m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT05486			[1]
m⁶A modification XIST XIST METTL3 Methylation : m⁶A sites Direct Enhancement Non-coding RNA XIST miR-302a-3p lncRNA miRNA circRNA
m6A Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
m6A Target	X inactive specific transcript (XIST)			Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	Non-coding RNA (ncRNA)
Epigenetic Regulator	X inactive specific transcript (XIST)		LncRNA	View Details
Regulated Target	hsa-miR-302a-3p			View Details
Crosstalk Relationship	m6A → ncRNA		Enhancement
Crosstalk Mechanism	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary	METTL3 regulates ossification of the posterior longitudinal ligament via the lncRNA X inactive specific transcript (XIST)/hsa-miR-302a-3p/USP8 axis.
Responsed Disease	Ossification of spinal ligaments	ICD-11: FA83		Disease Info
Cell Process	Cell differentiation
In-vitro Model	Human primary ligament fibroblasts (Ligaments were dissected from a non-ossified site)

References

Ref 1	METTL3 Regulates Ossification of the Posterior Longitudinal Ligament via the lncRNA XIST/miR-302a-3p/USP8 Axis. Front Cell Dev Biol. 2021 Mar 5;9:629895. doi: 10.3389/fcell.2021.629895. eCollection 2021.