Mar-Bate; Meprin (VAN); Mepro-Aspirin; Mepro-analgesic; Meprobamato [INN-Spanish]; Meprobamatum [INN-Latin]; Meprospan (TN); Meprospan-200; Meprospan-400; Milprem-200; Milprem-400; Miltown (TN); My-trans; Neo-Tran; PMB-200; PMB-400; Pan-tranquil; Q-Gesic; SK-Bamate; Tranquiline (Intra); Vio-Bamate; Cap-O-Tran; Carbamic acid 2-methyl-2-propyltrimethylene ester; Meprobamate (JAN/USP/INN); Meprobamate [USAN:INN:BAN:JAN]; Carbamic acid, 2-methyl-2-propyltrimethylene ester; [2-(carbamoyloxymethyl)-2-methylpentyl] carbamate; {2-[(carbamoyloxy)methyl]-2-methylpentyl} carbamate; 1,3-Propanediol, 2-methyl-2-propyl-, 1,3-dicarbamate; 1,3-Propanediol, 2-methyl-2-propyl-, dicarbamate; 2,2-Di(carbamoyloxymethyl)pentane; 2-Methyl-2-n-propyl-1,3-propanediol dicarbamate; 2-Methyl-2-propyl-1,3-propanediol dicarbamate; 2-Methyl-2-propylpropane-1,3-diol dicarbamate; 2-Methyl-2-propyltrimethylene carbamate; 2-Metil-2-n-propil-1,3-propanediol dicarbamato; 2-Metil-2-n-propil-1,3-propanediol dicarbamato [Spanish]; 2-[(carbamoyloxy)methyl]-2-methylpentyl carbamate; 3P Bamate; KAI-1455
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MOA Stimulator
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CID: 4064
TTD: D0Y4AW
DrugBank: DB00371
 Compound Name Bryostatin-1 Phase 2 [3]
Synonyms
Bryostatin 1; 83314-01-6
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MOA Activator
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CID: 5280757
TTD: D0E6AH
 Compound Name CDE-6960 Terminated [4]
Synonyms
Protein kinase C epsilon/theta inhibitors (inflammation); PKC epsilon/theta inhibitors (inflammation), Devgen; Protein kinase C epsilon/theta inhibitors (inflammation), Devgen
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MOA Inhibitor
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TTD: D0J7CE
 Compound Name LY-317644 Terminated [5]
Synonyms
CHEMBL294120; BDBM50285193
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MOA Inhibitor
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CID: 15391529
TTD: D0X0HN
 Compound Name RO-320432 Terminated [6]
Synonyms
ro 32-0432; Ro-32-0432; CHEMBL26501; (S)-3-(8-(Dimethylaminomethyl)-6,7,8,9-tetrahydropyrido(1,2-a)indol-10-yl)-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione hydrochloride; (S)-3-(8-((Dimethylamino)methyl)-6,7,8,9-tetrahydropyrido(1,2-a)indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrol-2,5-dione; (S)-3-(8-((Dimethylamino)methyl)-6,7,8,9-tetrahydropyrido(1,2-a)indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione; 151342-35-7; 1H-Pyrrole-2,5-dione, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido(1,2-a)in
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MOA Inhibitor
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CID: 127757
TTD: D0R5ZR
 Compound Name Phorbol 12-myristate Investigative [3]
Synonyms
Phorbol-12-myristate; Phorbol-12-monomyristate; BRN 2319156; (1ar,1bs,4ar,7as,7bs,8r,9r,9as)-4a,7b,9a-trihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1h-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate; 20839-06-9; Tetradecanoic acid, 1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b,9a-trihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa(3,4)benz(1,2-e)azulen-9-yl ester, (1aR-(1a-alpha,1b-beta,4a-beta,7a-alpha,7b-alpha,8-alpha,9-beta,9a-alpha))-
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MOA Activator
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CID: 107854
TTD: D0D4ZL
 Compound Name [2,2':5',2'']Terthiophen-4-yl-methanol Investigative [7]
Synonyms
CHEMBL76100; BDBM50217032
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MOA Inhibitor
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CID: 44313272
TTD: D00TWA
 Compound Name 4-[1-(4-hydroxyphenyl)-3-methyl-1-butenyl]phenol Investigative [8]
Synonyms
Phenol, 4,4'-(3-methyl-1-butenylidene)bis-; 66422-07-9; CHEMBL156843; CTK1J4765; DTXSID70441143; ZINC13650255
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MOA Inhibitor
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CID: 10515117
TTD: D02PUV
 Compound Name 2-(4-Hydroxy-phenyl)-3,3-diphenyl-acrylonitrile Investigative [8]
Synonyms
CHEMBL305128
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MOA Inhibitor
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CID: 14537253
TTD: D02QME
 Compound Name [2,2':5',2'']Terthiophene-4,5''-dicarbaldehyde Investigative [7]
Synonyms
CHEMBL74983; BDBM50217036
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MOA Inhibitor
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CID: 9972316
TTD: D05LRV
 Compound Name Ro-32-0557 Investigative [6]
Synonyms
CHEMBL538718
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MOA Inhibitor
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CID: 44274749
TTD: D09TSC
 Compound Name 3-(4-Hydroxy-phenyl)-2,3-diphenyl-acrylonitrile Investigative [8]
Synonyms
CHEMBL303801
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MOA Inhibitor
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CID: 14537255
TTD: D09XIE
 Compound Name 3,3-Bis-(4-methoxy-phenyl)-2-phenyl-acrylonitrile Investigative [8]
Synonyms
CHEMBL304867
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MOA Inhibitor
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CID: 14537244
TTD: D0A8MN
 Compound Name [2,2':5',2'']Terthiophene-4-carbaldehyde Investigative [7]
Synonyms
CHEMBL73495; BDBM50217040
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MOA Inhibitor
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CID: 44313051
TTD: D0D3MR
 Compound Name 4-cycloheptyliden(4-hydroxyphenyl)methylphenol Investigative [8]
Synonyms
4,4'-(Cycloheptylidenemethylene)diphenol; 4,4'-(Cycloheptylidenemethanediyl)diphenol; 14303-48-1; CHEMBL154947; SCHEMBL3468370; CTK0F0060; DTXSID10469043; XVTAYJKFHUKWSR-UHFFFAOYSA-N; 4,4'-(Cycloheptylidenemethylene)bis(phenol); Phenol, 4-[cycloheptylidene(4-hydroxyphenyl)methyl]-
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MOA Inhibitor
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CID: 11587420
TTD: D0Q3GQ
 Compound Name 2,3,3-Triphenyl-acrylonitrile Investigative [8]
Synonyms
Triphenylacrylonitrile; 2,3,3-Triphenylacrylonitrile; Triphenylcyanoethylene; 6304-33-2; Acrylonitrile, triphenyl-; 2,3,3-triphenylprop-2-enenitrile; alpha,beta-Diphenylcinnamonitrile; ACRYLONITRILE, 2,3,3-TRIPHENYL-; EINECS 228-610-4; NSC 42900; 2,3,3-Trifenylakrylonitril [Czech]; BRN 1980289; alpha-(Diphenylmethylene)benzeneacetic acid; AI3-63069; MLS002608486; CHEBI:34217; Benzeneacetic acid, alpha-(diphenylmethylene)-; NSC42900; Benzeneacetonitrile, .alpha.-(diphenylmethylene)-
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MOA Inhibitor
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CID: 22743
TTD: D0S9UK
 Compound Name 3,3-Bis-(4-hydroxy-phenyl)-2-phenyl-acrylonitrile Investigative [8]
Synonyms
3,3-bis(4-hydroxyphenyl)-2-phenylprop-2-enenitrile; CHEMBL65053
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MOA Inhibitor
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CID: 14537247
TTD: D0T0UH
 Compound Name 4-cyclohexyliden(4-hydroxyphenyl)methylphenol Investigative [8]
Synonyms
4,4'-(cyclohexylidenemethylene)diphenol; 5189-40-2; Cyclofenil diphenol; 4,4'-Cyclohexylidenemethylenediphenol; UNII-00W4083OML; EINECS 225-972-5; BRN 2055864; F 6060; 4-[cyclohexylidene(4-hydroxyphenyl)methyl]phenol; 4-(Cyclohexylidene(4-hydroxyphenyl)methyl)phenol; 00W4083OML; 4,4-Cyclohexylidenemethylenediphenol; Phenol, 4-(cyclohexylidene(4-hydroxyphenyl)methyl)-; alpha-Cyclohexylidene-alpha-(p-hydroxyphenyl)-p-cresol; p-CRESOL, alpha-CYCLOHEXYLIDENE-alpha-(p-HYDROXYPHENYL)-; AC1L2HYB
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MOA Inhibitor
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CID: 21260
TTD: D0V9SW
 Compound Name LY-326449 Investigative [9]
Synonyms
CHEMBL292495; BDBM50052039; 3,4-[[(S)-3-Oxa-4-(hydroxymethyl)hexane-1,6-diyl]bis(1H-indole-1,3-diyl)]-3-pyrroline-2,5-dione
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MOA Inhibitor
Activity IC50 = 79000 nM
External Link
CID: 10455969
TTD: D06ZCX
 Compound Name 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione Investigative [10]
Synonyms
CHEMBL380598; SCHEMBL3148490; HVQJGNALTWNDMX-UHFFFAOYSA-N; BDBM50375058; 2-(1H-Indole-3-yl)-3-phenylmaleimide
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MOA Inhibitor
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CID: 15422868
TTD: D06AOY
 Compound Name 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione Investigative [10]
Synonyms
1H-Pyrrole-2,5-dione, 3,4-bis(4-methoxyphenyl)-; 108774-82-9; ACMC-20mbs9; CHEMBL381099; CTK0G2626; DTXSID90449388
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MOA Inhibitor
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CID: 10946795
TTD: D00NYT
 Compound Name 3,4-diphenyl-1H-pyrrole-2,5-dione Investigative [10]
Synonyms
2,3-diphenylmaleimide; 1H-Pyrrole-2,5-dione, 3,4-diphenyl-; 31295-36-0; AC1MBL6S; SCHEMBL114611; CHEMBL201949; CTK1B9880; 3,4-diphenylpyrrole-2,5-dione; DTXSID70372903; ZINC3847556
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MOA Inhibitor
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CID: 2752461
TTD: D0C3WY
 Compound Name 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione Investigative [10]
Synonyms
CHEMBL372076; SCHEMBL3822337
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MOA Inhibitor
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CID: 11572699
TTD: D0EK0G
 Compound Name RO-316233 Investigative [11]
Synonyms
119139-23-0; bisindolylmaleimide iv; 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-dione; Arcyriarubin A; 3,4-Bis(3-indolyl)maleimide; 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione; UNII-MBK3OO5K8T; BIM IV; 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione; MBK3OO5K8T; CHEMBL266487; 3,4-bis(1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione; DQYBRTASHMYDJG-UHFFFAOYSA-N; 2,3-bis(1H-Indol-3-yl)maleimide; 1H-Pyrrole-2,5-dione, 3,4-di-1H-indol-3-yl-; Ro-31-6233; AK-15401; 3,4-bis(3-indolyl)-1H-pyrrole-2,5-dione; Bisindoylmaleimide; Bisindolyl deriv. 3
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MOA Inhibitor
Activity IC50 = 7516 nM
External Link
CID: 2399
TTD: D0L8HO
 Compound Name BALANOL Terminated [12]
Synonyms
63590-19-2; Azepinostatin; CHEMBL60254; Balanol, 1; 2-[2,6-dihydroxy-4-[(3R,4R)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acid; BA1; (-)-Balanol; (3R-trans)-Balanol; AC1NRA6W; SCHEMBL62128; MEGxm0_000504; GTPL8142; BDBM3149; Acyclic Balanol Analog (-)-1; BDBM36607; ACon0_001438; ZINC3871640; MCULE-9310625171; 167937-47-5; FT-0662471; 33879-EP2275420A1; 33879-EP2295416A2; 33879-EP2295055A2; 33879-EP2311453A1; 33879-EP2305642A2; 33879-EP2298764A1; 33879-EP2298765A1; 33879-EP2298748A2
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Activity IC50 = 10 nM
External Link
CID: 5287736
TTD: D0R2TM
 Compound Name ISIS 7942 Investigative [12]
External Link
TTD: D02VLL
 Compound Name ISIS 7948 Investigative [12]
External Link
TTD: D09RFD
 Compound Name chelerythrine Investigative [12]
Synonyms
broussonpapyrine; cheleritrine; chelerythrine hydroxide; toddalin
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External Link
CID: 2703
TTD: D0T9ZL
 Compound Name 8-Octyl-benzolactam-V9 Investigative [12]
Synonyms
CHEMBL206866; 8-Octylbenzolactam-V9
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Activity Ki = 510 nM
External Link
CID: 11574614
TTD: D04AXH
 Compound Name PROSTRATIN Investigative [12]
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CID: 454217
TTD: D04JNZ
 Compound Name Bisindolylmaleimide-I Investigative [12]
Synonyms
Bisindolylmaleimide i; 133052-90-1; GF 109203X; GF109203X; Go 6850; GF-109203X; RBT205 INHIBITOR; Go-6850; UNII-L79H6N0V6C; Bisindolylmaleimide I (GF 109203X); CHEMBL7463; 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE; 3-(1-(3-(Dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; L79H6N0V6C; QMGUOJYZJKLOLH-UHFFFAOYSA-N; 2-[1-(3-dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl)maleimide; GF-109203; Go6850
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Activity IC50 = 12 nM
External Link
CID: 2396
TTD: D0TO6S
DrugBank: DB03777
 Compound Name RO-316233 Investigative [11]
Synonyms
119139-23-0; bisindolylmaleimide iv; 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-dione; Arcyriarubin A; 3,4-Bis(3-indolyl)maleimide; 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione; UNII-MBK3OO5K8T; BIM IV; 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione; MBK3OO5K8T; CHEMBL266487; 3,4-bis(1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione; DQYBRTASHMYDJG-UHFFFAOYSA-N; 2,3-bis(1H-Indol-3-yl)maleimide; 1H-Pyrrole-2,5-dione, 3,4-di-1H-indol-3-yl-; Ro-31-6233; AK-15401; 3,4-bis(3-indolyl)-1H-pyrrole-2,5-dione; Bisindoylmaleimide; Bisindolyl deriv. 3
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MOA Inhibitor
Activity IC50 = 7516 nM
External Link
CID: 2399
TTD: D0L8HO
BA40-BA6Z: Ischemic heart disease 18 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name GS-6615 Phase 3 [13]
Synonyms
Eleclazine; 1443211-72-0; UNII-PUY08529FK; PUY08529FK; 4-(pyrimidin-2-ylmethyl)-7-(4-(trifluoromethoxy)phenyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one; Eleclazine [INN]; Eleclazine [USAN:INN]; Eleclazine (USAN/INN); Eleclazine(GS-6615); GTPL8413; CHEMBL3707392; SCHEMBL14480722; MolPort-044-723-855; YNUAEEJQYHYLMS-UHFFFAOYSA-N; GS6615; ZINC206191652; AKOS030627706; DB12394; SB19622; KS-000006B4; 1,4-Benzoxazepin-5(2H)-one, 3,4-dihydro-4-(2-pyrimidinylmethyl)-7-(4-(trifluoromethoxy)phenyl)-; AS-35245; J3.563.176C
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CID: 71183216
TTD: D0A4UC
DrugBank: DB12394
 Compound Name CHS-0214 Phase 3 [14]
External Link
TTD: D05FOF
 Compound Name Autologous endothelial progenitor cell therapy Phase 2/3 [15]
Synonyms
Autologous endothelial progenitor cell therapy (ischemia); Autologous endothelial progenitor cell therapy (ischemia), IBRI; Autologous stem cell therapy (critical limb ischemia), IBRI; Autologous CD34+ cells (peripheral vascular disease), IBRI
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TTD: D0P1SA
 Compound Name AC-607 Phase 2 [16]
Synonyms
NG-0711; Adult mesenchymal stem cell therapy (acute kidney injury), AlloCure; Multipotent stromal cell therapy (acute renal injury), AlloCure
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External Link
CID: 11414137
TTD: D05MHI
 Compound Name Allogeneic/autologous adult mesenchymal stem cell therapy Phase 1/2 [17]
External Link
TTD: D02XXW
 Compound Name Bone marrow stem cell therapy Phase 1 [18]
Synonyms
Bone marrow stem cell therapy (congestive cardiomyopathy)
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External Link
TTD: D05SJK
 Compound Name CRE-319M2 Discontinued in Phase 1 [19]
External Link
TTD: D0U7CO
 Compound Name REN-1053 Terminated [20]
External Link
TTD: D0WR7U
 Compound Name Zn-DPA-H Investigative [21]
Synonyms
Heart ischemia imaging agent, Molecular Targeting Technology
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External Link
TTD: D0W9ZS
 Compound Name Anti-miR-199a oligonucleotides Investigative [21]
Synonyms
Anti-miR-199a oligonucleotides (ischemic heart disease)
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TTD: D0S7HW
 Compound Name DX-2500 Investigative [22]
Synonyms
Anti-FcRn antibody (autoimmune disorder), Dyax Corp
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External Link
TTD: D0R3KS
 Compound Name MCP-205 Investigative [23]
Synonyms
Delta opioid receptor agonist (cardiac ischemia), Mt Cook Pharma
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External Link
TTD: D0O7NF
 Compound Name TAT-120 Investigative [24]
Synonyms
MIP-120, Vasade; Peptide mammalian sterile 20-like kinase 1 inhibitors (ischemic heart disease); Peptide Mst-1 inhibitors (ischemia), Vasade; Peptide mammalian sterile 20-like kinase 1 inhibitors (ischemic heart disease), Vasade
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External Link
TTD: D0A7HY
 Compound Name FHT-1106 Investigative [21]
External Link
TTD: D08UXQ
 Compound Name Leonurine Investigative [21]
Synonyms
SCM-198
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CID: 161464
TTD: D08KHD
 Compound Name NK-111 Investigative [21]
Synonyms
Cardioprotectant (cardiac ischemia), Nara Biosciences; Myokine (cardiac ischemia), Nara Biosciences
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TTD: D07KYK
 Compound Name EP-94 Investigative [21]
Synonyms
Peptide enkephalin analogs (acute myocardial ischemia), Eribis; Opioid receptor modulator (repurfusion injury/myocardial infraction/ischemic heart disease), Eribis Pharmaceuticals
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TTD: D02ZWJ
 Compound Name MGN-7455 Investigative [21]
Synonyms
Anti-miR-199 therapeutic (ischemic heart disease), miRagen Therapeutics
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TTD: D00YNK
References
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Ref 3 Protein kinase epsilon dampens the secretory response of model intestinal epithelia during ischemia. Surgery. 2001 Aug;130(2):310-8.
Ref 4 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025002)
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Ref 8 Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83.
Ref 9 (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta. J Med Chem. 1996 Jul 5;39(14):2664-71. doi: 10.1021/jm950588y.
Ref 10 Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. doi: 10.1021/jm0580297.
Ref 11 Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84. doi: 10.1021/jm00079a024.
Ref 12 TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751.
Ref 13 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8413).
Ref 14 ClinicalTrials.gov (NCT02115750) Comparison of CHS-0214 to Enbrel (Etanercept) in Patients With Rheumatoid Arthritis (RA). U.S. National Institutes of Health.
Ref 15 MyoCell, a cell-based, autologous skeletal myoblast therapy for the treatment of cardiovascular diseases. Curr Opin Mol Ther. 2008 Dec;10(6):611-21.
Ref 16 ClinicalTrials.gov (NCT01602328) A Study to Evaluate the Safety and Efficacy of AC607 for the Treatment of Kidney Injury in Cardiac Surgery Subjects. U.S. National Institutes of Health.
Ref 17 Mesenchymal stem cells: a new trend for cell therapy. Acta Pharmacol Sin. 2013 Jun;34(6):747-54.
Ref 18 Clinical pipeline report, company report or official report of Texas Heart Institute.
Ref 19 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010576)
Ref 20 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000247)
Ref 21 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
Ref 22 Fully Human Monoclonal Antibody Inhibitors of the Neonatal Fc Receptor Reduce Circulating IgG in Non-Human Primates. Front Immunol. 2015; 6: 176.
Ref 23 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317).
Ref 24 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2225).